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유해연(Yoo, Hae-Yeon),손태진(Son, Tae-Jin),송준엽(Song, Jun-Yeop),양지원(Yang, Ji-Won) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.1
This study is suggestion of the improvement direction of piloti space for the deteriorated low-rise residential block. Finally, this study suggests that the new community space in low-rise hosing block. The conclusions is as follows, first, previous case study and regulation related to the programs of piloti space were reviewed. Second, improvement points were obtained through the interview with residents. Third, module types of piloti space were classified. Lastly, think about various materials and test-bed.
노후 저층주거지 근린재생을 위한 필로티 하부공간 개선방향
유해연(Yoo, Hae-Yeon),손태진(Son, Tae-Jin),송준엽(Song, Jun-Yeop) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.1
This study is suggestion of the improvement direction for neighborhood regeneration of deteriorated low-rise residential block, and classified types of piloti space of multiplex housing. It is to find a way to utilize piloti space in the future. For this suggestion, first, previous study and regulation related to the plan of piloti space were reviewed. Second, improvement points were obtained through the interview with residents after selecting the site. Third, types of piloti space were classified.
김광연,이승진,지선영,배수진,송유림,윤언정,박선빈,송종국,손태진,손재동,김우현,양주혜,박선동,김상찬,김영우,박광일,Kim, Kwang Yeon,Lee, Seung Jin,Jee, Seon Young,Bae, Su Jin,Song, Yu Rim,Yun, Un-Jung,Bak, Seonbeen,Song, Jong Kuk,Son, Tae Jin,Son, Jae- 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.2
Objectives : This study investigated cellular-protective effects of Nardotidis seu Sulculii Concha water extract (NSCE) against oxidative stress induced by arachidonic acid (AA)+iron or tert-butylhydroperoxide (tBHP). Methods : In vitro, MTT assay was assessed for cell viability, and immunoblotting analysis was performed to detect expression of AMP-activated kinase (AMPK) signaling pathway and autophagy related proteins. In vivo, mice were orally administrated with the aqueous extract of NSCE of 500 mg/kg for 3 days, and then injected with CCl<sub>4</sub> 0.5 mg/kg body weight to induce acute damage. The level of liver damage was measured by serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) analysis. Results : Treatment with NSCE inhibited cell death induced by AA+iron and tBHP. NSCE induced the phosphorylation of AMPK, and this compound also induced the phosphorylation of LKB1, an upstream kinase of AMPK, and Acetyl-CoA carboxylase (ACC), a primary downstream target of AMPK. NSCE increased the protein levels of autophagic markers (LC3II and beclin-1) and decreased the phosphorylation of mammalian target of rapamycin (mTOR) and simultaneously increased the phosphorylation of unc-51-like kinase-1 (ULK-1) in time-dependent manner. Conclusions : NSCE has the ability 1) to protect cells against oxidative stress induced by AA+iron or tBHP. NSCE 2) to activate AMP-activated protein kinase (AMPK), and 3) to regulate autophagy, an important regulator in cell survival.
손태진,김소희,박건영 부산대학교 김치연구소 1998 김치의 과학과 기술 Vol.4 No.-
The antimutagenic acitivities of cell body of several lactic acid bacteria (LAB) isolated from kimchi were studied using the methods of Ames mutagenicity test and SOS chromotest. The mutagenicities mediated by 4-nitroquinoline-l-oxide (4-NQO), 2-amino3,4-dimethyl-imidazo (4, 5-f) quinoline (MeIQ), and 3-amino-l-methyl-5H-pyrido[4,3-b] indole (Trp-P2) were effectively supressed by LAB in both tests. However, the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was not markedly inhibited by LAB preparation. Cell body of Leuconostoc mesenteroides exhibited higher antimuatagenic activity on 4-NQO, MeIQ, MNNG than LABs from other lactic acid bacteria. Pediococcus acidilactici was not effective on direct mutagens (4-NQO, MNNG), but the antimatagenic effect on MeIQ and Trp-P2 were similar to those of other LAB preparations. In this study, LAB from kimchi (Leuconostoc mesenteroides, Lactobacillus brevis, Lactobacillus fermentum, Lactobacillus plantarum, Pediococcos acidilactici) revealed high capability of prevention of the mutation induced by 4-NQO, MeIQ and Trp-P2 as much as (or higher than) Lactobacillus acidophillus from yogurt, regardless of their viability. These results suggested that lactic acid bacteria in kimchi might have the cancer preventive function.