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      • KCI등재

        아세테이트 직물의 NaOH 처리시 무기염 첨가에 따른 영향

        성종미,김혜림,송화순 한국의류산업학회 2005 한국의류산업학회지 Vol.7 No.1

        The effect of sodium acetate to reduce the fiber damage and hardening of acetate fabrics during alkaline treatment is studied. The optimal condition is controlled concentration 2%, at 50°C for 6 minutes and at 70°C for 2 minutes through the result of weight loss, shrinkage and tensile strength. Alkaline treated acetate fabrics under optimal condition show softer than untreated acetate fabrics. Alkaline treatment with sodium acetate brings the reduction in hardening and shrinkage in internal fiber of acetate fabric. Also, alkaline treatment with sodium acetate improves the tensile strength of acetate fabrics compared with only alkaline treatment. The moisture regain of acetate fabrics is also improved by alkaline treatment under optimal condition.

      • KCI등재

        Comparison of the Safety of Seven Iodinated Contrast Media

        성종미,최남경,이중엽,장유수,김예지,양보람,Xue-Mei Jin,김주영,박병주 대한의학회 2013 Journal of Korean medical science Vol.28 No.12

        We aimed to determine the characteristic adverse events (AEs) of iodinated contrast media (IOCM) and to compare the safety profiles of different IOCM. This study used the database of AEs reports submitted by healthcare professionals from 15 Regional Pharmacovigilance Centers between June 24, 2009 and December 31, 2010 in Korea. All reports of IOCM, including iopromide, iohexol, iopamidol, iomeprol, ioversol, iobitridol and iodixanol, were analyzed. Safety profiles were compared between different IOCM at the system organ level using the proportional reporting ratio (PRR) and 95% confidence interval (95% CI). Among a total of 48,261 reports, 6,524 (13.5%) reports were related to the use of IOCM. Iopromide (45.5%), iohexol (16.9%), iopamidol (14.3%) and iomeprol (10.3%) were identified as frequently reported media. ‘Platelet, bleeding & clotting disorders’ (PRR, 29.6; 95%CI, 1.9-472.6) and ‘urinary system disorders’ (PRR, 22.3; 95% CI, 17.1-29.1) were more frequently reported for iodixanol than the other IOCM. In conclusion, the frequency of AEs by organ class was significantly different between individual media. These differences among different IOCM should be considered when selecting a medium among various IOCM and when monitoring patients during and after its use to ensure optimum usage and patient safety.

      • KCI등재

        세계보건기구 및 미국 FDA의 최신 약물감시체계 발전방향

        성종미 ( Jong Mi Seong ),박병주 ( Byung Joo Park ) 대한보건협회 2015 대한보건연구 Vol.41 No.2

        Objective: Pharmacovigilance(PV) aims to improve patient safety and welfare by reducing the risks of medicines, through the detection, assessment, understanding and prevention of adverse effects and other drug related problems. This study aimed to introduce recent advance in PV activities of World Health Organization (WHO) and U.S. Food and Drug Administration (FDA). Methods: Information on recent PV activities of WHO and U.S. FDA were collected and reviewed through lectures and educational materials by WHO-Uppsala Monitoring Centre (UMC)’s staffs and U.S. FDA’s staffs in the 16th international training course of WHO-UMC. Results: PV has seen rapid growth over the past decade and will continue to develop in response to the special needs. To support country for developing the stronger national systems of PV and adverse drug reaction (ADR) reporting, WHO has developed PV indicators that provide the standard of PV system. PV in principle involves the identification and evaluation of ADR signals. WHO-UMC has an intensified interest in the application of more advanced analysis methods to signal detection in PV. U.S. FDA build the process of postmarketing evaluation of new data on new molecular entities for the early release of safety information and post the summary information on the results of evaluation. Conclusion: To advance PV system in Korea, it will be good to benchmark these recent activities of WHO and U.S. FDA

      • KCI등재
      • KCI등재
      • KCI등재

        지역약국 약사의 처방중재 활동 평가

        구현지,성종미,정선영,정경혜 한국임상약학회 2024 한국임상약학회지 Vol.34 No.1

        Background: Drug-related problems have the potential to threaten patient health, and pharmacists are in a position to prevent such problems through prescription reviews and patient counseling, actively engaging in pharmaceutical care activities. This study aims to categorize and analyze the intervention activities of pharmacists in community pharmacies concerning drug-related problems, following international criteria. Methods: Over a six-month period, prescription interventions completed in a community pharmacy in Seoul were selected as the research subjects. The causes of interventions were classified according to the Pharmaceutical Care Network Europe (PCNE) drug-related problems (DRPs) classification system and the types and frequencies of DRPs were identified. Results: Among a total of 49,334 prescriptions, 527 interventions were completed, constituting approximately 1.07% of the daily average filled prescriptions. Individuals over 60 years of age represented more than 50%. The primary cause of DRPs was prescribing and drug selection issues, comprising 256 cases (48.58%), with specific subcategories including 109 cases of drug selection, 79 cases of treatment duration errors, 47 cases of dose selection, and 21 cases of inappropriate dosage form selection. Patient-related issues accounted for 204 cases (38.71%). Conclusion: The study demonstrated that the pharmacists’ intervention in community pharmacies contributes to the safe use of medication by patients.

      • KCI등재

        양성전립선비대증 증상 조절을 위해 투여되는 알파차단제의 골절위헙

        이중엽,최남경,정선영,김예지,성종미,오승준,박병주,Lee, Joong-Yub,Choi, Nam-Kyoung,Jung, Sun-Young,Kim, Ye-Jee,Seong, Jong-Mi,Oh, Seung-June,Park, Byung-Joo 대한예방의학회 2009 예방의학회지 Vol.42 No.3

        Objectives : We evaluated the risk of fracture associated with hypotension-related adverse drug reaction caused by taking alpha blockers to treat benign prostatic hyperplasia (BPH). Methods : We used the Health Insurance Review and Assessment Service database from January 1st 2005 to June 30th 2006 for this study. The male patients with BPH and who had a prescription for alpha blockers following any fractures were defined as the cases. We set the 20 day long hazard period prior to the index date and the four control periods whose lengths were same with hazard period. After 1:4 matching of the hazard and control periods, conditional logistic regression was used to calculate the odds ratios for the risk of fractures as related to the alpha blocker exposure. Results : Doxazosin and tamsulosin showed the increased risk of fractures, whereas terazosin did not. After stratification using the defined daily doses, a protective effect was shown for the patients who took terazosin at the doses lower than 0.4 DDD and the hazardous effect at the doses higher than or equal to 0.4 DDD. There was no significant difference for the risk of patients taking tamsulosin at the doses higher than 1.0 DDD but there was a statistically significant increase in the risk at the doses higher than or equal to 1.0 DDD. Conclusions : Alpha blockers for BPH may increase the risk of fracture in elderly patients who have comorbidities and take the concomitant medications. Alpha blockers need to be prescribed with caution, although some have high prostate specificity.

      • KCI등재

        의약품 정보 제공 용어의 이해도 평가: 당뇨 및 천식 처방약과 안전상비약을 중심으로

        이승미 ( Seung-mi Lee ),성종미 ( Jong-mi Seong ),송종화 ( Jong-hwa Song ),서동철 ( Dong-churl Suh ) 대한보건협회 2016 대한보건연구 Vol.42 No.4

        연구목적 : 본 연구는 의약품과 관련한 정보를 제공하기 위한 복약안내문과 의약품 포장에 다빈도로 포함된 단어가 일반인 수준에서 어느 정도 이해 가능한지 평가하기 위하여 수행되었다. 연구방법 : 응답자의 기본정보와 단어의 이해도를 동시에 측정하는 단면적 연구로 설계하였고, 유의할당표본추출 방식을 이용하여 20세 이상 69세 이하의 서울 지역에 거주하는 일반인 305명을 대상으로 설문조사하였다. 건강보험표본자료에서 당뇨병과 천식에 자주 처방되는 의약품을 추출한 후 복약안내문에서 다빈도로 사용하는 단어 100개를 선별한 세트와 안전상 비약 포장과 설명서에 제시된 다빈도 단어 100개를 선별한 세트에 대하여 4점의 리커트 척도로 각각의 이해도를 조사하였다. 의약품의 제형을 의미하는 단어를 정확하게 이해하고 있는지도 조사하였다. 대상자를 조사기관에 초청하여 자기기입식으로 작성하도록 하여 자료를 수집하였다. 연구결과 : 이해력이 낮은 단어(3점미만)는 처방의약품의 복약안내문에 포함된 단어 중 7%, 안전상비약에 포함된 단어 중24%를 차지하였다. 제형에 대한 단어의 이해정도를 조사하였을 때, 투여경로에 대한 오답은 트로키제(44.6%)와 서방정(25.6%)이 많았고 복용방법에 대한 오답은 박칼정(73.1%)과 트로키제(70.2%)에서 많았다. 결론 : 의약품 정보에 대한 단어 중에는 일반인들이 이해하기 어려운 단어들이 많이 포함되어 있었다. 투약오류를 줄이고 의약품을 안전하게 사용하기 위하여 환자의 건강정보 이해능력을 고려하여 의약품 정보를 이해하기 쉽게 개선하여야 한다. Objective: The present study was conducted to measure the extent to which the general public can understand the terms that are frequently included in medication instructions and patient packaging inserts/labels, which provide drug-related information. Methods: A cross-sectional study was designed to simultaneously measure both the basic information of respondents and their understanding of terms. Using purposive quota sampling, a survey was conducted with 305 non-health professionals aged between 20 and 69 years, living in Seoul. Drugs that are often prescribed for diabetes and asthma were extracted from health insurance sample data. Then the understanding of medical instructions was investigated via a four-point Likert scale regarding a selected set of 100 words frequently used in medication instructions and a selected set of 100 words provided on the packaging and leaflets of emergency household drugs. An investigation of whether the participants accurately understood words indicating the preparations of drugs was carried out. Data were collected by inviting participants to the study setting and asking them to complete a self-report survey. Results: Poorly understood words (lower than 3 points) accounted for 7% of words included in the medication instructions of prescription drugs and 24% of words included in emergency household drug instructions. Upon investigating the extent of understanding of words for drug preparations, many incorrect answers were found for “troche” (44.6%) and “slow-release tablet” (25.6%) among the routes of administration and for “buccal tablet” (73.1%) and “troche” (70.2%) among the administration methods. Conclusion: In the vocabulary for drug information, many words are difficult for the general public to understand. To reduce medication errors and use drugs safely, drug information should be improved for easy understanding, considering the patients` health literacy.

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