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비강내 점적 노출을 통한 산화 알루미늄 나노입자의 폐독성 평가
권정택,서균백,이미미,김현미,심일섭,조은혜,김필제,최경희,Kwon, Jung-Taek,Seo, Gyun-Baek,Lee, Mimi,Kim, Hyun-Mi,Shim, Ilseob,Jo, Eunhye,Kim, Pilje,Choi, Kyunghee 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.1
Objective: The use of nanoparticle products is expected to present a potential harmful effect on consumers. Also, the lack of information regarding inhaled nanoparticles may pose a serious problem. In this study, we addressed this issue by studying pulmonary toxicity after nasal instillation of Al-NPs in SD rats. Methods: The animals were exposed to Al-NPs at 1 mg/kg body weight (low dose), 20 mg/kg body weight (medium dose) and 40 mg/kg body weight (high dose). To determine pulmonary toxicity, bronchoalveolar lavage (ts.AnBAL) fluid analysis and histopathological examination were conducted in rats. In addition, cell viability was investigated at 24 hours after the treatment with Al-NPs. Results: BAL fluid analysis showed that total cells (TC) count and total protein (TP) concentrations increased significantly in all treatment groups, approximately two to three times. Also, lactate dehydrogenase (LDH) and cytokines such as TNF-alpha and IL-6 dose-dependently increased following nasal instillation of Al-NPs. However, polymorphonuclear leukocytes (PMNs) levels showed no significant changes in a dose dependant manner in BAL fluid. In the cytotoxicity analysis, the treatment of Al-NPs significantly and dose-dependently induced cell viability loss (20 to 30%) and damage of cell membrane (5 to 10%) in rat normal lung epithelial cells (L2). Conclusions: Our results suggest that inhaled Al-NPs in the lungs may be removed quickly by alveolar macrophages with minimal inflammatory reaction, but Al-NPs have the potential to affect lung permeability. Therefore, extensive toxicity evaluations of Al-NPs are required prior to their practical application as consumer products.
산화알루미늄 나노물질이 랫드의 대뇌와 신장에 미치는 영향
조은혜,서균백,김현미,최경희,권정택,김필제,엄익춘 한국환경보건학회 2016 한국환경보건학회지 Vol.42 No.1
Objectives: Alumina nanoparticles (Al2O3, Al-NPs) are used for various purposes, including as coating agentsand paint additives. Their potential toxicity has raised concern for human health. This study focuses on exploringthe toxic effects on the brain and kidneys caused by Al-NPs exposure in rats. Methods: The animals were orally administered Al-NPs at 10, 50 and 100 mg/kg body weight for 28 daysfollowing OECD TG 407. To determine the targeted toxicity of Al-NPs, histopathological examination and geneexpression analysis were conducted on the rats. Results: The Al-NPs treatment induced kidney tubular dilatation. In the rat cerebrums, the expressionlevels of 126 genes experienced two-fold or greater increases in response to Al-NPs, including othergenes encoding proteins involved in cell differentiation, transcription and signal transduction. In the ratkidneys, the expression levels of 152 genes also showed two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in apoptosis, transcription and signaltransduction. Conclusion: These results suggest that exposure to Al-NPs influences cellular signal pathways of kidney andcerebrum, and it can be a toxic indicators of nanometrials.