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The wound healing effect of four types of beta‑glucan
서가영,현창림,최승인,김영미,조문재 한국응용생명화학회 2019 Applied Biological Chemistry (Appl Biol Chem) Vol.62 No.-
Beta-glucans, which existed in the cell walls of cereals, bacteria, and fungi, comprise a group of β-d-glucose polysaccharides. We investigated the effects of four kinds of beta-glucan, that are derived from barley, yeast, mushroom, and euglena on wound healing. The migration and viability of keratinocyte or fibroblast were analyzed using the in vitro scratch wound healing assay, invasion assay, MTT assay, and in vivo assay. All the beta-glucans had a significant effect on keratinocyte migration at 20 μM and showed no toxicity on dermal fibroblast. Moreover, treatment of keratinocytes with the beta-glucan derived from the mushroom (Schizophyllum commune) promoted in vivo wound closure. The Integrin/FAK/Src pathway is known to affect cell migration by forming lamellipodia. Beta-glucan from S. commune activates the Integrin/FAK/Src signaling pathway in a time-dependent. Reactive oxygen species are associated with fibroblast differentiation to contract dermal layer and synthesize collagens. We found that fibroblast was activated by increasing NOX4 expression. We propose that beta-glucan derived from mushroom is capable of promoting keratinocyte migration via the induction of FAK/Src phosphorylation there by accelerating wound closure and activating dermal fibroblast differentiation through NADPH oxidase for matrix remodeling.
The Protective Effect of Glycitin on UV-induced Skin Photoaging in Human Primary Dermal Fibroblast
서가영,박상규,허정식,조문재 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Exposure of strong and repeated UV on the skin leadsto skin aging, characterized with wrinkling, sagging, dyspigmentation,and laxity. Numerous studies revealed that Matrix metalloproteinasesare related to skin aging and functions as degradingenzyme of various types of collagen. Here, we attempted toevaluate the effectiveness of glycitin (4'-hydroxy-6-methoxyisoflavone-7-D-glucoside) on skin aging and mechanisms ofaction in UV-irradiated human dermal fibroblasts. Especially wefocused on the expression of Matrix metalloproteinase-1 (MMP-1), which degrades procollagen type-I in dermis, by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, Westernblot, and reverse transcription polymerase chain reaction in celllysates or media. Our results showed that glycitin increased theviability of human dermal fibroblast and alleviated MMP-1expression caused by UV irradiation. In addition, synthesis oftype-I collagen was increased and UV-induced phosphorylation ofERK/JNK/p38 was decreased in dose-dependent manners. Takentogether, we demonstrated that treatment with glycitein have aprotective effect on skin aging by inhibiting of MMP-1 andincreasing of collagen through ERK/JNK/P38 down-regulation,which may be mediated by the inhibition of ERK, JNK, and p38mitogen-activated protein kinases. We suggest that glycitin is apotential agent for the treatment of skin ageing.
WRF 모형에서의 적운모수화 사용 여부에 따른 여름철 남한 지역 집중호우 모의 민감도 분석
서가영,안중배 건국대학교 기후연구소 2020 기후연구 Vol.15 No.4
In this study, the impact of cumulus parameterization usage in Weather Research and Forecasting (WRF) model on reproducing summer precipitation in South Korea is evaluated. Two sensitivity experiments are set up with using cumulus parameterization (ON experiment) and without using cumulus parameterization, which is called Convection Permitting Model (OFF experiment). For the both ON and OFF experiments, the horizontal grid resolution is 2.5km, and initial and lateral boundary conditions are derived from ERA5 reanalysis data. Overall, both of the two experiments can capture the spatial distribution of 2014 summer mean and extreme precipitation but show dry biases in the southern region of Korean Peninsula. Occurrence percentage analyses for different precipitation intensity reveal that OFF experiments show better performance than ON experiment for extreme precipitation. In the case of heavy rainfall over Gyeongnam region for 25 August 2014, OFF experiment shows similar characteristic of rainfall to the observations, although it simulates earlier precipitation peak. On the other hand, ON experiment underestimates the amount of precipitation. Also, vertical distribution of equivalent potential temperature and strong southerly wind which play an important role in developing heavy rainfall on 25 August 2014 are better simulated in OFF experiment.
RCP 시나리오 기반 WRF를 이용한 CORDEX-동아시아 2단계 지역의 가까운 미래 극한기온 변화 전망
서가영,최연우,안중배 한국기상학회 2019 대기 Vol.29 No.5
This study evaluates the performance of Weather Research and Forecasting (WRF) model in simulating temperature over the COordinated Regional climate Downscaling EXperiment- East Asia (CORDEX-EA) Phase 2 domain for the reference period (1981~2005), and assesses the changes in temperature and its extremes in the mid-21st century (2026~2050) under global warming based on Representative Concentration Pathway (RCP) scenarios. MPI-ESMLR forced by two RCP scenarios (RCP2.6 and RCP8.5) is used as initial and lateral boundary conditions. Overall, WRF can capture the observed features of temperature distribution reflecting local topographic characteristic, despite some disagreement between the observed and simulated patterns. Basically, WRF shows a systematic cold bias in daily mean, minimum and maximum temperature over the entire domain. According to the future projections, summer and winter mean temperatures over East Asia will significantly increase in the mid-21st century. The mean temperature rise is expected to be greater in winter than in summer. In accordance with these results, summer (winter) is projected to begin earlier (later) in the future compared to the historical period. Furthermore, a rise in extreme temperatures shows a tendency to be greater in the future. The averages of daily minimum and maximum temperatures above 90 percentiles are likely to be intensified in the high-latitude, while hot days and hot nights tend to be more frequent in the low-latitude in the mid-21st century. Especially, East Asia would be suffered from strong increases in nocturnal temperature under future global warming.
서가영,임윤호,고동수,허정식,현창림,김영미,조문제 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4′,6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system. This keratinocyte-fibroblast interaction occurred via the secretion of TGF-β, and the induction of differentiation and proliferation was confirmed in both indirect and direct co-culture assays. In an excisional and burn wound animal model, mice treated with a 1:1 ratio of TMF and glycitin showed faster wound closure, regeneration and scar reduction than even the positive control drug. These data indicate that two isoflavones, TMF and glycitin, act synergistically to promote wound healing and anti-scarring and could potentially be developed together as a bioactive therapeutic for wound treatment.