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Hyung-Joon Bae(배형준) 대한의생명과학회 2010 Biomedical Science Letters Vol.16 No.1
Sprague-Dawley(SD) rats were orally administered with N<SUP>G</SUP>-nitro-L-arginine methyl ester(L-NAME) which inhibits or blocks the production of nitric oxide from L-arginine in vascular endothelial cells and vessel tissue to statistically examine the effects of nitric oxide on some physiological changes such as blood pressure and heart rate, and to confirm the apoptosis induced by the suppressed nitric oxide activity in some related organs under light microscope. Systolic blood pressure significantly increased 28.5% by the chronic treatment of L-NAME for 8 weeks (P<0.001), no significant difference, however, was observed in heart rate between the control group and the L-NAME-treated group regardless of their age. Hematoxylin-eosin staining showed some histological alterations only in kidney among the examined organs; heart, liver, pancreas, and adrenal gland from the L-NAME-treated group. TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) test showed a strong positive reaction, representing that the chronic treatment of L-NAME facilitates apoptosis, in the cortex and medulla of kidney, but not any significance detectable in the other organs. These results conclude that chronic treatment of L-NAME significantly increases blood pressure, and that the followed inhibition of nitric oxide synthesis occurs a typical inducement of apoptosis in kidney.
산화질소 억제가 혈압, 섬박동수 및 체중에 미치는 영향
배형준 ( Hyung Joon Bae ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2
This study examined the physiological and histological changes in Sprague-Dawley rats with induced hypertension by chronic treatment of NG-nitro-L-arginine methyl ester(L-NAME), nitric oxide synthesis inhibitor. Systolic blood pressure of L-NAME treatement experimental group was significantly higher compared with untreated control group by 28.5%(44.2mmHg)(p<0.001). Changing rates on systolic blood pressure of L-NAME treated groups according to during L-NAME treatment period were significantly higher than control groups by 16.1% in 2weeks, 15.1% in 4weeks(p<O.05), 29.1% in 6weeks(p<0.01) and 28.5%(p<0.001). However, heart rate and body weight did all not significant differ between L-NAME treated group and control group, between L-NAME posttreated rats and pretreated rats. Systolic blood pressure had each low correlation with heart rate and body weight. In conclusion, chronic inhibition of nitric oxide by L-NAME treatment had significant effect on systolic blood pressure, but not affect on heart rate and body weight. Thus, this study suggested that nitric oxide had important role to control for blood pressure and to modulation for function of organs associated with blood pressure.
양병선,박상묵,배형준,김원식,박훈희,임용,김윤식,최세묵,배도희,박지애,Yang, Byoung Seon,Park, Sang Muk,Bae, Hyung Joon,Kim, Won Shik,Park, Hun Hee,Lim, Yong,Kim, Yoon Sik,Choi, Se Mook,Bae, Do Hee,Park, Ji Ae 대한임상검사과학회 2020 대한임상검사과학회지(KJCLS) Vol.52 No.3
본 연구는 질 가산율 산출 및 적용기준을 검토하여 우수검사실 신임인증 및 전문인력영역에 있어 임상병리사를 추가 가능성을 알아보았다. 연구에 참여한 6개 기관은 1,000병상 이상의 대형병원 규모이며, 상근 진단검사의학과 전문의 평균 5명, 임상병리사는 평균 53명으로 전문의 1명당 10.6명으로 나타났다. 임상병리사의 행위분류별 소요시간에 대한 분석결과, 분석 중 행위는 낮아지고 있는 반면 검사실 운영, 정도관리 등의 강화로 포괄적 분석 전 행위의 비율이 높게 나타났다. 분석 중 행위는 생화학 검사수행 등의 비중이 높았고, 분석 후 행위는 결과분석 등이 대부분을 차지하였다. 이와 같이 검체검사 질 향상을 위해 많은 시간이 소요되며, 그에 맞는 인력이 요구된다. 결론적으로 검체검사 질 향상을 위해 임상병리사의 채용 역시 중요하며, 그에 따른 인원 규정이 필요하다 할 수 있다. This study reviewed the quality addition rate, calculation, and application criteria needed to identify the possibility of additional medical technologists in the field for new certification and professional manpower to provide a superior laboratory. The six institutions that participated in the study were the size of large hospitals with more than 1,000 beds, with an average of five full-time laboratory physicians (also called clinical pathologists) and an average of 53 medical technologists, with 10.6 per laboratory physician. An analysis of the time required for each activity category of medical technologists revealed decreasing behavior during the analysis. In contrast, the ratio of the comprehensive pre-analysis activities was high due to the strengthening of laboratory operations and quality control. During the analysis, the proportion of biochemistry tests was high, and post-analysis of most of the results was performed. Hence, improving the quality of sample testing requires significant time, and appropriate personnel are required. In conclusion, the recruitment of medical technologists is also a key component to improving the sample quality, and corresponding personnel regulations are necessary.
발생중인 흰쥐에 전신적으로 투여된 불소가 골형성에 미치는 영향
임도선,안용순,김은숙,배형준,장병수,Lim, Do-Seon,Ahn, Yong-Soon,Kim, Eun-Sook,Bae, Hyung-Joon,Chang, Byung-Soo 한국현미경학회 2002 Applied microscopy Vol.32 No.3
본 연구는 전자현미경을 이용하여 음용 불소가 발생중인 경골의 성장변화와 골모세포의 조직학적 특성에 미치는 영향을 관찰하고 에너지분광분석기를 사용하여 불소의 투여 농도에 따른 골기질 성분변화를 알아보고자 하였다. 전자현미경 관찰 결과, 대조군에서는 입방형의 전형적인 골모세포가 관찰되었다. 100 ppm 불소투여군의 경우, 활성이 강한 골모세포에 의해 생성된 여러층의 반전선과 새로 형성된 골성조직이 관찰되었다. 또한 골모세포의 세포질은 잘 발달된 조면세포체와 미토콘드리아가 관찰되었고 세포막 주위에는 많은 분비소포들이 관찰되었으며, 일부는 세포막과 융합되어 분비물질이 세포 밖으로 방출되었다. 200 ppm 불소투여군에서는 활성이 저하된 골모세포가 관찰되었는데, 세포질내에는 미토콘드리아가 팽창되어 있었고 수조의 형태가 파괴되어 나타났다. 또한, 조면소포체의 표면에는 리보솜이 탈락되어 관찰되었다. 300 ppm의 고농도 불소투여군에서는 골내막과 인접한 골모세포는 불규칙하게 배열되어 있었고, 세포막은 파괴되어 세포성분이 세포 밖으로 용출되어 관찰되었다. 한편, 에너지분산분광분석 결과는 대조군에 비해 100 ppm 불소투여군에서 골기질 성분인 인과 칼슘이 증가하였으나 200 ppm 및 300 ppm 불소투여군에서는 더 이상 증가하지 않았다. 따라서 본 연구결과, 투여된 불소에 의해 골모세포의 활동이 활발해지고 왕성한 골기질 합성이 관찰되었으나, 고농도의 불소 투여는 골모세포를 파괴하고 활동을 억제한다는 것을 확인하였다. The purpose of this study was to observe the influences of the water fluoride concentration on the growth changes, the histologic characteristics of osteoblast in the tibia of growing newborn rats by using electron microscopy and on the composition changes of bone matrix in those by using energy dispersive x-ray system (EDX). The water fluoride concentration was respectively 0 ppm (contrast group), 100 ppm (100 ppm group), 200 ppm (200 ppm group) and 300 ppm (300 ppm group). The results of the investigation by using electron microscopy were as followed. In contrast group, the traditional cuboidal osteoblasts were observed. In 100 ppm group, several reversal line, the newly formed osteoid by the strongly activated osteoblast and the well developed rough endoplasmic reticulum, mitochondria in cytoplasm of osteoblast were observed. Also, many secretory vesicle around cell membrane were observed and some fused with cell membrane released secretory granule out of cell. In 200 ppm group, the depressed osteoblasts were observed, mitochondria in cytoplasm were expanded and cristae shape in mitochondria were destroyed. Also, the ribosome at the surface of rough endoplasmic reticulum were not observed. In 300 ppm group, the adjacent osteoblasts with endosteum were irregularly arranged, the cell membrane were destroyed and organelles were flowed out of cell. On the other hand, the results of the investigation by using energy dispersive x-ray system were as followed. P and Ca concentrations in 100 ppm group were increased more than those in contrast group. But, in 200 and 300 ppm group were not increased more than those in 100 ppm group. Therefore, the activities of the osteoblasts were increased, the bone matrix were actively synthesized by the supplied water fluoride. But, the osteoblasts were destroyed, inhibited by the higher water fluoride concentration.
강서구(Seo-Gu Kang),배형준(Hyung-Joon Bae),임성현(Seong-Hyeon Lim),이영숙(Young-Sook Lee) 한국컴퓨터정보학회 2017 한국컴퓨터정보학회 학술발표논문집 Vol.25 No.2
비트코인은 각국의 중앙은행이 화폐 발행을 독점하고 자의적인 통화 정책을 펴는 것에 대한 반발로 만들어진 암호화 된 디지털화폐이며, 2008년 10월에 처음 등장하였다. 새로운 전자화폐로 성장한 비트코인은 현재 여러 나라에서 서비스되고 있으나 보안상의 취약점들이 발견되면서 이를 보완해야 할 필요성이 대두되고 있다. 본 논문에서는 비트코인의 특징과 서비스현황을 알아보고 비트코인의 취약점 중 지나친 익명성, 이기적인 채굴 그리고 51% Attack의 취약점들을 대상으로 분석하고, 대응 방안에 대한 한계를 제시한다.