인천지역 청소년의 비만도와 혈청 콜레스테롤치와의 관계

김명현,김태완,홍영진,손병관,배수환,장경자,김순기,Kim, Myung Hyun,Kim, Tae Wan,Hong, Young Jin,Son, Byong Kwan,Pai, Soo Hwan,Chang, Kyung Ja,Kim, Soon Ki 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.2

목 적 : 경제발전과 더불어 영양과잉이 문제되고 있으며 비만한 소아가 매년 증가되고 있는 추세이다. 저자들은 인천의 도시와 농촌 지역을 대상으로 중고생 및 대학생을 대상으로 비만 및 체중미달의 유병율을 알아보고 비만도와 콜레스테롤과의 관계를 조사하여 이를 근거로 청소년기의 영양상태를 알아보고자 하였다. 방 법 : 2000년 4, 5월 인천지역의 3개의 중학교, 5개의 고등학교, 인하대학교 여대생 총 1,456명(남 : 여=685 : 771)을 대상으로 신체계측과 함께, 혈청 콜레스테롤치를 측정하였으며, 설문조사를 통해 영양섭취상태를 조사하였으며, 1998년 대한소아과학회에서 측정한 한국 소아 및 청소년의 신장별 체중 백분위의 50퍼센타일 값을 표준체중으로 하여 비만도를 측정하여, 20% 이상을 비만, -10% 이하를 체중 미달로 정하였고, 또한 1998년 대한 소아과 학회에서 제정한 각 연령별 체질량지수를 근거로 95 백분위수 이상을 비만으로 정하고 15 백분위수 미만을 체중미달로 정하였다. 결 과 : 1) 청소년 비만도의 분포를 정상, 비만, 체중미달로 구분하였을 때, 남자에서는 각각 60.7%, 12.1%, 27.2%이었으며, 여자에서는 각각 70.9%, 11.3%, 17.8%로 남녀 분포의 유의한 차이가 있었다(P=0.001). 2) 표준체중에 의한 비만 유병율은 11.7%(남 : 여=12.1 : 11.3)였고, 이 중 경도비만이 6.5%(남 : 여=6.7 :6.4), 중등도 비만 4.6%(남 : 여=4.4 : 4.8), 고도비만은 0.5%(남 : 여=1.0 : 0.1)였고, 체질량지수에 의한 비만 유병율은 남녀 각각 6.4%, 6.2%였다. 3) 남자에서 농촌 지역의 비만과 체중미달 유병율은 각각 8.5%, 34.1%였고, 도시 지역은 각각 14.3%, 22.9%로 분포의 유의한 차이가 있었다(P=0.002). 여자에서 농촌 지역의 비만과 체중미달 유병율은 각각 12.5%, 19.6%였고, 도시 지역은 각각 10.5%, 16.6%로 두 지역의 체중 분포의 유의한 차이는 없었다(P=0.529). 4) 연령별 비만 유병율은 나이가 많아지면서 증가하다가 16세에 16.3%(남자 15.8%, 여자 16.8%)로 가 장 많은 분포를 차지하고 그 이후로 감소하였다. 체중 미달의 연령별 유병율은 남자가 14세에 39.4%, 여자가 12세에 53.2%로 가장 많은 분포를 보였다. 5) 인문계, 실업계 남자에서 비만 유병율은 각각 13.7%, 9.7%로 인문계에서 더 많은 분포를 차지하였으나 통계학적인 차이는 없었고(P=0.116), 여자는 각각 6.8%, 18.0%로 실업계에 비만 청소년이 더 많은 분포를 차지하여 통계학적인 차이가 있었다(P=0.001). 6) 혈청 콜레스테롤치 200 mg/dL 이상은 비만 청소년에서 6.2%, 170-200 mg/dL인 경우는 비만군에서 22.2%로 비 비만군에 비해 높았고 서로 유의한 상관 관계를 가지고 있었다(r=0.111). 결 론 : 인천지역의 청소년 비만은 조사자의 약 12%로 적지 않음을 알 수 있으며 반면 체중미달도 적지 않은 것을 알 수 있었다. 따라서 청소년 영양에 대해 관심과 체계적인 교육이 필요하다고 사료되며 그리하여 성인병을 예방하고 한편 영양불량을 개선하는 것이 시급한 문제로 생각된다. Purpose : The purpose of this study was to investigate the prevalence of obese and underweight adolescents in Incheon area and to examine the relationship between serum cholesterol level and obesity, then to assess the nutritional condition of adolescents. Methods : With a questionnaire regarding their demographic characteristics, blood samples were obtained from apparently healthy students aged 12 to 24 years by venipuncture at April and May, 2000. We measured the obesity index using standard body weight and the body mass index(BMI) according to the criteria established by the Korean Pediatric Society in 1998. Obesity was defined as BMI more than 95 percentile, and underweight less than 15 percentile by age and sex. Results : A total of 1,456 students(M : F=685 : 771) aged 12 to 24 years were included in this study. The prevalence of obesity by standard body weight in adolescents in Incheon were 11.7% : mild obesity 6.5%, moderate 4.6%, and severe 0.5%. By BMI, the prevalence of obesity was 6.4% in males and 6.2% in females. In males, the prevalence of obesity in rural areas was 8.5%, lower than in urban areas(14.3%). The prevalence of underweight by obesity index was 34.1% in rural areas and 22.9% in urban areas. In females, the prevalence of obesity was 12.5% in rural areas and 19.6% in urban areas. There were no significant differences between the two regions(P=0.529). The prevalence of obesity increased with age till 16.3% of peak prevalence in 16 years of age, and then decreased. In males, the prevalence of obesity in academic and vocational school were 13.7% and 9.7%, respectively(P=0.116). In females of the academic and vocational school, the prevalence of obesity was 6.8% and 18.0%, respectively(P=0.001). In obese adolescents, serum total cholesterol was over 200 mg/dL in 6.2%. Conclusion : This study revealed that the prevalence of obesity in adolescents was about 12% and that the prevalence of underweight adolescents was considerably high. We think nutritional assessment and intervention are warranted for adolescent students.

감염 검출을 위한 4 가지 Enzyme Immunoassay 법의 평가

엄희섭(Hee Sub Eom),김범수(Pum Soo Kim),이종욱(Jong Wook Lee),배수환(Soo Hwan Pai),이진우(Jin Woo Lee),최 원(Won Choi),이돈행(Don Haeng Lee),권계숙(Kye Sook Kwon),조현근(Hyeon Geun Cho),김형길(Hyung Gil Kim),신용운(Yong Woon Shin) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.5

Background/Aims: Serologic methods for the diagnosis of Helicobacter pylori (H. pylori) infection are simple and inexpensive but have low sensitivity and specificity. We compared four different commercial kits commonly used in Korea for the diagnosis of H. pylori infection. Methods: Forty-one consecutive patients were involved in this study. They all underwent gastric endoscopy and biopsy. To detect H. pylori infection, the biopsy samples were analyzed by histology, culture, and CLO(TM) test and the results were used as a gold standard. We performed serologic tests including Bio-Rad GAP IgG, Radim H. pylori IgG, CLI H. pylori IgG ELISA, and Genedia H. pylori ELISA. The results were analyzed by receiver operating characteristic (ROC) curves. Results: In comparison with a predefined gold standard, the sensitivity of GAP(TM), Genedia(TM), Radim(TM), and Clarke(TM) was 60, 100, 88, and 68%, respectively. The specificity of the tests was 87.5, 81.3, 93.8 and 93.8%, respectively. The adjusted cut-off values using the ROC curves improved the performance of the tests. Conclusions: Four serologic test kits commonly used in Korea are not different in the diagnostic accuracy for the detection of H. pylori infection, but ROC analysis can enable us to reexamine the validity of the cut-off valuse indicated by the manufacturers. Therefore, to optimize accuracy, the diagnostic performances of various serologic kits should be evaluated locally. (Korean J Gastroenterol 2001;37:312-318)

경인 지역 소아의 A형 간염 항체 보유율

권영세,홍영진,최연호,김순기,손병관,강문수,배수환,홍광선,Kwon, Young Se,Hong, Young Jin,Choe, Yon Ho,Kim, Soon Ki,Son, Byong Kwan,Kang, Moon Su,Pai, Soo Hwan,Hong, Kwang Sun 대한소아감염학회 1998 Pediatric Infection and Vaccine Vol.5 No.2

목 적 : A형 간염은 수년동안 거의 발생 보고가 없었으나 최근 경인지역에서 A형 간염 발생이 증가하였다고 보고되고 있으며, 소아에서도 대전에서 집단 발생이 보고된 바가 있다. 이는 사회경제적으로 발전하고 주거환경이 좋아지면서 소아에서의 A형 간염에 대한 항체 보유율이 낮아진 결과, 감염원에 노출된 연장아와 성인에서 현증 감염이 증가된 것으로 추측된다. 이에 저자들은 경인 지역에서 건강한 소아의 A형 간염 항체 보유율을 조사하여 A형 간염의 역학적 특성을 이해하는데 도움이 되고자 이 연구를 시행하였다. 방 법 : 경인 지역의 l세 76명의 유아와 3세 78명 및 5세 58명의 유아원생과 11세, 13세, 15세, 17세의 초중고생 각각 100명씩을 채혈하였고 혈청을 분리하여 $-80^{\circ}C$에 보관하였다가 Abbott사의 AxSYM$^{(R)}$ HAVAB(Microparticle Enzyme Immunoassay : MEIA)를 이용하여 anti-HAV를 측정하였다. 결 과 : 1) 전부 612명을 검사하였고 남아 316, 여아 296명으로 남녀의 비는 1.1 : 1이었다. 2) 1세군에서는 10.5%(남아 6례, 여아 2 례)에서 anti-HAV가 양성이었고, 3, 5, 11, 13세 군에서는 전부 anti-HAV가 음성이었으며, 15세 군에는 6%(남학생 4례, 여학생 2례)에서 anti-HAV가 양성이었고, 17세 군에서는 11 %(남학생 7례, 여학생 4례)에서 양성이었으며 남녀간의 차이는 없었다. 결 론 : 경인 지역의 유아 및 학동기 소아에서 A형 간염 항체가 거의 형성되어 있지 않으므로 감염자와의 접촉이나 오염된 음식들을 통해 학동기 소아에서의 현증 환자 발생의 위험이 있어, A형 간염에 대한 관심을 가지고 진료에 임하는 것이 필요하며 예방 방법에 대한 지침이 만들어져야 될 것으로 생각된다. Purpose : The incidence of hepatitis A virus infection in Korea has decreased recently. However, the prevalence in children and young adults is on an increasing trend in Inchon-Kyunggi prefecture. Economic development that leads to better living conditions and improves hygiene facilities has reduced the rate of HAV infection. This study was designed to evaluate the recent seroprevalence rate of hepatitis A in children and adolescents. Methods : Study population consisted of 612 children and adolescents aged 1 to 17 years in Inchon-Kyunggi prefecture. Serum samples were collected between 1996 and 1997 and tested for anti HAV by Microparticle Enzyme Immunoassay(MEIA). Results : According to age, the seropositive rates were 10.5%(male 13%, female 6.7%) in 1 year-old group, 0% in 3, 5, 11 and 13 year-old group, 6%(male 8%, female 4%) in 15 year-old group, and 11%(male 14%, female 8%) in 17 year-old group. Conclusion : This study showed that seropositive rate of HAV infection increased with age. While it revealed extremely low incidence of HAV infection in children less than 13 years old, they are also likely 10 be exposed 10 the infection. Our findings suggest that the effective administration of vaccination is needed in selected and high risk groups.

원저(原著) : ABO 부적합 조혈모세포 이식에서의 혈액지원 경험

유승국 ( Seung Gug Yoo ),남정현 ( Chung Hyun Nahm ),배수환 ( Soo Hwan Pai ) 대한임상병리사협회 1999 임상수혈검사학회 발표자료집 Vol.5 No.1

From January 1997 to February 1999. 3 major ABO-incompalible PBSCT. 2 mlnor ABO-incompatible PBSCT. 2 allogenic BMT, 11 autologous PBSCT were performed in Inha University Hospital. Among 18 cases. We report 2 cases of ABO incompatible Peripheral Blood Stem Cell Transplantation and also recommended ABO group of blood components for use in patients receiving ABO incompatible marrow. Additionally We emphasized the blood components usage according to the type of ABO incompatible PBSCT and suggest a guidline for its optimal blood components. After Bone Marrow Transplantation(BMT).the recipient must receive transfusion support until engraftment occus and blood cell production is adequate. Especially Bone Marrow tranaplantation requires.such as filtered and irradiated blood cellular components. All cellular blood components must be irradiated to prevent multiplication of viable donor lymphocytes and consequent Graft Versus Host Disease(GVHD).Removed leukocytes from red blood cells or platelet concentrates is recogniged to be the most effective way of preventing such posttransfusion complications as Non-Hemolytic Febrile Transfusion Reaction. platelet refractoriness, CMV Infections,and Immunosupression.

가숭어(Liza haematocheila)가 감염원으로 추정되는 광절열두조충 집단감염

鄭坪林(Pyung-Rim CHUNG),孫運睦(Woon-Mok SOHN),鄭英憲(Younghun JUNG),裵秀煥(Soo-Hwan PAI),南文錫(Moon-Suk NAM) 대한기생충학열대의학회 1997 The Korean Journal of Parasitology Vol.35 No.4

원저 : Clotting Method에서 용혈이 PT, Aptt에 미치는 영향

조경주 ( Kyoung Ju Cho ),김철민 ( Chul Min Kim ),이명권 ( Myoung Kwon Lee ),배수환 ( Soo Hwan Pai ) 대한임상병리사협회 1997 임상혈액검사학회 발표자료집 Vol.4 No.1

The prothrombin time (PT) and activated partial thromboplastin time (aPTT) are commonly used screening tests in the coagulation disorders. The effect of be very much method dependent on PT`s and aPTT`s from hemolysis. Sometimes they are shortened, prolonged or have no effects. Total 28 set-normal and abnormal results of PT and aPTT, hemolysis and no hemoloysis-have no effects by STA based on clotting. And Results have no problem statistically.

A relapsed case of imported tertian malaria after a standard course of hydroxychloroquine and primaquine therapy

Kyoung-Ju YI(이경주),Moon-Hyun CHUNG(정문현),Hyun-Seog KIM(김현석),Chul-Soo KIM(김철수),Soo-Hwan PAI(배수환) 대한기생충학열대의학회 1998 The Korean Journal of Parasitology Vol.36 No.2

구강악안면 영역의 치성 감염 환자에 대한 세균학적 연구

김일규,윤승환,오성섭,최진호,오남식,김의성,이성호,배수환,강문수 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

Oral & maxillofacial infections are most commonly odontogenic in origin. Although such infections are usually self-limiting, they may occasionally spread deeply into fascial spaces or planes far from the initial site of involvement. If early diagnosis and appropriate therapy is delayed, complications such as mediastinal extension, retropharyngeal spread and airway obstruction could happen to the patients. For the study of the microbiology, we have retrospectively analysed the oral & maxillofacial infected patients in the Dept. of Oral & Maxillofacial Surgery, In-Ha University Hospital from 1997 September to 2000 April. The results were as follows 1.The male patients were more common than female, with male 61.9% and female 38.1%. 2.Dental originated infections were most common cause with the incidence of 62%. 3.Most common fascial space involved was buccal space 42cases(37.2%) followed by submandibular space 13cases(11.5%), infraorbital space 13cases(11.5%), masseteric space 11cases(9.7%) , periapical abscess 11cases(9.7%) . 4.The causative organisms isolated from the pus culture were Gram Positive Bacterial species, which were 46cases(31.9%) of Streptococcus viridans, 16cases(8.6%) of α and β-hemolytic streptococcus, 4cases(3.1%) of Strep.-group D non enterococci, 7cases(5.1%) of Staphylococcus Coa. Neg., 5cases(3.9%) of Staphylococcus aureus, 3cases(2.3%) of Enterococcus faecalis, 1case(0.8%) of Bacillus species, 1case(0.8%) of Peptostreptococcus, 1case(0.8%) of Clostridium and Gram negative bacterial species, which were 4cases(3.1%) of Acinetobacter baumannii, 2cases(1.6%) of Pseudomonas aeruginosa, 2cases(1.6%) of Burkholderia cepacia, 1case(0.8%) of Neisseria species, 1case(0.8%) of Klebsiella pneumoniae, 1case(0.8%) of Klebsiella oxytoca, 1case(0.8%) of Escherichia coli. 5.In drug sensitivity test, high resistant tendency was found in Penicillin system(Penicillin G 83.3%, Ampicillin 60%) and Aminoglycosides (Gentamycin 50%, Tobramycin 45.5%), but tertiary Cephalosporin system(Cefoperazone 9.1%, Ceftazidime 18.2%), and glycopeptides system (Teicoplanin 0% , Vancomycin 0%) showed lower resistancy.

다발성 골수종에서 Bcl-2 단백 발현과 동수 DNA 표지 양성 세포의 빈도

최종원,배수환 대한임상병리학회 1999 대한임상병리학회지 Vol.19 No.3

유방암 환자 혈액내 c-erbB-2 종양단백 탐색의 임상적 의의

김진주,배수환 대한임상병리학회 1996 대한임상병리학회지 Vol.16 No.6