Methyl 5-aminolaevulinic Acid 국소 광역동 요법을 이용한 광선각화증의 치료

박현선 ( Hyun Sun Park ),진선필 ( Seon Pil Jin ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.10

Background: Photodynamic therapy (PDT) is a treatment modality involving the use of a photosensitizer, oxygen and a light source to induce selective targeted cell death. It is used for various skin conditions, including actinic keratosis (AK). Both 5-aminolevulinic acid and methyl aminolevulinic acid (MAL) are currently available as photosensitizers. Although there are several studies on the treatment of AK using 5-aminolevulinic acid-PDT in Korea, there are few studies on using MAL-PDT for the treatment of AK. Objective: The purpose of this study is to evaluate the efficacy and safety of MAL-PDT for the treatment of AK. Methods: We performed a retrospective study and reviewed 64 AK lesions from 28 patients who were treated by MAL-PDT between January 2008 and April 2010. The data was collected through the medical records, the clinical photographs and the biopsy specimens. Results: The patients were treated with either a single treatment or double treatments 1 week apart. The treatment results were assessed after 12 weeks. Overall, complete remission was achieved in 42/64 lesions (65.6%). Although a single treatment was effective for thin lesions, the complete response rates were significantly lower for the moderately thick and severely thick lesions (100% vs 71.3% vs 22.2%, respectively). Repeated treatment tended to improve the complete response rate of the severely thick lesions. A favorable cosmetic outcome was achieved and only tolerable local side effects were reported after MAL-PDT. The patients were followed up for an average period of 6 months and 4 lesions recurred. Conclusion: MAL-PDT is an effective and well-tolerated treatment option for thin and moderately thick AK. However, further study is required for determining the optimal regimen for thicker lesions and the long-term treatment results of MAL-PDT. (Korean J Dermatol 2010;48(10):837~843)

냉전 유토피아 ‘한국’의 영화적 지리학-험프리 렌지 콜렉션을 중심으로-

박현선 ( Park Hyun-seon ) 인하대학교 한국학연구소 2017 한국학연구 Vol.0 No.47

험프리 렌지(Humphrey Leynse, 1921~1977)는 냉전을 전후해 미국과 유럽, 아시아를 가로지르며 군인에서 교육자문가, 미공보원, 민간 영화제작자, 다큐멘터리 감독, 교수 등 다양한 이력으로 활동했던 매우 독특한 인물이다. 특히 1960년부터 1966년까지 한국의 USIS 영화과에 근무하며 여러 문화영화를 만들었고 USIS 활동을 그만 둔 후에도 다시 한국에 돌아와 울릉도에 관한 다큐멘터리를 만들기도 했다. 이 글은 1960년대 활발히 활동했던 미공보원이자 영화인으로서 험프리 렌지가 수집한 영화 콜렉션을 중심으로, 1960년대 한국에서의 미공보 활동을 검토하고 이 영화들에 표상된 ‘한국’의 냉전 지리학을 살펴보고자 한다. <험프리 렌지 콜렉션> 작품들은 1960년대 문화 냉전의 시각체계를 보여주는 동시에 렌지 개인의 시각을 엿볼 수 있게 해주는 텍스트들로 그 의미가 독특하다. 이 글의 목적은 험프리 렌지의 영화들과 같이 그간 조명되지 못한 해외영화인 자료를 분석함으로써 한국을 둘러싼 ‘문화 냉전’에 대한 논의를 확장하고, 동시에 이데올로기 기구와 문화 텍스트 간의 긴장을 어떻게 다룰 것인가라는 방법론의 문제를 제시하는 것이다. 험프리 렌지 콜렉션은 1950년대를 지나 1960년대에 이르러 미국이 아시아 외교 정책에서 직면했던 문제와 연관하여 프로그램을 조정해가는 과정에서 USIS 영화가 보여준 변화를 흥미롭게 반영한다. 특히 이 글은 1960년대 한국의 냉전 로컬리티의 문제를 해양이라는 독특한 지리적 특성과 연결하여 살펴보고자 한다. 렌지 콜렉션에 담긴 미공보원의 문화영화 텍스트들은 한국의 로컬 공간들에 대한 흥미로운 심상지리를 드러내고 있는데, 특히 해양의 공간지리, 즉 섬과 바다를 다룬 작품들이 많다. 렌지가 미공보원 생활을 은퇴한 후 만든 <먼곳에 외로운 섬 하나>는 울릉도에 관한 다큐멘터리로, 1960년대 USIS 영화들의 전략적 변화의 특성과 더불어 냉전 시대 서구인의 시선에 포착된 한국 로컬 공간의 해양적 노모스를 담고 있다는 점에서 특별히 주목할 만하다. Humphrey Leynse (1921~1977) is a remarkable figure who worked as educational consultant, USIS officer, independent producer, documentary filmmaker, and professor, moving across the United States, Europe, and Asia during the Cold War era. When he was working as a section chief of USIS-Korea, he participarted in making a number of culture films. After he quited his job at the USIS, he stayed in Ullŭngdo for two years to make his own documentary of the island and its people. This paper pays crticial attention to the films that Leynse made and collected while he was in Korea as an officer and a producer, which have been recently retrieved by the Korean Film Archive under the title of the Humphrey Leynse collection. Korea-related films of the Humphrey Leynse collection are crucial materials for us to understand the visual regime of the 1960s cultural Cold War as well as to garner an individual perspective of someone who worked inside of the Cold War system. By illuminating the previously unknown collection of culture films by Leynse, the paper aims to analyze how the USIS films reflected the changes of the US public information policy in the shifting period of the 1960s and discuss how they engages in the projection of Korea as an idiosyncratic marine country. Especially, Leynse’s 1968 semi-documentary Out There, A Lone Island discloses the Cold War nomos of the 1960s that focuses on the Korean local seashores and islands and at the same time shows a Western filmmaker’s interactive passion toward the remote places and people in Korea.

축내 뇌종양으로 오인 된 탈수초성 가성종양

서현성 ( Hyun Sung Seo ),김은영 ( Eun Young Kim ),박인서 ( In Suh Park ),박현선 ( Hyun Seon Park ),박형천 ( Hyung Chun Park ),박종운 ( Chong Oon Park ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2009 대한뇌종양학회지 Vol.8 No.2

Acute tumor-like demyelination or demyelinating pseudotumor is a variant presentation of demyelinating diseases, such as multiple sclerosis. A 32 years old male developing left side hemiparesis for 4 days and general tonic clonic seizure lasting 2 minutes was admitted to the hospital. Brain magnetic resonance imaging(MRI) taken at other hospital showed a large and irregular well enhancing intra-axial mass in right fronto-parietal area with massive surrounding edema. Craniotomy was planned under the impression of the malignant glioma. The edema and hemiparesis subside by preoperative use of corticosteroid. Therefore we had to rule out lymphoma. Stereotactic biopsy revealed a demyelinating lesion consistent with demyelinating pseudotumor. The patient recovered from hemiparesis by corticosteroid treatment over several weeks. The demyelinating pseudotumor, which usually presents as a well enhancing and poorly defined intra-axial lesion with edema, is very hard to distinguish from intra-axial tumors such as lymphoma and malignant glioma. Neurosurgeons should be aware of the possibility of demyelinating pseudotumor though it is rare.

GM-CSF를 이용한 척수손상의 치료적 접근

최병현 ( Byung Hyune Choi ),하윤 ( Yoon Ha ),박현선 ( Hyeon Seon Park ),윤승환 ( Seung Hwan Yoon ),박형천 ( Hyung Chun Park ),민병현 ( Byoung Hyun Min ),박소라 ( So Ra Park ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.1

TCD를 이용한 두개강내 동맥류의 예후 예측 가능한 New Scale(NS) Score System

박상훈,박종운,박현선,현동근,하영수,Park, Sang Hoon,Park, Chong Oon,Park, Hyeon Seon,Hyun, Dong Keun,Ha, Young Soo 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.8

Objective : By conducing a review of clinical outcomes for patients with aneurysm treated using current microneurosurgical techniques and intensive care unit management, we speculated that grading systems based only on clinical condition or CT finding after admission failed to provide a significant stratification of outcome between individual grades of patients, because these systems did not include the factor for postoperative vasospasm. We hypothesized that postoperative blood flow velocity could have a significant impact on outcome prediction for patients surgically treated for intracranial aneurysms. Methods : We conducted a analysis on patient- and lesion-specific factors that might have been associated with outcome in a series of 55 aneurysm operations performed with measurements of blood-flow velocity with transcranial Doppler ultrasonography(TCD). In the new scale(NS) score system, 1 point is assigned additionally for the case with Hunt and Hess(H-H)/World Federation of Neurological Surgeons(WFNS) Grade IV or V, Fisher Scale(FS) score 3 or 4, aneurysm size greater than 10mm, patient age older than 60 years, blood-flow velocity higher than 120cm/sec, and posterior circulation lesion. By adding the total points, a 6-point scale score(score 0-6) is obtained. Results : Age of patient, size of aneurysm, clinical condition(H-H grade and WFNS), FS score, and blood flow velocity(TCD 1day after operation) were independently and strongly associated with long-term outcome. When NS scores were applied to 55 patients with at least 6 months follow-up, the correlation of individual scores with outcome was strongly validated the retrospective findings. Conclusion : It was speculated that TCD could be used to assess postoperative vasospasm and to monitor noninvasively the patients with aneurysmal SAH. This NS score system is easy to apply, divide patients into groups with different outcome, and is comprehensive, allowing for more accurate prediction of surgical outcome.

증기폭발 압력 하중에 대한 마이크로 버블 군집의 저감 효과 연구

김찬우(Chanwoo Kim),박현선(Hyun Sun Park),안호선(Ho Seon Ahn) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11

Steam explosion is a phenomenon which can threat the integrity of the containment structure with high pressure impulses when the molten core drops into a water pool either inside or under the reactor vessel bottom during a severe accident of a light water reactor. For suppressing steam explosion, we focus on the shock wave mitigation effect by microbubble clouds, i.e. the shock-bubble interaction (SBI). Using the SBI model which describes one-dimension shock tube containing bubbly liquid with microbubble clouds, dissipation energy (DE) and damping time (DT) are obtained, which are major indicators of shock mitigation under the microbubble-liquid media. To apply the SBI model to large scales such as steam explosion, candidates of shockwaves from steam explosion are listed for this research from previous researches conducting the steam explosion. Finally, moving distances of the shockwaves are calculated and discussed for shock mitigation.

3차원 그라핀 네트워크에서 천입등현상에 대한 실험적 연구

김지민(Ji Min Kim),김동억(Dong Eok Kim),박현선(Hyun Sun Park),김무환(Moo Hwan Kim),안호선(Ho Seon Ahn) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.4-3

GM-CSF가 골수줄기세포의 이동에 미치는 영향

한동하 ( Dong Ha Han ),곽민근 ( Min Geun Kwak ),최병현 ( Byung Hyune Choi ),하윤 ( Yoon Ha ),박현선 ( Hyun Seon Park ),민병현 ( Byoung Hyun Min ),우제홍 ( Ze Hong Woo ),박소라 ( So Ra Park ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.3

The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play an important role in the hematopoiesis of bone marrow-derived cells and the modulation of their functions as well as the maintenance of homeostasis and overall immune competence. In this study, we investigated the effects of GM-CSF on the activation of bone marrow stem cells in rats. GM-CSF was treated to SD rats via intraperitoneal injection everyday at 10 mg/ml for 5 consecutive days. After 6 days, the bone marrow (BM) and peripheral blood (PB) mononuclear cells (MNCs) were collected to analyze the colony forming units-fibroblasts (CFU-F), colony forming units-granulocyte macrophage (CFU-GM), and burst-forming units-erythroid (BFU-E). In result, the numbers of MNCs and the CFU-GM and BFU-E counts in BM were all decreased, while those of PB increased. These results suggest that GM-CSF induced the proliferation and mobilization of MNCs and hematopoietic stem cells (HSCs) to PB. The CFU-F counts showed no significant increase both in BM and PB suggesting that GM-CSF showed no significant effects on the proliferation of mesenchymal stem cells. In contrast, the increase in the alkaline phosphatase expression of CFU-F colonies in BM indicates that GM-CSF might induce the differentiation of MSCs at least to some extent. In conclusion, GM-CSF not only plays important roles in proliferation and differentiation of stem cells in BM but also promotes migration of HSCs into PB.

다양한 스마트 단말 장치를 위한 SMU 애플리케이션 설계 및 구현

이재선(Jae-sun Lee),심창준(Chang-jun Shim),박현선(Hyun-seon Park),이승형(Seung-hyung Lee),유인태(In-tae Ryoo) 한국정보과학회 2014 한국정보과학회 학술발표논문집 Vol.2014 No.6

전두동골절 수술 후에 발생한 점액낭종에 의한 안구돌출증

김진욱(Jin-Wook Kim),하윤(Yoon Ha),윤성환(Seung-Hwan Yoon),현동근(Dong-Keun Hyun),박현선(Hyeon-Seon Park),박형천(Hyung-Chun Park),박종운(Chong-Oon Park),김은영(Eunyoung Kim) 대한두개저학회 2008 대한두개저학회지 Vol.3 No.1

Mucoceles arise from the gradual accumulation of mucus material caused by obstruction of the sinus ostium. They may enlarge sufficiently to compress orbital or intracranial structures. We present a case of severe exophthalmos caused by frontal sinus mucocele developed after operation for frontal sinus fracture. At initial operation for depressed fracture of the anterior wall of left frontal sinus, all frontal sinus mucosa was extirpated and the space was obliterated with bovine artificial bone. The fractured pieces of the bone were replaced and fixed with titanium mesh and screws. The reason for the delayed development of mucocele in this patient was the unintentionally remained sinus mucosa and blockage of the natural drainage pathway by bone graft. Exophthalmos was relieved after surgical drainage of mucocele, resection of mucosa as much as possible and recreation of drainage pathway by the removal of grafted bovine bone. This case reminds surgeons that natural drainage pathway of sinus should be kept intact whenever possible, otherwise a mucocele may develop even many years after operation.