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위암에서 Helicobacter pylori cagA, vacA, iceA 유전자와 숙주 Interleukin-1β및 Interleukin-1 수용체 길항제 유전자 다형성
이성훈 ( Seong Hun Lee ),김태오 ( Tae Oh Kim ),이동현 ( Dong Hyun Lee ),박원일 ( Won Il Park ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1
Background: Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients. Methods: This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR. Results: H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma. Conclusions: Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.(Korean J Med 71:24-37, 2006)
사람의 자궁 내막 조직내에서 Phosphodiesterase IV Inhibitor에 의한 IL-12의 조절 및 이에 따른 Th-1, Th-2 cytokine 분비 양상의 변화
박원일 ( Park Won Il ),김은경 ( Kim Eun Gyeong ),고덕성 ( Go Deog Seong ),홍서유 ( Hong Seo Yu ),나중열 ( Na Jung Yeol ),김대운 ( Kim Dae Un ),신정환 ( Sin Jeong Hwan ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.8
목적 : 사람의 초기 임신 과정에서 phosphodiesterase type IV inhibitor인 rolipram이 탈락막내 IL-12를 억제하고 이에 따라 Th-1 계열의 cytokine이 감소하고 Th-2 cytokine이 증가하는지를 규명하는 것이 목적이다. 연구 방법 : 임신 12주 이전에 계류 유산으로 진단받은 10명과 정상임신에서 임신 중절 수술을 시행받은 10명에서 자궁 소파술을 통하여 탈락막 조직을 획득한 후 조직을 rolipram으로 Objective : To assess the capability of phosphodiesterase type IV inhibitor (rolipram) to suppress IL-12 in human decidua and the subsequent changes of Th-2 cytokine (IL-10) and Th-1 cytokine (TNF-α). Methods : Decidual tissues of 10 first-trimester pregn
염산 트라마돌을 함유하는 PLGA 미립구의 제조 및 방출거동
박종학 ( Jong Hak Park ),엄신 ( Shin Eom ),안식일 ( Sik Il Ahn ),김대성 ( Dae Sung Kim ),김원 ( Won Kim ),이동원 ( Dong Won Lee ),유일수 ( Il Sou Yoo ),이종문 ( John M Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Tramadol HCl(TH)-loaded poly(L-lactide-co-glycolide)(PLGA) microspheres were prepared by O/O solvent evaporation method for sustained release. We investigated the release behavior according to PLGA molecular weight and concentration. TH-loaded PLGA microspheres were characterized on the surface and cross-section morphology by SEM. TH-loaded PLGA microspheres had smooth surfaces and various pores in internal structure. As the PLGA molecular weight and PLGA concentration increased, the release rate of TH decreased. The behaviors of degradation was decreased according to increased PLGA molecular weight. These results showed that the release behaviors can be controlled by various of molecular weight and concentration of PLGA.
토끼의 난소 과자극증후군 유발에 미치는 내인성 Angiotensin 2의 작용 및 Angiotensin-converting Enzyme Inhibitor의 치료효과
박원일 ( Won Il Park ),송찬호 ( Chan Ho Song ),김병길 ( Pyung Kil Kim ),조동제 ( Dong Je Cho ),박기현 ( Ki Hyun Park ),장병철 ( Byung Chul Chang ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Ovarian hyperstimulation syndrome is most serious complication during ovulation induction. Although the incidence of this disease is increasing, the pathophysiology remains uncertain. Consensus is that main pathophysiology of the disease is increased vascular permeability, but the etiologic agent causing hyperpermeability is still unknown, Prostaglandin, histamine, angiotensin, some cytokines and growth factors have been suspected as etiologic agent. At present, angiotensin is mostly suspected agent of this disease. The purpose of this study is revealing etiologic role of angiotensin II in ovarian hyperstimulation and assessing the therapeutic or preventive effect of lowering angiotensin II by angiotensin converting enzyme inhibitor. After developing of ovarian hyperstimulation in rabbit, Captopril were administerd in study group. The correlations between angiotensin II and clinical parameters of severity of the disease such as ovarian volume, amount of ascites or changes of hematocrit were assessed. The correlations between angiotensin II and prostaglandin or estradiol were also assessed. The Microfil was perfused through the ovarian arteries and morphology of vascularities were revealed. The differences in ovarian volume, amount of ascites, changes of hematocrit, prostaglandin and estradiol were checked between study and control group. The parameters of severity of ovarian hyperstimulation were closely related with the level of angiotensin II. The levels of prostaglandin and estradiol were also positively correlated with the level of angiotensin II. The degree of neovascularization tended to be increased in control group, but the individual variations were existed. The parameters of severity of ovarian hyperstimulation were markedly improved in captopril group. From this data, we can conclude that angiotensin II is related with development of ovarian hyperstimulation syndrome and angiotensin converting enzyme inhibitor can prevent the development of this disease.
박원일(Park, Won-Il),최판길(Choi, Pan-Gil),이봉학(Yun, Kyong-Ku),윤경구(Lee, Bong-Hak) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.3
초속경 라텍스개질 콘크리트(VES-LMC)는 공용중 교량바닥판 콘크리트 긴급 덧씌우기를 목적으로 개발되었 으며, 콘크리트타설 후 3시간 만에 교통개방이 가능하도록 작업성, 내구성 및 강도특성을 만족하도록 특성화된 콘크 리트이다. VES-LMC 배합은 고유의 급속경화 특성으로 인해 콘크리트 타설 초기에 높은 수화열을 수반하고, 상대적 으로 낮은 물시멘트비로 인해 자기수축에 민감하게 반응할 수 있다. 본 논문에서는 간이수화열과 초기수축 실험을 수행하여 동일슬럼프 조건과 서로 다른 슬럼프 조건에서 라텍스함량 변화가 VES-LMC의 자기수축에 미치는 영향을 평가하였다. 실험결과는 다음과 같다. 라텍스는 콘크리트 내구성 향상에만 기여할 뿐 수화열에 미치는 영향이 매우 작게 나타났다. 서로 다른 슬럼프 조건 에서 자기수축은 라텍스함량 증가에 따라 증가하였고, 증가추세는 로그함수의 형태로 나타났다. 그러나 동일 슬럼프 조건에서 라텍스함량 변화는 두 가지 실험변수가 동시에 변화하므로 자기수축 특성에 미치는 상관성이 작게 나타났다. Very-early strength latex-modified concrete (VES-LMC) was developed for the purpose of fast-track overlay of a concrete bridge deck under heavy traffic, concentrated on the workability, durability, and strength gain so that it can be opened to the traffic only three hours after its placement. The mixture of VES-LMC might accompany very high heat of hydration at early-age because of its inherent rapid hardening property and could have susceptibility to autogenous shrinkage because of its relatively low water-cement ratio. This study evaluated the effect of the latex-cement ratio(L/C) both of the constant and variable slumps on the autogenous shrinkage of VES-LMC by carrying out simple temperature rise test and early-age shrinkage experiment. Test results are as follows: The latex contributes on the enhancement of the concrete durability but has little effect on its hydration and the accompanied heat of hydration in VES-LMC. Autogenous shrinkage increased with the increase in latex-cement ratio at variable slumps and its pattern followed regularly a logarithmic increase. However, the influence of water-cement ratio and latex-cement ratios for the test specimens at constant slump on early-age autogenous shrinkage property was found to be minor due to the simultaneous effect of the two experimental variables.
고혈압 전단계자들에 대한 골격근 Group Ⅲ 자극 시 시간에 따른 심혈관 반응
박원일(Won Il Park),박시영(Si-Young Park),최현민(Hyun-Min Choi),이준희(Joon-Hee Lee),전종목(Jong-Mok Jeon),김종경(Jong-Kyung Kim),심재근(Jae-Kun Shim),노호성(Hosung Nho) 한국생명과학회 2009 생명과학회지 Vol.19 No.11
본 연구는 고혈압전단계자들에 대한 지속적인 건 스트레치시 시간에 따른 생리학적 반응을 분석하여 정상혈압자와 고혈압전단계자에 대한 EPR의 한 요소인 기계적 수용기가 혈압 및 혈역학 반응에 어떠한 영향을 주는지를 검토하였다. 그 결과, 안정 시와 시간에 따른 혈압 반응은 고혈압전단계자에 있어 SBP, MAP가 평균 20sec에서 통계적으로 가장 높은 경향을 보였으며(p<0.05), 정상혈압자에서는 SBP, DBP, MAP가 평균 45sec에서 가장 높은 경향을 보였다(p<0.05). 이는 고혈압 전단계자의 지속적인 수동적 건 스트레치 시 정상혈압자에 비해 Group Ⅲ mechanoreceptors의 역기능에 따른 상승된 혈압 반응이 초기에 나타내었다고 사료된다. 또한 혈역학 반응에서 안정 시와 비교하여 지속적인 수동적건 스트레치 시 고혈압전단계자에서의 HR, SV, CO, TPR 모두 유의한 차이를 보이지 않았으나 정상혈압자에서 SV, CO가 통계적으로 유의한 차이를 보였다(p<0.05). 이는 CO, SV, HR, TPR이 정상혈압자에 비해 고혈압전단계자에 있어 높은 경향을 나타내었지만, 혈역학 반응은 본 연구를 통해 차이를 보이지 않아 앞으로 연구가 필요할 것으로 사료된다. The purpose of this study was to investigate whether group Ⅲ muscle afferents play an important role eliciting abnormal blood pressure response mediated during passive muscle stretch in prehypertensive individuals. Eleven middle-aged prehypertensive men (average BP 133/80 ㎜Hg) and nine middle-aged normotensive men (average BP 119/74 ㎜Hg) participated in this study. After 1 min rest baseline data collection, the subject’s foot was flexed (dorsiflexion) by an automated cybex for one minute. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate, stroke volume, cardiac output, and total peripheral resistance were continuously measured on a beat-by-beat basis from a finger via a Finapres device for 1 minute. To evaluate the role of mechanoreflex, a component of exercise pressor reflex, SBP, DBP, and MAP responses over the course of time were examined. The results showed that the pressor response mediated by the muscle mechanoreflex was faster in prehypertensive individuals compared to the normotensive individuals. The substantial pressor response was observed within mean 20 sec of the onset of passive stretch in prehypertension, while mean 45 sec in normotension (p<0.05). It is concluded that excessive pressor response produced during exercise in prehypertension may be due to the dysfunction of the mechano-receptors.
박원일 ( Won Il Park ),이동현 ( Dong Hyun Lee ),김태오 ( Tae Oh Kim ),이성훈 ( Seong Hun Lee ),최준림 ( Jun Lim Choi ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.2
Epiphrenic diverticulum is an uncommon condition and frequently associated with dysphagia and regurgitation. The treatment of symptomatic epiphrenic diverticulum is usually diverticulectomy and myotomy. Esophageal manometry is useful test for the diagnosi