위암에서 Helicobacter pylori cagA, vacA, iceA 유전자와 숙주 Interleukin-1β및 Interleukin-1 수용체 길항제 유전자 다형성

이성훈 ( Seong Hun Lee ),김태오 ( Tae Oh Kim ),이동현 ( Dong Hyun Lee ),박원일 ( Won Il Park ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1

Background: Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients. Methods: This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR. Results: H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma. Conclusions: Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.(Korean J Med 71:24-37, 2006)

점탄성 댐퍼가 설치된 축소 건물모델의 주파수 응답특성에 관한 연구

박진일(Jin-Il Park),박해동(Hae-Dong Park),최현(Hyun Choi),김두훈(Doo-Hoon Kim),민경원(Kyung-Won Min) 한국소음진동공학회 1999 한국소음진동공학회 학술대회논문집 Vol.1999 No.11

정상 월경주기를 가진 여성에서 초저용량 GnRH 유도체의 내분비학적 작용

박원일(Won Il Park),정화령(Hwa Ryung Chung),연혜정(Hye Jung Yeon),육진성(Jin Sung Yuk) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1

N/A Objectives : The microdose of gonadotrophin-releasing hormone agonist (GnRHa) has been suggested as a beneficial method of ovulation induction for poor responders. However, the effect of microdose of GnRHa itself has not been evaluated yet. We performed a prospective sutdy to assess the effect of microdose of GnRHa (5 μg of triptorelin acetate) on the luteinizing hormone (LH) and follicle stimulating hormone (FSH). Secondary objective of this study is to assess how long the down-regulation of gonadotrophin secretion by microdose GnRHa persists. Methods : Five μg of triptorelin was injected daily into five normally menstruating women for 7 days starting from cycle day 3. The blood sample was drawn for 12h with 4h interval, then for 6days with 4 h interval and once a day for 14days, In next cycle, same amount of triptorelin was injected into the same subjects daily for 3 days. The blood sample was drawn twice a day for 20days. Serum FSH, LH and extradiol level was measured. Results : The serum LH and FSH level increased rapidly after injection of first GnRHa. The FSH level reached peak (27.53±6.34 IU/l) in 5h while LH level reached peak (34.35±7.18 IU/l) in 4h. The flare of gonadotrophins persisted even after second and third day injection of GnRHa, although the peak levels were not as high as first injection. The down regulation of gonadotrophin was established in 4-5 days. The estradiol level increased for 4-5 days then decreased. When GnRHa was given for 7days, the estradiol level began to rise 7-8 days after last injection; when given for 3days, the estradiol level began to rise 3-6 days after last injection. Conclusion : Even with ultra-low dose of GnRHa, the down-regulation of gonadotrophin could be achieved. The flare-up of gonadotrophin would persist for 3days with this dose. The duration of down regulation was influenced by the duration of GnRHa administration.

MEA (monoethanolamine) 함침 메조포러스 물질을 이용한 CO2 회수

박예원 ( Ye Won Park ),백일현 ( Il Hyun Baek ),박상도 ( Sang Do Park ),이재욱 ( Jae Wook Lee ),박소진 ( So Jin Park ) 한국화학공학회 2007 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.45 No.6

라텍스함량 변화에 따른 VES-LMC의 자기수축

박원일(Park, Won-Il),최판길(Choi, Pan-Gil),이봉학(Yun, Kyong-Ku),윤경구(Lee, Bong-Hak) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.3

초속경 라텍스개질 콘크리트(VES-LMC)는 공용중 교량바닥판 콘크리트 긴급 덧씌우기를 목적으로 개발되었 으며, 콘크리트타설 후 3시간 만에 교통개방이 가능하도록 작업성, 내구성 및 강도특성을 만족하도록 특성화된 콘크 리트이다. VES-LMC 배합은 고유의 급속경화 특성으로 인해 콘크리트 타설 초기에 높은 수화열을 수반하고, 상대적 으로 낮은 물시멘트비로 인해 자기수축에 민감하게 반응할 수 있다. 본 논문에서는 간이수화열과 초기수축 실험을 수행하여 동일슬럼프 조건과 서로 다른 슬럼프 조건에서 라텍스함량 변화가 VES-LMC의 자기수축에 미치는 영향을 평가하였다. 실험결과는 다음과 같다. 라텍스는 콘크리트 내구성 향상에만 기여할 뿐 수화열에 미치는 영향이 매우 작게 나타났다. 서로 다른 슬럼프 조건 에서 자기수축은 라텍스함량 증가에 따라 증가하였고, 증가추세는 로그함수의 형태로 나타났다. 그러나 동일 슬럼프 조건에서 라텍스함량 변화는 두 가지 실험변수가 동시에 변화하므로 자기수축 특성에 미치는 상관성이 작게 나타났다. Very-early strength latex-modified concrete (VES-LMC) was developed for the purpose of fast-track overlay of a concrete bridge deck under heavy traffic, concentrated on the workability, durability, and strength gain so that it can be opened to the traffic only three hours after its placement. The mixture of VES-LMC might accompany very high heat of hydration at early-age because of its inherent rapid hardening property and could have susceptibility to autogenous shrinkage because of its relatively low water-cement ratio. This study evaluated the effect of the latex-cement ratio(L/C) both of the constant and variable slumps on the autogenous shrinkage of VES-LMC by carrying out simple temperature rise test and early-age shrinkage experiment. Test results are as follows: The latex contributes on the enhancement of the concrete durability but has little effect on its hydration and the accompanied heat of hydration in VES-LMC. Autogenous shrinkage increased with the increase in latex-cement ratio at variable slumps and its pattern followed regularly a logarithmic increase. However, the influence of water-cement ratio and latex-cement ratios for the test specimens at constant slump on early-age autogenous shrinkage property was found to be minor due to the simultaneous effect of the two experimental variables.

동파 방지를 위한 열선 제어 시스템 설계에 관한 연구

박정일(Jeung-Il Park),김은원(Eun-Won Kim),박화세(Hwa-Se Park) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.6

This paper is wrapped around the heating wire, such as water and sewage pipes in plumbing and fire protection water pipes and winter apartments and buildings for frost protection system to prevent freezing. Characteristics of the frost protection system is a system that generates heat by supplying current to the heating wire wound around the pipe. In this paper, we will effectively control the current supplied to the heating coil and to design a system.

체외 수정으로 임신된 쌍태아 중 발육 부전을 가진 태아에서 발견된 제대 막양 부착

박원일(Won Il Park),남종윤(Jong Yun Nam),김주오(Joo Oh Kim),주종은(Jong Eun Joo) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

To date, velamentous insertion of umbilical cord has not been a topic of interest. It has regarded as a phenomenon without clinical significance rather than a disease. Furthermore, antenatal diagnosis of velamentous insertion has been thought as an impossible task. Recently, some investigators raised the clinical importance of velamentous insertion of umbilical cord, especially in multiple gestation. Below we report on a case of velamentous insertion of umbilical cord in discordant twins conceived by in vitro fertilization. The aim of this report is to emphasis the clinical significance of velamentous insertion of umbilical cord in twin gestation. The velamentous insertion of umbilical cord can cause twin-twin transfusion syndrome (TTTS) and pseudo TTTS. Besides, the possible correlation between the high incidence of velamentous insertion of umbilical cord and discordancy in twin pregnancy obtained by in vitro fertilization is also discussed in this report in conjunction with the case.

RC건축물에 설치되는 몰드변압기 내진 성능 향상을 위한 회전형 마찰댐퍼의 이력특성에 대한 실험적 연구

박원일(Park, Won-il),이승재(Lee, Seung-Jae),이지언(Lee, Ji-Eon),최경규(Choi, Kyoung-Kyu) 한국콘크리트학회 2021 한국콘크리트학회 학술대회 논문집 Vol.33 No.2

본 장치는 내, 외부 마찰패드간의 마찰을 통해 지진력을 상쇄시키는 것으로 몰드변압기의 좌, 우측외곽에 설치되어 약축 방향의 과다변위를 제어하는 역할을 한다. 실험은 본 장치의 성능을 검증하기 위한 선행연구로 반복가력 실험을 수행하였다. This device offsets the seismic force through friction between the internal and external friction pads and is installed on the left and right external sides of the mold transformer to control excessive displacement in the weak axis direction. The experiment was conducted to verify the performance of this device as a previous study

고혈압 전단계자들에 대한 골격근 Group Ⅲ 자극 시 시간에 따른 심혈관 반응

박원일(Won Il Park),박시영(Si-Young Park),최현민(Hyun-Min Choi),이준희(Joon-Hee Lee),전종목(Jong-Mok Jeon),김종경(Jong-Kyung Kim),심재근(Jae-Kun Shim),노호성(Hosung Nho) 한국생명과학회 2009 생명과학회지 Vol.19 No.11

본 연구는 고혈압전단계자들에 대한 지속적인 건 스트레치시 시간에 따른 생리학적 반응을 분석하여 정상혈압자와 고혈압전단계자에 대한 EPR의 한 요소인 기계적 수용기가 혈압 및 혈역학 반응에 어떠한 영향을 주는지를 검토하였다. 그 결과, 안정 시와 시간에 따른 혈압 반응은 고혈압전단계자에 있어 SBP, MAP가 평균 20sec에서 통계적으로 가장 높은 경향을 보였으며(p<0.05), 정상혈압자에서는 SBP, DBP, MAP가 평균 45sec에서 가장 높은 경향을 보였다(p<0.05). 이는 고혈압 전단계자의 지속적인 수동적 건 스트레치 시 정상혈압자에 비해 Group Ⅲ mechanoreceptors의 역기능에 따른 상승된 혈압 반응이 초기에 나타내었다고 사료된다. 또한 혈역학 반응에서 안정 시와 비교하여 지속적인 수동적건 스트레치 시 고혈압전단계자에서의 HR, SV, CO, TPR 모두 유의한 차이를 보이지 않았으나 정상혈압자에서 SV, CO가 통계적으로 유의한 차이를 보였다(p<0.05). 이는 CO, SV, HR, TPR이 정상혈압자에 비해 고혈압전단계자에 있어 높은 경향을 나타내었지만, 혈역학 반응은 본 연구를 통해 차이를 보이지 않아 앞으로 연구가 필요할 것으로 사료된다. The purpose of this study was to investigate whether group Ⅲ muscle afferents play an important role eliciting abnormal blood pressure response mediated during passive muscle stretch in prehypertensive individuals. Eleven middle-aged prehypertensive men (average BP 133/80 ㎜Hg) and nine middle-aged normotensive men (average BP 119/74 ㎜Hg) participated in this study. After 1 min rest baseline data collection, the subject’s foot was flexed (dorsiflexion) by an automated cybex for one minute. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate, stroke volume, cardiac output, and total peripheral resistance were continuously measured on a beat-by-beat basis from a finger via a Finapres device for 1 minute. To evaluate the role of mechanoreflex, a component of exercise pressor reflex, SBP, DBP, and MAP responses over the course of time were examined. The results showed that the pressor response mediated by the muscle mechanoreflex was faster in prehypertensive individuals compared to the normotensive individuals. The substantial pressor response was observed within mean 20 sec of the onset of passive stretch in prehypertension, while mean 45 sec in normotension (p<0.05). It is concluded that excessive pressor response produced during exercise in prehypertension may be due to the dysfunction of the mechano-receptors.

한국식 초저열량 식이요법의 비만치료 효과

박원일(Won Il Park),이종협(Jong Hyup Lee),조심현(Shim Hyun Jo),백봉력(Bong Luck Paik),최충경(Chung Keung Choi),이성근(Seung Geun Lee),문한규(Han Kyu Moon),최영미(Young Mee Choi),정윤석(Yoon Sok Jung),이관우(Kwan Woo Lee),김현만(Hyeon 대한내과학회 2002 대한내과학회지 Vol.62 No.3

N/A Background: There is increasing interest in the use of a very low calorie diet (VLCD) as a treatment regimen for weight loss in obese subjects. This study was designed to investigate the effect s and safety of a traditional Korean very-low-calory diet Methods: Twelve hospitalized obese patients at Dong Eui hospital in Busan city from May 1998 to December 1998 were selected. Height, body weight, blood lipids, blood insulin level, body fat, lean body mass, subcutaneous fat and visceral fat were measured. A traditional Korean VLCD was supplied for 14 days. Results: Patient's body weight was significantly decreased from 83.8 kg to 78.6 kg, body fat from 32.2 kg to 28.6 kg, lean body mass from 32.2 kg to 28.6 kg, and BMI from 31.4 to 29.5, respectively (p <0.05). Total fat was significantly decreased from 807 cc to 659 cc, subcutaneous fat from 567 cc to 473 cc, visceral fat from 273 cc to 185 cc, respectively. However there were no significant changes in minerals. After VLCD intervention, total cholesterol was significantly decreased from 199 mg/dL to 166mg/dL, HDL-cholesterol from 42 mg/dL, to 35mg/dL, triglyceride from 158mg/dL, to 75mg/dL (p<0.05). The insulin area under the curve was also significantly decreased from 205μIU/mL·2hr to 168 μIU/mL·2hr(p <0.05). Conclusion: Above findings suggested that a traditional Korean VLCD is effective and safe for short term use in terms of reducing body fat and improving insulin resistance in obese patients. (Korean J Med 62:250-257, 2002)