황연해독탕(黃連解毒湯)과 건강부자탕(乾薑附子湯)이 LPS유도에 의한 마우스 혈중 IL-6와 $TNF-{\alpha}$ 변화에 미치는 영향

박수현,권용욱,이태희,Park, Su-Hyun,Kwon, Yong-Uk,Lee, Tae-Hee 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1

Objective : This study was conducted to investigate the effects of Hwangryunhaedok-Tang and Geongangbuja-Tang on the change of interleukin-6 (IL-6) and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) level induced by LPS I.C.V. injection in mice. Method : We devided group into 6 mice and 6 mice were assingned to each group. In the normal group only saline was administered intragastrically, and in the control group LPS was injected intracerebroventricularly 1 hr after intragastric administration of saline. In the experiment groups Hwangryunhaedok-Tang(0.5g/kg, 1.0g/kg, 3.0g/kg) was administered intragastrically to mice 1 hr prior to LPS(100mg/mouse) I.C.V. injection.. Also Geongangbuja-Tang (0.5g/kg, 1.0g/kg, 3.0g/kg) was administered intragastrically to mice 1 hr prior to LPS(100mg/mouse) I.C.V. injection. To measure the plasma IL-6 and $TNF-{\alpha}$ level of mice, their blood samples were collected from retro-orbital plexus, immediately centrifuged at $4^{\circ}C$, and plasma was removed and stored frozen at $-83^{\circ}C$ for later determination of IL-6 and $TNF-{\alpha}$. The level of IL-6 and $TNF-{\alpha}$ production was measured by enzyme-linked immunosorbent assay in the plasma. Result : Regarding IL-6 level, The 0.5g/kg and the 1g/kg groups of Geongangbuja-Tang decreased IL-6 level. Especially the 3g/kg control group decreased IL-6 level significantly than the normal group(p<0.01). Regarding $TNF-{\alpha}$ level, the 3g/kg group of Geongangbuja-Tang decreased it significantly(p<0.05). Conclusion : These data revealed that Hwangryunhaedok-Tang might not have the anti imflammatory effect and Geongangbuja-Tang(3g/kg)might have the anti imflammatory effect by reducing the plasma IL-6 and $TNF-{\alpha}$ level in mice LPS Injection.EIM (Eighteen Incompatible Medicaments) is an important component in Oriental pharmacology and is directly related to clinical prescriptions. Medical practitioners argued that the definite cause and meaning of EIM was ambiguous and therefore debated the issue of clinical application of the EIM. This study conducted an in-depth literary research on the origin, meaning and contents of EIM with the purpose to contribute in its efforts to be used clinically. Even after thousands of years have past since establishment of Oriental medicine, EIM is still tabooed and was an obstacle that hindered ideologies. Modern herbal medicine texts claim that the use of EIM can reduce treatment effects and promote poisoning and side effects. However, since long ago, there has been medical practitioners who reject this as false. Recently, poisoning caused by EIM has been claimed to be from the toxicity of the drug itself, rather than the result of interaction between the drugs, and therefore they suggest that EIM is not a forbidden domain. In addition, EIM showed a difference in number depending on the era. However, this can be understood not as a definite number, but instead as a warning to be careful during combination of drugs for use as clinical medicine. Historically, there were very few cases in which EIM was used for clinical tests and thus, the clinical value is not, while others applied EIM directly to their bodies, which showed signs for the usefulness and potential of EIM for us. A more concrete and in-depth study must be made on EIM.

U-Home Healthcare를 위한 분산객체 미들웨어의 설계 및 구현

박수현,Park Su-Hyun 한국정보통신학회 2006 한국정보통신학회논문지 Vol.10 No.8

의료서비스 분야에서 의료와 컴퓨터 기술을 결합하여 온라인상에서 언제, 어디서나, 휴대 가능한 헬스케어(Healthcare) 장비와 유 무선 인터넷을 통해 실시간으로 환자의 생체정보 데이터를 수집하고, 이를 이용하여 진단 및 응급상황 인지가 가능한 U-헬스케어(Ubiquitous Healthcare) 시스템이 생겨났다. U-헬스케어 시스템은 기존의 의료 환경에서와는 달리, 사용자(환자, 보호자, 의료인등)들은 다양한 의료서비스를 요구하게 되고, 당연히 헬스케어 장비들은 통합된 의료서비스를 제공할 수 있도록 연동되어져야 한다. 본 논문에서 홈 네트워크(Home Network) 환경에서 사용자들의 다양한 요구를 처리하기 위해 분산 객체를 이용한 U-홈 헬스케어 미들웨어를 설계하였고, 다양한 헬스케어 장비들로부터 발생되는 생체 데이터를 통합하기 위한 데이터 변환 객체를 구현하였다. This paper proposes the U-healtcare middleware that is based on mininumCORBA. Ubiquitous healthcare system is generated by combining the technologies of computer system and medical system. This makes available that the person can receive medical treatment anywhere, anytime at on-line. The Healthcare devices are connected to network system as wire or wireless internet. So, the computer system can gather the vital information from the person at the real time and transfers the information to the server system that processes the medical information. When a medical doctor makes a diagnosis they can get more information about the patient by using the information within the server. Users would like to receive more services in the ubiquitous healthcare system than the traditional medical system. And in U-healthcare system, every healthcare devices and the users have to be connected to network system and the information from them has to be integrated. U-Home Healthcare middleware I proposed in this paper will do everything that I mentioned above.

한국십진분류법 기록관리학 분야 분류체계 개선에 관한 연구

박수현,이명규,Park, Su-Hyun,Lee, Myoung-Gyu 한국비블리아학회 2016 한국비블리아학회지 Vol.27 No.3

기록관리학이 독자적인 학문영역으로 발전해가고 있다. 하지만 KDC를 비롯한 기존의 문헌분류표에서는 분류 항목 배열이 기록관리학의 특성을 제대로 반영하지 못하여 분류항목의 전개가 불합리한 부분이 있으며, 주제영역별 세목전개의 재배치가 필요하다. 따라서 이 연구에서는 기록관리학의 학문 특성에 따라 주제영역을 기록관리 일반, 기록관리 법 정책, 기록물의 수집 선별 평가, 기록물의 조직, 기록정보서비스, 기록물 관리 및 보존, 기록관 운영, 기록관리 기관 등 8개 영역으로 설정하고, 현대 주요 문헌분류표인 KDC, DDC, NDC, UDC, LCC의 분류체계를 분석한 후, "대한민국 국가서지"의 기록관리학 분야 유별 자료현황 및 주제어 분석 결과를 반영하여 KDC 기록관리학 분야의 분류체계 수정 전개 방안을 제시하였다. 기록관리학 관련 주제영역 8개 분야의 내용은 KDC 028로 통합할 수 있도록 변경하였다. Archives and Records Management Studies is being developed its own independent domains. However, the existing library classification scheme such as the KDC don't properly reflect the characteristics of Archives and Records Management Studies. This classification scheme has the irrational part of the arrangement of the subject items and should be required to rearrange subdivision of the subject areas. In this study, According to the characteristics of Archives and Records Management Studies, It is set up 8 subject areas, Records Management (General), the law and polices of records management, the collection and appraisal of the records, the documentary organization, recording information services, preservation of the records, archives management, archives and records center, etc. After analyzing the major contemporary library classification system such as KDC, DDC, NDC, UDC, LCC, then It is suggested that improvement measures through analyzing classification status and keywords of the Archives and Records Management data contained in Korean National Bibliography. In Archives and records management studies, The contents of the eight subject areas related to the field are changed to allow integration with KDC 028.

Mesangial 세포에서 고포도당에 의한 IGFs 분비와 PKC 및 산화성 스트레스와의 관련성에 관한 연구

박수현,허정선,강창원,한호재,Park, Su-hyun,Heo, Jung-sun,Kang, Chang-won,Han, Ho-jae 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.4

The proliferation of mesangial cells has been associated with the development of diabetic nephropathy. The cell proliferation has been regulated by diverse growth factors. Among them, insulin like growth factors(IGFs) are also involved in the pathogenesis of diabetic nephropathy. However, it is not yet known about the effect of high glucose on IGF-I and IGF-II secretion and the relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in the mesangial cells. Thus, we examined the mechanisms by which high glucose regulates secretion of IGFs in mesangial cells. High glucose(25 mM) increased IGF-I and IGF-II secretion. High glucose-induced increase of IGF-I and IGF-II secretion were blocked by taurine($2{\times}10^{-3}$ M), N-acetyl cystein(NAC, $10^{-5}M$), or GSH($10^{-5}M$) (antioxidants), suggesting the role of oxidative stress. High glucose-induced secretion of IGF-I and IGF-II were blocked by H-7, staurosporine, and bisindolylmaleimide I(protein kinase C inhibitors). On the other hand, high glucose also increased lipid peroxide (LPO) formation in a dose dependent manner. In addition, high glucoseinduced stimulation of LPO formation was blocked by PKC inhibitors. These results suggest that PKC is responsible for the increase of oxidative stress in the action of high glucose-induced secretion of IGF-I and IGF-II in mesangial cells. In conclusion, high glucose stimulates IGF-I and IGF-II secretion via PKCoxidative stress signal pathways in mesangial cells.

S-100 메타데이터의 OWL기반 온톨로지 변환 구현

박수현,Park, Su-Hyun 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.11

해양 분야에서는 최근 e-navigation 실현을 위한 차세대 표준에 관한 연구가 진행 중이다. IHO(국제수로기구)를 중심으로 전자해도뿐만 아니라 해양의 지리 정보 및 관련 데이터의 교환, 공유, 활용할 수 있도록 S-100기반 다양한 표준에 대한 연구가 진행되고 있다. 다양한 데이터를 통합하여 안전운항을 위한 새로운 정보를 제공하기 위해서는 프로파일링을 통해 S-101, S-102, S-10x 등 다양한 표준 프로파일이 만들어지면 각 표준에서 정의하는 데이터 모델의 요소를 일관성 있고 명확하게 해석하는 것이 필요하다. 본 논문에서는 S-10x 표준의 기반이 되는 S-100 표준을 일관된 의미 해석과 처리를 할 수 있도록 S-100 표준의 메타데이터를 온톨로지로 변환하는 방안을 제시한다. In the field of maritime transport, various researches on next generation of standards are underway to realize e-navigation. While IHO leading the way, many studies on several S-100 based standards for exchange, sharing and utilizing maritime geographical information and related data are going on. IHO S-100 as a profile of ISO 19100 series of standards. Based on their application and service they provide, there can be different S-10x standards. In order to support the safe operation, various information should be integrated. When integrating a various information, it is crucial to make sure the same data model should be treated consistently and interpreted clearly across different profiles, such as S-101, S-102, etc. in this case. In this paper, I suggested a way to covert maritime metadata of S-100 to ontology so that we can perform consistent semantic analysis and processing of data in S-100 standards, which is the basis of other S-10x standards.

『東醫壽世保元·性命論』의 ‘大同於協義’와 ‘各立於擅利’의 해석에 대한 고찰

朴修玄(Park Su Hyun),金鍾鉉(Kim Jong Hyun) 대한한의학원전학회 2019 대한한의학원전학회지 Vol.32 No.3

Objectives : This paper aims to suggest alternative interpretations to previous ones of ‘Daedong-eo-Hyeobui(大同於協義)’ and ‘Gakrip-eo-Cheonri(各立於擅利)’ in the chapter ‘Theories on Nature and Conduct(性命論)’ in Donguisusebowon(東醫壽世保元) which have been found to be inadequate. Methods : Previous interpretations were thoroughly examined, then evaluated based on the narrative form and logical probability of the Donguisusebowon(東醫壽世保元). Afterwards, correct interpretations of the contents were suggested based on the context of the chapter ‘Theories on Nature and Conduct(性命論).’ Results & Conclusions : Of ‘Daedong-eo-Hyeobui(大同於協義)’, Daedong(大同) should be interpreted as ‘to gather largely’ instead of ‘all the same.’ Hyeobui(協義) should be interpreted as ‘to submit willingly’ and not ‘to cooperate to Ui(義).’ In the case of ‘Gakrip-eo-Cheonri(各立於 擅利)’, Gakrip(各立) means for people of same minds to rise against evil individually while Cheonri(擅利) refers to the evil of coveting for gains individually. There are other cases where existing interpretations have been erroneous other than the suggested examples, which prompts thorough re-evaluation of the text.

사사무애(事事無礙)와 무한으로 열린 법계원융(法界圓融) - 사(事)·리(理)·법계(法界)의 개념을 중심으로 -

박수현 ( Park Su-Hyun ) 한국불교선리연구원 2021 禪文化硏究 Vol.30 No.-

본고에서는 화엄불교의 중요 이론인 사종법계설 중의 사사무애의 의미에 대해서 고찰하며, 그것이 ‘특정한 관점이나 종파’가 아니라는 것과, ‘모든 관점과 종파가 원융무애하게 활용될 수 있는 상태’라는 것을 논할 것이다. 우선 사(事)·리(理)·법계(法界)의 개념을 중관과 유식을 융합한 새로운 시각에서 분석한 후, 그것들을 사종법계의 각 단계에 적응해 본다. 구체적으로 사법계를 ‘자성(自性)을 가진 개별적인 현상들’로, 이법계를 ‘단멸공’ 혹은 ‘세속제를 배제한 승의제’로, 이사무애법계를 유식적인 입장에서 ‘일체 사법을 포괄하는 진여문 · 일심’으로, 사사무애법계를 ‘세속제의 적극적인 활용으로서의 승의제’로 해석한다. 결론적으로 사사무애는 각기 다른 관점들과 교파들을 하나의 방편으로 보고, 다시 그것들의 특유의 위치와 역할을 다할 수 있게 하는 수단임을 밝힌다. 또한 사사무애는 ‘모든 것을 설명할 수 있는 관점’과 ‘무한으로 열려 있는 다양한 관점들의 체계’임을 보이고, 그것을 일승사상과 연결하여, ‘모든 관점을 포괄하여 무한으로 연결해주는 가장 큰 관점’은 동교일승이며, ‘무한으로 열려진 관점의 실체 없음’은 별교일승임을 논한다. This paper will examine the meaning of ‘the realm of non - obstruction between phenomena’ in the core theory of Huayan Buddhist, the theory of the ‘Four realms of Reality’. And it will argue that it is not concepts as entities implying a specific point of view or sect, but merely an expression of a state in which all perspectives and sects use indefinitely. It will begin by analyzing the meanings of the concepts such as phenomena(事), principle(理), and the dharma realm(法界) from a new perspective that combines the Madhyamika and the Yogācāra, and will discusses how they can be applied to each stages of the ‘Four realms of reality’. Specifically, interpret ‘the realm of individual phenomena(事法界)’ as individual phenomena with intrinsic nature(自性), ‘the realm of the one principle(理法界)’ as ‘Annihilistic denial of emptiness(斷滅空)’ or ‘the ultimate truth(勝義諦) excludes the conventional truth(世俗諦)’, ‘the realm of non - obstruction between principle and phenomena(理事無礙法界)’ as ‘the true thusness aspect(眞如門)’ or ‘one mind(一心)’, and ‘the realm of non - obstruction between phenomena(事事無礙法界)’ as ‘the ultimate truth(勝義諦) as an active use of the conventional truth(世俗諦)’. In conclusion, ‘the realm of non - obstruction between phenomena’ is a way of recognizing different viewpoints and denominations as a comprehensive method for explaining the phenomenon, and again, as a mechanism allowing them to accurately occupy their position and play a unique role. And it will argue that this realm is 'the perspective that can explain everything' and' the system of infinitely open various perspectives'.

논문(論文) : 『동의수세보원(東醫壽世保元)』 소음인(少陰人) 표병(表病)의 병기(病機) 및 치법(治法)에 대한 고찰(考察) -익기(益氣)와 승양(升揚)을 중심으로-

박수현 ( Su Hyun Park ),정창현 ( Chang Hyun Jeong ),장우창 ( Woo Chang Jang ) 대한한의학원전학회 ( 구 대한원전의사학회 ) 2010 대한한의학원전학회지 Vol.23 No.2

한국어 Text-to-Speech 변환을 위한 음운 변동 시스템에 관한 연구

박수현(Su-Hyun Park),권혁철(Hyuk-Chul Kwon) 한국정보과학회 언어공학연구회 1995 한국정보과학회 언어공학연구회 학술발표 논문집 Vol.1995 No.10

한국어 정보검색 시스템을 위한 다양한 적합성 피드백 방법의 실험

박수현(Su Hyun Park),권혁철(Huck Chul Kwon) 한국정보과학회 1999 정보과학회논문지(B) Vol.26 No.5

정보검색 시스템의 검색 효율 향상을 위해서 다양한 적합성 피드백 방법이 개발되었다. 그러나 한국어 정보검색 시스템을 위한 적합성 피드백에 대한 연구는 거의 이루어지지 않은 실정이다. 이 논문에서는 기존에 개발된 적합성 피드백 방법을 한국어 정보검색 시스템에 적용하여 검색 효율을 비교하고, 새로운 적합성 피드백 방법을 개발 적용하여 기존의 방법들과 검색 효율을 비교 분석하였다. 적합성 피드백은 원질의문을 확장할 단어 선택과 선택된 단어 가중치 부여로 이루어진다. 원질의문이 입력되면 검색된 적합문서에서 원질의문의 단어와 밀접한 관계가 있는 단어를 선택하여 가중치를 부가한 후, 원질의문에 추가하여 질의문을 확장한다. 이 논문에서는 원질의문 확장을 위한 단어 선택과 단어 가중치 부여를 위해 3가지 값을 사용한다. 첫째, TF는 적합문서 내의 단어 빈도의 총합이다. 둘째, idf 는 해당 문서집단의 역문헌빈도이다. 셋째, r/R은 검색된 적합문서 중에서 해당 단어가 있는 적합문서의 비율을 나타낸다. TF와 idf는 정보검색 시스템에서 일반적으로 사용되는 값이고 r/R은 이 논문에서 제안한 새로운 값이다. Since the use of relevance feedback in information retrieval to improve precision and recall was first proposed in the late 1960's, many different techniques have been used to improve the results obtained from relevance feedback. There has been little research on relevance feedback for a Korean information retrieval system. In this paper we apply the relevance feedback techniques used for other languages to Korean information retrieval system. We discuss several techniques to improve relevance feedback including changing the tenn weighting formula and term selection formula. The impact of each technique on improving precision and recall is investigated using the KT-Set 2.0 document collection, KRIST document collection and newspaper document collection.