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RBL 2H3 비만세포에서 히스타민 유리와 칼슘과의 관계
박성훈,김수정,김정민,박주현,최방실,이지윤,최미영,심상수,Park, Sung-Hun,Kim, Soo-Jeong,Kim, Jung-Min,Park, Ju-Hyun,Choi, Bang-Shil,Lee, Ji-Yun,Choi, Mi-Yeong,Sim, Sang-Soo 대한약학회 2007 약학회지 Vol.51 No.1
To investigate the relation between extracellular Ca$^{2+}$ and histamine release, we observed agonist-induced histamine release from RBL 2H3 mast cells in the presence or absence of extracellular Ca$^{2+}$ concentration. Histamine release induced by melittin and thapsigargin were greater in the presence of extracellular Ca$^{2+}$ than in the absence of extracellular Ca$^{2+}$. Econazole-induced histamine release had nothing to do with extracellular Ca$^{2+}$, whereas arachidonic acid-induced histamine release increased in the absence of extracellular Ca$^{2+}$. Calmodulin antagonists did not affect melittin-induced histamine release but they may potentiate arachidonic acid-induced histamine release. These data suggest that arachidonic acid-induced histamine release may be mediated via Ca$^{2+}$-independent pathway and may be potentiated by the block of Ca$^{2+}$-dependent pathway.
무작위 속도 변화에 의한 트레드밀 보행훈련이 뇌졸중 환자의 폐기능에 미치는 영향
박성훈 ( Sung-hun Park ),차용준 ( Yong-jun Cha ),최윤희 ( Yoon-hee Choi ) 대한물리의학회 2016 대한물리의학회지 Vol.11 No.4
PURPOSE: The purpose of this study was to investigate which treadmill walking training mode is more effective strategy for improving pulmonary function of persons with chronic stroke. METHODS: Twenty-one chronic stroke patients were allocated and randomly to an experimental group (treadmill training with randomized speed control, n=11) and a control group (treadmill training without speed change, n=10). All participants received 30 minutes of neurodevelopmental treatment. In addition, the two groups performed treadmill training for 20 minutes each time with or without speed change. Speed change was applied 40%, 50%, 60%, 70% of Heart Rate Reserve. All the exercise programs lasted six weeks, with five times per week. Pulmonary function was assessed before and after exercise program by using forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and maximal voluntary ventilation (MVV). RESULTS: In the both groups, FEV1 was significantly increased after training (p<.05). Compared to the control group, the experimental group showed 11.9% larger amount of change (p<.05). In the experimental group, FVC and MVV were significantly increased after training (9.9%, 7.6%, respectively) (p<.05). But in the control group, there was no significant difference in the FVC and MVV after training. CONCLUSION: Treadmill training with randomized speed control will be a better positive rehabilitation program than treadmill training without speed change to improve pulmonary function in persons with chronic stroke.
환경분쟁의 일방대리인 모형에서 "비대칭배상 원칙"의 정책효과
박성훈 ( Sung Hun Park ),이명훈 ( Myung Hoom Lee ) 한국환경정책학회 2007 環境政策 Vol.15 No.1
This paper explores how the introduction of asymmetric reimbursement rule(ARR) affects the frequency of environmental conflicts and rent dissipation, within the framework of a unilateral delegate model(UDM). In UDM, polluting firms represent themselves in court at their in-house attorneys` legal advice, while citizens` attorneys are employed on a contingent fee basis. Under ARR, when defeated, firms must reimburse citizens` litigation fees in addition to damages. We then show: (i) For low degrees of firms` legality, ARR raises winning probability and lowers expected litigation fee while enhancing total litigation effort level. This increases frequency of conflicts as well as rent dissipation. (ii) Otherwise, ARR makes no changes in winning probability, expected litigation fee, total litigation effort level, thus leaving frequency of conflicts and rent dissipation intact. (iii) For low degrees of firms` legality, results from existent literature coincide with this paper`s. Otherwise, however, the two sets of results reveal conflicts.
박성훈 ( Sung Hun Park ),김대철 ( Dae Cheol Kim ) 한국생산성학회 2015 生産性論集 Vol.29 No.1
The purpose of the study is to verify the presence of congestion in the operations of public hospitals in South Korea. Moreover, the differences in congestion and efficiency among the types(foundation type/treatment function) of public hospitals are analyzed. To do these, a DEA model is developed and “the 2013 National Public Hospital Guidance” that was provided by the Public Health Support Unit of National Medical Center is utilized. For the DEA model of congestion and efficiency, the following five inputs are selected: number of doctors, number of nurses, number of medical technicians, number of administrative staffs and number of sick-beds. As for the outputs for the analyses of congestion and efficiency, number of hospitalized patients, number of outpatients and medical profits are considered. The summary of the major results of the study is as follows. First, we find that there are congestions in the operations of public hospitals. For each input, public hospitals generally show a high rate of congestion occurrence as well as a large size of congestion in the operations. There are some differences in the congestion among the foundation types of public hospitals. The national hospitals are found to have a larger occurrence rate and the size of congestion than the special corporate hospitals and geriatric hospitals with respect to every input except for the number of medical technicians. As for the types of treatment function, the special medical treatment-centric (diseases) hospitals are found to have a larger size of congestion than the general medical treatment-centric hospitals and elderly-specialized hospitals in all the inputs. Second, in the case of the differences in the efficiency among the foundation types of public hospitals, the special corporate hospitals show the highest efficiency, followed by the geriatric hospitals and the national hospitals. As for the types of treatment function, the general medical treatment-centric hospitals are found to have a higher degree of efficiency than the elderly-specialized hospitals. The followings state the contributions of the study. First, in this research, the congestion of public hospitals of South Korea is measured and the existence of the congestion is verified for the first time by leveraging the congestion DEA model which would measure the special case of an inefficient situation. These results provide the practical implication that could help determine the priority of management by comparing the congestion for each input. Second, the differences in the efficiency among the types of foundation and treatment function are also analyzed. This achievement helps to establish a foundation which could enhance the understanding of the public hospitals by the environmental factors.