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RBL 2H3 비만세포에서 히스타민 유리와 칼슘과의 관계
박성훈,김수정,김정민,박주현,최방실,이지윤,최미영,심상수,Park, Sung-Hun,Kim, Soo-Jeong,Kim, Jung-Min,Park, Ju-Hyun,Choi, Bang-Shil,Lee, Ji-Yun,Choi, Mi-Yeong,Sim, Sang-Soo 대한약학회 2007 약학회지 Vol.51 No.1
To investigate the relation between extracellular Ca$^{2+}$ and histamine release, we observed agonist-induced histamine release from RBL 2H3 mast cells in the presence or absence of extracellular Ca$^{2+}$ concentration. Histamine release induced by melittin and thapsigargin were greater in the presence of extracellular Ca$^{2+}$ than in the absence of extracellular Ca$^{2+}$. Econazole-induced histamine release had nothing to do with extracellular Ca$^{2+}$, whereas arachidonic acid-induced histamine release increased in the absence of extracellular Ca$^{2+}$. Calmodulin antagonists did not affect melittin-induced histamine release but they may potentiate arachidonic acid-induced histamine release. These data suggest that arachidonic acid-induced histamine release may be mediated via Ca$^{2+}$-independent pathway and may be potentiated by the block of Ca$^{2+}$-dependent pathway.
박성훈(Sung Hun Park),최승욱(Seung Uk Choi) 한국경영학회 2019 經營學硏究 Vol.48 No.6
The incentives of engaging in earnings management varies depending on the business environment. In this study, we explore the tendency of earnings management of rehabilitation firms based on time-series investigation. There are few studies who examine earnings management of rehabilitation firms. In particular, previous studies related to the rehabilitation process have focused on the firm performance after the completion of rehabilitation procedure. To the best of our knowledge, none of them directly examine the earnings management throughout the rehabilitation process. Therefore, this study investigates the earnings management of rehabilitation firms by using the time series method. Specifically, we divide the procedure into 5 steps which are: the year immediately preceding the start year (- 1 year), the start year, the progress year, the ending year, and the immediately following year after closing the procedure (+ 1 year). The results of this study are as follows. We first document significant negative relations between the discretionary accruals and the year -1 and the start year compare to control group. In contrast, significant and positive discretionary accruals are observed during the progress year. We also find evidence of positive earnings management at the progress year using performance matched discretionary accruals. We interpret this finding as the presence of incentive for the manager to overestimate earnings for the early termination of the rehabilitation process. Moreover, this higher discretionary accruals at the progress year incrementally decreases as the leverage ratio increases. Increasing leverage ratio may reflect the increase in creditors right to intervene the process, thereby restrict the incentive for management to manipulate reported earnings. Our findings are consistent in the results of using different samples as a control group and in the two-stage regression analysis models applied to control existing endogeneity issues in our models. Collectively, our study contributes to the literature and practice by finding significant earnings management during the rehabilitation process. However, this study has a limitation that the number of samples of rehabilitation firms is too small. We expect that the data will be accumulated through subsequent studies to overcome this limitation in the sample selection.
李漁의 劇作法의 原理와 原則 小考 - 結構第一을 중심으로
박성훈(Park, Sung-Hun) 중국문화연구학회 2020 중국문화연구 Vol.0 No.49
Li Yu was an important drama theorist and writer in the late Ming and early Qing Dynasties. Learning from the experience of his predecessors and combining it with his own writing experience, his drama theory has it unique features. Based on his structural theory(結構論), this paper extracted the drama writing method. Li Yu recognized that creating a play is really creating something new, and he practiced this perception himself. He wrote the principles and laws of script creation for the development of plays, This paper analyzed the play writing’s method in three areas: theme, conflict, and story. Theme can be said to be a topic, and it is thought to have been used as a proposition(命題). A proposition in a play, it can be interpreted as a short sentence that explains the content of a work. Setting up a proposition is a process of embodying the abstract ideas that the author has in his head into a sentence, and it is thought that if the proposition is established, he can enter the stage of creation of the play to a certain extent. This is because the proposition includes characters, conflicts, and endings. Li Yu realized that plays are the determinants of conflict. The play proceeds as conflicts arise, are resolved, and converted, then another conflict is created, resolved, and converted. He then set up a main force(主腦), whether it is the backbone of the so-called conflict, to make the main character act, and highlighted the conflict so that the plot can be developed with a connection. This is something unique that he created. Then It would be really hard to discover and create new materials and story. The creation of a play has become an inevitable factor in the success or failure of a drama creation. In this sense, LI Yu’s search and encouragement for new story are like map, which guides play writing on the path of new creation. The principles of Li Yu’s drama creation law are valuable and can still apply today.