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The Effects of Ethanol Ingestion on Respiratory Drive in Young, Nonobese, Nonsnoring, Sleeping Men
문화식 ( H. S. Moom ),김치홍 ( C. H. Kim ),권순석 ( S. S. Kwom ),김영균 ( Y. K. Kim ),김관형 ( K. H. Kim ),한기돈 ( K. D. Han ),송정섭 ( J. S. Song ),박성학 ( S. H. Park ) 대한결핵 및 호흡기학회 1992 Tuberculosis and Respiratory Diseases Vol.39 No.6
한기돈(K . D . Han),문화식(H . S . Moon),송정섭(J . S . Song),박성학(S . H . Park),변해원(H . W . Byun) 대한내과학회 1987 대한내과학회지 Vol.34 No.1
N/A In 37 patients with bronchial asthma with or without nocturnal dyspnea, the levels of plasma cortisol were measured at 8 A.M. and 11 P.M., and before and after ACTH infusion for 8 hours. The observed results were as follows: 1) In 20 patients with bronchial asthma without nocturnal dyspnea the value of plasma cortisol at 8 A.M. was 15.1±7.0 ㎍/dl and at 11 P.M. 8.8±5.7 ㎍/dl. 2) In 17 patients with nocturnal or morning dipper asthma, the value of plasma cortisol at 11 P.M. was 3. 2±1.1 ㎍/dl and was lower than that of bronchial asthmatics without nocturnal dyspnea (p < 0. 01). 3) In 20 bronchial asthmatics without noctunal dyspnea, the value of plasma cortisol before ACTH infusion was 12.6±5.9 ㎍/dl and after ACTH infusion 35. 1±3.2 ㎍/dl. The results of present study show that the patients with bronchial asthma have normal circardian rhythm of cortisol level, but the patients with nocturnal asthma have lower level of plasma cortisol at 11 P.M. than that of bronchial asthmatics without nocturnal dyspnea, The function of adrenal cortisol secretion after stimulation with ACTH infusion is normal. The circardian rhythm of corticosteroid secretion seems to be a possible factor of nocturnal asthma.
^(32)P-postlabelling法을 이용한 有機溶劑 작업장 근로자의 遺傳毒性 評價
홍대용,김장락,이장호,문중갑,이한우,김동일,박성학,정주화,이홍근 한국환경독성학회 1994 환경독성보건학회지 Vol.9 No.1
To evaluate the genotoxicities of workers exposed to glue and glue cleaning solution, ambient air monitoring of working place, animal study and human monitoring were carried out. By GC-MS analysis, air samples collected from shoesmaking plant were found to be toluene, xylene, cyclohexane, n-hexane, methyl ethyl ketone, trichloroethylene, butylacetate, isopropyl alcohol. Glue and glue cleaning solution from shoesmaking plant were applicated topically to the CD-1 mice. DNA was isolated from skin 24 hr following the application and analysed for DNA-adducts using the nuclease P₁ version of ^(32)P-postlabelling assay. RAL (Relative Adduct Labelling, adducts/10^(8) nucleotides) was significantly increased in a dose-dependent manner in the glue cleaning solution treated mice skin. Peripheral blood DNA-adducts of workers exposed to glue and glue cleaning solution were also analysed by the same method, but there were not significant differences in the peripheral blood DNA-adducts level between exposed and control workers. In addition, glue cleaning solution from shoes factory was evaluated for mutagenicity in the Salmonella plate incorporation assay using strains TA 100 and TA 1535 in the presence and absence of Arochlor 1254-induced rat liver S_(9). There was evident mutagenicity for cleaning solution in TA 100 regardless of S_(9), but TA 1535 showed positive only in the absence of S_(9) when predicted by Stead model of mutagenicity prediction (p=0.0000). The urine concentrates from workers and controls were also assayed for mutagenicity towards strain TA 100 of Salmonella typhimurium in the presence of S_(9) using Kado's microsuspension assay, but their mutagenic activities were not found to be significant. These data suggest that shoesmaking workers are exposed to genotoxic compounds and need to be monitored by testing the mutagenicity of human urines. However, ^(32)P postlabelling application requires further validation for the routine monitoring of human exposure.