우황청심원(牛黃淸心元)이 저산소증 유발 배양신경세포에 미치는 영향

조규선,신길조,문일수,이원철,정승현,Cho, Gyu-Seon,Shin, Gil-Cho,Moon, Il-Soo,Lee, Won-Chul,Chung, Sung-Hyun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.2

Objectives : The purpose of this investigation is to evaluate the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast. Methods : To evaluate the effect of Woohwangcheongsim-won on neuronal death caused by hypoxia, the survival rate of E18 cortical neuroblast was measured with MTT assay and the changes of several synaptic proteins and enzymes were investigated with the immunoblot assays. Results : The E18 cortical neuroblasts were added 50, 100, 500, 1,000, and $5,000{\mu}g/ml$ Woohwangcheongsim-won. They showed neurotoxicity, when the concentration of Woohwangcheongsim-won was above $1,000{\mu}g/ml$. The E18 cortical neuroblasts, which were added 50, 100, and $500{\mu}g/ml$ Woohwangcheongsim-won, were exposed 98% $N_2/5%\;CO_2$ for 3 hours to induce hypoxia, 3 days later, the survival rate of $50{\mu}g/ml$ Woohwangcheongsim-won was 141.5% when compared to the control group. On the immuneblot assays, the expressions of ${\alpha}$CaMKII, NR2A, NR28, PDE2, PSD-95, and eEF-$1{\alpha}$ were increased in normoxia, but those of NR2A, NR2B were decreased in hypoxia when compared to the control group. Conclusions : The data shows that the effects of Woohwangcheongsim-won on neuronal death of hypoxic E18 cortical neuroblast is a significant result.

“3-5세 연령별 누리과정” 만 5세 수학적 탐구하기와 “수학과 교육과정” 초등 1학년 연계성 고찰

문정원 ( Jung Won Moon ),임영심 ( Young Sim Lim ) 한국어린이문학교육학회 2014 어린이문학교육연구 Vol.15 No.3

본 연구의 목적은 3-5세 연령별 누리과정 5세 수학적 탐구하기와 초등 1학년 수학교육과정의 연계성이 어떠한지를 살펴보는 것이다. 각 교육과정의 목표, 내용, 교수·학습방법 및 평가의 연계정도와 연계형태를 계열성과 계속성, 역행, 격차, 소멸의 다섯가지 준거요소를 토대로 비교 분석하였다. 그 결과 두 교육과정의 목표, 내용, 교수 학습 목표, 목표의 연계정도와 연계형태는 높은 수준을 보였다. 목표는 수학과 교육과정의 초등학교 목표가 더 세부적이면서 포괄적으로 진술되고 있어 연계성이 높았다. 내용은 계속성과 계열성이 높아 전반적으로 높은 연계성을 보였고, 비연계로 분석된 부분은 교육과정 상에 언급이 되지 않을 뿐 다른 교과목이나 활동 전반에 포함되어 있었다. 교수학습 방법은 교육과정상에서는 연계 수준이 낮았으나 지도 지침 및 유의점에서는 활동의 연계가 높은 것으로 나타났다. 평가는 연계성의 수준이 중간인 것으로 나타났다. 평가 방법이 다양해지고 세분화되었지만 그 평가의 활용부분에서는 유아교육보다 더 좁아지기 때문이다. 연구 결과, 유아교육과 초등 1학년 수학교육의 연계성은 과거 교육과정에 비해 증진되었으며, 특히 3-5세 연령별 누리과정은 개정중점에서도 밝혔듯이 초등학교 1학년과의 연계 뿐 만 아니라, 3, 4, 5세 끼리의 연계성도 고려하여 과거에 비해 수학교육실천의 연계 가능성이 크게 높아 졌음을 알 수 있다. The purpose of this study was to analyze the articulations between the Mathematical Exploratory areas for age 5 in the 3-5 years old Nuri Curriculum and the first grade in Math Curriculum. Four curriculum elements, which are objectives of education, educational content, teaching-learning methods and educational evaluations, are analyzed in both curriculum by 5 criteria, which are continuance, sequence, retrogression, disparity, and extinction. The results of this study were as follows: As a whole the degree of articulations was high in every part in 3-5 years Nuri Curriculum and first grade in Math Curriculum. Objectives in Math Curriculum are more inclusive and detailed than 3-5 years Nuri Curriculum. Most educational content has high degree articulations, but some categories do not. It is because it is not stated in the official curriculum. The content which is not stated in the official curriculum is passed over potentially in 3-5 years old Nuri Curriculum and Math Curriculum. Teaching-learning methods have a low degree of articulations yet, in remarks on a map are shown differently. They are well-coordinated. In this case, it’s caused by different comparison units. Educational evaluations had a middle degree of articulations. These evaluation methods are more detailed and extensive, nevertheless the application scope is limited in Math Curriculum. In conclusion, 3-5 years old Nuri Curriculum and the First grade Math Curriculum are higher than former curriculums. Especially, since 3-5 years old Nuri - Curriculum has strong articulation between 3-4 years and 5years old too, there is a good possibility of articulation in Math Curriculum.

종 설 : 궤양성대장염에서 Golimumab 치료

문원 ( Won Moon ) 대한소화기학회 2016 대한소화기학회지 Vol.67 No.2

Ulcerative colitis is a chronic inflammatory condition of the colon, characterized by diffuse mucosal inflammation and blood-mixed diarrhea. The main treatment has been 5-aminosalicylic acid, steroid, thiopurine, and anti-tumor necrosis factor alpha (TNF-α) antibodies including infliximab, adalimumab, and golimumab. Golimumab, a new anti-TNF-α agent has been recently approved for patients with moderate to severe ulcerative colitis. Its efficacy and safety has been demonstrated in line with infliximab and adalimumab in preclinical and clinical studies. This review will focus on golimumab therapy in ulcerative colitis.

Ciprofloxacin에 의해 발생한 고정약진

문혜림 ( Hye Rim Moon ),원광희 ( Kwang Hee Won ),윤우진 ( Woo Jin Yun ),원종현 ( Chong Hyun Won ),장성은 ( Sungeun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.3

Fixed drug eruption is a pattern of a drug-induced cutaneous reaction. It is characterized by skin erythematous plaques that recur at the same site each time the drug is administered. Now, we report the case of a 26-year-old woman who presented with 2 ill-defined erythematous patches on her back with itching sensation. The patient had a history of ciprofloxacin medication. The patch test with suspected drugs showed negative reactions, but intradermal tests were positive reactions. The patient was diagnosed with fixed-drug eruption due to ciprofloxacin. (Korean J Dermatol 2013;51(3):192∼195)

지방층염으로 발현한 피부근염

문혜림 ( Hye Rim Moon ),원광희 ( Kwang Hee Won ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.4

Panniculitis is a rare cutaneous finding in dermatomyositis (DM), presenting as tender subcutaneous nodules. Because panniculitis may precede other symptoms of DM, and its complications, including pain, lipoatrophy and carcinosis, might be severe and irreversible, early diagnosis and treatment of panniculitis is important. We herein describe a case of dermatomyositis first presenting as panniculitis in a 45-year old man. (Korean J Dermatol 2013;51(4):284∼287).

K-IFRS 의무도입으로 인한 연결범위 변동과 관련기업 특성에 대한 연구

문해원(Moon, Hae Won),권경은(Kwon, Kyung Eun) 한국국제회계학회 2013 국제회계연구 Vol.0 No.52

본 연구는 2011년 K-IFRS을 의무도입한 상장기업을 대상으로 연결재무제표의 작성과 연결범위의 변동현황을 조사하였다. 그리고 연결범위 포함여부에 따라 관련기업의 재무적 특성을 파악함으로써 연결범위 결정요인을 알아보았다. 또한 지배력 판단 근거에 따라 관련기업을 재분류하여 재무적 특성을 살펴보고 판단기준의 차별적 특성 및 연결재무제표에 미치는 영향을 알아보았다. 표본은 K-IFRS를 의무도입한 유가증권 상장기업 666개와 코스닥 상장기업 897개, 총 1,563개의 상장기업과 이들이 보유한 7,661개의 관련기업이다. 연구결과, K-IFRS 도입 후 연결재무제표의 작성 비율이 약 26% 증가하였다. 종속기업 또한 증가하였는데, 유가증권 상장기업의 종속기업은 약 1.41배, 코스닥 상장기업의 종속기업은 약 3.11배 증가하였다. 연결범위를 결정하는 주된 판단근거는 지분율기준이었는데, 81.75%가 지분율기준을, 6.55%만이 실질지배력기준을 사용했다. 지배기업이 연결범위를 결정할 때 고려하는 주된 재무적 특성은 수익성으로 나타났으며 부채비율과 상대적 기업규모는 결정요인이 아닌 것으로 나타났다. 즉, 지배기업은 수익성을 고려하여 연결범위를 결정함으로써 연결실체의 수익성 향상을 도모하는 것으로 보인다. 또한 실질지배력기준은 지분율기준에 비해 수익성이 높고(낮고), 부채비율이 낮은(높은) 관련기업을 연결범위에 포함(제외)시키고 있었다. 따라서 실질지배력기준은 지분율기준에 비해 연결재무제표에 대한 긍정적 영향이 큰 경우에 사용되었다. 본 연구의 결과가 나타내듯이 연결범위의 주된 결정기준은 지분율이고 실질지배력의 사용빈도는 낮았다. 하지만 2013년부터 적용되는 「기준서 제1110호 ‘연결재무제표’」는 경제적 실질을 반영한 실질지배력기준을 더욱 강조하고 있다. 따라서 앞으로 실질지배력에 대한 전문가적 이해와 판단이 증진되어야 하고 실질지배력기준의 명확한 판단 근거 공시 및 일관된 적용이 요구된다. This paper investigates how many firms report consolidated financial statements and how firm’s consolidated coverage changes after the adoption of K-IFRS. We also investigate the financial characteristics of related firms which are included or excluded from consolidated entity. In addition, we compare the financial characteristics of firms that are included in consolidated financial statements based on the percentage ownership standards with those based on the de facto control standards. The sample is consisted of 666 KOSPI firms and 897 KOSDAQ firms in 2011. After the adoption of K-IFRS, the disclosure of consolidated financial statement has increased by 26%. The number of subsidiary companies is also increased by 1.41 times for KOSPI and 3.11 times for KOSDAQ respectively. Most firms use the percentage ownership as a standard to include subsidiaries in consolidated financial statements but they rarely employ the de facto control standard. 81.75% of the related firms are included based on the percentage ownership standard whereas 6.55% of them are included based on the de facto control standard. The findings also show that profitability of subsidiaries is the most important financial characteristics to be included in consolidated financial statements. Leverage ratio and relative firm size are not considered important. When the related firms induce favorable effect on consolidated entity, the de facto control is used as the consolidated coverage standard. Specifically, related firms that are included by the de facto standard are more profitable and have less leverage ratios, and larger relative size than other firms.

기능성 위장관 질환에 있어서 식이 요인

문원 ( Won Moon ),박무인 ( Moo In Park ) 대한소화기기능성질환·운동학회 2007 Journal of Neurogastroenterology and Motility (JNM Vol.13 No.1

사격선수의 자기관리가 대처방식에 미치는 영향

문원기(Moon, Won-Ki),성창훈(Seong, Chang-Hoon),장동수(Jang, Dong-Soo) 한국웰니스학회 2017 한국웰니스학회지 Vol.12 No.1

본 연구는 사격선수들을 대상으로 성별, 종목별, 소속별, 자기관리가 대처방식에 미치는 영향을 분석하였다. 본 연구의 대상은 대한사격연맹에 등록되어 있는 사격선수 293명(남자선수 159명, 여자선수 134명)이다. 사격선수들의 자기관리를 측정하기 위한 도구로는 운동선수 자기관리행동 질문지와 스포츠 대처척도 질문지를 사용하였다. 자료 분석은 상관분석과 중다회귀분석을 실시하였다. 연구결과 성별, 종목별, 소속별 자기관리와 대처방식은 유의한 상관관계를 보였다. 중다회귀분석 결과 사격선수들은 자기관리의 6개 영역에 의해 대처방식 요인이 영향을 받는 것으로 나타났다. 본 연구를 통하여 사격선수들이 관심 있게 다루어야할 자기관리 항목을 알 수 있었으며, 대처방식에 미치는 자기관리의 변인들도 확인할 수 있었다. 이러한 연구결과를 바탕으로 사격선수들의 최상의 운동수행에 도움이 되기를 바란다. This study examined the effect of shooting athletes self-management on sport coping according to gender, affiliation, item. The subjects of the study were 293 shooters(159 male, 134 female) who registered to Korea Shooting Federation. Self-management was examined by use of an athletes self-management behavior questionnaire, while sport coping was determined by the sport coping scale questionnaire. we used the pearson"s correlation and multiple regression for statistical analysis. The results showed that shooting athletes self-management and sport coping were correlated with gender, affiliation, item. The results of multiple regression analysis indicated that the shooting athletes sport coping was influenced by self-management. Could know self-management item that shooting athletes must handle to be interested through this research, and could confirm is self-management"s factor that influence to sport coping. With these study finding, want to aid in number of shooting athletes best exercise.

농촌지역 초중고 학생들의 김치 섭취실태 및 기호도 분석

문성원(Sung Won Moon),이명기(Myung Ki Lee),나태균(Tae Kyun Na) 한국조리학회 2011 한국조리학회지 Vol.17 No.1

The purpose of this research is to examine the awareness and preference for a variety of Kimchi and Kimchi intake patterns among the students living in Chungbuk province. Four hundred samples, consisting of elementary, middle, and high school students, were surveyed; and a total of 366 usable, completed copies of the questionnaire were used for the research. The collected data were statistically analyzed using SPSS 10.0. The results of the analysis were as follows: First, Kimchi was considered traditional (24.3%), nutritious (20.5%), fermented (19.2%), and healthy (16.1%). Second, the main reason Kimchi was preferred was its hot taste (25.4%), chewy texture (17.4%), and sour taste (14.0%). The students preferred their Kimchi a little hot, moderately salty, and properly fermented with a moderate amount of seasoning and did not care much about any particular parts of Kimchi. Third, 75.4% of the students ate Kimchi more than twice a day, and 78.0% of the students consumed more than 3 pieces(2.5×3.0cm) of Kimchi per meal. Fourth, elementary students wanted the school foodservice to develop bite-sized Kimchi while middle school students wanted to eat their favorite parts of Kimchi without the fishy smell. High school students wanted to eat cool and fresh Kimchi. Finally, the students wanted Kimchi to contain the following fruit and vegetables: pears (48.9%), apples (34.2%), and pineapples (30.0%), young radishes (44.9%), turnips (37.5%), and sesame leaves (34.9%). This study concludes that it is necessary to educate young students about traditional Korean food culture, serve them various types of Kimchi, change the service style, and develop new Kimchi recipes to increase Kimchi intake in school foodservices.

유아교사의 놀이교수효능감, 정서표현성, 교사 부모 협력이 교사 유아 상호작용에 미치는 영향

문정원(Jung-Won Moon),김민주(Min-Ju Kim) K교육연구학회 2024 사회과학리뷰 Vol.9 No.1

본 연구는 교사-유아 상호작용에 영향을 미치는 유아교사의 놀이교수효능감, 정서표현성, 교사-부모 협력 간의 관계 및 상대적 영향력을 알아보고자 한다. 이를 위하여 본 연구에서는 부산시 및 경상남도의 유치원 및 어린이집에 재원 중인 만 4, 5세 유아들 352명과 그 담임교사를 대상으로 하였다. 수집한 자료는 SPSS 25.0 프로그램을 활용하여 상관분석 및 단계적 중다회귀 분석을 통해 분석하였다. 연구결과는 첫째, 유아교사의 놀이교수효능감, 정서표현성, 교사-부모 협력, 교사-유아 상호작용 간의 정적상관이 나타났다. 둘째, 교사-유아 상호작용에 미치는 상대적 영향력을 살펴본 결과, 놀이교수효능감의 하위요인인 놀이교수 효능에 대한 신념이 전체 교사-유아 상호작용 및 하위변인에 대한 영향력을 가장 높게 예측하는 유의한 정적 예측 변인이었고 다음이 부모-교사 협력의 하위요인인 정보추구였다. 결론적으로 본 연구는 교사-유아 상호작용에 영향을 미치는 교사의 내적·외적 변인을 함께 분석하였다는 점에서 의의가 있으며, 이를 통해 교사-유아 상호작용의 질적 수준 증진 방안을 마련하기 위한 기초자료가 될 수 있음을 제안한다. The purpose of this study is to investigate the relationship and relative influence of early childhood teacher’s play teaching efficacy, emotional expressiveness, and teacher-parent partnership that affect teacher-child interaction. The subjects for this study were 352 children aged 4,5 and Early childhood teachers in kindergartens and daycare centers in Busan and Gyeongsangnam-do. The collected data were analyzed through correlation analysis and stepwise multiple regression analysis using the SPSS 25.0 program. As a result of the study, first, there was a positive correlation between early childhood teacher’s play teaching efficacy, emotional expressiveness, teacher-parent partnership, and teacher-child interaction. Second, as a result of the relative influence on teacher-child interaction, belief in the efficacy of play teaching, a sub-factor of play teaching efficacy, was a significant positive predictor that predicted the greatest influence on all teacher-child interaction and sub-variables and seeking information, a sub-factor of teacher-parent partnership was second. In conclusion, this study is significant in that it analyzes teacher’s internal and external variables that affect teacher-child interaction together and this suggests that it can serve as basic data for developing measures to improve the quality level of teacher-child interaction.