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윤병구 ( Byung Koo Yoon ),김도관 ( Doh Kwan Kim ),김종원 ( Jong Won Kim ),최두석 ( Doo Seok Choi ),배덕수 ( Duk Soo Bae ),나덕렬 ( Duk Lyul Na ) 대한폐경학회 2003 대한폐경학회지 Vol.9 No.1
배경 및 목적 : 치매는 낙상 가능성의 증가를 통하여 골절의 위험을 높힌다. 진행된 치매에서 관찰되는 골다공증은 영양실조에 의한 2차성 부갑상선항진증과 운동부족이 중요한 원인으로 알려져 있다. 본 연구의 목적은 알쯔하이머병 여성 환자에서 골다공증에 대한 유병률을 조사하는 것이다. 대상 및 방법 : 80명의 알쯔하이머병 환자를 대상으로 하였으며, 초기 치매는 임상치매척도가 1 이하이며, 운동 기능은 정상인 경우로 정의하였다. 과거력상 비외상성 골절의 유무를 조사하였고, osteocalcin과 deoxypyridinoline 등의 골대사지표와 함께 이중에너지 방사선흡수계측법을 이용하여 골밀도를 측정하였다. 결과 : 전체적으로 알쯔하이머병 여성에서 골다공증의 유병률은 58%이었다. 80명중 45명이 초기 치매에 해당하였다. 초기 치매환자에서 골다공증성 골절의 과거력이 38%, 골교체률이 증가한 경우가 72%이었으며 골다공증의 유병률은 62%이었다. 결론 : 여성에서 영양상태와 운동기능이 정상인 초기 알쯔하이머병은 골다공증과 매우 높은 연관성을 보이며, 이는 난포호르몬-알쯔하이머병 가설을 뒷받침하는 연구 결과이다. Background and objective : Dementia is one of the risk factors of fracture via increasing risk of falling down. Osteoporosis occurring in advanced dementia might be causally related to secondary hyperparathyroidism resulting from poor nutrition and physical activity. The purpose of this study is to examine the prevalence of osteoporosis (OP) in patients with Alzheimer`s disease (AD). Materials and methods : Past history of non-traumatic fracture, bone turnover markers such as osteocalcin and deoxypyridinoline and bone mineral density (BMD) using dual energy X-ray absorptiometry were assessed in 80 women with AD. Early AD was defined as clinicla dementia rating scale ≤ 1 and physical activity unimpaired. Results : In general, the prevalence of OP (T value on BMD ≤ -2.5) was 58% in women with AD. Forty-five out of 80 patients belonged to early AD. Thirty-eight percentage of early AD patients had history of fragility fracture, 72% increased bone turnover rate, and 62% osteoporosis. Conclusions : Early AD with normal nutritional status and physical activity might be highly associated with OP, which supports estrogen-AD hypothesis.
알쯔하이머병에서 양전자방출단층촬영을 이용한 국소뇌포도당대사의 변화에 관한 연구
김병태(Byung Tae Kim),김상은(Sang Eun Kim),최용(Yong Choi),이경한(Kyung Han Lee),최연성(Yearn Seong Choe),나덕렬(Duk Lyul Na),이정림(Jeong Rim Lee),김도관(Doh Kwan Kim),이광호(Kwang Ho Lee),김승태(Seung Tai Kim) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3
N/A The purpose of the present study was to validate the use of tissue radioactivity ratios instead of regional metabolic rates for the assessment of regional metabolic changes in Alzheimer's disease(AD) with [18F]FDG PET and to examine the correlation of ratio indices with the severity of cognitive impairment in AD. Thirty-seven AD patients(age 68±9 yrs, mean±s.d.; 36 probable and 1 definite AD), 28 patients with dementia of non-Alzheimer type(age 66±7 yrs), and 17 healthy controls(age 66±4 yrs) underwent [18F]FDG PET imaging. Two simplified radioactivity ratio indices were calculated from 37-66 min image: region-to-cerebellar radioactivity-ratio(RCR) and a composite radioactivity ratio(a ratio of radioactivity in the most typically affected regions over the least typically affected regions: CRR). Local cerebral metabolic rate for glucose(LCMRglu) was also measured using a three-compartment, five-parameter tracer kinetic model. The ratio indices were significantly lower in AD patients than in controls(RCR in temporoparietal cortex, 0.949±8.136 vs. 1.238±0.129, p=0.0004; PCR in frontal cortex, 1.027±0.128 vs. 1.361±0.151, p〈0.0001; CRR, 0.886±0.096 vs. 1.032±0.042: p=0.0024). On the RCR analysis, 86% of AD patients showed a pattern of bilateral temporoparietal hypometabolism with or without frontal involvement; hypometabolism was unilateral in 11% of the patients. When bilateral temporoparietal hypometabolism was considered to be suggestive of AD, the sensitivity and specificity of the RCR was analysis for the differential diagnosis of AD were 86% and 73%, respectively. The RCR was correlated significantly with the macroparameter K [K1k3/(k2+k3)] (r=0.775, p〈0.0001) and LCMRglu(r=0.633, p=0.0002) measured using the kinetic model. In patients with AD, both average RCR of cortical association areas and CRR were correlated with Mini-Mental Status Examination(r=0.565, p=0.0145; r=0.642, p=0.0031, respectively), Clinical Dementia Rating(r=-0.576, p=0.0124; r=-0.591, p=0.0077), and total score of Mattis Dementia Rating Scale (r=0.574, p=0.0648; r=0.737, p=0.0096). There were also significant correlations between memory and language impairments and corresponding regionl RCRs. The results suggest that the [18F]FDG PET ratio indices, RCR and CRR, reflect global and regional metabolic rates and correlate with the severity of cognitive impairment in AD. The simplified ratio analysis may be clinically useful for the differential diagnosis and seral monitoring of the disease.