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Probe EF 5.44 를 이용한 가족성선종성용종증 ( FAP ) 과 Gardner 증후군 ( GS ) 가계의 Linkage Analysis
김효종(H . J . Kim),김영관(Y . K . Kim),동석호(S . H . Dong),김병호(B . H . Kim),이정일(J . I . Lee),장영운(Y . W . Chang),장린(R . Chang),최영길(Y . K . Choi),이기형(K . H . Lee) 대한내과학회 1993 대한내과학회지 Vol.45 No.3
Background: Familial adenomatous polyposis (FAP) and Gardner's syndrome (GS) are conditions, inherited in an autosomal dominant fashion, that predispose affected family members to the development of colorectal cancer. The gene(s) responsible for FAP/GS is on the chromosome 5q21-22. Several RFLP markers for the chromosome 5q21-22 region are now available and can be used clinically for premobid diagnosis in affected FAP/GS family members. Probe EF5.44 is an RFLP marker that is tightly linked (Lod Score>3.0) to the FAP/GS locus. Methods: In FAP family, 10 mL of peripheral blood was sampled from the index case, his parents, brother and sister, and his wife and children. In GS family, similiar amount of blood was sampled from the index case, his wife and children. DNA was purified and five micrograms of each DNA was digested with restriction enzyme Msp I, and Southern blotting and hybridization using the probe EF5.44 were performed. Results: Probe EF 5.44 yielded only one band of 2.0 Kb without RFLP in al1 FAP/GS family members of this studay. Conclusion: Probe EF5.44 was found to be uninformative in both FAP/GS family members of this study. These results reveal that linked DNA probe has several limitations due to it's inherent low heterozygosity and so new DNA markers, such as microsatellite VNTRs, are preferable for genetic linkage analysis.
가족성선종성용종증과 Gardner 증후군가계의 유전학적 병전진단
김효종(H . J . Kim),동석호(S . H . Dong),김병호(B . H . Kim),이정일(J . I . Lee),장영운(Y . W . Chang),이기형(K . H . Lee),장린(R . Chang),최영길(Y . K . Choi) 대한내과학회 1995 대한내과학회지 Vol.48 No.4
Objectives: Familial adenomatous polyposis(FAP) and Gardner syndrome(GS) are inherited in an autosomal dominant manner and predispose affected family memebers to the development of colorectal cancer. Presymptomatic diagnosis of FAP/GS have been difficult to perform effectively in the past be- cause RFLP DNA markers surrounding the APC gene on chromosome 5q have not been very informative. But several polymorphic markers are now available for genetic diagnosis of the disease. We performed genetic linkage studies on both FAP and GS families by using CA repeat polymorphism at the DSS82, proximal to APC gene. Methods: Genomic DNA was extracted from the peripheral lymphocytes from 8 members of affected families with FAP and 5 members with GS. Using FCR with[α? 32P] dC'TP incorporated for labelling, DNA fragments were amplified and identified by ethidium bromide staining after agarose gel electrophoresis. The products of the PCR are loaded on 10 % denaturing(8M urea) polyacrylamide gels in TAE buffer, and the gels dried on the filter paper and the reactions visualized by autography. Results: Five and two alleles were detected in FAP and GS family members respectively. But two affected individuals in FAP family do not share a common D5S82 allele. Conclusion: A CA-repeat polymorphism offers improved diagnostic sensitivity for FAP/GS compared with RFLP DNA marker. But for the more accurate presymptomatic diagnosis, CA ? repeat. markers, more highly polymorphic and closer to the APC gene are preferable.
100% ASK 수신기를 위한 13.56㎒ RFID Tag용 클럭 복원회로 설계
김지곤(Jigon Kim),이경일(Kyeong-il Yi),김현식(Hyunsik Kim),김재환(J. H. Kim),김효종(Hyojong Kim),김시호(Shiho Kim) 대한전자공학회 2008 電子工學會論文誌-SD (Semiconductor and devices) Vol.45 No.11
ASK 100% RF 입력신호를 이용하는 13.56㎒ RFID 태그를 위한 클럭 복원회로를 제안하였다. 제안한 클럭 복원회로는, 레지스터로 조절되는 DLL을 이용하여 입력 RF 신호의 크기가 0인 구간에서도 기준 클럭 신호를 사용하지 클럭을 생성하도록 설계되었다. 제안한 회로는 TSMC 0.18㎛ 1P6M 공정을 사용하여 설계하였으며, 제안된 회로는 DLL의 위상 잠김 시간이 6.4usec 이하이며 공급전압이 3.3V에서 43uW를 소모한다. We have proposed a clock recovery circuit for 13.56㎒ RFID Tags using 100%, ASK RF input signal. The proposed clock recovery circuit generates clock pulses without reference clock by adapting register controlled DLL. The proposed circuit have designed by using a TSMC 0.18㎛ 1P6M CMOS technology. The simulated results show that the phase locking time of the proposed circuit is about 6.4 usec and power consumption is about 43㎼ at supply voltage of 3.3V.