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Probe EF 5.44 를 이용한 가족성선종성용종증 ( FAP ) 과 Gardner 증후군 ( GS ) 가계의 Linkage Analysis
김효종(H . J . Kim),김영관(Y . K . Kim),동석호(S . H . Dong),김병호(B . H . Kim),이정일(J . I . Lee),장영운(Y . W . Chang),장린(R . Chang),최영길(Y . K . Choi),이기형(K . H . Lee) 대한내과학회 1993 대한내과학회지 Vol.45 No.3
N/A Background: Familial adenomatous polyposis (FAP) and Gardner's syndrome (GS) are conditions, inherited in an autosomal dominant fashion, that predispose affected family members to the development of colorectal cancer. The gene(s) responsible for FAP/GS is on the chromosome 5q21-22. Several RFLP markers for the chromosome 5q21-22 region are now available and can be used clinically for premobid diagnosis in affected FAP/GS family members. Probe EF5.44 is an RFLP marker that is tightly linked (Lod Score>3.0) to the FAP/GS locus. Methods: In FAP family, 10 mL of peripheral blood was sampled from the index case, his parents, brother and sister, and his wife and children. In GS family, similiar amount of blood was sampled from the index case, his wife and children. DNA was purified and five micrograms of each DNA was digested with restriction enzyme Msp I, and Southern blotting and hybridization using the probe EF5.44 were performed. Results: Probe EF 5.44 yielded only one band of 2.0 Kb without RFLP in al1 FAP/GS family members of this studay. Conclusion: Probe EF5.44 was found to be uninformative in both FAP/GS family members of this study. These results reveal that linked DNA probe has several limitations due to it's inherent low heterozygosity and so new DNA markers, such as microsatellite VNTRs, are preferable for genetic linkage analysis.
단일 기관에서 경험한 크론병에서 Infliximab의 치료 효과
김연주 ( Yeon Ju Kim ),김정욱 ( Jung Wook Kim ),이창균 ( Chang Kyun Lee ),박현진 ( Hyun Jin Park ),심재준 ( Jae Jun Shim ),장재영 ( Jae Young Jang ),동석호 ( Suk Ho Dong ),김효종 ( Hyo Jong Kim ),김병호 ( Byung Ho Kim ),장영운 ( Y 대한소화기학회 2013 대한소화기학회지 Vol.61 No.5
Background/Aims: Our aim was to assess the long-term data regarding efficacy and safety of infliximab (IFX) treatment for refractory Crohn`s disease (CD) patients in our tertiary teaching hospital. Methods: We have retrospectively analyzed the medical records of 89 CD patients who underwent IFX treatment between March 2003 and February 2011 at Kyung Hee University Hospital (Seoul, Korea). The primary outcome measurements were the rates of initial clinical response (CR) at 10 weeks after the 1st IFX infusion and sustained CR at the end of the follow-up. Overall adverse events related to IFX treatment were also evaluated. Results: The mean (SD) follow-up period of eligible 80 patients was 33.7 (21.9) months. A total of 77 patients (96%) showed initial clinical response, but 8 patients showed loss of response to IFX during the follow-up. Finally, 59 patients (59/77, 76.6%) showed sustained CR at the end of the study. Logistic regression analyses showed that an initial CR at 10 weeks was the independent predictor associated with sustained CR (OR 22.286, 95% CI 2.742-132.717, p=0.001). Overall adverse events reported in 18 patients (18/80, 23.3%), including 3 serious infection (pulmonary tuberculosis and herpes zoster). Conclusions: Treatment with IFX was efficacious and relatively safe for refractory CD patients in Korea. An initial CR at 10 weeks was significantly associated with sustained CR.
한민수(M . S . Han),홍성화(S . H . Hong),이상목(S . M . Lee),장린(R . Chang),이정일(J . I . Lee),장영운(Y . W . Chang),김병호(B . H . Kim),김효종(H . J . Kim),동석호(S . H . Dong) 대한내과학회 1996 대한내과학회지 Vol.50 No.2
N/A Objectives: There is no difficulty in the diagnosis of hilar cholangiocarcinoma because of early occurrence of obstructive jaundice. Though prolonged survival can be expected with surgical resection, being advanced stage at the time of diagnosis, radical resection has been impossible in most cases. Recently the significant interest has been focused on this lesion and the aggressive surgical resection increased, but the results were various. Thus, the present study was performed to evaulate the clinical characteristics of hilar cholangiocarcinoma. Methods: We evaluated retrospectively 63 cases of hilar cholangiocarcinoma which were diagnosed at Kyung Hee University Hospital from January 1988 to July 1994. Results: 1) The mean age of the patients was 58±12.0 years and the ratio of male to female was 2.9: 1. 2) Jaundice was the most common symptom (85.7%) followed by abdominel pain(53.9%), weight loss (34.9%) and pruritus(30.1%). 3) Of 13 cases(20.6%) who underwent surgical resection, 7 cases(11.1%) had curative resection. PTBD was performed in 4i cases(73%), radiotherapy in 7 cases(11.1%), chemotherapy in 4 cases (6.3%) and metallic stent insertion in 7 cases (11.1%). 4) The mean survival time was 15.3±3.0 months in resection group(13 cases, 20.6%) and 4.8±0.5 months in non-resection group(50 cases, 79.4%). The survival time of resection group was longer than that of non-resection group(p<0.01). Conclusion: In conclusion, the prognosis of hilar cholangiocarcinoma is extremely poor and the prolonged survival can be expected with surgical resection. Thus, to determine the resectability, early diagnosis is important and accurate preoperative staging is necessary