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김현규(Hyeon-kyu Kim),유호영(Ho-young Yoo) 한국전기전자학회 2018 전기전자학회논문지 Vol.22 No.4
전통적으로 CRC 하드웨어는 선형 되먹임 시프트 레지스터를 이용하여 한 클럭 싸이클 당 하나의 비트를 처리하는 직렬처리 방식을 사용하였다. 최근 다양한 응용 시스템에서 빠른 데이터 처리를 요구하면서 이를 만족시키기 위하여 다양한 병렬화 기법들이 제안되었고, Look-Ahead 병렬화 기법이 짧은 최대 경로 지연을 가지는 장점 덕분에 가장 널리 적용된다. 하지만 Look-Ahead 병렬 하드웨어의 경우 각 레지스터 값과 입력 데이터의 이동에 대하여 예측을 하여야 하기 때문에 직렬 하드웨어 대비 HDL 코드의 작성이 복잡하다. 따라서 본 논문에서는 다양한 CRC 다항식과 병렬화 계수를 지원할 수 있는 Look-Ahead 기반의 CRC 병렬화 하드웨어 생성기를 제안한다. 생성된 HDL 코드의 합성 결과를 분석함으로써 제안된 생성기의 활용 가능성을 판단한다. Traditionally, Linear Shift Feedback Register (LFSR) has been widely employed to implement Cyclic Redundant Check (CRC) codes for a serial input. Since many applications including network and storage systems demand as high throughput as ever, various efforts have been made to implement CRC hardware to support parallel inputs. Among various parallel schemes, the look-ahead scheme is one of the most widely used schemes due to its short critical path. However, it is very cumbersome to design HDL codes for parallel CRC codes since the look-ahead scheme is inevitable to consider how register and input values move in the next cycles. Thus, this paper proposes a novel CRC hardware generator, which automatically produces HDL codes given a CRC polynomial and parallel factor. The experimental results verify the applicability to use the proposed generator by analyzing the synthesis results from the generated HDL code.
경구 Colchicine 의 과복용에 의한 전신적 독성 1 예
김현규(Hyeon Kyu Kim),김원석(Won Seok Kim),김근호(Gheun Ho Kim),안규리(Cur Le Ahn),한진석(Jin Suk Han),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee),오미혜(Mee Hye Oh),지제근(Je Geun Chi) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A administered orally over 7 days for an acute attack of gouty arthritis. The resultant multi-organ diseases, including gastrointestinal toxicity, acute renal failure, bone marrow suppression, sepsis, acute respiratory failure, hepatic dysfunction, myopathy, and alopecia, were managed sucessfully with fluid resuscitation, antibiotic treatment, mechanical venatilation, hemodialysis and other supportive therapies. For pathologic confirmation of colchicine myopathy, we performed quadriceps femoris muscle biopsy and electron microscopic examination, in which some sarcolemmal vacuoles were found but sarcolemmal membranous bodies characteristic to colchicine myopathy were not seen. We report the first case of colchicine toxicity in Korea with literature review and emphasize that severe systemic toxicity can be induced by inadvertent oral administration of colchicine in patients with risk ractors such as renal insufficiency, hepatic dysfunction, or old age.
김현규(Kim, Hyeon Kyu),전병권(Jun, Byung-Kweon) 한국주거학회 2019 한국주거학회 학술대회논문집 Vol.31 No.2
The problems such as the increasing of ideologist not willing to marry, job insecurity, economic condition degeneration and so on have been raised on the young people class and one person household and single parent family due to the increasing of divorce rate and bereavement are increased on the middle age and old age classes. Accordingly, the type of family are changing as small scale nuclear family as time goes by. Mutual communication is decreased and other social problems such as loneliness and die alone and so on due to the increasing of these family type. Share house to form the community through the communication and meeting with various people by the residence plan and common use space for the vulnerable social group in residence as the plan to recognizing and solving these problems are suggested in this research.
류현열(Hyeon Yeol Ryu),이소민(Somin Lee),안규섭(Kyu Sup Ahn),연용(Yeon Yong),김혜진(Hye Jin Kim),김성은(Seong-Eun Kim),이학성(Hak Sung Lee),홍수영(Su-Young Hong),김현규(Hyun-Kyu Kim),황인국(In Guk Hwang),송경석(Kyung Seuk Song) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.4
본 연구에서는 항당뇨에 유효성이 있는 천연물질인 여주 추출물을 이용하여 여주에 포함된 독성물질인 vicine의 분석과 경구투여에 따른 독성을 조사하기 위하여 단회 경구투여 독성시험과 13주 반복 경구투여 독성시험을 진행하였다. 본 시료는 여주 미숙과 열매추출물로 vicine의 분석 결과 존재하지 않거나 극미량일 것으로 판단된다. 단회 경구투여 독성시험과 시험물질에 의한 이상증상과 사망동물은 발생하지 않아 여주 추출물의 ALD는 암수 모두 5,000 mg/kg/d 이상으로 판단된다. 13주 반복 경구투여 독성시험의 투여용량을 결정하기 위하여 0, 1,250, 2,500 및 5,000 mg/kg/d의 투여용량으로 2주 반복투여 용량결정시험을 실시한 결과, 모든 시험군에서 시험물질에 의한 이상증상 및 독성 변화가 관찰되지 않아 동일한 용량으로 13주 반복 경구투여 독성시험을 진행하였다. 실험기간 동안 사망률, 일반증상, 체중 변화, 사료섭취량, 안검사, 요검사, 혈액학적 검사, 혈액응고시간 검사, 혈액생화학적 검사, 부검소견, 장기중량 및 조직병리학적 소견을 관찰한 결과, 시험물질에 의한 전신적인 독성학적 변화는 관찰되지 않았다. 따라서 여주 추출물의 NOAEL은 5,000 mg/kg/d로 판단되었고, 표적장기는 관찰되지 않았다. 본 연구의 결과로 볼 때 여주 추출물은 투여 가능한 최대 용량에서도 독성이 나타나지 않는 안전한 천연물로 확인하였고, 본 시험 결과를 바탕으로 ADI는 3,000 mg/man으로 판단된다. 따라서 기능성 식품으로서의 개발 가능성을 확인하였다. This study was performed to evaluate repeated dose oral toxicity upon administration of the test substance 1,2-benzisothiazolin-3-one for 90 days and to determine NOAEL (no observed adverse effect level) and target organs in Sprague-Dawley rats. Single, 2-week repeated, and 13-week repeated oral dose toxicity studies were conducted in Sprague-Dawley rats. The dose levels of groups were 1,250, 2,500, and 5,000 mg/kg/d. All dose groups were compared with the vehicle control group. The animals were observed for clinical signs and weekly body weight. Urinalysis, hematology, and serum biochemistry analyses were conducted. Subsequently, animals were sacrificed and subjected to histopathological examination. For the result, NOAEL of ethanol extract from unripe fruit of bitter melon had an optimal dose of 5,000 mg/kg/d and acceptable daily intake up to 3,000 mg/man. There was no target organ detected. Therefore, bitter melon, which contains a variety of bioactive substances, could be widely used as a health functional food ingredient.
과도하게 교정된 저나트륨혈증에 대한 바소프레신의 투여 경험 2예
장지선 ( Ji Sun Jang ),김성은 ( Sung Eun Kim ),이상규 ( Sang Kyu Lee ),김현규 ( Hyeon Kyu Kim ),김두만 ( Doo Man Kim ),김수진 ( Soo Jin Kim ),이영기 ( Young Ki Lee ),박태진 ( Tae Jin Park ),윤종우 ( Jong Woo Yoon ),오지은 ( Ji Eun 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.6
Rapid correction of chronic hyponatremia can be associated with osmotic demyelinating syndrome leading to irreversible brain injury. Therefore, the primary efforts must be focused on maintaining appropriate correction rate (<10-15 mEq/L/24hr). But overcorrection may occur unpredictably in various circumstances. However, several reports showed that rapid relowering of the serum sodium level prevents osmotic demyelinating syndrome and reduces neurological injury. We report two cases of overcorrected chronic hyponatremia. After overshooting, we considered the risk of osmotic demyelinating syndrome and injected vasopressin to patients. The serum sodium concentrations were relowered immediately with no neurological deficit. There was no significant side effect of vasopressin. (Korean J Nephrol 2006; 25(6):1007-1011)
박영식,김현규,임서규,박경유,이현용,Park, Young-Shik,Kim, Hyun-Kyu,Lim, Seo-Kyu,Park, Kyung-You,Lee, Hyeon-Yong 한국미생물 · 생명공학회 1994 한국미생물·생명공학회지 Vol.22 No.4
8 X 10$^{6}$(viable cells/ml) of maximum cell density and 9000(IU/ml) of $\gamma$-IFN production were obtained at 55(ml/hr) of a perfusion rate by cultivating HSF cells using a moving membrane aeration bioreactor. This system proves to be an efficient culture process by maintaning 90% of viable cells during the whole cultivation periods. The metabolic molar quotient of glucose to lactate was 0.81 for overall ranges of glucose consumed while the evolution of ammonia was not linearly related to the consumption of glutamine. Low molar conversion ratio was observed in low consumptions of glutamine and high molar conversion ratio in high comsumptions. It also shows that the glutamolysis plays important role in the steady state conditions by evolving larger quantities of ammonia than lactate. At the above of 50 rpm, which is the optimum agitation speed for this bioreactor, the cell growth was severely affected while the IFN production was less decrea- sed, maintaing 1.5 X 10$^{-3}$(IU/cell/day) specific IFN production rate. The cumulatvie $\gamma$-IFN production was 7.2 X 10$^{8}$(IU) for 70 days of the cultivation, which yields 1 X 10$^{7}$ (IU/day) of IFN production rate. Therefore, a commercial production of $\gamma$-IFN by this culture process can be achievable by maintaining the above IFN productivity in a scaled-up culture system.
결핵성 뇌수막염에 동반된 뇌성 염분소실증후군(Cerebral salt wasting syndrome)
이자영 ( Ja Young Lee ),이은실 ( Eun Sil Lee ),이재형 ( Jae Hyong Lee ),임은주 ( Eun Ju Lim ),김형수 ( Hyoung Su Kim ),장지선 ( Ji Seon Jang ),김현규 ( Hyeon Kyu Kim ),김두만 ( Doo Man Kim ),박용범 ( Yong Bum Park ),이재영 ( Jae Y 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.3
다절편 전산화단층촬영을 이용한 관상동맥촬영의 통계적 고찰 : 일산백병원을 중심으로
홍성완(Seong Wan Hong),박기수(Ki Su Park),강종식(Jong Sik Kang),황중식(Jung Sik Hwang),이동준(Dong Jun Lee),김현규(Hyeon Kyu Kim) 대한전산화단층기술학회 2009 대한CT영상기술학회지 Vol.11 No.1
Purpose Mainly on patients who have taken coronary angiography using 64 channel MDCT instaⅡed in our hospital, frequency, meaningful correlation and feasibility of the heart CT was studied by statistic analysis. Materials and methods From Apr. 12, 2006 to Dec. 31, 2008, 4677 inpatients or outpatients were tested ECG-gated coronary artery CTA(computed tomographic angiography; CCTA) in Inje UnⅣersity Ilsanpaik Hospital. Their test results were analyzed with SPSS 10 (SPSS Inc. Chicago, IⅡinois). Results The analysis difference in sex showed 53.1% of male patients were normal in the results. It was higher than 46.9% in female results. Stent were executed on 67.5% of male patients which is also more than female. Male patients read to have more than 30% constriction in coronary were 67.5% of the total patients. It also is the higher rate compared with female patients. The analysis difference in age showed results of 83.3%, 98.5% and 98.1% in cases of normal, stent and more than 30% constriction each with patients who is 40 or older. The analysis difference in weight showed meaningful rate of 67.5% normal and 78.3% stent with female patients who weigh 60kg or more. Patients with chest pains showed 53.8% normal, 6.2% stent and 41.9% more than 30% constriction in their test results. In case of dose, male patients showed higher rate of 64.2% compared to female patients, and it was absolutely higher with the patients who is 40 or older with rate of 91.9%. Dose was also high with female patients who weigh 60kg or more with rate of 91.7%. Conclusion The image view obtained by CCTA made it possible to view the range of stenosis of coronary in three dimensions. The study result using the reading outcome of coronary constriction and the basic image data showed statisticaⅡy meaningful differences in physical conditions, age and sex.