특발성(特發性) 동안신경마비(動眼神經麻痺)로 진단된 안검하수(眼瞼下垂) 환자 치험 1례

김태연,김현정,이창원,김창환,Kim, Tae-Yeon,Kim, Hyun-Jung,Lee, Chang-Won,Kim, Chang-Hwan 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.3

Objective : This study reports the effect of korean medicine on ptosis patient 1 case diagnosed as idiopathic oculomoter nerve palsy. Methods : We experienced one case of ptosis diagnosed as idiopathic oculomoter nerve palsy treated with herbal medicine and acupuncture. Ptosis and associated symptoms had been estimated with difference of both eye's interpalpebral fissure and VAS(Visual Analogue Scale). Result : After the treatment, symptoms were decreased and almost disappeared. In this case, difference of both eye's interpalpebral fissure decreased from 6mm to 1mm in a month. Conclusion : This study suggests that korean medicine is effective on ptosis diagnosed as idiopathic oculomoter nerve palsy.

자락발관법(刺絡拔罐法)을 병행한 한방치료로 호전된 대상포진 후 신경통환자 치험 1례

김태연,김현정,김창환,Kim, Tae-Yeon,Kim, Hyun-Jung,Kim, Chang-Hwan 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.3

Objective : This study reports the effect of oriental medicine with depletion and cupping therapy on post-herpetic neuralgia(PHN) 1 case. Methods : We experienced one case of PHN treated by oriental medical treatment with depletion and cupping therapy. To evaluate the effectiveness of this treatment, we used the Visual Analogue Scale(VAS). Result : After the treatment the grade of VAS was decreased and clinical symptoms were improved. Conclusion : Oriental medicine with depletion and cupping therapy can be available for relieving symptoms related with PHN.

한방병원에 입원한 두위 현훈 환자의 임상 분석

김태연,김기태,고흥,Kim, Tae-Yeon,Kim, Gi-Tae,Go, Heung 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.3

Background : Vertigo is a very common complaint in clinical practice. The number of patients who complain of vertigo has been increasing due to rapid growth of the elderly population. This study was designed to review the clinical features and success of oriental medical treatment of positional vertigo. Methods : This observation was made on 70 subjects diagnosed with positional vertigo. They were hospitalized in the Semyung University Oriental Medicine Hospital. Results : The results were as follows 1. Female patients (82.9%) were more than male patients. The most common age group was 8th decade and the patients rapidly increased after the 5th decade of age. 2. The most common past history of positional vertigo was hypertension, the second was cerebral infarction, and the third was hyperlipidemia. 3. In the oriental medicine diagnosis, phlegm-dampness syndrome (痰濕交阻 眩暈) was the most common disease (92.9%), and in western medicine, BPPV was the most (82.9%). 4. In herbal medication, Banhabaekchulchunma-tang gami (45.7%) was the most commonly used, the second being Taeksa-tang (30%). 5. The vertigo score of 94.3% patients improved and none got worse. 6. In general characteristics, men over 64 years improved best. Past history had no effect on the improvement of vertigo. 7. The sooner patients visited hospital after onset, the shorter hospitalization time was. Conclusions : Vertigo attacks patients well in advanced age, with various causative diseases. Oriental medical treatments have considerable effects on positional vertigo, especially treated with Banhabaekchulchunma-tang gami and Taeksa-tang.

진전을 동반한 Fahr Disease 환자 치험례

김태연,신우재,박유진,문주호,신선미,김기태,고흥,Kim, Tae-Yeon,Shin, Woo-Jae,Park, Yu-Jin,Moon, Joo-Ho,Shin, Seon-Mi,Kim, Gi-Tae,Go, Heung 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.3

Fahr disease (FD) is a rare neurological disorder characterized by presence of abnormal and associated cell loss in certain areas of the brain, mostly in basal ganglia, thalamus, cerebellum and subcortical areas. Approximately two-thirds of the patients are symptomatic. The most common neurological manifestations include movement disorders, cognitive impairment, cerebellar signs and speech disorders. We report one case of estimated FD through brain computed tomography (bilateral calcifications of basal ganglia, thalamus, centrum semiovale, subcortical white matter of occipital lobes, cerebellum). At the first time of treatment, he complained of tremors in his upper limbs. We diagnosed the patient as deficiency of qi (氣) and movement of phlegm-heat-wind (痰熱風動) type according to symptoms and treated by herbs and acupuncture of oriental medicine. During treatments, we evaluated how well the oriental medical treatments were working using visual analogue scale (VAS) and amplitude of hands. After the oriental medical treatments about tremor, VAS dropped from 10 to 2 and amplitude of hands from 20 mm to 2 mm, but the ratio of brain calcifications was not changed. This study suggests that oriental medical treatments can be applicable to improve FD.

과체 토법을 병용한 한방치료의 비정형안면통 치험 2례

김태연,이창원,강주영,김창환,Kim, Tae-Teon,Lee, Chang-Won,Kang, Ju-Young,Kim, Chang-Hwan 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.4

Objective : The purpose of this study is to report the efficacy of using oriental medical treatment(herb-medicine, acupuncture) with Melonix Calyx Vomiting Therapy for atypical facial pain. Methods : We experienced two cases of atypical facial pain treated with oriental medical treatment(herb-medicine, acupuncture) and Melonix Calyx Vomiting Therapy(MCVT). MCVT is a traditional treatment, which induces vomiting by eating Melonix Calyx powder with water. To evaluate the results of this treatment, we used the Visual Analogue Scale(VAS) and Pain Rating Scale(PRS). Result : After using MCVT with oriental medical treatment, VAS, PRS and clinical symptoms of 2 patients were improved remarkably. Conclusion : This study suggests that using MCVT with oriental medical treatment is effective on atypical facial pain.

Silybin Synergizes with Wnt3a in Activation of the Wnt/${\beta}$-catenin Signaling Pathway through Stabilization of Intracellular ${\beta}$-Catenin Protein

김태연,오상택,Kim, Tae-Yeoun,Oh, Sang-Taek The Korean Society for Microbiology and Biotechnol 2012 한국미생물·생명공학회지 Vol.40 No.1

Wnt/${\beta}$-catenin 신호전달체계는 세포의 분화와 증식, 기관의 발생과 조절을 담당하는 중요한 세포내 신호전달체계이다. 발생과정에서 Wnt/${\beta}$-catenin 신호전달체계의 작용이 지방세포로의 분화를 억제하고 조골세포와 신경세포로의 분화는 촉진한다는 많은 연구들이 보고되어 있으며, 현재 Wnt/${\beta}$-catenin 신호전달체계의 조절을 통한 여러 질병의 치료와 예방에 대한 관심이 대두되고 있다. 본 연구에서는 세포를 기반으로 한 초고속 저분자 스크리닝 시스템을 이용하여 Wnt의 상승제인 silybin을 발굴하였다. silybin은 Wnt가 존재 않을 경우에는 ${\beta}$-catenin 단백질의 수준에 영향을 미치지 않지만 Wnt가 존재할 경우, mRNA 발현양의 변화 없이 세포질내의 ${\beta}$-catenin 단백질의 수준을 증가시킨다. 또한 silybin에 의해 증가된 ${\beta}$-catenin으로 인해 지방세포분화에 중요한 전사인자라고 알려진 PPAR-${\gamma}$와 C/EBP-${\alpha}$의 발현을 억제한다. 따라서 이 연구에서는 silybin이 세포질내 ${\beta}$-catenin 단백질의 수준을 증가시킴으로써 Wnt/${\beta}$-catenin 신호전달체계를 활성한다는 사실을 제시하였다. The Wnt/${\beta}$-catenin signaling pathway regulates diverse developmental processes and adult tissue homeostasis. Inappropriate regulation of this pathway has been associated with human diseases, such as cancers, osteoporosis, and Alzheimer's disease. Using a cell-based chemical screening with natural compounds, we discovered silybin, a plant flavonoid isolated from the Silybum marianum, which activated the Wnt/${\beta}$-catenin signaling pathway in a synergy with Wnt3a-conditioned medium (Wnt3a-CM). In the presence of Wnt3a-CM, silybin up-regulated ${\beta}$-catenin response transcription (CRT) in HEK293-FL reporter cells and 3T3-L1 preadipocytes through stabilization of intracellular ${\beta}$-catenin protein. Silybin and Wnt3a-CM synergistically reduced expression of important adipocyte marker genes including peroxisome-proliferator-activated $receptor{\gamma}$ ($PPAR{\gamma}$) and CAATT enhancer-binding protein ${\alpha}$ (C/$EBP{\alpha}$) in 3T3-L1 preadipocytes, accompanied by the activation of Wnt/${\beta}$-catenin signaling pathway. Taken together, our findings indicate that silybin is a small-molecule synergist of the Wnt/${\beta}$-catenin signaling pathway and can be used as a controllable reagent for investigating biological processes that involve the Wnt/${\beta}$-catenin signaling pathway.

급성 허혈성 뇌졸중에 있어 한방치료와 지속적 유로키나제 정주요법과의 병행요법의 효과와 안전성

김태연,조영,이준희,류재환,이범준,Kim, Tae-Youn,Jo, Young,Lee, Jun-Hee,Lew, Jae-Hwan,Lee, Beom-Jun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4

Objective : Stroke is the most frequent cause of death in Korea. Because it remains severe disablities disturbing normal life, it is important to carry out intervention preventing from progression of condition in patients with acute ischemic stroke within therapeutic time window. Thus early thrombolysis is beneficial for patients with acute ischemic stroke. However its therapeutic efficacy is not known in combination with oriental medical therapy. In this study, we investigated the safety and the clinical effect of continous intravenous urokinase therapy and oriental medical therapy. Methods : Twenty eight patients with acute onset of ischemic stroke no later than three days received continous infusion of urokinase and oriental medical therapy. We estimated the subjects's neurological deficit and functional status with National institute of Neurologic Disorders and Stroke Scale(NIHSS) and Europian Stroke Scale (ESS) prior to therapy, on day 3, 7, 14 after the starting urokinase therapy and on day at discharge. Results: After day 7, the scores of NIHSS and ESS were improved significantly. There are no differences in therapeutic effects of the interval between onset of stroke and initiation of therapy. Complication were noted in four(14%) patients, but these are not fatal complication and make no neurological deficiency. Conclusion : The results of these investment suggest that continuous intravenous urokinase with oriental medical therapy could be a safe and effective intervention to prevent from progression in acute ischemic stroke. But this findings should be confirmed in multicenter double blind controlled trial.

진동특성을 이용한 고추원료공급장치 개발

김태연,고학균 ( T . Y . Kim,H . K . Koh ) 한국농업기계학회 1997 한국농업기계학회 학술발표논문집 Vol.2 No.1

한국개화기의 외인관(2)

김태연,Kim, Tae-Yeon 대한건축사협회 1989 建築士 Vol.1989 No.6

무선 센서 네트워크를 위한 새로운 키 사전 분배 구조

김태연,Kim, Tae-Yeon 한국정보처리학회 2009 정보처리학회논문지 C : 정보통신,정보보안 Vol.16 No.2

무선 센서 네트워크는 실세계에 광범위하게 배치되어 다양한 응용에 활용되고 있다. 센서 노드들 사이에 안전한 통신을 위한 필수 조건은 그들의 신뢰관계를 유지할 수 있는 세션키를 생성하는 것이다. 여기에서 고려되어야 할 문제는 어떻게 통신 노드들을 식별하고 키 동의 과정에서 상대방에게 키 정보의 노출을 최소화할 것인가이다. 현재 기존의 구조들에서는 몇 가지 취약점으로 인해 이러한 문제를 완전히 해결하지 못하고 있다. 따라서 본 논문에서는 다음과 같은 이점을 가진 새로운 키 사전 분배 프로토콜을 제안한다. 첫째, 노드간의 인증 서비스를 지원한다. 둘째, 공유하지 않은 키 스페이스의 식별자는 공개하지 않을 뿐만 아니라 공유하고 있는 식별자들의 공개를 최소화한다. 마지막으로 노드 공격에 대해 네트워크의 보안이 기존의 방식에 비해 강건하다. 그리고 성능과 보안 분석을 통해 제안된 구조가 무선 센서 네트워크에 적합함을 증명한다. Wireless sensor networks will be broadly deployed in the real world and widely utilized for various applications. A prerequisite for secure communication among the sensor nodes is that the nodes should share a session key to bootstrap their trust relationship. The open problems are how to verify the identity of communicating nodes and how to minimize any information about the keys disclosed to the other side during key agreement. At any rate, any one of the existing schemes cannot perfectly solve these problems due to some drawbacks. Accordingly, we propose a new pre-distribution scheme with the following merits. First, it supports authentication services. Second, each node can only find some indices of key spaces that are shared with the other side, without revealing unshared key information. Lastly, it substantially improves resilience of network against node capture. Performance and security analyses have proven that our scheme is suitable for sensor networks in terms of performance and security aspects.