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뇌종양에서 Survivin의 발현:세포자멸사와 조직학적 악성도와의 연관성
김충현,정진환,백광흠,김재민,고용,오석전 대한신경외과학회 2003 Journal of Korean neurosurgical society Vol.33 No.6
Objective:Survivin is one of the inhibitor of apoptosis protein family proteins, which inhibits apoptosis through pathway different from that involving the Bcl-2 family. Overexpression of survivin has been reported in the most common human cancers. The purpose of this study is to investigate survivin expression and its relevance to histological malignancy and apoptosis of brain tumors. Methods:Seventy-eight consecutive patients with brain tumor, who underwent operation, were included in this study. Pathological types of brain tumor were classified by World Health Organizaton classification. Survivin expression was detected by Western blot analysis and apoptosis was examined by DNA fragmentation. Results:Survivin was expressed in 32(41.0%) of 78 patients with brain tumor and apoptosis was detected in 14(21.9%) patients. Histological malignancy of brain tumors was not correlated with survivin expression or apoptosis(p>0.05). However, survivin-positive tumors were strongly associated with anti-apoptosis(p=0.000) and apoptosis was significantly relevant to survivin-negative tumors(p=0.006). Conclusion:These results suggest that survivin expression is strongly related to the apoptosis of brain tumors, but not associated with biological malignancy. Therefore, survivin may be a potential target for brain tumor therapy based on apoptosis. Key words:Microtubule-associated proteins(survivin);Apoptosis;Brain neoplasms.
김충현,임홍재,하영일 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.12
A case of rare intracranial, skull and orbital metastasis is presented. A 34-year-old man was found to have mental deterioration with proptosis of the right eye and scalp swellings. The intracranial, skull and orbital tumors were verified to be hepatocellular carcinoma and the patient died 3 days after admission. The literature of hepatoma with cranial and orbital metastasis is briefly reviewed.
외상성 시신경손상에 대한 시신경관 감압술에 따른 시력평가
김충현,송관영,하영일 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.4
Nine patients with traumatic optic nerve injury were treated with optic canal decompression via transcranial approach. Postoperative visual function evaluated by visual acuity in all patients and monitoring of visual evoked potential in 3 patients. 4 of 8 patients showed improvement in visual acuity and 2 of 3 patients also improved in the results of visual evoked potential monitoring. The mean duration between injury and operation of whom showed postoperative improvement of visual function was 6.8 days but 13 days in 5 unimproved or deteriorated patients. These findings indicate that optic canal decompression is recommended for patients with traumatic optic nerve injury who show no neurological improvement by conservative management. And also, the shorter preoperative duration, the better visual outcome postoperauvely.
두개강내 척색종에 대한 임상적 고찰 및 치료성적 : Clinical Review and Therapeutic Outcome
김충현,하영일,송관영,한윤경 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.7
Chordomas are uncommon tumors arising from the embryonic remnants of the fetal noto-chord. The spheno-occipital region accounts for 36 percent of chordomas. The authors are presenting four cases of intracranial chordomas with clinical manifestation was analyzed. All patients were men and their mean age was 37 years old. The presenting complaints were diplopia in 2 patients and decreased visual acuity in the other two. Radiologic studies demonstrated extensive bony destruction of the skull base and soft mass with punctate calcification in all 4 cases. Treatment consisted of subtotal removal of tumor and subsequent radiotherapy). Histo-pathologically. three of the four patients had typical chordomas and the remaining case was confirmed as chondroid chordoma. The three typical chordomas recurred after initial treatment. 2 of these three were reoperated but in the 10 months and 33 months, respectively after initial diagnosis. The patient with chondroid chordoma remained well for 46 months after initial treatment without significant neurological deficits. In conclusion. therapeutic outcome of intracranial chordomas are grim because of their aggressive that frequent recurrence and inability to remove tumors completely. With the exception. chondroid chordoma has good prognosis and long term survival.
김충현,안효석 한국공작기계학회 2002 한국공작기계학회 추계학술대회논문집 Vol.2002 No.-
It is an object of this research to develop a fine friction tester capable of analyzing a friction characteristics of a small size specimens in a load range of 0.03 ~ 2.0 N. According to the test results using the developed precision friction tester, it is expected to get the experimental data with fine resolution and high reliability.
김충현,백광흠,김재민,김남규 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.1
We report a case of 23-year-old right-handed male who had transcortical mixed aphasia caused by severe head injury. On admission, Glasgow Coma Scale(GCS) score of the patient was 8, and he had already undergone a craniotomy for acute subdural hematoma in the left frontotemporal region. He also had right spastic hemiparesis and aphasia on neurological examination. At 4 months after injury, he had echolalia. his object naming, spontaneous speech, auditory comprehension, reading and writing on dictation were also severely impaired. Magnetic resonance(MR) images showed cortical and subcortical lesions in the left frontoparietal lobes and intact perisylvian speech area. The causes of speech and language disturbance may be variously localized and distinguishing characteristics according to location of the lesion are discussed.
Tuning fork형 micro-cantilever sensor
김충현,안효석 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-
An experimental investigation of the basic characteristics of a micro-cantilever sensor was performed by inspecting the amplitude and frequency characteristics using a commercial tuning fork. Application of acetone and ethanol with a volume of 1μl on the tine of a vibrating tuning fork cause immediate response in its amplitude and frequency. It has shown that the tuning fork has ability to recognize a chemical agent with high sensitivity.
Cortisone acetate 투여한 마우스의 Pneumocystis carinii 감염양상 및 세포매개성 면역반응에 관한 연구
김충현,이영하,나영언,신대환 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2
This study was attempted to find the cell-mediated immune responses and infection aspects of Pneumocystis carinii in immunosuppressive mice. The experimental groups were administered the suppressive regimen consisting of cortisone acetate 2.5mg injected subcutaneously twice a week, a low(8%) protein diet, and tetracycline in the drinking water(1mg/ml) for 10 weeks. From the 1st week after cortisone acetate injection, the number of P. carinii cysts in the lung specimens were examined by Gomori's methenamine silver stain at 1 week interval for 10 weeks. And the blastogenic response of spleen cells treated with Con. A (5.0㎍/ml) was examined by [^3H]-thymidine incorporation assay at the same time. The results obtained in this study were as follows: 1. The number of P. carinii cysts were remarkably increased in the lungs from 2 weeks to 4 weeks, and thereafter was slowly increased throughout the experiment. 2. The blastogenic response of Con. A treated-splenocytes from mice injected with cortisone acetate was significantly declined as compared with those of the control mice(p<0.05). 3. There were not correlation between the number of P carinii cysts in the lung specimens and the blastogenic responses of splenocytes to Con. A(correlation coefficient, r=0.38285, p<0.2749).
김충현,이성철,안효석,정태형,Kim, Chung-Hyeon,Lee, Seong-Cheol,An, Hyo-Seok,Jeong, Tae-Hyeong 대한기계학회 2000 大韓機械學會論文集A Vol.24 No.9
Wear and operation characteristics of Nylon and Acetal pinion against steel gear were studied to gain a better understanding of their tribological and mechanical behavior. Tests were conducted with power circulating gear test rig under unlubricated conditions. Specific wear rates were measured as a function of applied load and total revolution. The worn tooth surfaces were examined with a profile projector and camera. Nylon pinion showed lower specific wear rates than Acetal pinion, but it revealed breakage at high load. Principal wear depths were developed at tooth tip and below the pitch line of pinion. Life estimation for the Nylon pinion was made by taking into account steel gear equivalent Hertz stress and average sliding velocity. The dominant wear mechanisms were adhesion and abrasion.