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An Information-based Model for an Interactive Web Service with Agricultural Biotechnology
김창국,설영주,박동석,한장호 한국유전체학회 2011 Genomics & informatics Vol.9 No.2
The National Agricultural Biotechnology Information Center (NABIC) constructed an agricultural biology-based infrastructure and developed a biological informationbased database. The major functions of the NABIC are focused on biotechnological developments for agricultural bioinformatics and providing a web-based service to construct bioinformatics workflows easily, such as protein function prediction and genome systems biology programs. The NABIC has concentrated on the functional genomics of major crops, building an integrated biotechnology database for agro-biotech information that focuses on the proteomics of major agricultural resources,such as rice, Chinese cabbage, rice Ds-tagging lines, and microorganisms.
정상인에서 저혈당성 자극에 의한 Catecholamines, Cortisol 및 Growth hormone의 변화
김창국,이복희 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1
To characterize the hormonal responses to hypoglycemia in normal man, plasma catecholamines, serum cortisol, growth hormone, glucose, blood pressure and pulse rate were measured in insulin induced hypoglcemic states. The blood samples were taken before and 15, 30, 60, 90, 120 min after i. v. injection of 0.1 U/B. W. kg regular insulin in 16 health volunteers after a 12-hours overnight fast. The results were as follows; 1. The basal serum glucose level was 74.4±8.0mg/dl(M±SD) which was decreased to 34.1±5.2 mg/dl at 30 min after insulin injection, returned to 84.7±10.5 at 120 min after insulin injection. 2. The basal plasma norepinephrine level was 121.3±42.5 pg/ml and there was no significant change with insulin injection. (p>0.05) On the other hand, the basal plasma epinephrine level was 43.8±14.7 pg/ml. A 5 fold increase in epinephrine to 214.4±4.7.4 pg/ml was observed 30 min after insulin injection. (p<0.05) 3. The basal serum cortisol level was 10.9±2.1 pg/dl which was increased significantly to 16.4±4.1 pg/dl(p<0.01) at 60 min after insulin injection. 4. The basal serum growth hormone level was 0.5±0.1 ng/dl. A 45-fold increase in growth hormone to 24.5±5.6 ng/dl (p<0.005) was observed 60 min after insulin injection. 5. The blood pressure levels remained unchanged and pulse rate showed mean increase to 10/min at 30 min after insulin. The results of this study indicate that epinephrine plays a major role in the metabolic response to insulin-induced hypoglycemia in normal man, growth hormone and cortisol may well function to argument the early hyperglycemic effect of epinephrine.
Genetic Analysis of Seed-specific Gene Expression for Pigmentation in Colored Rice
김창국,Shoshi Kikuchi,Kouji Satoh,김진아,김동헌,김용환,박성한,윤웅한,이점호 한국바이오칩학회 2009 BioChip Journal Vol.3 No.2
Anthocyanin is a major class of flavonoids that tissues produce in response to environmental signals. The pigmentation of colored rice was analyzed by oligo microarray based on two factors, cultivar and developmental stage. As many as 250 and 350 genes were identified to be significantly up- and down-regulated. Using hypergeometric analysis for transcription factor function, the Myb and GT families, PBP, PBF, RAV, and STF factors were identified have potential anthocyanin-specific functions. We also obtained seventeen unknown genes which display novel functions. Among the genes within the GT-1 and Myb1 groups, three unknown genes were found to be upregulated significantly in both combinations of cultivar and developmental stage. These results showed functional diversity of TF families and that the biological functions of the particular TFs may be activated in a pigmentation pathway in rice.
The Genes Associated with Drought Tolerance by Multi-Layer Approach in Potato
김창국,오재현,나종국,조철오,김경화,유고은,김둘이 한국육종학회 2019 Plant Breeding and Biotechnology Vol.7 No.4
We have developed a multi-layer pipeline that uses transcriptomic data to identify candidate genes associated withcomplex pathways in plants. We used this multi-layer approach, incorporating microarray, RNA sequencing, polymerase chain reaction(PCR), and protein-protein interaction analyses, to identify 14 genes associated with drought tolerance in potato. We generatedtransgenic potato lines that over-express bZIP28, one of the genes selected by our pipeline, to confirm the involvement of that gene indrought tolerance. The protein interactions of the products of the screened genes were assessed using yeast two-hybrid and bimolecularfluorescence complementation analyses. Overall, this study demonstrated the utility of our multi-layer approach for decipheringcomplex biosynthetic pathways using transcriptomic data.
김창국,한장호,지현소 한국농업정보과학회 2003 농업정보과학 Vol.4 No.1
Bioinformatics is believed to be a powerful measure to change agricultural biotechnology. Basic and applied researches related to bioinformatics have been extensively and intensively performed in universities, research institutes and in industries. Many countries recognized the importance of bioinformatics for the development of biotechnology and established national programs. Korea government also recognized this and recently launched a funding program to structure national wide research networks among government research organizations, research institutes and universities. National Agricultural Biotechnology Information Center (NABIC), Biological Research Information Center (BIUC), Center for Computational Biology & Bioinformatics (CCBB) had been established as national system centers of leading the bioinformatics in 21th century. The center has been constructed of networks for national planning, cooperation and have extensive national research projects by industry-college-institute consortium. Through there programs, research capacity increase for agricultural biotechnology and crop variety development will be achieved.
김창국,이대연,이영철,Shim, Jae-Kun,Junfeng Huang 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.31
Development of Muscle Force Generation and Force Control ofHand Digit:Age-related Changes
An Integrated Database and Web Service for Microbial Resources at KACC
김창국,전영아,조규택,권순우,김용환,홍승범 한국유전체학회 2009 Genomics & informatics Vol.7 No.1
The Korean Agricultural Culture Collection (KACC) has developed a web-based system to provide an integrated database with information updates about microbial resources. This integrated database consists of 5 major functions and contains general information, which includes identification numbers, culture media composition, image information, DNA sequences, patent information, and general forms for ordering and depositing microorganisms. In 2008, KACC started providing characterization information. KACC maintains 9,801 cultures of microorganisms, including 3,296 strains of bacteria, 4,734 fungi, 784 actinomycetes, 64 yeasts, and 923 others.