농약의 물리화학적 특성 연구 (II) Flupyrazofos의 수용성, 가수분해, 증기압, 옥탄올/물 분배계수

김정한,김용화,김균,Kim, Jeong-Han,Kim, Yong-Hwa,Kim, Kyun 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.43 No.1

국내에서 최초로 합성, 개발된 유기인계 살충제인 flupyrazofos(KH-502)의 물리화학적 특성으로 수용성, 가수분해, 증기압, 분배계수를 EPA와 OECD 방법에 준하여 측정하였다. 수용성은 $25^{\circ}C$에서 0.80 ppm으로 낮았고 가수분해 반감기는 $25^{\circ}C$에서 266.5시간(pH 4.0), 180.0시간(pH 7.0), 120.9시간(pH 9.0)으로 알칼리 조건에서 불안정하였으며 $40^{\circ}C$에서는 $25^{\circ}C$보다 $2{\sim}4$배 정도 가수분해가 빠르게 진행되었다. 상은($25^{\circ}C$)에서의 증기압은 $2.81{\times}10^{-5}$ torr로 측정되었고, 다른 두 온도(35, $45^{\circ}C$)에서 증기압을 측정하여 log P=0.673-(1565.4/T)라는 관계식을 구하였다. Flupyrazofos의 상온($25^{\circ}C$)에서의 증기압은 diazinon과 유사한 수준이었고, DDVP보다는 약 1,000배 정도 낮은 수치로 휘발에 의하여 환경에 영향을 미칠 가능성은 낮을 것으로 판단되었다. Flupyrazofos의 옥탄올/물 분배계수치를 보면(log Kow=5.24) 먹이연쇄를 통한 생물농축이 예상되나 비교적 가수분해가 빠르기 때문에 비록 수계에 노출된다고 하여도 그 가능성은 매우 낮을 것으로 사료된다. Several physicochemical properties such as water solubility, vapor pressure, hydrolysis and octanol/water partition coefficient(Kow) of flupyrazofos, the first organophosphorus insecticide developed in Korea, were measured based on EPA and OECD methods. Water solubility was low showing 0.80 ppm at $25^{\circ}C$ and in hydrolysis study, half-life at $25^{\circ}C$ was 266.5 hr(pH 4.0), 180.0 hr(pH 7.0) and 120.9 hr(pH 9.0) demonstrating instability in alkaline solution. At $40^{\circ}C$ hydrolysis rate was $2{\sim}4$ times higher than that at $25^{\circ}C$. The equation log P=0.673-(1565.4/T) was obtained from vapor pressure experiments at three different temperatures (25, 35, $45^{\circ}C$) and $2.81{\times}10^{-5}$ torr was obtained at $25^{\circ}C$. This value is similar to that of diazinon and 1,000 times lower than that of DDVP suggesting it would not give environmental contamination by volatilization. High log Kow(5.24) was observed and this might result in bioconcentration through food chain. However, its possibility is not likely to be high due to its relatively rapid hydrolysis.

족근골 유합의 발생 빈도: 단일 기관 자기공명영상 분석

김정한,곽희철,이창락,김영준,김전교,이선주,이정한,박준호,Kim, Jung-Han,Gwak, Heui-Chul,Lee, Chang-Rak,Kim, Young-Jun,Kim, Jeon-Gyo,Lee, Sun-Joo,Lee, Jeong-Han,Park, Jun-Ho 대한족부족관절학회 2016 대한족부족관절학회지 Vol.20 No.3

Purpose: Tarsal coalition results from defects during the developmental stage and produes ankle pain and limitations in the range of motions. Its incidence has been reported to be 1%, but there has not been any reports with respect to Koreans. Therefore, we evaluated the prevalence of tarsal coalition in Koreans. Materials and Methods: Between 2005 and 2014, we analyzed a total of 733 cases of foot and ankle magnetic resonance imaging (MRI) in our hospital. There were 391 men and 342 women. All MRI readings were read by a radiologist in our hospital. We classified the coalitions in accordance with the histological and anatomical characteristics, and calculated the prevalence in each group. Moreover, we tried to determine the prevalence of tarsal coalitions in accordance with sex, age, and proportion of the symptomatic tarsal coalitions. Results: There were a total of 11 MRIs of tarsal coalition - 9 talocalcaneal coalitions, 1 calcaneocuboidal coalition, and 1 calcaneonavicular coalition. Nine tarsal coalitions were observed in men and 2 in women. Conclusion: Through this study, we found that the prevalence of tarsal coalition, including the asymptomatic patients, is similar to the previously known prevalence (1%). By getting more MRIs of the foot and ankle, we could better represent the prevalence of tarsal coalitions in Koreans.

시퀀셜 로테이션 분배기 구조를 이용한 X-band 마이크로스트립 4×4 광대역 원형 편파 배열 안테나

김정한,김중관,김용진,이홍민,Kim, Jung-Han,Kim, Joong-Kwan,Kim, Yong-Jin,Lee, Hong-Min 한국전자파학회 2007 한국전자파학회논문지 Vol.18 No.2

본 논문은 X-band에서 동작하는 마이크로스트립 원형 편파 $4{\times}4$ 배열 안테나의 설계와 제작에 대해 다룬다. 단일 안테나는 정사각형 패치를 사용하고 비대칭 십자 개구 결합 급전 구조를 사용하여 RHCP(Right Handed Crcularly Polarization)로 동작하도록 하였다. 기존의 배열 안테나의 소자간의 간격을 0.8 ${\lambda}_0$에서 0.45 ${\lambda}_0$로 간격을 줄여 실장 면적을 감소시켰다. 급전 선로는 시퀀셜 로테이션 분배기로 $2{\times}2$ 배열 안테나를 설계하여 양호한 이득과 축비 대역폭을 나타내었다 ${\lambda}/4$ Transformer와 T-junction 전력 분배기로 $4{\times}4$ 배열 안테나로 확장하였다. 시뮬레이션으로 확인한 결과 최대 방사 이득은 15.09 dBi로 나타났으며, 축비 대역폭은 3 dB 기준 $9.05{\sim}10.4$ GHz(13.5%)의 양호한 특성을 보였다. 제작된 $4{\times}4$배열 안테나는 10 GHz에서 측정 결과 임피던스 대역폭($VSWR{\leq}2$)은 $8.45{\sim}11.84$ GHz(33.9%)로 나타났으며, 최대방사 이득은 11.10 dBi를 얻었다. 또한 측정된 축비 대역폭은 $9.42{\sim}10.47$ GHz(10.5%)를 얻었다. In this paper, the circularly polarized $4{\times}4$ array antenna is proposed for the X-band. A single antenna consists of square patch and unequal cross-aperture coupled feeding. The RHCP(Right Handed Circularly Polarization) is generated by unequal cross-aperture coupled feeding. By reducing space among elements of way antenna from 0.8 ${\lambda}_0$ to 0.45 ${\lambda}_0$, the mounting area of array antenna is miniaturized. The $2{\times}2$ array antenna is designed using sequential rotation feeding network. The good level of gain, axial ratio, and impedance bandwidth are achieved. The $4{\times}4$ array antenna is extended by ${\lambda}/4$ transformer and T-junction power divider. The simulated maximum radiation gain is 15.09 dBi at 10 GHz. The simulated 3 dB Axial Ratio bandwidth is from 9.05 to 10.4 GHz(13.5%). Also the measured impedance bandwidth($VSWR{\leq}2$) of manufactured $4{\times}4$ array antenna is from 8.45 to 11.84 GHz(33.9%). The measured maximum radiation gain is 11.10 dBi at 10 GHz. The measured 3 dB Axial Ratio bandwidth is from 9.42 to 10.47 GHz(10.5%).

종골의 사체 실측 결과와 방사선학적 측정 결과의 비교

김정한,곽희철,이창락,정동우,노상명,Kim, Jung-Han,Gwak, Heui-Chul,Lee, Chang-Rack,Jeong, Dong-Woo,Roh, Sang-Myung 대한족부족관절학회 2015 대한족부족관절학회지 Vol.1 No.2

Purpose: We wanted to compare the results between cadaveric and radiological measurements of calcaneus. Materials and Methods: Sixty three calcaneus of 33 cadavers donated between December 2012 and December 2014 were actually measured. Computed tomography (CT) images of 244 calcaneus in 122 patients of the same age group with cadavers were radiologically measured. Maximum length, maximum width, maximum height, $B{\ddot{o}}hler$ angle, Gissane angle, Fowler-Phillip angle, and tala-articular angle were measured. Results: In cadaveric measurement, the mean maximal height, length, and width were $41.8{\pm}3.3mm$, $73.3{\pm}3.4mm$, and $40.7{\pm}2.2mm$, respectively. In radiological measurement, the mean maximal height, length, and width were $38.5{\pm}4.3mm$, $74.0{\pm}5.7mm$, and $44.7{\pm}1.4mm$, respectively. In cadaveric measurement, the mean $B\ddot{o}hler$ angle, Gissane angle, Fowler-Phillip angle, and tala-articular angle were $32.1^{\circ}{\pm}6.2^{\circ}$, $110.8^{\circ}{\pm}8.1^{\circ}$, $55.8^{\circ}{\pm}6.8^{\circ}$, and $59.7^{\circ}{\pm}4.6^{\circ}$, respectively. In radiological measurement the mean $B{\ddot{o}}hler$ angle, Gissane angle, Fowler-Phillip angle, and tala-articular angle were $32.6^{\circ}{\pm}3.8^{\circ}$, $113.7^{\circ}{\pm}5.7^{\circ}$, $62.2^{\circ}{\pm}3.9^{\circ}$, and $61.6^{\circ}{\pm}6.3^{\circ}$, respectively. The mean maximal height was significantly higher in the cadaveric measurement group (p<0.001) and the mean maximal length and width were significantly higher in the radiologic measurement group (p<0.001, p<0.001). The mean Gissane angle, Fowler-Philip angle, and $B{\ddot{o}}hler$ angle were significantly higher in the CT group (p=0.001, p<0.001, p=0.016, respectively). There was no significant difference in the mean tala-articular angle (p=0.352). Conclusion: Significant differences in length parameters were observed between the cadaveric measurement group and the radiologic measurement group. However, no significant differences in angular measurements were observed between the two groups. The authors carefully conclude that radiological measurement values may be different from actual values in the calcaneus.

회원작품 - 성북구립 길음동 글빛도서관 인테리어

김정한,Kim, Junghan 대한건축사협회 2022 建築士 Vol.634 No.-

Isoguanosine과 Berberine 1 : 1 혼합물의 항암효과

김정한,이상준,한영복,문정조,김종배,Kim, Jung-Han,Lee, Sang-Jun,Han, Young-Bok,Moon, Jung-Jo,Kim, Jong-Bae 대한약학회 1994 약학회지 Vol.38 No.2

Isoguanosine and berberine 1:1 mixture[l:[1(mole:mole)] has been prepared and evaluated by measuring antitumor effects against various tumor cell lines in culture and in mice. We reported that the synergistic effect of isoguanosine and berberine mixture has been revealed compared with each of isoguanosine and berberine increased by $3{\sim}8$ times than that of each components in various tumor cell lines in vitro. The most effective dose of isoguanosine and berberine mixture was 60 mg/kg/day in mice bearing S-180 solid tumor, the %(1-T/C) values were 70%. Against the P-388 leukemia, isoguanosine-berberine mixture was the most effective at the dose of 60 mg/kg/day, the %T/C values were 163%.

일반화 공간변조를 위한 저복잡도 강인 최대 우도 신호 검파

김정한,윤태선,오세훈,이경천,Kim, Jeong-Han,Yoon, Tae-Seon,Oh, Se-Hoon,Lee, Kyungchun 한국정보통신학회 2017 한국정보통신학회논문지 Vol.21 No.3

본 논문에서는 다중 안테나 구조 중 일부 송신 안테나만 활성화하고 활성 안테나의 인덱스를 통해 정보를 전송하는 일반화 공간변조(Generalized Spatial Modulation)시스템을 위한 최대우도 신호 검파 방법을 제안한다. 제안 최대 우도 수신기는 기존의 채널 정보 오차에 강인한 최대 우도 수신기와 비교하여 공분산 행렬을 추정할 때 후보 해 집합을 확률적으로 추출하여 공분산 행렬을 추정함으로써 시스템 복잡도를 크게 줄이도록 한다. 모의 실험을 통해 제안 최대 우도 수신기가 기존의 채널 정보 오차를 고려하지 않는 수신기보다 높은 수신 성능을 가지며, 기존 강인 최대우도 수신기와 비교하여 동일한 비트 오류율 성능을 가지면서도 큰 폭으로 계산 복잡도를 낮춤을 확인하였다. In this paper, we propose a maximum likelihood signal detection scheme for a generalized spatial modulation system that activates only a subset of transmit antennas among multiple antennas and transmits information through the indexes of active antennas as well as through the transmit symbols. The proposed maximum likelihood receiver extracts a set of candidate solutions based on their a posteriori probabilities to lower the computational load of the robust receiver under channel information errors. Then, the chosen candidate solutions are exploited to estimate the covariance matrix of effective noise. Simulation results show that the proposed maximum likelihood detection scheme achieves better error performance than a receiver that does not take into account the channel information errors. It is also seen that it reduces the computational complexity with the same bit error rate performance as the conventional robust maximum likelihood receiver.

제초제는 잡초를 어떻게 죽이나? 1

김정한,Kim, Jeong-Han 한국작물보호협회 2006 자연과 농업 Vol.27 No.10

농약잔류허용기준? 안전사용기준?

김정한,Kim, Jeong-Han 한국작물보호협회 2005 자연과 농업 Vol.26 No.10

“시중 채소류 잔류농약 범벅”신문이나 TV에 자주 등장하는 낯익은(?) 제목이다. 그리고는“조사대상 농산물 중 OO% 허용기준치초과. 최고 OO배에 달해, 사용이 금지된 농약도 나와, 잔류농약은 식품과 함께 일생동안 섭취되기 때문에 만성중독 가능성을 배제할 수 없다”같은 내용이 그 뒤를 잇는다. “일생동안 섭취”문제는 이미 지난 10월호에서“1일 섭취허용량” 을 다루었기 때문에 이해가 된다. 하지만 식생활을 하면서 농약 섭취가 1일섭취허용량 이하로 되도록 하려면 식품에 농약이 어느 정도까지 있어야 안전한가?”가 의문이다. 그 허용기준이 농산물(식품) 중“농약잔류허용기준”이다. 이는 보통“기준치, 허용치, 허용기준, 허용기준치, 잔류허용기준”등으로 불리우고 있다.

농약은 어떤 모양일까?

김정한,Kim, Jeong-Han 한국작물보호협회 2005 자연과 농업 Vol.26 No.8