전이 췌장암 환자의 Gemcitabine과 방암탕 가감방 및 건칠단 병용투여 치험 1례

김은혜,윤성수,이지영,윤성우,Kim, Eun Hye,Yoon, Sung Soo,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2018 大韓癌韓醫學會誌 Vol.23 No.2

Objectives: This study was aimed to report a patient with metastatic pancreatic cancer treated with modified Bangam-tang and Gunchil-dan in conjunction with gemcitabine. There were better survival-related outcomes compared to gemcitabine alone. Methods: The patient with metastatic pancreatic cancer received gemcitabine as palliative chemotherapy since June 2016 concurrent with modified Bangam-tang and Gunchil-dan since October 2016 to October 2017. To evaluate the effect of treatment, tumor markers (carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA)), Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, and overall survival were checked. Adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Results: After 12 months with the combination treatment, levels of CA19-9 were decreased from 8747 to 265.7 ng/ml and CEA from 42.2 to 6.5 U/ml. Clinical partial response state was shown until May 2, 2017 and stable disease state was maintained from August 4, 2017. In March 2018, the patient got an operation including pancreatectomy and diagnosed with no evidence of disease state in September, 2018. In conclusion, it showed the overall survival of 29 months from June, 2016 to November, 2018. Serious adverse events were not identified. Conclusions: This study suggested that combined treatment with modified Bangam-tang and Gunchil-dan may show better outcome in patient with metastatic pancreatic cancer than gemcitabine alone.

항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석

김은혜,윤지현,이지영,윤성우,Kim, Eun Hye,Yoon, Jee-hyun,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2020 大韓癌韓醫學會誌 Vol.25 No.2

Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

불로 구기 부위별 자유라디칼 소거효과에 관한 연구

김은혜,김현위,김수동,이보희,이철호,고경희,Kim, Eun-Hae,Kim, Hyeon-Wee,Kim, Su-Dong,Lee, Bo-Hee,Lee, Cherl-Ho,Koh, Kyung-Hee 한국식품과학회 2005 한국식품과학회지 Vol.37 No.1

Free radical-scavenging activities of Korean Bulro Kugi (Lycium chinense Mill) fruit, leaf, and root were evaluated. Total phenolic contents of fruit, leaf, and root were $1,078.4{\pm}61.0$, $939.9{\pm}19.8$, and $3,792.2{\pm}106.6mg/L$, and their flavonoids were $396.7{\pm}15.2$, $1,952.9{\pm}21.3$, and $425.3{\pm}13.5mg/L$, respectively (p<0.001). HPLC revealed main polyphenolic compounds in fruit were p-coumaric and syringic acids in fruit, p-coumaric, syringic, and procatechuic acids in leaf, and p-coumaric, syringic, caffeic, and procatechuic acids in root. Highest radical-scavenging activities of superoxide anion and hydroxyl were found in leaf and root, respectively (p<0.001). 불로 구기의 부위별 열매, 잎, 뿌리의 라디칼 소거 효과를 연구하였다 총 페놀함량은 불로 구기열매, 잎, 뿌리에서 각각 $1,078.4{\pm}61.0mg/L$, $939.9{\pm}19.8mg/L$, and $3,792.2{\pm}106.6mg/L$의 함량은 나타내었으며 총 플라보노이드 함량은 구기열매, 잎, 뿌리에서 각각 $396.7{\pm}15.2$, $1,952.9{\pm}21.3$, and $425.3{\pm}13.5mg/L$의 함량을 나타내었다(p<0.001) 열매에서는 p-coumaric acid 0.018 mg/100g, syringic acid 0.006 mg/100g이 검출되었고, 잎에서는 p-coumaric acid 0.068 mg/100g, syringic acid 0.064 mg/100 mg, procatechuic acid 0.05 mg/100 mg이 검출되었다. 뿌리에는 p-coumaric acid 0.178 mg/100 mg, syringic acid 0.046 mg/100 mg, caffeic acid 0.043 mg/100 g과 procatechuic acid 0.022 mg/100 mg이 검출되었다. 불로구기의 주요 폴리페놀 성분들은 p-coumaric acid과 syringic acid이었으며 잎에서는 열매에서 확인되지 않은 caffeic acid가 뿌리에서는 caffeic acid procatechuic acid 성분이 함유되어 있었다. 총 폴리페놀 함량은 뿌리 0.29 mg/100 g, 잎 0.18 mg/100 g, 열매 0.03 mg/100 g의 순으로 뿌리에 가장 많이 함유되어 있는 것으로 나타났다. 불로 구기의 부위별 superoxide anion radical 소거능력은 잎, 뿌리, 구기열매가 각각 $60{\pm}0.1%$, $47.7{\pm}0.1%$, $21.6{\pm}0.1%$의 순으로 잎에서 가 장 높은 소거효과가 나타났으며, hydroxyl radical 소거능력은 superoxide anion radical 소거능력에 비해 효과가 약하나 뿌리에서 $34.6{\pm}0.1%$로 높은 소거효과를 나타내었다(p<0.001).

겹치기 마찰교반접합 된 Al6061/HT590 합금의 기계적 특성 평가

김은혜,이광진,송국현,Kim, Eun-Hye,Lee, Kwang-Jin,Song, Kuk-Hyun 대한용접접합학회 2015 대한용접·접합학회지 Vol.33 No.2

This study was carried out to evaluate mechanical properties of the jointed Al6061/HT590 alloys by friction stir welding (FSW). FSW was conducted under the conditions with tool rotating speed of 500 RPM and traveling speed of 300 mm/min., where Ar gas was introduced to prevent the materials from corrosion during the welding process. Electron back-scattering diffraction (EBSD) was used to characterize microstructures such as grain size, misorientation angle and crystal orientation. Evolution of intermetallic compounds in Al6061 during the process were examined in terms of morphology, size and aspect ratio at three distinct zones Al base material, heat affected zone and stir zone, where transmission electron microscope (TEM) was used. It was revealed that FSW gave rise to refinement of grains as well as growth of intermetallic compounds in Al6061. The morphological changes of intermetallic compounds exerted an influence on mechanical properties, resulting in occurrence of fracture in the part of the base material instead of the jointed parts (heat affected zone and stir zone). This study systematically evaluated the microstructural evolutions during the FSW for joining Al6061 with HT590 and their effect on mechanical properties.

마찰접합 된 A6063 합금의 미세조직과 기계적 특성 평가

김은혜,조형환,송국현,Kim, Eun-Hye,Cho, Hyung-Hwan,Song, Kuk-Hyun 한국재료학회 2017 한국재료학회지 Vol.27 No.5

This study was carried out to evaluate the developed microstructures and mechanical properties of friction welded A6063 alloy. For this work, specimens were prepared at a size of 12 mm ${\O}{\times}80mm$, and friction welding was carried out at a rotation speed of 2,000 RPM, friction pressure of $12kgf/cm^2$ and upset pressure of $25kgf/cm^2$. To perform an analysis of the grain boundary characteristic distributions, such as the grain size, orientation and misorientation angle distributions, the electron back-scattering diffraction method was used. In addition, in order to identify the dispersed intermetallic compounds of the base and welded materials, transmission electron microscopy was used. The experimental results found that the application of friction welding on A6063 led to significant grain refinement of the welded zone relative to that of the base material. Besides this, intermetallic compounds such as AlMnSi and $Al_2Cu$ were found to be dispersed with more refined size relative to that of the base material. This formation retains the mechanical properties of the welds, which results in the fracture aspect at the base material zone. Therefore, based on the developed microstructures and mechanical properties, the application of friction welding on A6063 could be used to obtain a sound weld zone.

청소년이 지각한 사회적 자본이 유데모니아에 미치는 영향: 인권의식을 매개로

김은혜,손한결,Kim, Eun Hye,Sohn, Han Gyeol 한국학교ㆍ지역보건교육학회 2021 한국학교지역보건교육학회지 Vol.22 No.3

Objectives: The purpose of this study was to examine the mediating effect of human rights consciousness on the relationship between social capital and eudaimonia perceived by adolescents. Methods: The participants of this study were 9,021 adolescents, with data taken from the 6^th year(2018) panel survey. All variables were evaluated by self-report of adolescents. The data were analyzed by SPSS 21.0 and AMOS 21.0. Results: First, social capital perceived by adolescents had a direct effect on eudaimonia. Second, social capital perceived by adolescents had an indirect effect on the eudaimonia through human rights consciousness. Conclusions: This study highlighted that human rights consciousness was identified as important mediator in the relationship between capital perceived by adolescents and eudaimonia. These results can be used as an important contribution to further research and educational practices for promoting the eudaimonia in adolescents.

파클리탁셀을 함유한 지질나노입자의 제조와 인공 소화액에서의 안정성 평가

김은혜 ( Eun Hye Kim ),이정은 ( Jung Eun Lee ),임덕휘 ( Deok Hwi Lim ),정석현 ( Suk Hyun Jung ),성하수 ( Ha Soo Seong ),박은석 ( Eun Seok Park ),신병철 ( Byung Cheol Shin ) 한국약제학회 2008 Journal of Pharmaceutical Investigation Vol.38 No.2

코로나 19 상황에서 성인 발달장애인의 미래설계 지원프로그램을 통한 사회적 관계망 변화

김은혜(Kim Eun-hye),한정은(Han Jeong-Eun),정은주(Jung Eun-Jue) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.20

목적 본 연구의 목적은 코로나 19 상황에서 진행된 성인 발달장애인의 미래설계 지원프로그램을 통한 참여자들의 사회적 관계망 변화를 파악하는데 있다. 방법 이를 위하여 2020년 6월부터 7개월간 프로그램을 진행하였으며, 20대에서 50대까지 성인 발달장애인 12명이 최종 사회적 관계망 연구에 참여하였다. 연구는 사회적 관계망 척도를 사용한 양적연구와 개별인터뷰 및 관찰기록지를 활용한 질적연구의 혼합연구방법론을 사용하여 진행되었다. 결과 양적연구 결과, 프로그램에 참여한 성인 발달장애인의 사회적 관계망은 정서적 지지, 정보적 지지, 친밀도, 접촉빈도의 부분에서 증가하였고, 물질적 지지는 감소한 것으로 나타났다. 또한 연령별(35세 기준)로 청년 그룹과 중장년 그룹의 사회적 관계망 변화를 살펴본 결과, 중장년 그룹이 청년 그룹에 비해 사회적 관계망이 더욱 뚜렷하게 변화된 것을 알 수 있었다. 질적연구 결과, 프로그램에 참여한 성인 발달장애인의 사회적 관계망 변화로 ‘다양한 경험을 통한 사회적 관계망의 긍정적 변화’와 ‘사회 환경 변화에 따른 사회적 관계망 구축 및 지속적인 지원 필요’의 상위주제가 도출되었다. 결론 성인 발달장애인의 미래설계 지원프로그램이 사회적 관계망의 변화에 효과적인 것으로 나타나, 향후 이들에 대한 평생과정설계로서 체계적이고 지속적인 지원정책이 마련되어야 함을 제안하였다. Objectives The purpose of this study is to identify the change in the social network of future design support program participants who are adults with developmental disabilities, which took place during COVID-19 situation. Methods The program went on for 7 months from June 2020, and 12 adults with developmental disabilities in their 20s to 50s participated in the final study of social network. The study was conducted by both quantitative method using social network criteria and qualitative method using individual interview and observation records Results The quantitative research method showed that the social network of adults with developmental disabilities who participated in the program increased in the parts of emotional support, informational support, closeness and contact frequency whereas material support decreased. Additionally, when the change in social network of youth and middle age group was studied (age 35 as the dividing point), middle age group showed more evident change in their social network compared to the youth group. The qualitative research showed that the change in social network of participants who are adults with developmental disabilities led to higher topic of ‘positive change in social network through various experiences’ and ‘need for continuous support and construction of social network according to changes in the society’. Conclusions It was shown that future design support program was effective in change of social network of adults with developmental disabilities, and thus it can be proposed that systematic and continuous support policy as lifelong course design should be arranged.

고린도전서 5:1-8을 통해 본 직설법과 명령법의 관계

김은혜(Eun Hae Kim) 한국기독교학회 2019 한국기독교신학논총 Vol.111 No.-

고린도전서 5:7은 “너희는 누룩 없는 자인데 … 묵은 누룩을 내버리라 … 그리스도께서 희생이 되셨느니라”라고 쓴다. 이 본문이 명시하는 ‘누룩 없는 자’라는 직설법과 ‘묵은 누룩을 내버리라’는 명령법 사이에는 그리스도의 희생 사건이 놓여 있다. 이처럼 바울의 신학에서 구원을 얻는 것과 윤리는 아무 상관이 없지만(롬 4:25–5:1) 윤리는 구원을 확인하고 누리는 것과 밀접한 관련성을 가진다. 즉, 그리스도의 영역으로 신자들의 실존을 옮기는 수단인 직설법은, 엄밀히 말하자면 명령법과 직접적인 상관이 없다. 그리고 명령법도 이미 된 사건을 의미하는 직설법을 강화하거나 무효화시킬 수 없다는 점에서 둘은 직접적인 관계성이 없다. 만약 둘 사이에 상관성이 존재한다면 그것은 반드시 그리스도의 십자가 사건을 통해 관계적으로 연결될 수 있는 성질의 것이다. 그러므로 본 연구의 결론은 바울의 신학과 윤리의 중심에 그리스도의 십자가 희생이 있었음을 다시금 확인시킨다. 즉, 신학적 축약으로서의 직설법과 윤리적 축약으로서의 명령법은 독립적인 카테고리가 아니다. 이 둘의 역동적인 관계는 그리스도라는 중심축을 두고 파생된 것이며, 그리스도의 십자가 사건을 통해 볼 때에만 그 참된 의의가 나타난다. The main discussion(1 Cor 5:18) consists of two parts: verse 1–5 and 6–8. In the first part I dealt with the issue of what πνεῦμα and σάρξ can mean in the context, and the purpose of expulsion of the man who committed sin. Through the discussion was identified that Paul thoroughly concerned keeping the it community’s holiness, for it was the ultimate code that the Christ has fulfilled for the community. In this regard, as I argued in the second part of the discussion, ethics of Paul has no relation to bringing more elaborated ethical life to the believers. Rather, it concerns with believers’ newly gained identity in Christ (cf. 2 Cor 2:14; 3:2–3). So it demands believers to keep their focus on the cross of Christ where their existence originated. In conclusion, indicative and imperative are not directly related each other. They are related only by having the Christ event in the center of the relationship. Only in and through this scheme, the proper explanation on the indicative and imperative can be given.

`96 도쿄 세계도시박람회 중지의 딜레마: 개발간담회를 중심으로

김은혜(Kim. Eun-hye) 한국아시아학회 2021 아시아연구 Vol.24 No.2

1980년대 서구 세계도시들은 산업 재구조화로 인한 항만 지역의 쇠퇴를 극복하고자 ‘텔레포트’(teleport, 텔레커뮤니케이션과 항구의 합성어) 개발 프로젝트를 앞다투어 시행했다. 일본에서도 중앙정부 및 도쿄도와 민간자본, 그리고 유명한 건축가 단게 겐조 등이 연합해서 워터 프런트 개발 촉진을 위한 이벤트로서 `96 세계도시박람회(도쿄 프런티어)를 추진했다. 그러나 과열되었던 거품경제가 꺼지고 90년대 불황이 장기화되면서 도쿄도(東京都, TMG)뿐만 아니라, 여러 광역 지자체들도 재정 문제를 겪게 되었다. 1995년 도쿄도지사 선거에서 당선된 무당파 아오시마 유키오 도지사는 도시박람회 중지 논의를 위해 ‘도쿄 임해부도심 개발간담회’라는 자문 기관을 설치한 후 총 17회에 이르는 회의를 진행시켰다. 개발간담회에서는 개발의 목적과 운영 책임, 그리고 토지이용과 처분 등 여러 쟁점이 논의되었고, ‘1일 도민 간담회’ 등을 통해 의견 수렴 과정도 거쳤다. 그러나 개발간담회는 합의점에 이르지 못한 채, 이례적으로 완전 재검토와 부분 재검토를 병기한 보고서를 제출한 채 종결되고 말았다. 이후 개발 계획은 큰 변경 없이 계속되어 갔지만, ‘생활 도시’를 지향하는 아오시마 도지사는 신자유주의적 구조개혁을 표방하는 중앙정부와 대립했다. 1999년 우파 포퓰리즘 성격의 이시하라 신타로가 도지사 선거에 승리하면서 도쿄만의 재개발 방향은 2016·2020년 도쿄올림픽 유치 활동으로 전환되었다. 이 연구는 최근 코로나 확산과 도쿄올림픽 개최 논란 가운데 재소환되는 ‘96 세계도시박람회 중지를 둘러싼 딜레마를 분석해 본다. The global cities rushed to develop a ‘teleport’ (a compound word of telecommunication and port) projects to overcome the urban decline of bay areas with industrial restructuring in the 1980s. The 96 Urban Expo (also known as the Tokyo Frontier) was the city boosterism to promote such a huge waterfront development project by coalition of the central government, Tokyo, private capital, and architect Kenzo Tange. However, the Japanese economy in the 1990s suffered the prolonged recession that followed the collapse of the overheated economic bubble of the 1980s, Tokyo Metropolitan Government (TMG) had the huge fiscal deficit. The non-partisan Yukio Aoshima won in 1995 Tokyo governor election, decided to stop the `96 World City Expo. To reconsider the development plan, the Governor’s advisory committee was held a total of 17 times. Various issues such as the purpose of development, responsibility, land use and disposal were discussed in committees. The round-table meeting for rethinking development plan which the citizens participated went through public comment to collect the opinions. But the committees were noted both complete and partial review, without reaching an agreement. Moreover, as the development plan continued without major revisions, the Aoshima governor oriented toward the resident-friendly city came up against the central government advocated for neoliberal structural reform. After that, the election of governor Shintaro Ishihara and his right-wing populism promoted the 2016/2020 Olympic Games in Tokyo. Amid the recent controversy over the spread of covid-19 and the hosting of the Tokyo Olympics, it needs to analyze the dilemma of cancellation in the World City Expo.