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김용봉(Kim Yong-Bong),현창택(Hyun Chang-Taek),홍태훈(Hong Tae-Hoon),박소현(Park So-Hyun),문현석(Moon Hyun-Seok) 대한건축학회 2009 大韓建築學會論文集 : 構造系 Vol.25 No.10
The design-Value Engineering(VE) has been introduced in 2000 to eliminate the waste of cost and noneffective factors in construction projects. However, VE team members tended to make ideas by their experiences rather than value improvement based on the function analysis of the VE methodology. In this study, the problems of function analysis of VE have been investigated through the analysis of cases by design-VE of mechanical system in multi-family housing project. To resolve these problems, the function analysis has been applied to mechanical system and the mechanical system is broken down by work types and components. And the estimation method of present cost has been established linking the function and the breakdown structure of mechanical system. It is expected that the suggested method could help practitioners to implement the functional analysis of design-VE more efficiently.
김광원(Kwang Won Kim),최영길(Young Kil Choi),고은미(Eun Mi Koh),김덕윤(Deog Yoon Kim),김병호(Byung Ho Kim),장영운(Young Woon Chang),장린(Rin Chang),김용봉(Yong Bong Kim) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A Scintigraphic measurement of gastric emptying time has been reported to be influenced by the variation in depth of radionuclide within the stomach. In order to determine the effect of tissue attenuation in the measurement of gastric emptying time, 15 gastric emptying studies were performed with Tc-99m labeled egg sandwiches. Single anterior detector method overestimated the T1/2 by an average of 13% than geometric mean method and the range of overestimation was wide (from -13% to +32%). Therefore, to evaluate the gastric empthying time accurately, methods of attenuation correction are needed.
김태은 ( Kim Tae Eun ),강윤경 ( Kang Yun Gyeong ),정명철 ( Jeong Myeong Cheol ),노지현 ( No Ji Hyeon ),심의섭 ( Sim Ui Seob ),김용봉 ( Kim Yong Bong ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4
The immature teratoma is the 3rd most common germ cell tumor and represents 10-20% of all ovarian malignancies occurring in the first two decades of life. The initial clinical manifestation is abdominal/pelvic mass with pain. This tumor is usually unilate
SPICE 기반의 LED 회로 모델을 이용한 신뢰성 분석
김진환(Jin-Hwan Kim),엄해용(Hae-yon Eom),정현준(Hyun-Jun Jung),김용봉(Yong-Bong Kim,),서종욱(Jong-Wook Seo) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
A SPICE-based 3-dimensional circuit model of LED(Light-Emitting Diode) was used to analyse the failure mechanism of high-brightness LEDs The distributions of internal current and electric field strength were calculated under forward and reverse bias. It was found that the field distribution In the p-layer plays the most significant role in reverse breakdown of blue LEDs.
황체기 결함이 있는 불임환자에서 클로미펜 투여 여부에 따른 자궁내막 내의 Prolactin의 발현 양상의 비교 연구
고승희,황정혜,심의섭,고재환,김용봉,장세진,Goh, Seung-Hee,Hwang, Jung-Hye,Sim, Ey-Sub,Koh, Jae-Whoan,Kim, Yong-Bong,Jang, Se-Jin 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.1
Objective : Clomiphene citrate is one of the most commonly used drugs in the treatment of infertility, but the pregnancy rate achieved with clomiphene citrate is significantly lower than the ovulation rate due to its antiestrogenic effect on the endometrium. Endometrial prolactin is considered to be a marker and an inducer of predecidualization that is characteristic of secretory endometrium. The purpose of this study was to evaluate the association of clomiphene citrate and unsatisfactory endometrial differentiation to secretory endometrium by examining the endometrial expression of prolactin in clomiphene citratetreated infertile women with luteal phase defect. Methods : The endometrial samples from infertile women with luteal phase defect (n=27) were examined. Five cases during secretory phase and six cases during proliferative phase were obtained by biopsy. Sixteen cases were obtained by biopsy during secretory phase after clomiphene citrate treatment. By immunohistochemical staining for prolactin, all obtained endometrial tissues were examined. The differences in the endometrial expression of prolactin were evaluated between proliferative phase and secretory phase, and between clomiphene citrate treated group and no treatment group during secretory phase. Results: The staining of endometrial prolactin was significantly more intense in the glandular epithelial cells and stromal cells in the secretory endometrium than in the proliferative endometrium. The glandular expression of prolactin in the secretory endometrium was not significantly different between the clomiphene citrate-treated group and no treatment group (p=0.719), but the staining of prolactin in the stromal cells was significantly less intense in the clomiphene citrate-treated group than no treatment group (p=0.019). Conclusion: In this investigation, we demonstrated that the endometrial stromal expression of prolactin in the secretory phase was significantly lower in the clomiphene citrate-treated group campared with no treatment group in infertile women with luteal phase defect. And our finding suggests that clomiphene citrate may have an adverse effect on the endometrial predecidualization in infertile women.
Concurrent Weekly Cisplatin and Radiation Therapy for High risk group of Uterine Cervical Cancer
서현숙,강승희,김주리,이응수,김용봉,박성관,Suh Hyun Suk,Kang Seung Hee,Kim Ju Ree,Lee Eung Soo,Kim Yong Bong,Park Sung Kwan The Korean Society for Radiation Oncology 1992 Radiation Oncology Journal Vol.10 No.2
국소적으로 진행된 자궁경부암(종괴크기가 5 cm이상혹은 FIGO병기 III, IV) 환자에 있어 방사선 치료 단독으로 근치적치료를 시행한 경우 골반내에서 약 50$\%$까지의 높은 재발율이 보고되고 있다. 따라서 이들 환자에 있어서 국소관해율 및 생존율을 증가 시키기 위하여 본 연구에서는 방사선 민감제로서 가장 효과적인 약제로 알려진 cisplatin을 방사선치료와 동시에 투여하는 방사선-화학요법을 시행하였다. 1988년 5월부터 1991년 9월까지 인제대학교 부속 서울백병원치료방사선과에서 자궁경부암으로 진단된 환자중 국소적으로 진행된(FIGO병기 III, IV, 종괴크기가 5 cm이상의 IIb) 환자로서 방사선치료와 cispiatin의 동시병행요법이 시행되었던 12명을 대 상으로 후향적 임상분석을 하였다. 12명의 환자에 대한 치료는 골반부위에 5000 cGy이상 (4980-6480 cGy)의 외부방사선치료및 1회이상의 강내치료가 시행되었고 동시에 cisplatin 50 mg을 1주 간격으로 반복투여하였다. 총 투여횟수는 $3\~7$회로 평균 5회였다. 추적기간은 $3\~53$개월 (중앙값 34개월) 이며, 연령 분포는 $26\~69$세(중앙값 54세) 였다. 병기별 분포는 IIb, III, IV가 각각 5, 3, 4명 이었다. 조직학적 분류상 편평상피세포암이 11명 이었다. 11명의 관찰대상중 완전관해는 7명 ($64\%$), 부분관해는 4명 ($35\%$)에서 이루어졌다. 7명의 완전관해중 6명이 무병상태였다. 관찰종로시의 전체국소관해율은 $73\%$로서 완전관해군은 $100\%$, 부분관해군은 $25\%$,에서 국소관해를 보였다. 병기별 생존분포를 보면 FIGO병기 IIb, III, IV에서 각각 4/4, 2/3, l/3 이었으며 5년생존율은 $61\%$이었다. 사망자는 4명으로 이중 3명은 일차적인 질병으로, 1명은 패혈증으로 사망하였다. 재발환자는 3명으로 국소재발이 1명, 원격전이가 1명, 국소재발과 원격전이가 1명 이었다. 병합치료에 의한 독성을 살펴보면 오심증상이 3명, 식욕부진이 4명, 백혈구감소증이 4명, 그리고 혈소판감소증이 1명에서 관찰되었다. 다른 1명은 치료종료후 패혈증으로 사망하였다. 그 외의 혈액적독성, 신독성의 증상을 나타낸 경우는 없어 cisplatin 추가에 의한 독성은 경미한 것으로 나타났다. 국소적으로 진행된 자궁경부암 환자에서 방사선-화학요법을 동시 병행할 경우 국소관해율이 $100\%$(완전관해율이 $64\%$)이었고 골반내 재발율은 $27\%$, 이었으며 cisplatin추가로 인한 독성은 경미하였다. 이는 대조군과 비교할때 보다 나은 성적으로 예비결과이기는 하나 국소적으로 진행된 자궁경부암환자에서 방사선치료와 cisplatin 동시 병행요법이 국소관해율을 향상시킬 수 있을 것으로 기대된다. Locally advanced cervical carcinoma has shown high rate of local failure and poor survival rate despite the advances in modern radiation therapy techniques. Combination of chemotherapy and radiation therapy demonstrated benefit in improving local control and possibly the overall survival. Twelve patients with advanced stages (Figo stage III, IV) or 11b with bulky tumors (>5 cm in diameter) were treated with combination of radiation therapy and concurrent weekly cisplatin between May of 1988 and September of 1991 at Inje University Paik Hospital. Cisplatin was administered in bolus injections of 50 mg at weekly intervals during the courses of radiation therapy. Median follow-up period was 34 months with ranges from 3 to 53 months. Eleven patients were evaluable for the estimation of response. Response was noted in all the 11 patients: complete response (CR) in 7 ($64\%$), partial response (PR) in 4 ($36\%$). Of the 7 patients with CR, all maintained local control, whereas only 1 of 4 with PR showed local control. Six of 7 with CR are alive disease free on the completion of follow-up. Eight of 11 patients ($73\%$) maintained local control in the pelvis. The median survival for CR patient is 27 months and 9 months for the PR patients. Analysis of survival by stage shows 11 b 4/5, III 2/3 and IV 1/3. Overall survival rate was $61\%$. Three patients recurred: 1 at local, 1 in distant site and 1 with local and distant site. Toxicity for the combination therapy was not excessive. These results are preliminary, but definitely encouraging in view of markedly improved response rate compared with the results of historical control group.