Complication of Intraoperative Radiation Therapy (IORT) in Gastric Cancer

김명세(Myung Se Kim),김성규(Sung Kyu Kim),송선교(Sung Kyo Song),김홍진(Hong Jin Kim),권굉보(Koing Bo Kwan),김흥대(Heung Dae Kim) 대한방사선종양학회 1992 Radiation Oncology Journal Vol.10 No.2

영남대학교 의료원 치료방사선과에서 1988년 6월 15일에 위함 환자의 수술중 방사선치료를 시작한 이래 1992년 8월 30일까지 총 58예에서 시도하여 그중 53예에서 IORT를 실시하였으며, 정기적인 추적검사에서 한명의 국소개발 환자도 보고되지 않고 있다. 출혈(3예), 장관폐쇄(3예), 폐혈증(2예), 골수기능저차(1예)를 포함한 총 9예(17%)의 합병증이 보고되었고, 이중 6예(13%)가 사망하였다. IORT(1500cGy), 외부 방사선치료 (-4500cGy)와 강한 항암제를 병합치료 하였음에도 불구하고 주등(수술과 항암제 치료)의 25.2%, 김등(수술 불가능한 환자에서 항암제 투여)의 18%, 리등(수술)의 18.5%, Kraming등(IORT 2800-3500cGy)의 35.3%에 비해 낮은 합병증을 보여 IORT가 위암의 치료에 공헌할 수 있음을 시사하였다. 그러나 비교적 높은 치사율(11.3%)은 더욱 세심한 수술수기 및 수술 후 환자의 치료가 필요하며 외부 방사선치료와 항암제치료의 적절한 시기 조절 및 치료선량의 가감이 필요할 것으로 생각된다. Local control is the important prognostic factor in cancer treatment because local control decrease the relative risk of metastatic spread and increase distant metastasis free survival. IORT is the modality which could increase local control without increasing complication, combined with curative operation. Eventhough we could achieve significant deacreased local failure by IORT and curative resection, it should not be committed as a main treatment modality without proving acceptable complications. Therapeutic Radiology Department of Yeungnam University Medical Center have tried 58 IORT from June 15, 1988 and performed 53 IORT in patients with gastric cancer. No local failure had been reported including interstinal obstrution, hemorrhage, sepsis, and bone marrow depression. These complications could be comparable to Jo's 25.2% (chemotherapy + operation), Kim's 18% (chemotherapy only in inoperable patients), because our treatment regimen is consisted of IORT (1500cGy), external irradiation (--4500cGy) and extensive chemotherapy (FAM, 5FU + MMC, BACOP). Our data encouraged us to re-inforce further IORT in stomach cancer treatment.

무궁화 위성, 본격적인 우주시대를 열다

김성규,노태수,Kim, Seong-Gyu,No, Tae-Su 한국방위산업진흥회 1995 國防과 技術 Vol.- No.199

미국의 해기사 교육제도와 취업현황에 관한 연구

김성규,Kim, Seong-Kyu 한국항해항만학회 2001 한국항해학회지 Vol.25 No.2

This paper presents the educational methodology shipboard training methods of Maritime Colleges in U.S.A. and the fields of engagement in business of the graduates from them. There are two Maritime Academies, i.e. U.S. Merchant Marine Academy (USMMA) and U.S. Coast Guard Academy, which are supported by federal government and six Maritime Colleges operated by each State. Maritime Administration (MARAD) in the Department of Transportation (DOT) supports the training of merchant marine officers and crew members with a focus on safety in U.S. waterborne commerce. The shipboard training methods are not unique, but have various process. One is continuous sea term training onboard during sophomore (100 days) and junior year (200 days) in case of USMMA, the other is summer sea term training onboard every three months during freshman, sophomore and junior years in case of SUNY Maritime College. They offer also one month ship simulator training ashore. The employment status for the 1999 year graduates from USMMA shows 43 percent in the field of maritime afloat, 34 percent of maritime ashore, 22 percent of active duty military and 1 percent of others.

호흡기 질환-기관지 천식

김성규,Kim, Seong-Gyu 한국건강관리협회 1995 건강소식 Vol.19 No.7

"선박안전기술공단"출범에 즈음하여

김성규,Kim, Seong-Gyu 선박안전기술공단 2007 선박안전기술공단소식 Vol.14 No.-

해운물류정보(海運物流情報)시스템의 활성화요인(活性化要因)이 물류성과(物流成果)에 미치는 영향(影響)에 관한 연구(硏究)

김성규,조성무,이용호,안기명,Kim, Seong-Kyu,Cho, Sung-Mou,Lee, Yong-Ho,An, Ki-Myung 한국항해항만학회 2001 한국항해학회지 Vol.25 No.2

The information technology(IT) development of telecommunication, along with the information analyzation over the world, enables the firms to process their inner and outer operations through Electronic Data Interchange (EDI) system. And the concept of logistics has become more important to the enterprises in strategic sense because it had aggrandized itself to more comprehensive and integrative concept. Also the world shipping market is more competitive than any other market. In these environment, to maintain competitive power, shipping firms process operations by Logistics Information system(LIS), And then, reduce the working processes, working time and its costs. So the LIS has become more important in developing our national logistics system and industry. Therefore, this study purposes on empirically analyzing the activation factors of shipping LIS and the relationship these, factors with logistic performances in the shipping industry. Considering environments of Shipping logistics information system, this study sets up the research model and hypothesis to examine the activation factors of shipping LIS and the relationship these factors with logistic performances. We used the field data on the 163 numbers of firms(29 overseas shipping companies and 133 forwarding Agency) to get the empirical evidence. According to the study results, The shipping LIS activation factors which the sample firms recognized as important: were top managers support, well structured communication channel, strategic plans connection and inner information analyzation level. And IS organization & human resources, IS discipline & training, software development, IS organizational alignment, database management system, information standardization, competitive advantage, financial support and government support represent partially significant. Also, the current shipping LISs main problems are expensive system cost, standardization of working processs, institutions imperfection and systems interaction defect. So these problems must be improved to activate shipping LIS.

전립선암에서 세기조절방사선치료의 선량분포 특성

김성규,최지훈,윤상모,Kim, Sung-Kyu,Choi, Ji-Hoon,Yun, Sang-Mo 한국의학물리학회 2010 의학물리 Vol.21 No.3

전립선암에서 세기조절방사선치료와 입체조형방사선치료의 선량분포 특성을 비교하였다. 세기조절방사선치료에서는 치료계획표적용적에 200 cGy를 33회 조사하여 6,600 cGy가 조사되도록 하였다. 세기조절방사선치료에서는 PTV의 최대선량이 104.4%이었으며, 최소선량이 89.5%였으며, 삼차원입체조형치료에서는 PTV의 최대선량이 105.3%이었으며, 최소선량이 85.5%을 나타내었다. 100%에 대한 CI는 세기조절방사선치료에서 1.02였으며, 삼차원입체조형치료에서는 0.97을 나타내었다. 중요장기 직장에 대해서 세기조절방사선치료에서는 5,000 cGy 이상이 34.0%였으며, 삼차원입체조형치료에서는 63.3%였고, 방광에 대해서 세기조절방사선치료에서는 4,000 cGy 이상이 30.1%였으며, 삼차원입체조형치료에서는 30.6%였고, 오른쪽 대퇴골두부에 대해서 세기조절방사선치료에서는 2,000 cGy 이상이 9.5%였으며, 삼차원입체조형치료에서는 17.5%였고, 왼쪽 대퇴골두부에 대해서 세기조절방사선치료에서는 2,000 cGy 이상이 10.6%였으며, 삼차원입체조형치료에서는 18.3%을 나타내었다. 삼차원입체조형치료와 세기조절방사선치료의 비교에서 세기조절방사선치료가 삼차원입체조형치료에 비해 PTV의 선량분포에서는 5%의 정도 선량분포의 이득이 있었으며, 직장 선량에 대해서는 5,000 cGy 이상 선량에서 29.3%의 감소가 있었고, 방광 선량에 대해서는 거의 비슷한 분포를 나타내었고, 오른쪽 대퇴골두부의 선량에서는 8.0%, 왼쪽 대퇴골두부의 선량에서는 7.7%의 선량 이득을 나타내었다. The aim of this study was to compare the dose distribution of intensity modulated radiation therapy (IMRT) with 3 dimensional conformal radiation therapy (3DCRT) in prostate cancer. The IMRT plan and the 3DCRT plan used the 9 fields technique, respectively. In IMRT, tumor dose was a total dose of 66 Gy at 2.0 Gy per day, 5 days a week for 5 weeks. All cases were following the dose volume histogram (DVH) constraints. The maximum and minimum tumor dose constraints were 6,700 cGy and 6,500 cGy, respectively. The rectum dose constraints were <35% over 50 Gy. The bladder dose constraints were <35% over 40 Gy. The femur head dose constraints were <15% over 20 Gy. Tumor dose in the 3DCRT were 66 Gy. In IMRT, the maximum dose of PTV was 104.4% and minimum dose was 89.5% for given dose. In 3DCRT, the maximum dose of PTV was 105.3% and minimum dose was 85.5% for given dose. The rectum dose was 34.0% over 50 Gy in IMRT compared with 63.3% in 3DCRT. The bladder dose was 30.1% over 40 Gy in IMRT compared with 30.6% in 3DCRT. The right femur head dose was 9.5% over 20 Gy in IMRT compared with 17.5% in 3DCRT. The left femur head dose was 10.6% over 20 Gy in IMRT compared with 18.3% in 3 DCRT. The dose of critical organs (rectum, bladder, and femur head) in IMRT showed to reduce than dose of 3DCRT. The rectum dose over 50 Gy in IMRT was reduced 29.3% than 3DCRT. The bladder dose over 40 Gy in IMRT was similar to 3DCRT. The femur head dose over 20 Gy in IMRT was reduced about 7~8% than 3DCRT.

Perennial ryegrass 품종의 계절적 생육특성 - I. 봄철생육의 품종간 차이

김성규,이주삼,조익환 ( Sung Kyu Kim,Joo Sam Lee,Ik Hwan Cho ) 한국낙농학회 1991 韓國酪農學會誌 Vol.13 No.1

디지털 홀로그래피에서 퓨리어 변환을 이용한 0차 회절광의 제거와 위상홀로그램의 생성에 대한 전산 모사

김성규,박민철,이석,김재순,손정영,Kim, Sung-Kyu,Park, Min-Chul,Lee, Seok,Kim, Jae-Soon,Son, Jung-Young 한국광학회 2004 한국광학회지 Vol.15 No.1

CCD의 입력면에서의 물체광과 참조광의 간섭을 수치적 방법으로 생성한 광 강도 분포 홀로그램을 대상으로 퓨리어 변환방법을 이용한 0차 회절광의 제거를 전산 모사 방법으로 구현하였고, 0차 회절광 성분이 제거된 광 강도 분포와 위상을 갖는 홀로그램을 생성하였다. 그리고 그 결과를 수치적 재생 방법을 사용하여 0차 회절광 성분의 제거를 확인하였다. 그리고 퓨리어 변환 방법에 의한 0차 회절광 성분이 제거된 위상홀로그램의 생성이 가능하다. 0차 회절광을 제거하기 위한 제거 함수를 도입하였고 제거 영역에 따른 0차 회절광의 제거와 재생되는 실상의 정보 손실 정도를 비교하였고, 기존의 방법에 비하여 효과적임을 증명하였다. A computer simulation about removal of the 0-th order diffraction is achieved by using numerical reconstruction in digital holography and the Fourier transform method. A light intensity distribution hologram is generated through numerical calculation of the interference pattern. Additionally a phase hologram without the 0-th order diffraction is generated. The removal function for elimination of the 0-the order diffraction is introduced and the numerical reconstructions with several conditions for the removal of the 0-th order diffraction and the production of high quality numerically reconstructed images are tested and compared. The removal function is proven to be more effective at the suppression of the 0-th order diffraction compared with the DC suppression method.

Cu/Sn Rim 본딩을 이용한 MEMS 패키지의 Cap 형성공정

김성규,오태성,문종태,Kim, S.K.,Oh, T.S.,Moon, J.T. 한국마이크로전자및패키징학회 2008 마이크로전자 및 패키징학회지 Vol.15 No.4

캐비티 형성이 불필요한 MEMS 캡 본딩을 위해 전기도금법을 이용하여 Cu/Sn rim 구조를 형성하였으며, $25{\sim}400{\mu}m$ 범위의 rim 폭에 따른 본딩특성을 분석하였다. Cu/Sn rim의 폭이 증가함에 따라 rim 패키지 내부의 유효 실장면적비가 감소하는 반면에 파괴하중비가 증가하며, Cu/Sn rim 폭이 150 ${\mu}m$일 때 유효 실장면적비와 파괴하중비를 최적화할 수 있을 것으로 예측되었다. 폭 25 ${\mu}m$ 및 폭 50 ${\mu}m$인 Cu/Sn rim 접합부에서는 모든 계면에서 본딩이 이루어진 반면에, 100 ${\mu}m$ 이상의 폭을 갖는 rim 접합부에서는 Sn 도금표면의 거칠기에 의해 본딩이 이루어지지 않은 기공 부위가 관찰되었다. To develop the MEMS cap bonding process without cavity formation, we electroplated Cu/Sn rim structures and measured the bonding characteristics for the Cu/Sn rims of $25{\sim}400{\mu}m$ width. As the effective device-mounting area ratio decreased and the failure strength ratio increased for wider Cu/Sn rim, these two properties were estimated to be optimized for the Cu/Sn rim with 150 ${\mu}m$ width. Complete bonding was accomplished at the whole interfaces of the Cu/Sn packages with the rim widths of 25 ${\mu}m$ and 50 ${\mu}m$. However, voids were observed locally at the interfaces with the rim widths larger than 100 ${\mu}m$. Such voids were formed by local non-contact between the upper and lower rims due to the surface roughness of the electroplated Sn.