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랫트에서 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) 유발 생체 독성에 대한 조직배양 산삼부정근 사포닌의 치유효과
황석연,박선우,박정숙,한건,Hwang, Seock-Yeon,Park, Sun-Woo,Park, Jeong-Sook,Han, Kun 대한약학회 2006 약학회지 Vol.50 No.4
The therapeutic effect of tissue cultured root of mountain ginseng (Panax ginseng) (tcMG) on 2,3,7,8-tetrachlorodaibenzo-p-dioxin (TCDD) induced toxicity in rat was investigated. The rats were assigned into three groups (10 rats/group), control, TCDD exposed group and tcMG treated group after TCDD exposed. $50\;{\mu}g/kg$ of TCDD was injected by i.p. for TCDD exposed group and 30 mg/kg of tcMG saponin was administered for 4 weeks by oral gavage for tcMG treated group. The weights of body, spleen, kidney, thymus, testes and epididymides were decreased in the single TCDD treatment. However these organs was significantly recovered by tcMG saponin except thymus (p<0.05). tcMG decreased the level of hepatic demage maker enzymes, AST and ALP. It also lowered total cholesterol and triglyceride. The level of serum triglyceride was significantly decreased in tcMG saponin treated group compared with the control. Histopathological examination revealed morphological change in the liver spleen, thymus and testes of TCDD treated rats. However they were relatively well preserved in the tcMG treatment group. In conclusion, TCDD induced toxicity was some repaired by tcMG. tcMG may be useful for prevention and treatment of TCDD induced toxicity.
황석연,이혜숙 한국인체미용예술학회 2009 한국인체미용예술학회지 Vol.10 No.3
There has been a great deal of interest in the applications of plant-based extracts to both cosmetic and medicinal industries. The aim of this study was to evaluate the single-dose dermal toxicity test on Rosin® from an extract of Pine tree which is well-known as a very powerful antioxidant, anti-inflammatory, and antibiotic material according to the guidelines of Korea Food and Drug Administration. Total of 80 rats(40 female rats and 40 male rats) were divided into 4 groups: control(vehicle(80% ethanol)), Rosin® 1%(in 80% ethanol), Rosin® 5% and Rosin® 10 %, which was used for the test of dose toxicity. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and Rosin® treatment groups. The result of this study indicated that Rosin® was able to be used for Atopy Dermatitis to 10% and it is a safe material to skin without skin irritation or allergic sensitization.
기니피그에서 홍삼 사포닌의 2,3,7,8-TCDD 독성 방어 효과
황석연,이찬용,Hwang, Seock-Yeon,Lee, Chan-Yong 한국환경보건학회 2009 한국환경보건학회지 Vol.35 No.4
This study was carried out to investigate the protective effect of Red Ginseng Saponins on 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced toxicities in guinea pigs ($200{\pm}10$ g). Normal control (NC) group guinea pigs ($200{\pm}10$ g) received vehicle and saline, while the TCDD-treated (TT) group was given water-extract (WE), saponin fraction (SF) and non-saponin fraction (NSF). Korean red ginseng fractions were administered from 1 week before TCDD-exposure for 4 weeks. Body weight loss and deteriorated clinical parameters related to sugar metabolism and liver function such as lipase and AST, respectively, these were significantly reduced by both saponin and non-saponin fractions. However, increase of lipase was attenuated by the saponin fraction in a dose-dependent manner. Only AST was affected by the saponin fraction. The results suggest that saponins are active substances in the Korean red ginseng water extract against TCDD induced toxicities in Guinea pigs.
Hydrogel-laden substrates for origami-based tissue engineering
황석연 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
In this study, we present a novel method to assemble biofunctionalized paper into 3-dimensionally (3D) structured complex scaffold system for reliable tissue regeneration through origami-based method. The surface of paper scaffold was conformally modified with poly(styrene-co-maleic anhydride) (PSMa) layer via initiated chemical vapor deposition (iCVD) followed by immobilization of poly-L-lysine (PLL) and Ca<sup>2+</sup>. This procedure ensures the gelation of a thin cell laden-alginate hydrogel film strongly adhesive on the paper substrate due to the diffusion of Ca<sup>2+</sup> to form electrostatic interaction between the hydrogel film and PLL. The developed scaffold system was highly versatile, allowing area-selective cell seeding, which enabled the hydrogel-cell laden paper scaffold to achieve optimal biological cues for the regeneration of desired tissue. In addition, the paper-based scaffold can be folded freely into 3D tissue-like structures by simple origami-based method. Hydrogel-chondrocyte-laden cylindrical shaped paper origami was transplanted into three-ring defect trachea in rabbit for tracheal reconstruction. Transplanted engineered tissues replaced the native trachea without stenosis after 4 weeks. As for the custom-built scaffold system, the origami-based 3D scaffold system will provide a robust and versatile method to form complex tissues mimicking native tissue constructs. Keywords: Paper scaffolds, origami, tissue engineering, hydrogel, initiated chemical vapor deposition
자근으로부터 acetylshikonin의 분리 및 함량분석
황석연,황방연,강삼식,김창민,박정일,배기환,손건호,이승호,장승엽,강신정,노재섭,이경순,Hwang, Suk-Yeon,Hwang, Bang-Yeon,Kang, Sam-Sik,Kim, Chang-Min,Park, Jeong-Hill,Bae, Ki-Hwan,Son, Kun-Ho,Lee, Seung-Ho,Chang, Seung-Yeup,Kang, Shin-Jung 한국생약학회 2000 생약학회지 Vol.31 No.3
Lithospermi Radix has been used in traditional medicine for antimicrobial, antiinflammatory, immunostimulating, antitumor and wound-healing activities. For the quality control of this drug, acetylshikonin was isolated from the hexane extract of Lithospermum erythrorhizon(Boraginaceae) and identified by the spectroscopic evidences. A quantitative analysis of acetylshikonin using HPLC method showed that the average contents were $0.084{\pm}0.026%$ in 31 samples collected throughout the various regions of Korea.