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김경원,윤정구 대한미생물학회 1988 大韓微生物學會誌 Vol.23 No.1
Non-specific cellular immunity may play an important role in the immune defense mechanism against tumors and has recently become of great interest to many researchers. Among the effector cells involved in non-specific cellular immune reactions, natural killer(NK) cells and antibody dependent cell-mediated cytotoxicity(ADCC) effector cells are the principal targets in many of the investigations studying the hosts immune defense aginst tumors. In general most chemotherapeutic agents are known to depress host immune functions. However, such an effect in non-specific cellular immunity particulary on NK cell and ADCC activities has not been fully determined. In this report, the effects of 5-fluorouracil(5-FU) and adriamycin(ADM), which are widely used for the chemotherapy of human cancer, on mouse NK and ADCC activities were studied. Adult ICR mice were injected with either one of the drugs or a combination of them and then at given interval, splenocytes were collected. NK and ADCC activities were measured in vitro using a 4hr ^(51)Cr release assay employing YAC-1 and L1210 target cells respectively. The following results were obtained. 1, The administration of different doses of 5-FU or ADM either alone or in combination resulted in a dose-dependent inhibition of NK activity 48 hours post injection. In these experiments, the doses which showed the most significant inhibition were 12.0mg/ml and 1.2mg/ml or greater for 5-FU and ADM respectively. No difference in NK activity was observed between mice treated with the drugs in combination. In contrast, assays of AD- CC activity in splenocytes from the same mice showed no appreciable change in the level of cytotoxicity. 2. Kinetic studies revealed t4at splenocytes from mice treated with a single dose of 5-FU (12mg/kg) or ADM(1.2mg/kg) alone or in combination showed significantly decreased levels of NK activity 48 72 hours after treatment. Thereafter NK activity progressively increased and reacked the level of the controls at 7 days. Again, no significant changes in ADCC activity were observed in these experiments. 3. Splenocytes from mice treated 48 hours previously with the drugs significantly suppressed the NK activity of normal mice. 4. Futhermore, these splenacytes had an impaired in-vitro production of interleukin-2 as compared to those from normal controls. In conclusion, mice treated with 5-FU or ADM either alone or in combination, exhibited significantly depressed NK activities 2 3 days after treatment, but the level of ADCC activity was not effected. This suggest that NK-suppressing mechanisms which involve the appearance and activation of suppressor cells and which impair the production of interleukin-2, may de- velope following chemotherapy.
김경원,이미정,김정희,심영현 대한지역사회영양학회 1998 대한지역사회영양학회지 Vol.3 No.1
The purpose of this study was to investigate the weight control attempts and related factors among 220 female college students in Seoul. Factors examined included body image, body satisfaction, interest in weight control, beliefs related to weight control, social norms, social expectations regarding subjects' body size and weight change. Data were analyzed using t-test and chi-square test(at <T$\alpha$=0.05). The average height and weight of subjects were 160.7cm, 52.2kg respectively. BMI and body fat(%) were 20.2 and 25.2%, respectively. One hundred seventy two students(78.2%) had attempted to control their weight, mainly to lose weight, and were categorized as the weight control attempt group. Subjects used diet modification as well as unhealthy method to control weight. 48.2% in the attempt group were underweight or normal weight(by BMI), suggesting that their weight control attempts were was unnecessary. Students in the attempt group described their own size as heavier than those in the no-attempt group(p<0.01) or other girls of their age(p<0.05) ; more dissatisfied with their body size(p<0.01), and showed more interest in weight control(p<0.01). Several differences in beliefs were also noted(p<0.001). The attempt group believed less strongly in the harmful effects or difficulties in weight control and believed more strongly in the advantages of weight control. With respect to social factors, the attempt group perceived that their family and friends wanted them to be smaller than they were(p<0.001), perceived that significant others felt that they should lose weight(p<0.05). These results suggest that educational programs for college female students should start focusing on the harmful effects of excessive dieting and information about desirable weight control methods. Students should be helped to have a correct body image. In addition, educational programs should incorporate strategies to change beliefs regarding weight control, as well as modifying social expectations from significant others.
다문화 여성의 양육적응 증진을 위한 교육자료 개발과 평가 -양육 동안 알아야 하는 기본 핵심내용을 중심으로-
김경원 사단법인 인문사회과학기술융합학회 2019 예술인문사회융합멀티미디어논문지 Vol.9 No.12
Purpose: This study was done to develop and evaluate education materials to promote health and adaptation to child rearing for immigrant women in Korea. Method: This study had three procedures: First, contents of the education materials were developed according to immigrant women’s needs, literature reviews, and group discussions of experts, health workers and multicultural interpreters. Details in contents were constructed based on Roy’s adaptation model; Second, validity verification was accomplished; Thirds, evaluation of the education materials was done through a survey of immigrants women. Results: The education materials for child rearing that include 7-key concepts were developed. In the evaluation, the average response score for the questionnaire items was high(3.48 score on a 4point Likert scale). Conclusion: The developed education materials for immigrant women developed in this research will help community health nurse to educate immigrant women who have difficulty raising babies. 본 연구의 목적은 다문화 여성과 그 가족이 양육 동안 알아야 하는 핵심내용을 중심으로 아기 양육증진을 위한 교육자료를 개발하고 평가하는 것이다. 연구는 3단계로 진행되었다. 첫 번째는 교육자료의 내용 구성 단계로, 보건소 보건요원과 다문화 통역요원을 중심으로 요구도 조사, 선행연구 고찰과 전문가 그룹의 토의를 통해서 이루어졌다. 핵심개념은 7개였으며, Roy의 Adaptation Model을 개념적 틀로 하였다. 두 번째는 자료의 내용 타당도를 검증하는 단계로, 첫 번째 단계에 참여하지 않은 전문가들과 다문화 여성을 중심으로 진행되었다. 마지막 단계는 일차 구성된 양육적응 증진을 위한 교육자료의 평가단계로 한국어에 능통한 다문화 여성 76명이 평가에 참여하였다. 평가 결과는 평균, 3.48점(4점 Likert 척도)으로 높게 나타나 교육자료를 최종적으로 확정하였다. 본 연구에서 개발된 아기 양육적응 증진 교육자료는 우리 사회에서 아기 양육에 어려움을 겪고 있는 다문화 여성과 가족은 물론 다문화 여성의 양육을 지도하는 간호사에게 도움을 줄 것으로 사료한다.