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Influence of Aspirin on Pilocarpine-Induced Epilepsy in Mice
정경훈,김주연,최윤식,이문용,김성윤 대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.1
Aspirin (acetylsalicylic acid) is one of the most widely used therapeutic agents based on its pharmacological actions, including anti-inflammatory, analgesic, anti-pyretic, and anti-thrombotic effects. In this study, we investigated the effects of aspirin on seizure susceptibility and hippocampal neuropathology following pilocarpine-induced status epilepticus (SE). SE was induced by pilocarpine hydrochloride (280 mg/kg, i.p.) administration in C57BL/6 mice (aged 8 weeks). Aspirin was administered daily (15 mg/kg or 150 mg/kg, i.p.) for 10 days starting 3 days before SE, continuing until 6 days after SE. After pilocarpine injection, SE onset time and mortality were recorded. Neuronal cell death was examined using cresyl violet and Fluoro-Jade staining, and glial responses were observed 7 days post SE using immunohistochemistry. In the aspirin-treated group, the onset time of SE was significantly shortened and mortality was markedly increased compared to the control group. However,in this study, aspirin treatment did not affect SE-induced neuronal cell death or astroglial and microglial responses in the hippocampus. In conclusion, these results suggest that the safety of aspirin should be reevaluated in some patients, especially with neurological disorders such as temporal lobe epilepsy.
정경훈,김선기,소진남,정봉섭,어환,이규호 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.10
This retrospective analysis describes the clinical characteristics, treatment and outcome of 15 patients with C₂ fracture. The Age of the patients varied from 28 to 71. Theree were only two female patients whose mean age was 25.5 while the mean age of 13 male patients was 44.6. Five patients showed odontoid process fracture, three had C₂body fracture and the remainder were traumatic spondylolisthesis of the axis. The fractures were caused by falls in two patients(13.3%) while in 11 patients(73.3%) they were associated with motor-vehicle accidents. The other two patients were injured by falling objects. No patients suffered a neurological injury associated with the fracture. Three patients are still hospitalized, and follow up was lost for 2 patients. In 10 patients mean follow-up period was 7 months. External immobilization with halovest was done on all patients. Additionally, anterior interbody fusion was done on 1 patient(Case NO. 3). All patients showed the union radiologically, and resumed routine activity. Only 4 of them complained minor limited range of motion of the neck.
정경훈 르몽드코리아 2015 르몽드 디플로마티크 Vol.- No.79
다이어트, 몸짱, 얼짱, S라인, V라인, M라인, 성형, 자연미인, 식스팩, 메트로섹슈얼, 지방흡입수술, 선풍기 아줌마, 거식증, 외모지상주의, 취업성형. 이것들은 요즘 “외모”란 말을 생각했을 때 필자의 머리에 즉각적으로 연상되는 단어들이다. 외모에 대한 관심과 관리가 우리 삶의 한복판을 점하기 시작한 지 이미 오래되어 이 말들이 필자의 뇌와 감각에 각인된 것이다. 여러 조사들에 의하면, 정상체중자 여대생의 95%가 몸매를 관리할 의향을 나타냈고, 여성뿐 아니라 성인 남성의 21%가 외모 때문에 체중을 조절했다고 하며, 저체중여성 넷 중 한명은 자신이 뚱뚱하다고 생각하고 있다. 한참 잘 먹어야할 청소년들도 무리하게 다이어트를 시도하여 생리불순, 골다공증, 성장부진, 위장병, 빈혈 등의 부작용을 겪는 경우가 많다. 일부 성인들은 몸매를 비관하여 우울증에 걸리기도 하고, 다이어트 때 여성 2%는 자살충동을 느낀다고 한다. 외모가 좋은 사람이 성공한다는 연구가 심심치 않게 미디어에 보도되고, ‘외모가 경쟁력’이라는 인식이 널리 퍼지고 있다.
Fine Structural of the Hemopoietic Tissues in the Mealworm Beetle, Tenebrio molitor
정경훈,문명진 한국곤충학회 2004 Entomological Research Vol.34 No.2
The fine structure of the hemopoietic tissue and its detailed reticular organization inthe mealworm beetle, T. molitor were examined using light and scanning electron microscopes.The major hemopoietic tissues in the abdomen were located on the upper surface of the dorsal diaphragmwhich continuous over the ventral wall of the heart. Histologic characteristics of this hemopoietictissues are dense clusters of cells. They are irregular in outline and are not surrounded byany connective tissue sheath. The hemopoietic tissue of this insect is consisted of three cellularcomponents which are the reticular cells, hemocytic stem cells and several kinds of mature hemocytes.The reticular cells had numerous cytoplasmic processes and forming a complex network.The stem cells give rise to differentiating hemocytes of the different cell lineages. Mature hemocyteswithin this hemopoietic tissue are originated from the stem cells and differentiated into severaltypes of hemocytes including prohemocytes, plasmatocytes, and granulocytes.