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신희철,김동준,정성엽,문장원,Shin, Hee-Cheol,Kim, Dong-Jun,Jeong, Seong-Yub,Moon, Jang-Won 한국토지주택공사 토지주택연구원 2011 LHI journal of land, housing, and urban affairs Vol.2 No.2
비효율적인 자동차 중심의 교통체계에서 효율적인 친환경 인간중심의 교통체계로의 전환이 필요하다. 특히 무동력, 비탄소 교통수단 중 생활교통수단으로 활용이 가능한 자전거에 대한 중요성이 인식되면서, 최근 우리나라 뿐만 아니라 전 세계적으로 자전거 이용활성화를 위한 노력을 기울이고 있다. 그러나 우리나라의 경우 자전거 이용활성화에 대한 부정적 인식과 함께 자전거 수단분담률은 1.2%로 자전거 선진국에 비해 매우 낮은 수준이다. 이러한 배경하에 본 연구에서는 우리나라 자전거 이용활성화 가능성을 진단하고, 자전거이용이 활성화된 자전거 선진도시의 사례 분석을 통해 자전거 이용활성화 결정요인을 도출하였다. 또한 자전거의 특성을 고려하여 도시 유형을 구분하고, 자전거 인프라 확충 측면의 결정요인별 중요도를 제시하였다. 자전거 이용률 및 보유율, 기술 발전, 경제적 측면, 통행거리 및 목적, 공공자전거 도입 등 7가지 항목에 대해 우리나라 자전거 이용활성화 가능성을 진단한 결과, 잠재적 가능성이 존재하는 것으로 나타났다. 다음으로 자전거 선진도시 사례를 통해 자전거 인프라 확충 측면, 안전 및 이용활성화 측면, 지속가능성 확보 측면 등 3개 분야의 총 41개 결정요인을 도출하였다. 이와 함께 자전거를 고려한 도시 유형을 구분하고, 자전거 인프라 확충 측면의 21개 결정요인별 중요도를 제시하였다. Automobile-oriented urban transport system, continued from the past in Korea, is giving rise to inefficiency and social costs in transport sector. With revitalizing usage of bicycle, human-powered transport mode, it is possible to enhance sustainable green growth, improvement of the city-competitiveness, and the quality of life. In this study, the possibility of bicycle usage promotion in Korean cities is examined at 7 points of views. As a result, though the bicycle usage is low now, we figured that there are many positive signs to increase bicycle usage in Korea. Also, we draw a diverse key policies for building green urban transport system that bicycle have a most important role on transport system. So policies to promote bicycle usage are reviewed to analyze on bicycle-oriented 5 cities, in which have high bicycle mode share. By this review, this study could draw 41 key effective policies to 3 aspects (bicycle infrastructure, safety and promotion, and policy sustainability). In addition to, importance of 21 key effective policies about bicycle infrastructure is suggested as considering city's characteristics.
신희철,이한별,유태경,이은신,김룡남,박보영,윤경아,박찬이,이은숙,문형곤,노동영,공선영,한원식 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency of germline mutations using an nextgeneration sequencing (NGS)–based multiple-gene panel containing 64 cancer-predisposing genes in Korean breast cancer patients with clinical features of hereditary breast and ovarian cancer syndrome (HBOC). Materials and Methods A total of 64 genes associated with hereditary cancer syndrome were selected for development of an NGS-based multi-gene panel. Targeted sequencing using the multi-gene panel was performed to identify germline mutations in 496 breast cancer patients with clinical features of HBOC who underwent breast cancer surgery between January 2002 and December 2017. Results Of 496 patients, 95 patients (19.2%) were found to have 48 deleterious germline mutations in 16 cancer susceptibility genes. The deleterious mutations were found in 39 of 250 patients (15.6%) who had breast cancer and another primary cancer, 38 of 169 patients (22.5%) who had a family history of breast cancer (! 2 relatives), 16 of 57 patients (28.1%) who had bilateral breast cancer, and 29 of 84 patients (34.5%) who were diagnosed with breast cancer at younger than 40 years of age. Of the 95 patients with deleterious mutations, 60 patients (63.2%) had BRCA1/2 mutations and 38 patients (40.0%) had non- BRCA1/2 mutations. We detected two novel deleterious mutations in BRCA2 and MLH1. Conclusion NGS-based multiple-gene panel testing improved the detection rates of deleterious mutations and provided a cost-effective cancer risk assessment.