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김재욱,김세광,서경,임영구,김완기,주수길,임종철,이용제 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.4
The varicella during pregnancy is rare. The incidence of varicella among pregnant women is about 5 in 10,000 pregnancies. In 1947, Laforet and Lynch were the first to describe an association between maternal varicella infection in early pregnancy and congenital anomalies in the offspring. the existence of a syndrome was first postulated by Srabstein et al(1974), Brunell(1983), Kotchmar(1984), and recently Higa et al.(1987) described most of the malfomations associated with maternal varicella infection. Varicella-Zoster viurs(VZV) infections acquired during pregnancy may result in serio us disease for both the mother and the fetus. The effects on maternal health can range from a mild chikenpox exanthem to servere life-theatenig illness often complicated by viral pneumonitis. The fetus may remain unaffected, but VZV infection during early pregnancy has been associated with a congeital syndrome including muliplie defects of the skin, limb, eyes, and brain. We reports our experience with a varicella during pregnancy with a brief literature review.
IAN5 polymorphisms are associated with systemic lupus erythematosus
Lim, MK,Sheen, DH,Kim, SA,Won, SK,Lee, S-S,Chae, S-C,Chung, H-T,Shim, SC SAGE Publications 2009 Lupus Vol.18 No.12
<P>Systemic lupus erythematosus (SLE) is a representative autoimmune disease, which is frequently associated with lymphopenia. Biobreeding (BB) rat is a typical animal model which develops autoimmune diseases with lymphopenia which results from a frame-shift mutation in the immune-associated nucleotide (<I>IAN</I>) <I>5</I> gene. <I>IAN5</I> is involved in the regulation of T-cell activation and survival. To examine the association of <I>IAN5</I> gene with SLE, we scrutinised the single nucleotide polymorphisms (SNPs) in the <I>IAN5</I> gene. We conducted a case–control study where 132 SLE patients, 505 rheumatoid arthritis (RA) patients, and 546 controls were genotyped for four SNPs in the <I>IAN5</I> gene. Two SNPs (+2071C?>?T and +2677G?>?A) were associated with susceptibility to SLE (<I>P</I>?=?0.040 and 0.045, respectively), and −4432G?>?A SNP was associated with the development of leukopenia (<I>P</I>?=?0.028) and the requirement of steroid pulse therapy (<I>P</I>?=?0.040) in SLE patients. Haplotype analyses showed that Ht1(CTCG) was associated with susceptibility to SLE (<I>P</I>?=?0.036), and Ht4(ACCG), Ht5(ACTA) and Ht6(GCCG) were associated with the development of nephritis (<I>P</I>?=?0.017, 0.019, 0.022, respectively). In conclusion, the <I>IAN5</I> polymorphisms were associated with susceptibility to SLE and the development of clinical disease manifestations in a strictly Korean population.</P>