실험적 진폐증에서 투여약제에 따른 면역학적 병리학적 조직변화

윤임중,임현우,노영만,오상용,정장영,임영,김경아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1993 韓國의 産業醫學 Vol.32 No.2

To access the effects of some drugs such as piperazine phosphare, azathioprine and allopurinol in the experimental pneumoconiosis, 263 rats weighted 240-320 gm was divided into the control and eight experimental groups. To each group, the turbid solution mixed free silica, talc and natural coal dust of 50 mg in 0.8 ml saline were instilled intratracheally. At the begining and 5th week of experiment, piperazine phosphate(8mg/week orally), aspirin(1.5mg/day intramuscularly), azathioprine(25mg/day orally) and allopurinol(1.5mg/day orally) were administered simultaneously, while the dust turbid solution was only given to the control group. For each group the change of body weight. dry right lung weight, cellularity including total cell, macrophage, lymphocyte and neurtrophil in bronchoalveolar lavage fluid, superoxide ion, hydroxyproline, leukotriene B₄, tumor necrotsis factor, prostaglandin E₂were examined, and observed the pathological chages in lung tissue. The results were as follow : 1. The larger amount of their instilled dust and the longer observation period, the severer pathological findings were found in the lung tissue of each experimental group. 2. The body and dry right lung wight was not significantly changed in the experimental groups compared with the control group. 3. The number of total cell in bronchoalveolar lavage fluid was markedly less in the experimental group than the control one, while no significant difference was found in the percent alveolar macrophages and lymphocytes in both groups. However, the percent of neutrophiles was usually lower than in the control group. 4. The amount of superoxide ion was frequently less in the experimental group compared with the control one. 5. The amount of hydroxyproline was significantly lower in the experimental group than in the control one. 6. The amount of leukotriene B₄was usually less in the drug administered group than in the control one. 7. The amount of tumor necrotic factor was also frequently lower in each experimental group than in the control one. 8. The amount of prostaglandin E₂was usually higher in each experimental group than in the control one.

세라믹 정밀여과막 생물반응기를 이용한 매립지 침출수 처리

윤영재,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.2

The results that the membrane bioreactor allows the treatment of ammonia and part of the COD, with a limited production of sludges. The elimination yields observed on the membrane bioreactor are high, starting from a biologicaly equilibrated efflent, since the ratio C/N/P is slightly deficient in P. The Chemical Oxygen Demand and Total Organic Carbon are climinated more than 70%. The Nitrification rate nears 98% despite the important variability of the ammonia concentrations inside the raw leachate. The Suspended Solids are eliminated 100% thanks to the microfiltration membrane.

다환계 방향족 유기오염물을 함유한 폐수의 전기화학 처리

윤영재,강태구,김희정,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.1

This work has concerned the possibility to apply both direct and indirect electrolysis process for the treatment of waste containing poliaromatic compounds. Two different kinds of electrode materials have been used: DSA-type anodes to carry out direct electrolysis and carbon felt cathodes to ferform indirect electrolysis. On the contrary, in the case of the tested wastewater especially containing naphthalen- and anthraquinon sulphonic compounds they do not seem to be very suitable materials. Better results have been achieved using the carbon felt cathodes. In this case the COD of the tested wastewater can be remarkably decreased using H_2O_2 as oxidation agent.

Fluoride, Bisphosphonate 및 Gallium이 상아질 흡수 억제에 미치는 영향

백은영,유윤정,노병덕,최윤정,이승종 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.2

Replacement resorption is followed by the delayed replantation of an avulsed tooth. Currently no effective treatment is substantiated for replacement resorption. The purpose of this study was to investigate the effect of stannous fluoride, bisphosphonate(etidronate disodium) and gallium nitrate, which have been shown to reduce dentin resorption, on human dentin. Osteoclasts were collected from tibeas of chich embryo. The cells were well agitated to prevent adhesion and seeded onto the sliced human dentin wafers which had been soaked in either culture media(control), or several different concentrations of stannous fluoride, etidronate disodium(1-hydroxyethylidene-1, 1-bisphosphonate disodium), and gallium nitrate. Resorption was measured by counting the number of resorptive pit produced by the cells. Results are ad follows. Stannous fluoride and etidronate disodium showed statistically significant reduction of dentin resorption(p<0.05) but the effect of stannous fluoride seemed to be its high cytotoxicity. Etidronate disodium did not show cytotoxicities in all experimented concentrations. Gallium nitrate did not show differences in resorption either between different concentrations of from the control group.

연속 냉각에 의한 저탄소 보론 강의 베이나이트 변태 특성에 관한 연구

이상윤,김영희,노용식,김영재 동아대학교 공과대학 부설 한국자원개발연구소 1989 硏究報告 Vol.13 No.1

This study has been carried out to investigate into bainitic transformation characteristics systematically with changes in both austenitizing temperature and time. The rapid changes in the slope of cooling curves are thought to occur due to the evolution of transformation latent heat during air cooling to room temperature from austenitizing temperatures. From this rapid change, it is possible to establish the inflection point as bainitic transformation strat temperature which is shown to gradually increase with increasing austenitizing time in a temperature range of 900℃ To 1150℃. Bainitic transformation start temperature has been found to depend on austenite grain size showing that bainitic transformation start temperature increase as austenite grains are coarsened.

노령의 대퇴 전자간 골절 치료에서 압박고 나사못의 안정성 및 유용성

김종오,노권재,윤여헌,고영도,유재두,정준모,방한천,정재학 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 노령의 대퇴 전자간 골절에서 압박고 나사못의 안정성에 영향을 주는 인자들간의 상관 관계와 골절 양상에 따른 술후 고관절 기능을 평가 및 분석하였다. 대상 및 방법: 압박고 나사를 이용하여 수술적 치료를 시행한 231명의 환자 중 6개월 이상 추시가 가능하였던 60세 이상 84명의 환자들을 대상으로 했다. 방사선적 계측은 압박고 나사못의 활강 길이 및 내반각, 가압 나사 위치, 정복 상태, 원위 골편의 내측 전위를 측정하였으며 술후 기능은 Clawson의 기능 평가표로 하였고 골절 양상에 따라 방사선 계측과 기능 회복과의 상관 관계를 평가하였다. 결 과: 임상 결과는 불안정 골절에서 양호가 10례, 불량이 23례, 안정 골절에서는 양호 40례, 불량이 11례로 안정 골절에서 임상 결과가 좋았고(p<0.001), 압박고 나사 활강은 10 ㎜ 이상일 때 양호가 4례, 불량이 21례, 10 ㎜ 이하에서 양호가 46례, 불량이 13례로 10 ㎜ 이상 활강시에 술후 결과가 불량했다(p<0.001). 다르 방사선적 계측 요인은 결과에 의미있는 차이를 보이지 않았다. 또한, 불안정 골절 중에서 전위 양상 골절의 경우 10㎜ 이상 활강이 12례, 10㎜ 이하 활강이 8례, 분쇄 양상 골절의 경우는 10㎜ 이상이 11례, 10㎜ 이하가 2례로 분쇄 양상의 불안정 골절에서 10㎜ 이상 활강이 의미있게 많았다 (p<0.001). 결 론: 10㎜ 이상의 지연 나사 활강은 고관절 기능 회복 약화를 유발시킬 수 있으며 불안정 골절 분쇄 양상 골절은 이런 지연 나사의 활강이 과도하게 유발될 수 있으므로 불안정 분쇄 양상 골절에서 압박고 나사의 단독 사용은 재고해 보아야 할 것이다. Purpose: To evaluate the relationship between fracture stability and functional results, and analyze the correlation between stability factors and the outcome in intertrochanteric fracture of the elderly. Materials and Methods: Of the 231 patients, 84 patients with age above 60 were able to follow up for minimum 6 months. We measured the sliding length of the lag screw, varus degree, position of lag screw, reduction status and medialization of distal fragment radiologically. The functional outcome of the treatment was evaluated with the Clawson's result classification and we evaluated the correlation between the radiological results of measurement and the functional recovery depending on the Evans fracture classification. Results: There were good results in 40 cases out of 51 stable fractures, and in 10 cases out of 33 unstable fractures (p<0.001). In case of sliding of lag screw more than 10㎜, good results were obtained in 4 cases, and poor in 21. And in case of sliding less than 10㎜, good results were obtained in 46, and poor in 13. (p<0.001).But there was no relationship between other radiologic factors and clinical results. In unstable type, there were 12 cases with lag screw sliding more than 10㎜ and 10 cases with less than 10㎜. In comminuted type, there were 11 cases with lag screw sliding more than 10㎜ and 2 cases with less than 10㎜(p<0.001). Conclusion: The sliding of lag screw more than 10㎜ may result in poor outcome. As in comminuted unstable pattern, sliding of lag screw might be excessive, the use of compression hip screw alone is not good treatment option.

전해질로 나피온을 사용한 Ti/IrO_2 전극상에서 유기물의 양극산화 반응

강태구,윤영재,김희정,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.1

This paper describes the anodic oxidation od various alphathic alcohols in pure water using Nafion cation exchange membrane as solid polymer electrolyte. The oxidation has been carried out on an IrO_2 anode under conditions of simultaneous oxygen evolution. The experimental results for the anodic oxidation of four different alcohols are in good agreement with the theoretical model presented in a previous paper. Finally a simple experimental method is described for the determination of the relative reactivity of organics oxidation on IrO_2 anodes.

스포츠센터 종사자들의 직무스트레스가 조직몰입에 미치는 영향

이병익,--,노동연,장영광 龍仁大學校 體育科學硏究所 2002 體育科學硏究論叢 Vol.12 No.1

The purpose of this study is to find out the influence to organization-absorption caused by duty stresses of employees in sports centers. To achieve this purpose, I analyzed the difference of job stresses under social and demographic characteristics, first and then the difference of organization-absorption under the same condition and finally the relationship between job stresses and organization absorption. I used a random cluster sampling to collect data from 250 respondents who worked for 12 sports centers, and actually used data were from 214 respondents excluding 36 persons who were considered to respond insincerely or omit some parts. I consisted of totally 55 questions --- six related to social and demographic characteristics, 25 related to job stress-causing factors, and the others related to organization-absorption from the measuring tools used as research tools. The statistic analysis methods used in the study are frequency, t-test, one-way analysis of variance (Oneway-ANOVA) and Scheffe's multiple range test. I finally got the following results in this study through the data analysis from the above-stated methods and procedure. First, among the job characteristics, role related factor, human relation, rewarding, and organization characteristics showed a statistically significant difference at the level of 5 percent in gender, in position, and monthly payment, in age, in service period, and position and in monthly payment, respectively. Second, among the organization absorption, defined absorption, long-service absorption, and regulatory absorption also showed the significant difference at the level of five percent in age and educational background, in age, service period, educational background, position and monthly payment and in gender, age, service period, educational background, position and monthly payment.

cAMP-Binding Site of PKA as a Molecular Target of Bisabolangelone against Melanocyte-Specific Hyperpigmented Disorder

Roh, Eunmiri,Yun, Cheong-Yong,Young Yun, Ji,Park, Dongsun,Doo Kim, Nam,Yeon Hwang, Bang,Jung, Sang-Hun,Park, Sun Ki,Kim, Yun-Bae,Han, Sang-Bae,Kim, Youngsoo The Society for Investigative Dermatology, Inc 2013 The Journal of investigative dermatology Vol.133 No.4

Microphthalmia-associated transcription factor (MITF) is inducible in response to cAMP and has a pivotal role in the melanocyte-specific expression of tyrosinase for skin pigmentation. Here we suggest that the cAMP-binding site of protein kinase A (PKA) is a target in the inhibition of the melanogenic process in melanocytes, as evidenced from the molecular mechanism of small molecules such as bisabolangelone (BISA) and Rp-adenosine 3′,5′-cyclic monophosphorothioate (Rp-cAMPS). BISA is a sesquiterpene constituent of Angelica koreana, a plant of the Umbelliferae family, whose roots are used as an alternative medicine. BISA competitively inhibited cAMP binding to the regulatory subunit of PKA and fitted into the cAMP-binding site on the crystal structure of PKA under the most energetically favorable simulation. In α-melanocyte-stimulating hormone (α-MSH)–activated melanocytes, BISA and Rp-cAMPS nullified cAMP-dependent PKA activation, dissociating catalytic subunits from an inactive holoenzyme complex. They resultantly inhibited cellular phosphorylation of the cAMP-responsive element-binding protein (CREB) or another transcription factor SOX9, thus downregulating the expression of MITF or the tyrosinase gene with decreased melanin production. Taken together, this study defined the antimelanogenic mechanism of BISA or Rp-cAMPS with a notable implication of the cAMP-binding site of PKA as a putative target ameliorating melanocyte-specific hyperpigmented disorder.

The effects of maternal body mass index and plurality on maternal and umbilical cord serum magnesium levels in preterm birth at less than 32 weeks of gestation

( Yun Sun Choi ),( Ji Young Hong ),( Jee Youn Hong ),( Yoo-min Kim ),( Ji-hee Sung ),( Suk-joo Choi ),( Soo-young Oh ),( Cheong-rae Roh ),( Hye Seon Kim ),( Se In Sung ),( So Yoon Ahn ),( Yun Sil Chan 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.1

Objective To evaluate the effects of maternal body mass index (BMI) and plurality on maternal and umbilical cord serum magnesium levels after antenatal magnesium sulfate treatment. Methods This was a retrospective cohort analysis of 135 women treated with antenatal magnesium sulfate at less than 32 weeks of gestation between January 2012 and June 2018. Subjects were stratified into groups according to maternal BMI (group I [18.5-22.9 kg/m²], group II [23.0-24.9 kg/m²], and group III [≥25.0 kg/m²]) and plurality (singleton and twin). Univariable and multivariable analyses were performed to compare the umbilical cord serum magnesium levels between the groups. Results Maternal serum magnesium levels were not significantly different between the maternal BMI groups and singleton and twin pregnancies. Umbilical cord serum magnesium levels were significantly different among the maternal BMI groups (3.3±1.2 mg/dL in group I, 3.3±1.2 mg/dL in group II, and 4.0±1.4 mg/dL in group III, P=0.003). The trend of increase in magnesium levels was statistically significant (P=0.001, Jonckheere-Terpstra test). Umbilical cord serum magnesium levels were not significantly different according to plurality. However, in the multivariable analysis, maternal BMI and plurality were not significantly associated with umbilical cord serum magnesium levels after adjusting for indication and total dose of magnesium sulfate treatment, gestational age at delivery, mode of delivery, neonatal sex, and birth weight. Conclusion Maternal BMI and plurality were not significantly associated with maternal or umbilical cord serum magnesium levels after exposure to antenatal magnesium sulfate treatment.