Pelvic organ prolapse is correlated with osteoporosis: HIRA NPS Data analysis

( Yu Ra Ko ),( Hyun Jin Kim ),( Do Young Kim ),( Sa Ra Lee ),( Sung Hoon Kim ),( Hee Dong Chae ),( Byung Moon Kang ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Deficiencies in pelvic collagen are believed to exist in pelvic organ prolapse (POP). Conversely, a predisposition to POP is identified in women with generalized connective tissue disorders. However few data were reported on the relationship between the POP and osteoporosis (OP). Therefore To examine the association between OP and POP in Korean women. Methods: We used the Health Insurance Review and Assessment Service-National Patient Samples (HIRA-NPS) between 2015 and 2017. The HIRA-NPS, including approximately 1.4 million individuals, is a stratified random sample of 3% of the entire Korean population using 16 age groups and 2 sex groups. Total 4,368,141 individuals were included in HIRA-NPS between 2015 and 2017 and a total of 842,228 individuals aged 50 years and above were included in the final analysis. POP patients were defined by KOICD (KCD-7, N81 or N99.3) and patients who proceeded pelvic reconstructive operation. The OP patients were defined by KOICD (KCD-7, R4113, R3620, R0402) & Patients who prescribed medication(BP, SERM, PTH, Denosumab). 1:10 Age-stratified Matching and Chi-squared test was used for statistical analysis and P<0.05 was considered as significant. Results: A total of 7,359 women were included in this analysis. The advanced pelvic organ prolapse is correlated with osteoporosis in Korean women aged 50 years and above in 2015-2017(P<.0001). After adjusting the age, advanced pelvic organ prolapse is correlated with osteoporosis in 2015, 2016, 2017 dataset (P = 0.013, 0.0009, 0.0119, respectively). Conclusion: The advanced pelvic organ prolapse is correlated with osteoporosis in Korean women aged 50 years and above. Evaluation of the osteoporosis and education about the bone health can be especially important even in relatively young, aged 50-59 years, POP patients.

특성화고등학교에서 블렌디드 프로젝트 학습을 활용한 이모티콘 디자인 수업 과정 연구

고유라(Ko, Yu Ra),김관배(Kim, Kwan Bae) 한국디자인리서치학회 2020 한국디자인리서치 Vol.5 No.4

이모티콘 시장의 성장으로 학습자를 위한 이모티콘 디자인 교육이 요구되지만, 특성화고등학교 교육과정에서 이모티콘 디자인 교육 목표는 제시하나 목표를 달성할 수 있는 학습 내용은 부족하다. 또한, 코로나 19로 인해 온·오프라인 학습을 병행하고 있으며 학습자의 참여를 끌어내기 위해 블렌디드 프로젝트 학습이 주목받고 있다. 이에 본 연구는 블렌디드 프로젝트 학습을 활용하여 교육 목표가 달성될 수 있도록 학습 내용을 재구성한 이모티콘 디자인 수업 과정을 개발하고자 하였다. 이를 위해 문헌 조사와 선행연구를 통해 사전학습, 프로젝트 학습, 사후학습으로 구성된 블렌디드 프로젝트 학습을 활용한 이모티콘 디자인 수업 과정을 개발하여 수업을 실행하였으며, 수업 후 수업 효과와 만족도 중심으로 설문조사를 하였다. 그 결과, 수업 효과는 평균 4.21~4.47, 수업 만족도는 평균 4.19~4.37, 수업 과정의 전체적인 만족도는 평균 4.33으로 평가되어 실효성을 입증하였다. Due to the growth of the emoticon market, emoticon design education is required for learners. However in the curriculum of specialized high school, while the aim for emoticon design education is being presented, there is a lack of actual learning content to achieve. Furthermore as a result from Covid-19 both on line and off line classes are being proceeded and to attract participation of the learners, blended project based learning is drawing attention. Accordingly this study attempts to develop an emoticon design course by reorganizing existing learning content to accomplish a successful educational goals using blended project based learning. To this end, through literature research and prior research, blended project based learning composed of pre- learning, project learning and post learning were applied for classes. After the class a survey was done to discover effects and satisfaction on this new way of learning. The result showed that the effect on the lesson was 4.21~4.47, satisfaction on the lesson was 4.19~4.37 and the overall satisfaction on the lesson was 4.33 in average on each items. The effectiveness could be verified by the result shown numerically.

Robot-assisted myomectomy versus abdominal myomectomy for huge myoma

( Yu Ri Ko ),( Sa Ra Lee ),( Ju Hee Kim ),( Jeong Yeol Park ),( Dae Yeon Kim ),( Sung Hoon Kim ),( Dae Sik Seo ),( Yong Man Kim ),( Hee Dong Chae ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: To assess the feasibility and efficacy of robot-assisted myomectomy for huge myoma by comparing to abdominal myomectomy. Methods: This is a retrospective study for robot-assisted myomectomy(RAM) and abdominal myomectomy(AM) performed from April 2019 to June 2020 in a single tertiary hospital. Huge uterine myoma was defined as the longest diameter of dominant myoma equal to or larger than 10cm or total myomas weight over 250g. Results: 132 patients in RAM and 151 patients in AM were administered. There is no difference in the mean age(37.8 vs 39.1) and the mean BMI(23.0 vs 23.5). The operative time(160.8 vs 108.6) is longer in RAM compared with AM. The estimated blood loss(362.1 vs 297.2) and mean decrease in Hb(3.4 vs. 3.2) is comparable. The length of hospital stay(2.7 vs 4.1) is shoter, and the number of complications(25.0% vs 55.0%) is lower in RAM compared with AM. There is no intraoperative complications in both. Conclusion: Robot-assisted myomectomy is feasible and safe option for managing huge uterine myomas.

웰빙 라이프스타일이 친환경 브랜드에 대한 지각된 가치, 브랜드 선호도 및 구매의도에 미치는 영향

고재윤(Ko Jae-Youn),음미라(Eum Mi-Ra),이유양(Lee Yu-Yang) 한국관광레저학회 2011 관광레저연구 Vol.23 No.6

Effects of 12-week Vegetarian Diet on the Nutritional Status, Stress Status and Bowel Habits in Middle School Students and Teachers

( Bo Ra Lee ),( Yu Mi Ko ),( Mi Hee Cho ),( Young Ran Yoon ),( Seung Hee Kye ),( Yoo Kyoung Park ) 한국임상영양학회 2016 Clinical Nutrition Research Vol.5 No.2

This study investigated the effect of switching normal diet to vegetarian diet rich in vegetables and fruits for school foodservice and home meal on the nutritional status, bowel habit improvement and stress reduction of teachers and adolescents. A total of 40 research subjects (26 students, 14 teachers) from one middle school voluntarily participated in the research. Questionnaire surveys and blood analysis were conducted before and after a 12-week vegetarian diet period. The participants were asked on their dietary habit, bowel habit and stress measurement. After 12 weeks, reduction of BMI (kg/m²) in the students (p < 0.05) and reduction of TC (mg/dL) in both teachers and students (p < 0.05) were observed. Also reduction of LDL-C (mg/dL) was observed in the teachers (p < 0.05) whereas serum calcium and Vitamin B12 was increased in the students and teachers (p < 0.005). The teacher`s stress level was reduced (p < 0.05) after the 12-week vegetarian diet. As for the changes in bowel habit, the number of the students and teachers classified as experiencing functional constipation was decreased respectively from 10 to 7, from 7 to 5. Based on the result, it is considered that the vegetarian diet rich in fruits and vegetables improved general health status of study subjects suggesting that such a dietary habit would substantially contribute to improving nutritional status and bowel habit.

Analyses on the Appointment Status and Teaching Activities of Foreign Faculty in Korean Higher Education Institutions

고장완(Ko Jang Wan),김선주(Kim Seon Joo),위옥정(Yu ting Wei),김세희(Kim Se Hee),문소라(Moon So Ra) 한국비교교육학회 2016 比較敎育硏究 Vol.26 No.2

본 연구는 외국인 교원의 급격한 증가에 따른 다양한 쟁점이 제기되고 이에 따라 외국인교원을 위한 적절한 정책의 필요성이 제기되고 있는 시점에서 국내 대학에 재직하고 있는 외국인 교원의 임용 현황 및 강의활동을 분석하고 이를 바탕으로 외국인 교원에 대한 정책적 시사점을 모색하고자 하였다. 이를 위하여 전국의 4년제 대학에 임용되어 있는 외국인 교원을 대상으로 이들의 임용 현황과 강의활동을 대학특성별, 임용형태별, 지위별로 살펴보았다. 연구결과 연구대상 외국인 교원의 박사학위 취득 비율은 34%로 비교적 낮았으며, 약 22% 정도는 학사 학위취득자였다. 임용형태별로는 전임교원이 85%, 비전임교원이 15% 정도로 나타났으며, 대부분의 외국인 교수는 조교수로 근무하고 있었다. 이러한 현황은 지역별과 규모별에 따라 큰 차이가 없었다. 다만 수도권과 대규모 대학에서 정교수의 비율이 비수도권이나 소규모 대학보다 더 높았다. 강의활동과 관련하여, 외국인 교수는 전공과목은 약 7학점, 교양과목은 약 9학점을 가르치고 있었고, 이러한 경향은 지역별, 규모별로 의미 있는 차이가 없었다. 다만, 교양과목의 경우는 전반적으로 전임교원의 강의비율이 비전임교원의 강의 비율보다 더 높았고, 수도권과 대규모 대학의 경우 비전임교원이 전임교원보다 더 많은 강의를 하고 있었다. 정책적 시사점으로는 외국인 교원의 교육 및 강의 활동과 관련한 체계적인 분석, 외국인 교원의 임용에 대한 정책적 가이드라인 마련 등이 제시되었다. The purposes of this study were to investigate the current status of the foreign faculty appointment and the actual conditions of teaching activities, and to provide policy implications for the foreign faculty in Korean HEIs. To accomplish the purposes of this study, the survey questionnaire including questions about the current status of the foreign faculty appointment and the actual conditions of teaching activities were distributed to all the four-year HEIs in Korea. The t-test and ANOVA analysis were employed to compare statistical differences between groups based on institutional characteristics, appointment status, and position. The results indicated that the distribution of faculty analyzed by position did not differ much from the analysis results by institutional location and size. Related to teaching activities, foreign faculty members are teaching about 7 credit hours of major courses and 9 credit hours of elective courses. This trend did not show significant differences from the results analyzed by location and by size, yet for elective courses, overall the proportion of lectures offered by full-time faculty members was higher than that provided by part-time faculty members. Two policy recommendations including further systematic analyses to understand foreign faculty members' engagement in Korean universities and establishing and providing policy guidelines for the appointment of foreign faculty to HEIs were offered.

Clinical and Virologic Effectiveness of Remdesivir Treatment for Severe Coronavirus Disease 2019 (COVID-19) in Korea: a Nationwide Multicenter Retrospective Cohort Study

Joo Eun-Jeong,Ko Jae-Hoon,김성은,Kang Seung-Ji,Baek Ji Hyeon,Heo Eun Young,Shi Hye Jin,Eom Joong Sik,Choe Pyoeng Gyun,Bae Seongman,Ra Sang Hyun,Kim Da Young,Kim Baek-Nam,Kang Yu Min,Kim Ji Yeon,Chung Jin 대한의학회 2021 Journal of Korean medical science Vol.36 No.11

Background: Remdesivir is widely used for the treatment of coronavirus disease 2019 (COVID-19), but controversies regarding its efficacy still remain. Methods: A retrospective cohort study was conducted to evaluate the effect of remdesivir on clinical and virologic outcomes of severe COVID-19 patients from June to July 2020. Primary clinical endpoints included clinical recovery, additional mechanical ventilator (MV) support, and duration of oxygen or MV support. Viral load reduction by hospital day (HD) 15 was evaluated by calculating changes in cycle threshold (Ct) values. Results: A total of 86 severe COVID-19 patients were evaluated including 48 remdesivir-treated patients. Baseline characteristics were not significantly different between the two groups. Remdesivir was administered an average of 7.42 days from symptom onset. The proportions of clinical recovery of the remdesivir and supportive care group at HD 14 (56.3% and 39.5%) and HD 28 (87.5% and 78.9%) were not statistically different. The proportion of patients requiring MV support by HD 28 was significantly lower in the remdesivir group than in the supportive care group (22.9% vs. 44.7%, P = 0.032), and MV duration was significantly shorter in the remdesivir group (average, 1.97 vs. 5.37 days; P = 0.017). Analysis of upper respiratory tract specimens demonstrated that increases of Ct value from HD 1–5 to 11–15 were significantly greater in the remdesivir group than the supportive care group (average, 10.19 vs. 5.36; P = 0.007), and the slope of the Ct value increase was also significantly steeper in the remdesivir group (average, 5.10 vs. 2.68; P = 0.007). Conclusion: The remdesivir group showed clinical and virologic benefit in terms of MV requirement and viral load reduction, supporting remdesivir treatment for severe COVID-19.

Omental Incarceration over Twenty Years Presenting as a Hyperechoic Endometrial Mass in a Postmenopausal Woman

( Gina Nam ),( Sa Ra Lee ),( Yu Ra Ko ),( Gwang Jun Kim ) 대한폐경학회 2021 대한폐경학회지 Vol.27 No.1

Uterine perforation related with dilatation and curettage (D&C) is an uncommon event. Combined complications such as hemorrhage, adjacent organ injury, and omental incarceration may require an emergent surgical treatment. These are usually evident immediately or several days after the D&C, and a delayed presentation of uterine perforation are extremely rare. Herein, we report a rare case of omental incarceration presenting as a hyperechoic endometrial mass in a postmenopausal woman, diagnosed twenty-three years after the D&C. According to this case, when we encounter a hyperechoic endometrial lesion penetrating the uterine wall in women with a history of an intrauterine procedure such as D&C, we need to consider the possibility of an incarcerated omentum.

Articles : Life Science ; Inhibitory Effect of Simvastatin on the TNF-α-and Angiotensin 2-Induced Monocyte Adhesion to Endothelial Cells Is Mediated through the Suppression of Geranylgeranyl Isoprenoid-Dependent ROS Generation

( Su Young Park ),( Jong Suk Lee ),( Yu Jin Ko ),( Ah Ra Kim ),( Mi Kyoung Choi ),( Mi Kyoung Kwak ),( Han Gon Choi ),( Chul Soon Yong ),( Jung Ae Kim ) 영남대학교 약품개발연구소 2008 영남대학교 약품개발연구소 연구업적집 Vol.18 No.-

Inhibitory Effect of Simvastatin on the TNF-α- and Angiotensin II-Induced Monocyte..

Su-Young Park,Jong-Suk Lee,Yu Jin Ko,Ah Ra Kim,Mi Kyoung Choi,Mi-Kyoung Kwak,최한곤,용철순,김정애 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.2

Vascular endothelial cell activation by cytokines and other pro-inflammatory mediators is an initial event in atherosclerosis and in other vascular diseases. Simvastatin, a HMG-CoA reductase inhibitor, suppressed both tumor necrosis factor (TNF)-α- and angiotensin (Ang) IIinduced monocyte adhesion to endothelial cells (an initial step in vascular inflammation) and reactive oxygen species (ROS) production. Diphenyleneiodonium and apocynin, both NADPH oxidase inhibitors, also suppressed TNF-α-induced ROS and monocyte-endothelial cell adhesion, demonstrating that TNF-α-induced monocyte adhesion is mediated through ROS produced by NADPH oxidase activation. Furthermore, exogenously applied mevalonate or geranylgeranylpyrophosphate in combination with simvastatin completely prevented the inhibitory effects of simvastatin on ROS generation and monocyte-endothelial cell adhesion by TNF- α and Ang II. These results suggest that monocyte adhesion to endothelial cells induced by TNF-α or Ang II is mediated via the geranylgeranyl isoprenoid-dependent generation of ROS, and that this is inhibited by simvastatin.