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Kim, Byung Chan,Kim, Hyerim,Lee, Hye Soo,Kim, Su Hyun,Cho, Do-Hyun,Jung, Hee Ju,Bhatia, Shashi Kant,Yune, Philip S.,Joo, Hwang-Soo,Kim, Jae-Seok,Kim, Wooseong,Yang, Yung-Hun The Korean Society for Microbiology and Biotechnol 2022 Journal of microbiology and biotechnology Vol.32 No.6
Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infections and poses a global healthcare challenge. The utilization of novel molecules which confer synergistical effects to existing MRSA-directed antibiotics is one of the well-accepted strategies in lieu of de novo development of new antibiotics. Thymol is a key component of the essential oil of plants in the Thymus and Origanum genera. Despite the absence of antimicrobial potency, thymol is known to inhibit MRSA biofilm formation. However, the anti-MRSA activity of thymol analogs is not well characterized. Here, we assessed the antimicrobial activity of several thymol derivatives and found that 4-chloro-2-isopropyl-5-methylphenol (chlorothymol) has antimicrobial activity against MRSA and in addition it also prevents biofilm formation. Chlorothymol inhibited staphyloxanthin production, slowed MRSA motility, and altered bacterial cell density and size. This compound also showed a synergistic antimicrobial activity with oxacillin against highly resistant S. aureus clinical isolates and biofilms associated with these isolates. Our results demonstrate that chlorinated thymol derivatives should be considered as a new lead compound in anti-MRSA therapeutics.
사구체신염에서 N-acetyl-β-D-glucosaminidase의 예후 인자로서의 유용성
김혜영,김미경,오동진,김범,김대중,오하영,김윤구,허우성 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.4
Backgrounds:N-acetyl-β-D-glucosaminidase (NAG) is one of many enzymes that exist in the renal proximal tubular cells. It is said that functional impairment of renal tubule can be detected by checking NAG in the urine. But, it has never been known whether urinary NAG value can be used as a predictor for the prognosis of patients with glomerulonephritis. In this study, we evaluated the relationship between urinary NAG level and the degree of injury in cortical interstitium which has been known to influence the prognosis of renal function in glomerulonephritis closely. Methods:Before renal biopsy was performed in each patient, urinary NAG(isoenzyme A and B), urinary β2-microglobulin, serum blood urea nitrogen (BUN), serum creatinine, serum albumin, creatinine clearance and 24 hour urinary protein excretion were measured. Then, we calculated volume density of cortical interstitium〔Vv(i/c)〕 in each specimen using point count morphometry method after getting a confirmative diagnosis from pathologist. Simple coation analysis and multivariate regression analysis were carried out. Results:The number of total patients was 32(male:16), whose median age was 60(32-80). Vv (i/c) had significant correlation with serum creatinine, creatinine clearance and serum BUN. But it was not correlated well with urinary NAG and urinary β2-microglobulin. Urinary NAG concentration(2.131 2.549unit/mmol Cr) was higher than that of normal control and showed significant correlation with urinary β2-microglobulin, serum albumin and 24 hour urinary protein excretion in patients. Conclusion:Urinary NAG had no significant correlation with Vv(i/c) that has been known as an important prognostic factor for the renal function in glomerulonephritis, but had significant correlation with urinary protein excretion. We concluded that urinary NAG was not regarded to be an appropriate marker for predicting the prognosis of renal function in patient with glomerulonephritis.
Hwang, Jin Ho,Han, Seung Seok,Huh, Wooseong,Park, Su-Kil,Joo, Dong Jin,Kim, Myoung Soo,Kim, Yu Seun,Min, Sang-Il,Ha, Jongwon,Kim, Sang Joon,Kim, Suhnggwon,Kim, Yon Su Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.6
<P>Idiopathic focal segmental glomerulosclerosis (FSGS) occurring at young age is known to predispose to poor graft outcome, but the outcome of adulthood-onset FSGS (A-FSGS) has not been thoroughly investigated. Here, we compared the graft outcomes between kidney recipients with A-FSGS and childhood-onset FSGS (C-FSGS).</P>
한국인에서 혈청 크레아티닌을 이용한 크레아티닌 청소율의 계측
김대중,오하영,오동진,김범,이숭구,서기현,강우헌,이방훈,김혜영,이윤하,허우성,김윤구 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.6
Cockcroft and Gault's formula is frequently used to estimate creatinine(Ccr) in clinical practice. To determine the accuracy of such estimation in Korean patients, we measured simultaneously, serum creatinine and 24-hour urinary creatinine excretion in 696 Korean patients(male:350, female:346). Measured Ccr was significantly different from estimated Ccr in several age groups and the decrease of creatinine excretion with age is less than Cockcroft and Gault's estimation. We assumed that this difference can be due to difference of the body habitus and difference of urinary creatinine excretion per body weight between different races. So we divided the sample population into two groups and derived the new formula in one group with regression analysis between age and 24 hour urinary creatinine excretion per body weight for estimation of Ccr as Cockcroft and Gault derived their formula and applied it to another group to compare the new formula with Cockcroft and Gault's formula in Korean patients. The new formula was Ccr(mL/min)=[(260-age)?weight(kg)]/[160?serumCr(mg/dL)] for male and Ccr (mL/min)?[(236-age)?weight(kg)]/[180?serum Cr(mg/dL)] for female. Predictive accuracy of the new formula was significantly better than the Cockcroft and Gault's formula in the other sample population and also in subgroup of the patients with azotemia.
Dithiocarbamate chitosan as a potential polymeric matrix for controlled drug release
Kim, Youn Taeg,Yum, Soohwan,Heo, Jeong Soon,Kim, Wooseong,Jung, Yunjin,Kim, Young Mi Informa Healthcare USA, Inc. 2014 Drug development and industrial pharmacy Vol.40 No.2
<P><I>Objective</I>: To develop a polymer matrix for controlled release of drugs, chitosan, a linear aminopolysaccharide, was chemically modified to dithiocarbamate chitosan (DTCC) to afford a matrix where metal-drug complexes could be attached and released in a controlled manner depending on the binding nature between the drugs and the metals.</P><P><I>Materials and methods</I>: DTCC was treated with metal-tetracycline (Tc) complexes to prepare DTCC-Ca(II)-Tc, DTCC-Mg(II)-Tc, DTCC-Cu(II)-Tc and DTCC-Zn(II)-Tc.</P><P><I>Results</I>: The binding amount of Tc was in the order of DTCC-Zn(II)-Tc ≈ DTCC-Mg(II)-Tc ≈ DTCC-Ca(II)-Tc > DTCC-Cu(II)-Tc. The biphasic binding profiles, where Tc binding increased initially and then decreased, were shown for DTCC-Cu(II)-Tc and DTCC-Zn(II)-Tc. In a flow method, Tc was released slowly from DTCC-metal-Tc complexes except for DTCC-Cu(II)-Tc compared with Tc release from DTCC-Tc. In parallel with the results of the release experiment, DTCC-metal-Tc complexes except for DTCC-Cu(II)-Tc presented a prolonged antibacterial activity in an antibacterial test. The antibacterial activity of DTCC-Ca(II)-, -Mg(II)- and -Zn(II)-Tc complexes lasted for 28-44 days, while free Tc and DTCC-Tc lasted for 7-12 days.</P><P><I>Discussion and conclusion</I>: Taken together, our data suggest that DTCC could be used for a polymeric matrix for controlled release of drugs such as Tc, which possess functional groups for ionic and/or coordinate bond with metals.</P>
일란성 쌍둥이 형제에서 발병한 미세 변화 신질환과 초점 분절성 사구체 경화증
김혜영,정윤재,김대중,오하영,고영혜,김윤구,박중일,허우성,이윤하 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.4
The simultaneous occurrence of primary glomerulonephritis in identical twins has been rarely reported previously. It has suggested that genetic factors may play an important role in the pathogenesis of primary glomerulonephritis. We describe a pair of 17-year-old identical twin brothers with asymptomatic proteinuria, one with histologically proven minimal change disease and the other with focal segmental glomerulosclerosis. HLA typing in twin brothers revealed an identical phenotype consisting of A25, A33, B44, B54, Cwl, Cw7, DR7 and DRB1. To our knowledge, this is the first case of glomerulonephritis in identical twins in Korea.