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( Wen-tao Yan ),( Jia-he Wang ),( Ming-da Wang ),( Zheng Wang ),( Bing Quan ),( Ya-hao Zhou ),( Wei-min Gu ),( Hong Wang ),( Ting-hao Chen ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: According to the BCLC treatment guidelines, surgery does not be recommended for intermediate/advanced hepatocellular carcinoma (HCC). In real world, however, liver resections are often performed in patients with intermediate/ advanced but resectable HCC, especially in the East. Methods: We retrospectively evaluated multicentric data of 1,325 patients newly diagnosed with intermediate/advanced HCC who underwent curative resection. We randomly divided the subjects into development (n = 875) and validation (n = 450) samples. Multivariate Cox proportional hazards models were developed and separately validated on the basis of patients’ clinicopathological variables assessed for associations with 1-year recurrence and 3-year mortality. The discriminatory accuracy of these models was compared with conventional tools by analyzing receiver operating characteristic (ROC) curves. Results: He statistical nomograms built based on performance status, Child-Pugh grade, portal hypertension, preoperative alpha-fetoprotein level, tumor rupture, largest tumor diameter, tumor number, macrovascular and microvascular invasion, and satellites had good calibration and discriminatory abilities, with c-indices of 0.70 (1-year recurrence) and 0.68 (3-year survival), respectively. These models showed satisfactory goodness-of-fit and discrimination abilities in the validation cohort (c-index, 0.68 for 1-year recurrence and 0.69 for 3-year survival). The areas under the ROC curve using these nomograms exceeded those of traditional staging systems, indicating superior discriminatory capability (c-indices, 0.60-0.63 and 0.56-0.62, respectively). Conclusions: Our proposed online nomograms, which present graphically postoperative prognostic models for recurrence and survival in patients with intermediate/advanced but resectable HCC, offer valuable guidance to surgeons and hepatologists for individually predicting survival benefits from surgery and planning recurrence surveillance and adjuvant therapy.
Wen-Ting Ting,Ru-Wen Chang,Chih-Hsien Wang,Yih-Sharng Chen,Jih-Jong Lee 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.1
Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was induced in 18 male Wistar-Kyoto rats, which were assigned to normal saline (NS), Ringer's solution (RS), and TBS groups. During the hemorrhagic state, their hemodynamic parameters were recorded using an Abbott i-STAT analyzer with the CG4+ cartridge (for pH, pressure of carbon dioxide, pressure of oxygen, total carbon dioxide, bicarbonate, base excess, oxygen saturation, and lactate), the CG6+ cartridge (for sodium, potassium, chloride, blood glucose, blood urea nitrogen, hematocrit, and hemoglobin), and enzyme-linked immunosorbent assay kits (calcium, magnesium, creatinine, aspartate aminotransferase, alanine aminotransferase, bilirubin, and albumin). Similar trends were found for the parameters of biochemistries, electrolytes, and blood gas, and they revealed no significant changes after blood withdrawal-induced hemorrhagic shock. However, the TBS group showed more effective ability to correct metabolic acidosis than the NS and RS groups. TBS was a feasible and safe resuscitation solution in this study and may be an alternative to NS and RS for resuscitation in hemorrhagic shock patients without liver damage.
Ting-Ting Su,Wen-Feng Ren,Jiang-Meng Yuan,Ke Wang,Bing-Yu Chi,Run-Cang Sun 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
The commercial application of silicon (Si) anodes with high theoretical capacity is hampered by the poorcyclic stability because the huge volume change of Si during discharge/charge processes results in thepulverization of electrode materials and the electric contact loss of electrode materials with copper(Cu) foils. Binders play an important role for adhering active materials and conductive additives togetheronto Cu foils. Herein, we design and develop a three-dimensional networked composite binder (PAA-co-SN) via an amidation reaction between polyacrylic acid (PAA) and thiourea (SN). The granular anchors(CuxS) are constructed at the interface between PAA-co-SN binders and Cu foils, resulting from the reactionof S and Cu during the drying processes of Si electrodes. When used as binders for Si nanoparticles,they exhibit stable cyclic performance (1580 mAh g1 after 500 cycles). The anchoring mechanismbetween composite binders and Cu foils provides a strategy for the improvement of electrochemicalproperties of Si-based anodes for lithium-ion batteries.
Cushion Polyurethane Sandwich Composite Structures Strengthened by a Concave-Convex Fabric Panels
Ting-Ting Li,Peiyao Liu,Bing-Chiuan Shiu,Hongyang Wang,Hao-Kai Peng,Jia-Horng Lin,Ching-Wen Lou 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
In order to improve the low velocity impact resistance, flexible PU foam composites (FPUC) with a sandwichstructure are proposed. The interlayer is composed of a concave-convex fabric structure while the top/bottom layers are madeof polyurethane foam (PU). The core is prepared as follows. Seven warp knitted spacer fabric types (WKSF) (WKSF.1-7) arelaminated with different number of layers to form cuboids, which are fixed firmly between two layers of low melting pointpolyester (LMPET) fabrics via hot melting. The effects of spacer yarn density, spacer yarn inclination angle, combination ofspacer fabrics, and number of lamination layers on the dynamic cushion performance are evaluated. With the impact energybeing 16 J, FPUs demonstrate an energy absorption level that is 19 % and 39 % greater than PU and WKSF. Furthermore,ultra-high molecular weight polyethylene fabric can effectively enhance the surface strength. Finally, the results arecomputed via theoretical prediction formulae of dynamic buffer resistance is in conformity with the experimental test results.
Grain Size Effect on Multi-Stage Micro Deep Drawing of Micro Cup with Domed Bottom
Wen Ting Li,Ming Wang Fu,Ji Lai Wang,Bao Meng 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.6
A two-stage micro deep drawing system was designed and developed to manufacture a micro cup with domed bottom. The copper blank was annealed at three different conditions to obtain different grain sizes in such a way to study the grain size effect on the deformation behavior and thickness variation of the micro part. To investigate the instantaneous effect and deformation behavior, finite element simulation was used to simulate the whole drawing process. It revealed that the fracture in the place with the thinnest thickness in the micro part drawn from a circle blank with residual stress induced in blanking can be easily happen and the deformation load in the first-stage decreases more than that in the second-stage with the increase of grain size. Moreover, the micro part with a larger grain size has more nonuniform thickness and severer thinning around the punch corner. The surface roughness at the bottom of micro part increases with the grain size. The surface roughness at the wall of it, however, decreases with the deformation stage mainly due to the ironing effect. The research promotes the understanding of grain size effect on multi-stage micro deep drawing and facilitates the development of microforming process.
Fang Wang,Jian-fang Lou,Yan Cao,Xin-hui Shi,Peng Wang,Jian Xu,Er-fu Xie,Ting Xu,Rui-hong Sun,Jianyu Rao,Pu-wen Huang,Shi-yang Pan,Hong Wang 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
MicroRNAs (miRNAs), a class of small non-coding RNAs, mediate gene expression by either cleaving target mRNAs or inhibiting their translation. They have key roles in the tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC). The aim of this study was to investigate the clinical significance of miR-638 in the evaluation of NSCLC patient prognosis in response to chemotherapy. First, we detected miR-638 expression levels in vitro in the culture supernatants of the NSCLC cell line SPC-A1 treated with cisplatin, as well as the apoptosis rates of SPC-A1. Second, serum miR-638 expression levels were detected in vivo by using nude mice xenograft models bearing SPC-A1 with and without cisplatin treatment. In the clinic, the serum miR-638 levels of 200 cases of NSCLC patients before and after chemotherapy were determined by quantitative real-time PCR, and the associations of clinicopathological features with miR-638 expression patterns after chemotherapy were analyzed. Our data helped in demonstrating that cisplatin induced apoptosis of the SPC-A1 cells in a dose- and time-dependent manner accompanied by increased miR-638 expression levels in the culture supernatants. In vivo data further revealed that cisplatin induced miR-638 upregulation in the serum derived from mice xenograft models, and in NSCLC patient sera, miR-638 expression patterns after chemotherapy significantly correlated with lymph node metastasis. Moreover, survival analyses revealed that patients who had increased miR-638 levels after chemotherapy showed significantly longer survival time than those who had decreased miR-638 levels. Our findings suggest that serum miR-638 levels are associated with the survival of NSCLC patients and may be considered a potential independent predictor for NSCLC prognosis.
Xiayun Zhang,Ting-Ting Li,Ting-Ting Li,Hao-Kai Peng,Zhike Wang,Jia-Horng Lin,Ching-Wen Lou 한국섬유공학회 2022 Fibers and polymers Vol.23 No.8
This paper fabricated two types stab-resistant nonwoven fabric and the stab/puncture resistance of nonwoven werestudied. Nylon fibers, Kevlar fibers, and two types of low-melting point fibers-low-melting point polyester (LPET) fibers andpolypropylene(PP) fibers-are made into PP/nylon/Kevlar and LPET/nylon/Kevlar nonwoven fabrics. Needle punching andthermal bonding technology are used to made stab-resistant nonwoven fabric, thereby examining the influence of lowmeltingpoint fibers content (i.e. LPET or PP fibers) and bonding mode with other fibers on the stab/puncture resistanceproperty of nonwoven fabrics. The quasi-static stab resistance and bursting properties were compared between nonwovenfabrics and nonwoven fabric of PET filament reinforced nonwovens. The test results show that PET filament reinforcementhas a positive influence on the mechanical properties of composite nonwoven fabrics, especially puncture/stab resistanceperformance.
Cui, Zhi-Wen,Xia, Ye,Ye, Yi-Wang,Jiang, Zhi-Mao,Wang, Ya-Dong,Wu, Jian-Ting,Sun, Liang,Zhao, Jun,Fa, Ping-Ping,Sun, Xiao-Juan,Gui, Yao-Ting,Cai, Zhi-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
The molecular mechanisms involved in the progression of clear cell renal cell carcinomas (ccRCCs) are still unclear. The aim of this study was to analyse the relationships between expression of RALYL and clinical characteristics. In 41 paired samples of ccRCCs and adjacent normal tissues, we used real-time qPCR to evaluate the expression of RALYL mRNA. RALYL protein levels were determined in 146 samples of ccRCC and 37 adjacent normal tissues by immunohistochemistry. Statistical analysis was used to explore the relationships between expression of RALYL and the clinical characteristics (gender, age, tumor size, T stage, N stage, M stage, survival times and survival outcome) in ccRCC. In addition, these patients were follow-up period 64 months (range: 4~116months) to investigate the influence on prognosis. We found significantly differences between ccRCC tissues and normal tissues (p<0.001, paired-sample t test) in mRNA levels of RALYL. Immunohistochemistry analyses in 146 ccRCC samples and 37 adjacent normal tissues showed significantly lower RALYL protein levels in ccRCC samples (${\chi}^2$-test, p<0.001), inversely correlating with tumour size (p=0.024), T stage (0.005), N stage (p<0.001) as well as M stage (p=0.019), but not age (p=0.357) and gender (p=0.348). Kaplan-Meier survival analysis demonstrated that people with lower level of RALYL expression had a poorer survival rate than those with a higher level of RALYL expression, significantly different by the log-rank test (p=0.011). Cox regression analysis indicated that RALYL expression (p=0.039), N stage (p=0.008) and distant metastasis (p<0.001) were independent prognosis factors for the overall survival of ccRCC patients. We demonstrated that the expression of RALYL was significantly low in ccRCC and correlated with a poor prognosis in a large number of clinical samples. Our findings showed that RALYL may be a potential therapeutic target as well as a poor prognostic factor.