http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hypoallergenic and Physicochemical Properties of the A2 β-Casein Fraction of Goat Milk
Tae-Hwan Jung,Hyo-Jeong Hwang,Sung-Seob Yun,Won-Jae Lee,Jin-Wook Kim,Ji-Yun Ahn,Woo-Min Jeon,Kyoung-Sik Han2.6* 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.6
Goat milk has a protein composition similar to that of breast milk and contains abundant nutrients, but its use in functional foods is rather limited in comparison to milk from other sources. The aim of this study was to prepare a goat A2 β-casein fraction with improved digestibility and hypoallergenic properties. We investigated the optimal conditions for the separation of A2 β-casein fraction from goat milk by pH adjustment to pH 4.4 and treating the casein suspension with calcium chloride (0.05 M for 1 h at 25°C). Selective reduction of β- lactoglobulin and αs-casein was confirmed using sodium dodecyl sulphate-polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography. The hypoallergenic property of A2 β-casein fraction was examined by measuring the release of histamine and tumor necrosis factor alpha from HMC-1 human mast cells exposed to different proteins, including A2 β-casein fraction. There was no significant difference in levels of both indicators between A2 β-casein treatment and the control (no protein treatment). The A2 β-casein fraction is abundant in essential amino acids, especially, branched-chain amino acids (leucine, valine, and isoleucine). The physicochemical properties of A2 β-casein fraction, including protein solubility and viscosity, are similar to those of bovine whole casein which is widely used as a protein source in various foods. Therefore, the goat A2 β-casein fraction may be useful as a food material with good digestibility and hypoallergenic properties for infants, the elderly, and people with metabolic disorders.
Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells
Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4
The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.
Han, Jung Wan,Hong, Sung Noh,Jang, Hyun Joo,Jeon, Seong Ran,Cha, Jae Myung,Park, Soo Jung,Byeon, Jung Sik,Ko, Bong Min,Kim, Eun Ran,Choi, Hwang,Chang, Dong Kyung Hindawi Publishing Corporation 2015 Gastroenterology Research and Practice Vol.2015 No.-
<P><I>Background</I>. We aimed to evaluate the efficacy of various diagnostic tools such as computerized tomography (CT), small bowel follow-through (SBFT), and capsule endoscopy (CE) in diagnosing small bowel tumors (SBTs). Additionally, we aimed to evaluate the clinical features of SBTs missed by CE. <I>Methods</I>. We retrospectively studied 79 patients with histologically proven SBT. Clinical data were analyzed with particular attention to the efficacy of CT, SBFT, and CE in detecting SBT preoperatively. We also analyzed the clinical features of SBTs missed by CE. <I>Results</I>. The most common symptoms of SBT were bleeding (43%) and abdominal pain (13.9%). Diagnostic yields were as follows: CT detected 55.8% of proven SBTs; SBFT, 46.1%; and CE, 83.3%. The sensitivity for detecting SBTs was 40.4% for CT, 43.9% for SBFT, and 79.6% for CE. Two patients with nondiagnostic but suspicious findings on CE and seven patients with negative findings on CE were eventually found to have SBT. These nine patients were eventually diagnosed with gastrointestinal stromal tumor (4), small polyps (3), inflammatory fibroid polyp (1), and adenocarcinoma (1). These tumors were located in the proximal jejunum (5), middle jejunum (1), distal jejunum (1), and proximal ileum (1). <I>Conclusion</I>. CE is more efficacious than CT or SBFT for detecting SBTs. However, significant tumors may go undetected with CE, particularly when located in the proximal jejunum.</P>
( Sang Il Choi ),( Sun Young Kim ),( Ji Yeon Baek ),( Sung Chan Park ),( Jae Hwan Oh ),( Dae Yong Kim ),( Hee Jin Jang ),( Min Jung Kim ),( Seung Duk Lee ),( Sung Sik Han ),( Seoung Hoon Kim ),( Sang 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Perioperative chemotherapy is the standard treatment option for resectable colorectal liver metastasis (CRLM), but the optimal sequence of surgical and systemic treatment has been debated. We retrospectively examined progression free survival (PFS) and postoperative complications between patients who received preoperative chemotherapy and upfront surgery for resectable CRLM. Methods: Patients who underwent surgical resection for CRLM from Aug. 2001 to Apr. 2012 in National Cancer Center, Korea were identifi ed and their medical records were reviewed. They were classifi ed into two groups: patents who had preoperative chemotherapy (preCTx) and who underwent upfront liver resection (UFLR). Patients with < 6 liver metastases were included. Those who had major vessel invasion, extrahepatic metastasis, prior liver resection or other advanced malignancy were excluded.Results: Of the 451 patients who underwent liver resection, 333 who met above criteria were analyzed. 50 (15%) patients received preoperative chemotherapy followed by liver resection and 283(85%) patients underwent upfront surgery. Among those who had upfront surgery, 231(81.7%) patients received post-operative chemotherapy. There was no signifi cant difference in baseline characteristics including number and distribution of metastases, CEA, and proportion of patients who received prior or adjuvant chemotherapy, while R0 resection rate was higher in preCTx group (98% vs 89%, p = 0.04). 3-year PFS in preCTx and UFLR group were 22% versus 37% (p value = ). In multivariate analysis, number of liver metastasis, incomplete resection and synchronicity of metastasis were associated with poor PFS. There was no statistical difference in post-operative complications. Conclusions: Although R0 resection rate in preCTx group was signifi cantly higher than UFLR group, it did not affect PFS. Preoperative chemotherapy did not offer benefi t in terms of PFS and post-operative complications compared to upfront surgery.
( Sang-hyub Han ),( Ji Hae Nahm ),( Do Young Kim ),( Seung Woo Park ),( Young Nyun Park ),( Kyung Sik Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Obesity is well known as a risk factor for gallstone disease and is also a risk factor for fatty liver. Before laparoscopic cholecystectomy, it is not easy to detect fatty liver, except for the cases of severe fatty liver by blood chemistry and imaging diagnostic tools. However liver biopsy is particularly useful in patients without definite clinical manifestations. Liver biopsy is invasive and is not recommended except in special cases, but hepatic biopsy is not a relatively risky procedure during laparoscopic cholecystectomy. Therefore, we investigated the clinical characteristics in biopsy proven non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in obese patients during laparoscopic cholecystectomy for gallstone disease. Methods: We retrospectively reviewed medical records in obese patients with gallstone disease who underwent laparoscopic cholecystectomy with liver biopsy. The definition of obesity was based on the Asian obesity criteria. (overweight :23~24.9, obese class I :>25, & obese class II >30). Total 74 patients were included, and 30 patients were diagnosed as fatty liver(A) and compared with patients without fatty liver disease(B) using various parameters. Results: There were 9 male and 21 female in fatty liver group and 18 male and 26 female without fatty liver. In the fatty liver group, 6 overweight, 19 obese class I, & 5 obese class II, but in the group without fatty liver, 21 overweight, 19 obese class I, & 4 obese class II. The degree of obesity in the fatty liver group was more severe(P=.022). Except level of aminotransferase, all biochemical parameters were not different between two groups. Conclusions: The liver biopsy could be recommended in obese I & II patients with abnormal levels of aminotransferase.
(Sang Ah Chang),(Bong Yun Cha),(Soon Jib Yoo),(Yo Bae Ahn),(Ki Ho Song),(Je Ho Han),(Jong Min Lee),(Hyun Sik Son),(Kun Ho Yoon),(Moo Il Kang),(Kwang Woo Lee),(Ho Young Son),(Sung Ku Kang) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2
N/A Background : It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. Methods : About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. Results : In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. Conclusion : These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.