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Comparative proteomic analysis of plant responses to sound waves in Arabidopsis
권영상,Mi-Jeong Jeong,Jaeyul Cha1,Sung Woo Jeong,박수철,신성철,정우식,배한홍,Dong-Won Bae 한국식물생명공학회 2012 식물생명공학회지 Vol.39 No.4
Environmental factors greatly influence the growth,development, and even genetic characteristics of plants. The mechanisms by which sound influences plant growth,however, remain obscure. Previously, our group reported that several genes were differentially regulated by specific frequenciesof sound treatmentusing a sound-treated subtractive library. In this study, we used a proteomic approach to investigate plant responses to sound waves in Arabidopsis. The plants were exposed to 250-Hz or 500-Hz sound waves,and total proteins were extracted from leaves 8 h and 24 h after treatment. Proteins extracted from leaves were subjected to 2-DE analysis. Thirty-eight spots were found to be differentially regulated in response to sound waves and were identified using MALDI-TOF MS and MALDI-TOF/TOF MS. The functions of the identified proteins were classified into photosynthesis, stress and defense, nitrogen metabolism,and carbohydrate metabolism. To the best of our knowledge,this is the first report on the analysis of protein changes in response to sound waves in Arabidopsis leaves. These findings provide a better understanding of the molecular basis of responses to sound waves in Arabidopsis.
Conversion to Veno-arteriovenous Extracorporeal Membrane Oxygenation for Differential Hypoxia
Cha Ho Jeong,Kim Jong Woo,Kang Dong Hoon,Moon Seong Ho,Kim Sung Hwan,Jung Jae Jun,Yang Jun Ho,Byun Joung Hun 대한심장혈관흉부외과학회 2023 Journal of Chest Surgery (J Chest Surg) Vol.56 No.4
Background: Patients who require initial venoarterial extracorporeal membrane oxygenation (VA ECMO) support may need to undergo veno-arteriovenous ECMO (VAV ECMO) conversion. However, there are no definitive criteria for conversion to VAV ECMO. We report 9 cases of VAV ECMO at Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine. Methods: Of 158 patients who received ECMO support between January 2017 and June 2019, 82 were supported by initial VA ECMO. We retrospectively reviewed the medical records of 9 patients (7 men and 2 women; age, 53.1±19.4 years) who had differential hypoxia and required VAV ECMO support. Percutaneous transaortic catheter venting was used to detect the differential hypoxia. Results: Among the 82 patients who received VA ECMO support, 9 (10.9%) had differential hypoxia and required conversion to VAV ECMO support. The mean time from VA ECMO support to VAV ECMO support and the mean duration of the VAV support were 2.1±2.2 days and 1.9±1.5 days, respectively. The average peak inspiratory pressure before and after VAV ECMO application was 23.89±3.95 cmH2O and 20.67±5.72 cmH2O, respectively, decreasing by an average of 3.2±3.5 cmH2O (p=0.040). The PaO2/FiO2 ratio was kept below 100 mm Hg in survivors and non-survivors for 116±65.4 and 250±124.9 minutes, respectively (p=0.016). Six patients underwent extracorporeal cardiopulmonary resuscitation, of whom 4 survived (67%). The overall survival rate of patients who underwent conversion from VA ECMO to VAV ECMO was approximately 56%. Conclusion: Rapid detection of differential hypoxia is required when VA ECMO is applied, and efficient conversion to VAV ECMO may be critical for patient survival.
( Sung Hee Jung ),( Yun Jung Lee ),( Sung Hoon Lee ),( Hyang Le Lee ),( Hyeon Woong Yang ),( An Na Kim ),( Sang Woo Cha ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Alms: The frequency of intestinal involvement in Behcet`s disease is known to be 3~25% with geographic differences which is higher in East Asian patients including Koreans. We tried to find out the reliable gastrointestinal symptoms and laboratory data which can predict the verification of intestinal Behcet`s disease by colonoscopy. Methods: Between April 2004 and August 2007, 29 patients underwent colonoscopy among 186 patients who were diagnosed with complete or incomplete type Behcet`s disease at the department of rheumatology internal medicine, Eulji medical school hospital, Daejeon, Korea. We analyzed the relations among their symptoms, colonoscopic findings, and laboratory data, retrospectively using medical records. A p value of less than 0.05 was considered as statistically significant. Results: The mean age of the 29 patients was 43.3 years; most (23/29) of them were female. Twenty two (75.9%) patients complained of gastrointestinal symptoms, such as abdominal pain (41.1%), hematochezia, diarrhea, loose stool. On laboratory examination, mean Hb was 12.3 g/dL, ESR 31.8 mm/hr, and CRP 2.30 mg/dL. On colonoscopy, lesions were found in only 50% of the symptomatic patients. There was no significant relation with the presence of gastrointestinal symptoms and colonoscopic lesions (p>0.05). Hematochezia (p=0.004) and anemia (p=0.042) were strongly correlated to colonoscopic lesions unlike diarrhea, loose stool, abdominal pain, ESR, and CRP elevation Conclusions: We should consider the colonoscopic examination including terminal ileum to the Behcet`s disease patients who showed hematochezia and anemia for the early recognition of intestinal Behcet`s disease.
Cha, In Pyo,Shin, Hee Jae,Lee, Min Sang,Hong, Sung Woo,Kwon, Jin Young,Ko, Sun Ho,Kim, Hong Gun,Kwac, Lee Ku Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.1016 No.-
<P>The prepreg process among the CFRP (Carbon Fiber Reinforced Plastic) forming methods is the short term of ‘Pre-impregnation’, which is widely used for aerospace composites that require a high quality property such as a fiber-reinforced woven fabric, in which an epoxy hardening resin is impregnated. the reality is, however, that this process requires continuous researches and developments for its commercialization because the delamination characteristically develops between the layers when a great weight is loaded from outside. to supplement such demerit, three lamination methods among the prepreg lamination methods of CFRP were designed to minimize the delamination between the layers due to external impacts. Further, the newly designed methods and the existing lamination methods were analyzed through a mechanical characteristic test, tensile test and infrared thermal device during the tensile tests, to obtain a better property than the existing lamination methods. the tensile test result showed that the newly designed three lamination methods, i.e. Roll, Half and Zigzag lamination methods, appeared superior to the Play lamination method in the aspects of the strength and strain. The strength of the Zigzag lamination method, which was the highest, was confirmed as being improved by about 20% than that of the Ply method.</P>
Effects of Calcining Temperature on SnO₂ Sensors for CO and NO_(x) Gases
Cha, Geon-Young,Bui, Anh-Hoa,Baek, Won-Woo,Lee, Sang-Tae,Lee, Duk-Dong,Huh, Jeung-Soo 대한금속재료학회 2004 METALS AND MATERIALS International Vol.10 No.2
Nitrogen oxides (NO,) and carbon monoxide (CO) are among the most dangerous chemical species to human health present in the atmosphere. Acute GO toxicity leading to unconsciousness, respiratory failure or death can occur after 1 hr of exposure when ambient CO levels reach l000 ppm, whilst increase of NO, emissions can contribute to acid deposition, pollution of groundwater, eutrophication of surface waters, and tropospheric ozone and ecosystem damage. In this work, pure SnO₂ sensors for CO and NO, were prepared by spin coating solutions derived from a washed Gel-precipitate followed by a calcining step. SnO₂ sensors of nanometer grain size prepared by this process showed good sensitivity to CO and NO, gases. The increase of calcining temperature not only affected grain size and surface morphology, but also caused a decrease in sensitivity of the SnO₂ sensors.
Cha, Shin Woo,Gu, Hee Kyoung,Lee, Ki Poong,Lee, Mun Han,Han, Sang Seop,Jeong, Tae Cheon 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
Ethyl carbamate, a potent carcinogen, has been characterized to be metabolized by cytochrome P450(P450) and esterase. It has recently been demonstrated that P450 may activate ethyl carbamate to immunotoxic metabolites. To investigate the role of esterase in ethyl carbamate-induced immunosuppression, mice were pretreated intraperitoneally with an esterase inhibitor, diazinon, at 20 ㎎/㎏ 30min prior to the administration of ethyl carbamate intraperi-toneally at 100 and 400㎎/㎏ for 7 consecutive days. Pretreatment with diazinon completely blocked the serum esterase activity. Histopathologically splenic and thymic atrophy was observed when mice were treated with ethyl carbamate, which was potentiated by he pretreatment with diazinon. In spleen, lymphocytes in the periarteriolar lymphoid sheath and the marginal zone appeared to be depleted in the white pulps. In thymus, ethyl carbamate caused a marked depletion of cells in cortex. The antibody response to sheep red blood cells(SRBCs) was more suppressed by ethyl carbamate in diazinon-pretreated groups. These results suggest that the metabolism of ethyl carbamate by esterase may be an inactivation pathway in ethyl carbamate-induced immunosuppression. In addition, ethyl N-hydroxycarbamate, a P450 metabolite, suppressed the lymphoproliferative response induced by lipopolysaccharide and concanavalin A in splenocyte cultures. These results indicate that the metabolism of ethyl carbamate by P450 may be an activation pathway in immunosuppression by ethyl carbamate. ⓒ 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.