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김홍직,이종석,김영근,현경준 순천향대학교 1989 논문집 Vol.12 No.3
Hydroa vacciniforme is a rare, light sensitive dermatitis characterized by discrete vesicles followed by varioliform scar formation, which was first described by Bazin on 1862. Our case was a 10-years-old girl who had umblicated vesicles, crusts, varioliform scars on both cheeks, nose, dorsum of hands in symmetrical distribution with itching sensation, which had used to recur in every summer since last five years ago. Histologic examination showed necrosis and multilocular bullae due to reticular degeneration in the epidermis, extravasation of red blood cell and lymphohistiocytic infiltration in the dermis. On urine examination, porphyrin was negative. Diagnosis was established by clinical characteristics and laboratory findins and histologic pictures.
현경준(Kyeong Joon Hyeon),김홍직(Hong Jig Kim),김종일(Jong Il Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1
We investigated on how the nature of vehicles influenced on the efficacy of mo isturizer s, cutaneous hydrat,ion, physical property and roughness. Hydration was measured with corneometer, physical property with fermometer, and mughness with image analyser. Used vehicles were as follows : hydrous gel, vater in oil(W/0) emulsion, oil in water(0/W) emulsion. I.Jsed moisturizers were as follows . glycerine, polypeptide and sodium lactat,e, hyaluronic acid-triethanolamine, sodium lactate, pvopylene glycol, The results are summarized as follows : 1. The increment of the hydration effect according to vehicles was in this order. C/ W emulsion, W/0 emulsion, hydrous gel(After 2 hours). 2. The increment of extensibility as physical property was correlated to the in crcment, of hydration effcet(r=0.924). 3. It was shown that, the roughness was decreased after treatment of all mo isturizers except propylene glycol but, there was not significant st.atistically and alsa was no meaningful difference among the vehicles. 4. Among t,he moisturizers, glycerine was superior to other moisturizers on the hydration effect and extensihility. We conclude that 0/W emulsion was suitable vehicle on cutaneous hydration effect and hydration effect is proportion to the increment of flexibility. (Kor J Devmatol 29(1): 8--17, 1991)
Joon Ha Park,Tae Kyeong Lee,Ji Hyeon Ahn,Bich Na Shin,Jeong Hwi Cho,In Hye Kim,Jae Chul Lee,Jong Dai Kim,Young Joo Lee,Il Jun Kang,Seong kweon Hong,Yang Hee Kim,Yong Hwan Jeon,Yun Lyul Lee,Moo Ho Won 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.4
The genus Populus (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study regarding protective effects of Populus species against cerebral ischemia has been reported. Therefore, in the present study, we examined neuroprotective effects of ethanol extract from Populus tomentiglandulosa (Korea poplar) in the hippocampal cornu ammonis (CA1) area of gerbils subjected to 5 minutes of transient global cerebral ischemia. Pretreatment with 200 mg/kg of P. tomentiglandulosa extract effectively protected CA1 pyramidal neurons from transient global cerebral ischemia. In addition, glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium binding adapter molecule 1 immunoreactive microglia were significantly diminished in the ischemic CA1 area by pretreatment with 200 mg/kg of P. tomentiglandulosa extract. Briefly, our results indicate that pretreatment with P. tomentiglandulosa extract protects neurons from transient cerebral ischemic injury and diminish cerebral ischemia-induced reactive gliosis in ischemic CA1 area. Based on these results, we suggest that P. tomentiglandulosa can be used as a potential candidate for prevention of ischemic injury.
박경현 ( Kyeong-hyeon Park ),오창욱 ( Chang-wug Oh ),김준우 ( Joon-woo Kim ) 대한골절학회 2018 대한골절학회지 Vol.31 No.3
최근 평균 수명의 증가와 더불어 노인성 골반 및 비구 골절의 빈도가 증가하고 있다. 노인 연령에서의 이러한 골다공성 골절은 젊은 성인에서의 골절과 여러 가지 면에서 차이가 있으며 저 에너지 손상에 의해 유발되지만 결과는 정상 성인에서의 골절보다 나쁜 경우가 흔하다. 여러 가지 치료 옵션이 있으나 어떤 것도 표준적 치료라고 하기 어렵다. 환자 개개인의 상태에 따라 적절한 치료 전략을 수립해야 한다. 보존적 혹은 수술적 치료 등 치료 방법에 상관없이 노인 환자에서는 침상안정에 따른 합병증을 최소화하기 위해서 조기 거동이 중요하다. Owing to the increase in life expectancy, the incidence of osteoporotic fracture of the pelvis and acetabulum is increasing. Fractures in the elderly population is different from those in younger patients. Pelvic ring and acetabular fractures in geriatric patients are more likely the result of low-energy trauma, but the outcomes are generally poorer than those of the younger population. Multiple management options are available, but no intervention has become the standard of care for these fractures in the elderly. A treatment strategy should be established depending on the state of the individual patient. Regardless of whether nonsurgical or surgical treatment is selected, early ambulation should be considered to avoid the complications associated with prolonged immobilization.
Park, Joon Ha,Shin, Bich Na,Ahn, Ji Hyeon,Cho, Jeong Hwi,Lee, Tae-Kyeong,Lee, Jae-Chul,Jeon, Yong Hwan,Kang, Il Jun,Yoo, Ki-Yeon,Hwang, In Koo,Lee, Choong Hyun,Noh, Yoo Hun,Kim, Sung-Su,Won, Moo-Ho,Ki Medknow PublicationsMedia Pvt Ltd 2018 Chinese medical journal : CMJ Vol.131 No.6
<P><B>Background:</B></P><P><I>Glehnia littoralis</I> has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of <I>G. littoralis</I> have not yet been considered. Therefore, in this study, we examined effects of <I>G. littoralis</I> extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice.</P><P><B>Methods:</B></P><P>A total of 39 male ICR mice (12 weeks old) were randomly assigned to vehicle-treated and 100 and 200 mg/kg <I>G. littoralis</I> extract-treated groups (<I>n</I> = 13 in each group). Vehicle and <I>G. littoralis</I> extract were orally administrated for 28 days. To examine neurogenic effects of <I>G. littoralis</I> extract, we performed immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU, an indicator for cell proliferation) and doublecortin (DCX, an immature neuronal marker) and double immunofluorescence staining for BrdU and neuronal nuclear antigen (NeuN, a mature neuronal marker). In addition, we examined expressional changes of brain-derived neurotrophic factor (BDNF) and its major receptor tropomyosin-related kinase B (TrkB) using Western blotting analysis.</P><P><B>Results:</B></P><P>Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive (<SUP>+</SUP>) and DCX<SUP>+</SUP> cells (48.0 ± 3.1 and 72.0 ± 3.8 cells/section, respectively) in the subgranular zone (SGZ) of the dentate gyrus (DG) and BrdU<SUP>+</SUP>/NeuN<SUP>+</SUP> cells (17.0 ± 1.5 cells/section) in the granule cell layer as well as in the SGZ. In addition, protein levels of BDNF and TrkB (about 232% and 244% of the vehicle-treated group, respectively) were significantly increased in the DG of the mice treated with 200 mg/kg of <I>G. littoralis</I> extract.</P><P><B>Conclusion:</B></P><P><I>G. littoralis</I> extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases of BDNF and TrkB proteins by <I>G. littoralis</I> extract treatment.</P>
Adaptive Non-speculative DFE with Extended Time Constraint for PAM-4 Receiver
Do-Hyeon Kwon,Hyung-Wook Lee,Kyeong-Min Ko,Taek-Joon An,Jin-Ku Kang 대한전자공학회 2021 Journal of semiconductor technology and science Vol.21 No.2
This paper presents a novel approach to solve the time constraint issue of DFE with PAM4 signaling. By using track and hold operation to sample signals of the same level at two points, the time constraint of 1 UI in direct DFE can be extended to 1.5UI. The FIR-tap employs LVDS structure to maintain common voltage and SS-LMS algorithm is used to obtain the optimal tap weight. The first post-cursor ISI cancellation is done by the LVDS tap and a sufficient settling time is provided by the proposed DFE. The proposed structure may eliminate the loop unrolling speculative DFE for PAM-4, which leads to less hardware for PAM-4 DFE implementation. A PAM-4 serial link using the proposed DFE was designed in a 65nm CMOS technology and analyzed. Channels with 11.9 dB and 13.8 dB losses were compensated through CTLE and the proposed 1 tap DFE, and simulation results demonstrate the time constraint can be extended without deterioration of the eye opening.
Rufinamide pretreatment attenuates ischemia-reperfusion injury in the gerbil hippocampus
Tae-Kyeong Lee,Jeong Hwi Cho,In Hye Kim,Jae-Chul Lee,Hyun Jung Kim,Min Ah Song,Bich-Na Shin,Ji Hyeon Ahn,Joon Ha Park,Ki-Yeon Yoo,Choong Hyun Lee,Jung Hoon Choi,Moo-Ho Won 한국실험동물학회 2017 한국실험동물학회 학술발표대회 논문집 Vol.2017 No.2
김준우(Joon-Woo Kim),박경현(Kyeong-Hyeon Park),오창욱(Chang-Wug Oh) 대한정형외과학회 2021 대한정형외과학회지 Vol.56 No.2
비록 수술적 치료의 발전에 의해 부정유합의 발생은 감소하였으나 복합적 골절 또는 동반된 손상 등으로 인하여 드물지 않은 합병증이다. 관절 연골에 과한 하중이나 관절의 불안정성이 예상되는 부정유합이 있다면 교정 절골술이 필요하다. 부정유합에 대한 절골술을 시행하기 위해서는 수술 전 계획이 매우 중요하다. 적절한 계획이 없을 경우 의인성 부정정렬, 수술중 골절, 변형의 재발, 연부조직의 손상과 같은 심각한 합병증이 따르게 된다. 또한 적절한 환자를 선택하지 않았을 경우 불량한 기능적 결과가 나타날 수 있다. 본 종설은 부정유합을 치료하기 위하여 수술적 적응증, 수술 전 계획, 그리고 수술방법과 고정물 종류에 따른 다양한 교정절골술의 방법에 대하여 기술하였다. Although current surgical techniques have reduced the incidence of malunion, it is still observed because of the complexity of the fracture or associated injuries. Osteotomy is needed when the amount of malunion is expected to result in an overload of cartilage and instability of the joint. Preoperative planning is essential when performing an osteotomy for malunion. Inadequate planning can result in serious complications, such as iatrogenic malalignment, intraoperative fracture, postoperative recurrence of deformity, or soft tissue injuries. In addition, a poor functional result can occur secondary to poor patient selection. This review article includes the surgical indications and planning to correct malunion. Various methods of corrective osteotomy are described according to the kinds of plane and fixation implants.