Lymphovenous anastomosis for the treatment of lower extremity lymphedema in patients with gynecologic malignancy

( Hyon Jee Yoon ),( Eun Young Ki ),( Sung Jong Lee ),( Min Jong Song ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: We investigated the feasibility and efficacy of lymphovenous anastomosis (LVA) for the treatment of lower extremity lymphedema resulting from lymphadenectomy or radiation therapy in treatment of gynecologic malignancies. Methods: Between December, 2017 and July, 2019, 55 patients with secondary lower extremity lymphedema underwent lymphovenous anastomosis in the groin area. Campisi staging was used for the clinical staging of lymphaedema. All patients underwent lymphoscintigraphy to ensure accurate diagnosis of lymphatic edema. Surgery was performed on patients with a modified transport index (TI)> 10 calculated by lymphscintigraphy or patients with recurrent lymphangitis. Indocyanine green (ICG) was injected into dorsal subcutaneous space (between 1st and 2nd toes) 12 hours before the operation to assess Yamamoto stage. Lymphatic vessels afferent to the blue dye or ICG stained nodes were used to perform LVA using a collateral branch of the great saphenous vein.Treatment effects were assessed using lower extremity lymphedema index (LELI) before and 3 months after surgery. Results: There were 7 patients with stage II, 30 patients with stage III, 15 patients with stage IV, 3 patient with stage V. Thirteen patients had recurrent lymphangitis. Mean preoperative transport index by lymphoscintigraphy was 36.3 Mean operation time was 189 minutes. Forty eight patients achieved reduction in affected leg volume (87.3%). Among these cases, 31 (56.4%)patients showed reduction of over 3 cm in the circumference of the lower leg. Mean reduction rate of excessive volume 3 months after surgery was 36.3% (7.2-90%) by LELI measurement. Pitting edemas were improved in 51 paitients (92.3%). Conclusion: Lymphovenous anastomosis is a feasible and effective surgical procedure for those struggling with lower extremity lymphedema arising from the treatment of gynecologic malignancies This approach could be a reasonable choice for the treatment of secondary lymphedema refractory to complex physical therapy.

Giant perineal condyloma acuminatum in adolescent pregnancy

( Hyon Jee Yoon ),( Jae Young Pae ),( Ji Hye Cho ),( Kicheol Kil ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

The giant condyloma acuminatum is a type of human papilloma virus-associated sexually transmitted infection. Treatment options for condyloma acuminatum remain controversial, but surgery seems to be the best option. We present a case in a 16-year old pregnant woman with giant masses that covered the perineal and perianal region in labor. After delivered the baby vaginally, we removed the tumor at postpartum 2 months.

Ferritin-ZnSe Nano Dots as Sensor Media for Neurotransmitter

Jee Hyun MOON,Ting WANG,Hyon Hee YOON,Sang Joon PARK 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.4

Original Articles : Genetic Variation in Wild and Cultured Populations of the Sea Squirt Halocynthia roretzi Inferred from Microsatellite DNA Analysis

( Hyon Sob Han ),( Bo Hye Nam ),( Jung Ha Kang ),( Yi Kyoung Kim ),( Young Ju Jee ),( Young Baek Hur ),( Moon Geun Yoon ) 한국수산과학회(구 한국수산학회) 2012 Fisheries and Aquatic Sciences Vol.15 No.2

We used nine microsatellite DNA markers to estimate genetic variation among wild and cultured populations of the sea squirt Halocynthia roretzi. The loci were polymorphic, with 6-32 alleles, and allelic richness ranged from 6.0 to 26.1 in each population. The wild and the cultured populations had similar mean heterozygosities (HO and HE), allele numbers, and allelic richness. One cultured population with softness syndrome had a lower mean in the observed heterozygosity (HO = 0.57) and higher mean inbreeding coefficient (FIS = 0.261) than any other populations. This suggests that the loss of genetic variation in the diseased population might be due to increased inbreeding. A neighbor-joining tree and pairwise population estimates of FST showed moderate genetic differentiation between the wild and the cultured populations. Additionally, the softness syndrome population was genetically divergent from wild populations, but it was genetically close to the cultured populations.

Genetic Variation in Wild and Cultured Populations of the Sea Squirt Halocynthia roretzi Inferred from Microsatellite DNA Analysis

Han, Hyon-Sob,Nam, Bo-Hye,Kang, Jung-Ha,Kim, Yi-Kyoung,Jee, Young-Ju,Hur, Young-Baek,Yoon, Moon-Geun The Korean Society of Fisheries and Aquatic Scienc 2012 Fisheries and Aquatic Sciences Vol.15 No.2

We used nine microsatellite DNA markers to estimate genetic variation among wild and cultured populations of the sea squirt Halocynthia roretzi. The loci were polymorphic, with 6-32 alleles, and allelic richness ranged from 6.0 to 26.1 in each population. The wild and the cultured populations had similar mean heterozygosities ($H_O$ and $H_E$), allele numbers, and allelic richness. One cultured population with softness syndrome had a lower mean in the observed heterozygosity ($H_O$ = 0.57) and higher mean inbreeding coefficient ($F_{IS}$ = 0.261) than any other populations. This suggests that the loss of genetic variation in the diseased population might be due to increased inbreeding. A neighbor-joining tree and pairwise population estimates of $F_{ST}$ showed moderate genetic differentiation between the wild and the cultured populations. Additionally, the softness syndrome population was genetically divergent from wild populations, but it was genetically close to the cultured populations.

제 la 형 당원병 1 예

정윤석,최영인,박지원,김현주,최영일 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4

Glycogen storage diseases are inherited disorders of carbohydrate metabolism caused by a deficiency of enzymes that are involved in degradation of glycogen in the liver. The accumulation of glycogen occurs in the liver and other organs. Type Ia is the most common form and clinically may manifest of glycogen storage disease itself rather than growth hormone deficiency. But in this case the patient showed exceptional extreme growth retardation. Growth hormone stimulation test with clonidine and L-dopa revealed that the patient had growth hormone deficiency. Therefore, we report of a case of glycogen storage disease type Ia with the presence of GH deficiency with review of literature. A 16-year-old male was admitted for the evaluation of hepatomegaly and extreme short stature. The height was 113.5cm, less than third percentile of same age group, and compatible with fiftieth percentile of height of 6 years of age. After laboratory work up including liver biopsy, he was diagnosed with type I glycogen storage disease. The patient was presented with metabolic acidosis, hyperuricemia, and hypoglycemia. Hypoglycemia was managed with frequent feeding with high starch diet and intravenous glucose infusion. Metabolic acidosis was treated with sodium bicarbonate. Secondary hyperuricemia was treated with allopurinol. The patient is being followed at out-patient clinic with clinical improvement after of GH administration (J Kor Soc Endocrinol 14:786-792, 1999)

부인두농양,후인두농양 및 종격동염을 동반한 Ludwig's Angina의 1례

이지성,이창배,김광옥,조승호,윤희로,조건현 대한이비인후과학회 1986 대한이비인후과학회지 두경부외과학 Vol.29 No.6

발작성 야간혈색소뇨증에서 병발한 양측성 신정맥혈전증 1 예

한대석,한지숙,윤정한,주현영 대한내과학회 1986 대한내과학회지 Vol.30 No.5

Paroxysmal nocturnal hemoglobinuria is a rare, acquired hemolytic disorder of unknown etiology characterized by two major clinical features; chronic hemolytic anemia and diffuse venous thrombosis. Venous thrombosis is a common problem in patients with paroxysmal nocturnal hemoglobinuria and is a leading cause of death in reports. Here we report a case of paroxysmal nocturnal hemoglobinuria developed acute renal failure due to bilateral renal vein thrombosis and treated by acute peritoneal dialysis and oral anticoagulant.

지렁이 이동방식을 이용한 캡슐형 내시경용 마이크로 로봇

지창열(Chang-yeol Jee),김병규(Byungkyu Kim),박석호(Seokho Park),권지운(Jiwoon Kwon),윤석진(Seok-jin Yoon),박장현(Jahng-hyon Park) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5

A wireless capsule endoscope, M2A, has been developed to replace the conventional endoscope. However, the commercialized capsule endoscope moves passively by peristaltic waves (and the gravity), which has some limitations for doctors to diagnose more thoroughly and actively. In order to solve this problem, a locomotive mechanism is proposed for wireless capsule endoscopes. Based on the tests of various actuators, a piezo actuator is selected as a micro actuator for capsule endoscope. Piezo actuators are known to have limited displacement with high voltage supply. In order to overcome the limitation of common Piezo actuator, the impact based piezo actuator, is developed to realize long stroke up 11㎜. Moreover, clampers mimicked the claw of a insect are employed. A prototype of an earthworm-like locomotive mechanism with an impact based piezo actuator and engraved clampers was developed. It has 15 ㎜ in diameter and 30㎜ under retraction stage and 41 ㎜ under elongation stage in total length. Hollow space is allocated to comprise essential endoscope components such as a camera, a communication module, bio sensors, and a battery. For the feasibility test of proposed locomotive mechanism, a series of experiments were carried out including invitro tests. Based on results of the experiments, we conclude that the proposed locomotive mechanism is effective to be used for micro capsule endoscopes.

Term Low Birth Weight or Macrosomia among Immigrant Mothers in Korea

( Jung Eum Lee ),( Hyon Jee Yoon ),( Yu-ri Jang ),( Hyun Sun Ko ) 대한주산의학회 2020 Perinatology Vol.31 No.4

Objective: The aim of this study was to analyze the relationship between maternal origin and risks of term low birth weight (TLBW) or macrosomia in Korea. Methods: Using Korean birth statistics from 2009 to 2015, we examined the association between maternal nationality and risks of TLBW (less than 2.5 kg) or term macrosomia (over 4.0 kg). Birth statistics included singleton live births in women, from 37 to 41 weeks’ gestation, during the period 2009-2015. Immigrant mothers were defined as women born in any country other than Korea, and were grouped by economic level of maternal country of origin. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with multivariate logistic regression analysis. Results: There were significant differences in neonatal birth weights between Korean mothers and immigrant mothers (3.28±0.38 kg vs. 3.24±0.39 kg, P<0.001). In multivariate logistic regression analysis, the risk of TLBW was significantly higher (OR: 1.268, 95% CI: 1.181-1.361, P<0.001) and the risk of macrosomia was significantly lower (OR: 0.607, 95% CI: 0.518-0.71, P<0.001), in mothers from low and lower middle income countries, compared to Korean mothers. The risk of macrosomia was significantly higher (OR: 1.387, 95% CI: 1.228-1.566, P<0.001) and the risk of TLBW was significantly lower (OR: 0.879, 95% CI: 0.81-0.954), in mothers from high and upper middle income countries, compared to Korean mothers. Conclusion: After adjustment for relevant characteristics, the risk of TLBW was higher in immigrant mothers from low and lower middle income countries, but the risk of macrosomia was higher in immigrant mothers from high and upper middle income country. Prenatal care and education needs to consider the origin of immigrant mothers.