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Kim, Jae-Ouk,Rho, Semi,Kim, Su Hee,Kim, Heejoo,Song, Hyo Jin,Kim, Eun Jin,Kim, Ryang Yeo,Kim, Eun Hye,Sinha, Anuradha,Dey, Ayan,Yang, Jae Seung,Song, Man Ki,Nandy, Ranjan Kumar,Czerkinsky, Cecil,Kim, American Society for Microbiology 2015 CLINICAL AND VACCINE IMMUNOLOGY Vol.22 No.4
<P>In developing countries, <I>Shigella</I> is a primary cause of diarrhea in infants and young children. Although antibiotic therapy is an effective treatment for shigellosis, therapeutic options are narrowing due to the emergence of antibiotic resistance. Thus, preventive vaccination could become the most efficacious approach for controlling shigellosis. We have identified several conserved protein antigens that are shared by multiple <I>Shigella</I> serotypes and species. Among these, one antigen induced cross-protection against experimental shigellosis, and we have named it pan-<I>Shigella</I> surface protein 1 (PSSP-1). PSSP-1-induced protection requires a mucosal administration route and coadministration of an adjuvant. When PSSP-1 was administered intranasally, it induced cross-protection against <I>Shigella flexneri</I> serotypes 2a, 5a, and 6, <I>Shigella boydii</I>, <I>Shigella sonnei</I>, and <I>Shigella dysenteriae</I> serotype 1. Intradermally administered PSSP-1 induced strong serum antibody responses but failed to induce protection in the mouse lung pneumonia model. In contrast, intranasal administration elicited efficient local and systemic antibody responses and production of interleukin 17A and gamma interferon. Interestingly, blood samples from patients with recent-onset shigellosis showed variable but significant mucosal antibody responses to other conserved <I>Shigella</I> protein antigens but not to PSSP-1. We suggest that PSSP-1 is a promising antigen for a broadly protective vaccine against <I>Shigella</I>.</P>
Heejoo Ko(Heejoo Ko),Dohwan Kim(Dohwan Kim),Seong-Sik Cho(Seong-Sik Cho),Mo-Yeol Kang(Mo-Yeol Kang) 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: The physical activity paradox suggests that occupational physical activity (OPA), unlike leisure-time physical activity (LTPA), may detrimentally impact health. We explored the relationships of OPA and LTPA with work ability (WA) and health-related productivity loss (HRPL). METHODS: This study included 5,501 workers in Korea who were recruited in 2021 through a web-based cross-sectional questionnaire. The questionnaire was utilized to quantify OPA and LTPA in metabolic equivalents, while WA and HRPL were also measured. Non-parametric regression, using a generalized additive model (GAM), was employed to visualize the relationships of LTPA and OPA with WA and HRPL. Mean differences in WA and HRPL, in relation to OPA and LTPA, were examined using linear regression models. These models were adjusted for covariates including sex, age, body mass index, education level, alcohol consumption, smoking history, insomnia, occupation, hours worked, and income. RESULTS: The GAM and linear regression analyses revealed that higher LTPA corresponded with higher WA and lower HRPL. In contrast, as OPA increased, WA decreased and HRPL increased. However, within the group with high OPA, HRPL was not significantly lower in the high-LTPA subgroup relative to the low-LTPA subgroup (mean difference=1.92%, p=0.343). This pattern was especially pronounced among workers aged 60 years and older, with an increase in HRPL observed with increasing LTPA among the respondents with high OPA. CONCLUSIONS: High LTPA levels were associated with elevated WA and diminished HRPL. In contrast, higher levels of OPA were associated with lower WA and higher HRPL.
황 산화를 통해 퍼클로레이트를 분해하는 미생물 군집 분석
김영화(Young-Hwa Kim),한경림(Kyoung-Rim Han),황희재(Heejae Hwang),권혁준(Hyukjun Kwon),김예림(Yerim Kim),김건우(Kwonwoo Kim),김희주(Heejoo Kim),손명화(Myunghwa Son),최영익(Young-Ik Choi ),성낙창(Nak-Chang Sung),안영희(Yeonghee Ahn) 한국생명과학회 2016 생명과학회지 Vol.26 No.1
퍼클로레이트(ClO₄<SUP>-</SUP>)는 지표수 및 토양/지하수에서 검출되는 신규 오염물이다. 이전 연구에서 저렴한 원소 황(elemental sulfur, S<SUP>0</SUP>) 입자와 쉽게 구할 수 있는 활성슬러지를 이용하여 독립영양방식으로 ClO₄<SUP>-</SUP>를 제거할 수 있다는 실험적 증거가 제시되었다. 또한 식종균으로서 농화배양 미생물을 사용했을 때 활성슬러지보다 제거효율과 시간면에서 우수한 결과를 나타내었다. 그래서 본 연구에서는 황을 산화하여 독립영양방식으로 ClO4-를 분해하는 농화배양 미생물 군집을 PCR-DGGE로 분석하였다. 이 농화배양 미생물은 초기농도가 약 120 mg ClO₄<SUP>-</SUP>/l 일 때 7일 후 99.71% 이상의 ClO₄<SUP>-</SUP> 제거 효율을 나타내었다. 농화배양 미생물과 그것의 식종균으로 부터 genomic DNA를 추출하여 16S rRNA 유전자의 PCR-DGGE 분석에 사용하였다. PCR-DGGE 분석결과 농화배양 미생물과 식종균 시료들이 다른 밴드패턴을 나타냄에 따라 이 두 시료의 군집조성이 다름을 확인하였다. 이는 농화배양되는 동안 식종된 미생물이 그 환경에 잘 생장하는 미생물로 군집조성이 변화한 것으로 여겨진다. 농화배양 미생물군집에는 β-Proteobacteria, Bacteroidetes, 그리고 Spirochaetes 강에 속하는 개체군들이 우점하는 것으로 나타났다. 향후 이 우점 개체군들의 순수분리와 더불어 황 산화를 통한 ClO₄<SUP>-</SUP> 분해 환경에서 이들의 대사적 역할을 규명할 필요가 있다. Perchlorate (ClO₄<SUP>-</SUP>) is an emerging pollutant detected in surface water, soil, and groundwater. Previous studies provided experimental evidence of autotrophic ClO₄<SUP>-</SUP> removal with elemental sulfur (S<SUP>0</SUP>) particles and activated sludge, which are inexpensive and easily available, respectively. In addition, ClO₄<SUP>-</SUP> removal efficiency was shown to increase when an enrichment culture was used as an inoculum instead of activated sludge. PCR-DGGE was employed in the present study to investigate the microbial community in the enrichment culture that removed ClO₄<SUP>-</SUP> autotrophically. Microorganisms in the enrichment culture showed 99.71% or more ClO₄<SUP>-</SUP> removal efficiency after a 7-day incubation when the initial concentration was approximately 120 mg ClO₄<SUP>-</SUP>/l. Genomic DNA was isolated from the enriched culture and its inoculum (activated sludge), and used for PCR-DGGE analysis of 16S rRNA genes. Microbial compositions of the enrichment culture and the activated sludge were different, as determined by their different DGGE profiles. The difference in DGGE banding patterns suggests that environmental conditions of the enrichment culture caused a change in the microbial community composition of the inoculated activated sludge. Dominant DGGE bands in the enrichment culture sample were affiliated with the classes β-Proteobacteria, Bacteroidetes, and Spirochaetes. Further investigation is warranted to reveal the metabolic roles of the dominant populations in the ClO₄<SUP>-</SUP> degradation process, along with their isolation.
Kwon, Sooncheol,Park, Jin Kuen,Kim, Jehan,Kim, Geunjin,Yu, Kilho,Lee, Jinho,Jo, Yong-Ryun,Kim, Bong-Joong,Kang, Hongkyu,Kim, Junghwan,Kim, Heejoo,Lee, Kwanghee The Royal Society of Chemistry 2015 Journal of Materials Chemistry A Vol.3 No.15
<P>Processing additives have been widely utilized for high-performance organic bulk-heterojunction (BHJ) photovoltaic devices. However, the role of processing additives remained unclear due to the limited information relying on the final BHJ film state rather than the intermediate film state during solvent evaporation. Here, by using<I>in situ</I>GIWAXS measurements on the intermediate BHJ film, we propose a possible phase separation mechanism in efficient BHJ solar cells consisting of a narrow band gap polymer (P1) and PC71BM<I>via</I>the use of 1-chloronaphthalene (1-CN) as a processing additive. We found that adding small amounts of an additive, 1-CN, with a high boiling point and a high PC71BM solubility can prolong the solvent evaporation time and dissolve many PC71BM molecules, promoting the strong P1 polymer:solvent and PC71BM:solvent interaction to produce pure domains of each component. Thus, the bi-continuous networks for both P1 and PC71BM and their enlarged interfacial area are well fabricated in the BHJ films, inducing balanced photo-charge carrier densities for the electrons and holes and improving the overall photovoltaic performance. Therefore, our findings elucidate the kinetic motions of two organic phases affected by the physical properties of the solvents in the process of film formation and establish criteria for BHJ systems.</P>
Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia
( Heejoo Han ),( Ja Min Byun ),( Dong-yeop Shin ),( Sung-soo Yoon ),( Youngil Koh ),( Junshik Hong ),( Inho Kim ),( Chansup Lee ),( Hyeonjoo Yoo ),( Hongseok Yun ),( Man Jin Kim ),( Sung Im Cho ),( Mo 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.2
Background/Aims: Understanding leukemic stem cell (LSC) is important for acute myeloid leukemia (AML) treatment. However, association of LSC with patient prognosis and genetic information in AML patients is unclear. Methods: Here we investigated the associations between genetic information and the various LSC phenotypes, namely multipotent progenitor (MPP)-like, lymphoid primed multipotent progenitor (LMPP)-like and granulocyte-macrophage progenitors (GMP)-like LSC in 52 AML patients. Results: In secondary AML patients, MPP-like LSC was significantly higher than de novo AML (p = 0.0037). The proportion of MPP-like LSC was especially high in post-myeloproliferative neoplasm AML (p = 0.0485). There was no correlation between age and LSC phenotype. Mutations of KRAS and NRAS were observed in MPP-like LSC dominant patients, TP53 and ASXL1 mutations in LMPP-like LSC dominant patients, and CEBPA, DNMT3A and IDH1 mutations in GMP-like LSC dominant patients. Furthermore, KRAS mutation was significantly associated with MPP-like LSC expression (p = 0.0540), and TP53 mutation with LMPP-like LSC expression (p = 0.0276). When the patients were separated according to the combined risk including next generation sequencing data, the poorer the prognosis, the higher the LMPP-like LSC expression (p = 0.0052). This suggests that the dominant phenotype of LSC is one of the important factors in predicting the prognosis and treatment of AML. Conclusions: LSC phenotype in AML is closely associated with the recurrent mutations which has prognostic implication. Further research to confirm the meaning of LSC phenotype in the context of genetic aberration is warranted.