Clinical characteristics of pyometra: 10-year experience from a single institution

( Darae Lee ),( Yung-taek Ouh ),( Heejoo Hong ),( Boram Lee ),( Chorong Kim ),( Yoon Hyeon Hu ),( Tae Yeon Kim ),( Se Jin Lee ),( Tae Gyu Ahn ),( Hyang Ah Lee ),( Sunghun Na ),( Jong Yun Hwang ),( Don 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Corpus luteal cyst Rupture with Tubal Abortion

( Darae Lee ),( Yoon Hyeon Hu ),( Chorong Kim ),( Tae Gyu Ahn ),( Hyang Ah Lee ),( Sunghun Na ),( Jong Yun Hwang ),( Dong Hun Lee ),( Se Jin Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Corpus luteum cyst rupture with consequent hemoperitoneum is a common disorder in women in their reproductive age. And ectopic pregnancy has also hemoperitoneum. Tubal abortion, which is a rare type of ectopic pregnancy, is characterized by the extrusion of an ectopic product of conception implanted in the fallopian tube through the abdominal ostium into the peritoneal cavity. A 39-year-old woman visited emergency room because of abnormal bleeding and lower abdominal pain since 3 days ago. She was an infertile patient. She had In vitro fertilization and embryo transfer a month ago, but she failed pregnancy and continued to had vaginal bleeding. In urine test, human chorionic gonadotropin (hCG) was positive. Ultrasonographic findings showed that the absence of an intrauterine gestational sac, with bilateral ovarian anechoic cyst and small echogenic free fluid in posterior Cul-de-Sac(PCDS). According to the blood test, beta-hCG was 3,679 mIU/mL and hemoglobin was 8.4 g/dL. The vital sign was stable. She was hospitalized and monitored, and the next morning on a blood test, beta-hCG dropped to 2,905mIU/mL and hemoglobin 7.3 g/dL. Ultrasound findings, fluid collection was increased, and emergency surgery was determined. In the surgical findings, hematoma of the right fallopian tube was observed, cyst rupture was found in the right ovary, and ovarian cyst was also observed in the left ovary. She had right salpingectomy, bilateral ovarian cystectomy, and dilatation and curettage with biopsy. Pathologic results were hematoma in tubal lumen, hemorrhagic corpus luteal cyst. In uterine endometrium, there are proliferative glands with predecidualized stroma. After surgery, she was received routine post-operation care and discharged home. We report a rare hemoperitoneum case in which both hemorrhagic corpus luteal cyst and tubal abortion developed simultaneously.

Multilayered Graphene Electrode using One-Step Dry Transfer for Optoelectronics

Lee, Seungmin,Jo, Yeongsu,Hong, Soonkyu,Kim, Darae,Lee, Hyung Woo Optical Society of Korea 2017 Current Optics and Photonics Vol.1 No.1

In this study, multilayered graphene was easily transferred to the target substrate in one step using thermal release tape. The transmittance of the transferred graphene according to the number of layers was measured using a spectrophotometer. The sheet resistance was measured using a four-point probe system. Graphene formed using this transfer method showed almost the same electrical and optical properties as that formed using the conventional poly (methyl methacrylate) transfer method. This method is suitable for the mass production of graphene because of the short process time and easy large-area transfer. In addition, multilayered graphene can be transferred on various substrates without wetting problem using the one-step dry transfer method. In this work, this easy transfer method was used for dielectric substrates such as glass, paper and polyethylene terephthalate, and a sheet resistance of ~240 ohm/sq was obtained with three-layer graphene. By fabricating organic solar cells, we verified the feasibility of using this method for optoelectronic devices.

The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia

Lee, Min Jung,Park, Seung Hwan,Han, Ju Hua,Hong, Yoon Ki,Hwang, Soojin,Lee, Soojin,Kim, Darae,Han, Seung Yeop,Kim, Eun Soo,Cho, Kyoung Sang Springer-Verlag 2011 Molecules and cells Vol.31 No.4

A case of Mowat-Wilson syndrome with developmental delays and Hirschsprung's disease

Lee, Darae,Kim, Ja Hye,Cho, Ja Hyang,Oh, Moon-Yun,Lee, Beom Hee,Kim, Gu-Hwan,Choi, Jin-Ho,Yoo, Han-Wook Korean Society of Medical Genetics and Genomics 2014 대한의학유전학회지 Vol.11 No.2

Mowat-Wilson syndrome is an extremely rare genetic disease that is characterized by intellectual disability, facial dysmorphism, Hirschsprung's disease, and other congenital anomalies. This disorder is caused by heterozygous mutations or deletions in the zinc finger E-box-binding homeobox-2 gene (ZEB2). Thus far, approximately 200 cases of Mowat-Wilson syndrome have been reported worldwide. In Korea, only one case with a 2q22 deletion, which also affects ZEB2, has been previously reported. Here, we describe a patient with Mowat-Wilson syndrome who presented with developmental delays, typical facial dysmorphism, and Hirschsprung's disease. Molecular analysis of ZEB2 identified a novel heterozygous mutation at c.190dup ($p.S64Kfs^*6$). To our knowledge, this is the second report of a Korean patient with Mowat-Wilson syndrome that has been confirmed genetically.

L-type amino acid transporter SLC43A2 in ovarian cancer regulate accumulation and suppressive function of MDSC in TME

( Darae Lee ),( Iseul Kim ),( Eun-jeong Park ),( Boram Lee ),( Chorong Kim ),( Yoon Hyeon Hu ),( Heejoo Hong ),( Se Jin Lee ),( Tae Gyu Ahn ),( Hyang Ah Lee ),( Sung Hun Na ),( Jong Yoon Hwang ),( Yun 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: Ovarian cancer is the most lethal malignant cancer in women. Myeloid-derived suppressor cells (MDSCs) accumulation in tumor microenvironment (TME) contribute poor prognosis of ovarian cancer patients. Tumor cells consume high amount of nutrition to meet their bioenergetics/biosynthetic demands. High nutrition demand of tumor cells leads to deprivation of several nutrition in TME, making that tumor-infiltrating immune cells compete with cancer cells for nutrition to maintain their own function. SLC43A2 is a type of L-type amino acid transporter found in various cancers, resulting in methionine deprivation in TME. Methods: The TCGA data sets were used for analyzing the correlation of SLC43A2 mRNA, MDSC markers, and overall survival of ovarian cancer patients. Whole blood was collected from fifteen patients who underwent debulking surgery in Kangwon National University Hospital. PBMC and serum was isolated from the whole blood. Immune cells in PBMC were analyzed with flowcytometry. Methionine was measured with LC/MS method. Results: We found that SLC43A2 mRNA negatively correlates with overall survival and mRNA of MDSC markers including CD33, CD14, CD15 and PD-L1 from ovarian cancer patients as assessed with TCGA data sets. Additionally, serum methionine concentration showed negative correlation with percent of CD11b+ CD33+ cells (represented as MDSC phenotype) in PBMCs donated from ovarian cancer patient cohort. We also found that tumor growth was delayed and tumor-infiltrating granulocytic MDSCs was reduced in SLC43A2 KO melanoma-bearing mice as compared to WT-bearing mice. Gr-1+ MDSCs isolated from SLC43A2 KO melanoma-bearing mice revealed reduced T cell suppression activity than MDSCs isolated from WT melanoma-bearing mice. Conclusion: These findings suggested that alteration of TME metabolism due to high level of SLC43A2 expression in cancer cells resulting in methionine deprivation can affect MDSC physiology and anti-cancer immunity.

A case of tubo-ovarian abscess with arthritis at sacroiliac joint

( Boram Lee ),( Darae Lee ),( Chorong Kim ),( Heejoo Hong ),( Iseul Kim ),( Eun-jeong Park ),( Yoon Hyeon Hu ),( Yung-taek Ouh ),( Tae Gyu Ahn ),( Hyang Ah Lee ),( Jong Yun Hwang ),( Sunghun Na ),( Se 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Tubo-ovarian abscess (TOA) is an encapsulated, complex infectious mass of the adnexa that usually involves the fallopian tubes and ovaries, but may also involve other pelvic organs. A 44-year-old woman with a referred to the emergency room with low abdominal pain and left hip pain 5 days before visit. Since the insertion of an intrauterine device in 2008, she removed that device and was treated with antibiotics 5 days ago at local hospital. Except body temperature (38.0), other vital signs were all normal. In physical examination she had only remarkable for Lt. hip thigh tenderness. The blood tests showed elevated white cell count of 13,200/L with elevated C-reactive protein, 16.053mg/dL. Contrast-enhanced computed tomography (CT) showed multiloculated cystic lesion with thick enhancing wall and septa at left adenexa; a pelvic inflammatory disease with tubo-ovarian abscess was suspected, and the patient was admitted to the hospital for treatment. After admission, she was taken Magnetic Resonance Imaging (MRI), Sacroiliac(SI) joint due to left hip pain and the result was abnormal marrow signal intensity at left SI joint with enhancement, a left sacroilitis was suspected. The fever and left hip pain persisted despite of empirical antibiotics therapy and blood culture revealed the presence of gram-positive bacteria, thus surgical intervention was arranged. During the operation, there were adhesions between bowel and left adnexa and left adnexa mass was observed. She had pelviscopic left salpingo-oophorectomy and drainage insertion. After surgery, her lab findings were improved but left hip pain got worsen. So, she was taken MRI, SI joint again and the results was increased joint effusion with synovial thickening, with microabscess. After cunsultation with orthopedics doctor, she got surgery of incision and drainage at S-I joint. After surgery, her hip pain was improved, and she discharged.

한반도에서의 수증기 경년변화와 기후인자와의 상관성 분석

이다래(Darae Lee),한경수(Kyung-soo Han),권채영(Chaeyoung Kwon) 대한공간정보학회 2017 한국지형공간정보학회 학술대회 Vol.2017 No.5

수증기는 지구 장파복사 에너지의 주요 흡수인자로서 지표 온도 상승을 가속화시킨다. 이러한 변화는 대기 중 물 순환의 변화를 야기해 다양한 기상 현상을 발생시키고 있다. 이에 기상의 변화를 이해하고 예측하기 위해서는 수증기량의 변화를 모니터링 하는 것은 필수적이다. 따라서 본 연구에서는 시공간적 변동성을 파악하기 용이한 위성관측을 통해 수집된 수증기 자료를 사용하여 수증기의 장기적인 변화패턴을 모니터링 하였으며, 기후인자들 중 수증기를 통해 생성되는 강수량과 다른 기후인자들에 비해 비교적 주기적으로 나타나는 엘니뇨와의 상관성을 분석하였다. 위성관측을 통해 수집된 수증기자료는 Moderate-Resolution Imaging Spectroadiometer(MODIS) 센서를 통해 관측된 Total Precipitable Water (TPW) 자료를 사용하였으며, 시계열 분석을 통해 TPW와 중부지방 강수량의 변화를 정량적으로 산출하고, 아노말리분석을 통해 이들 간의 상관관계를 엘니뇨와 함께 분석하였다. 그 결과 엘니뇨가 발생한 후 TPW와 강수량의 상관관계가 정 상관관계에서 역 상관관계로 나타나는 것을 확인하였다.

Landsat 8 위성 기반 고해상도 지표면 광대역 알베도 산출

이다래 ( Darae Lee ),서민지 ( Minji Seo ),이경상 ( Kyeong-sang Lee ),최성원 ( Sungwon Choi ),성노훈 ( Noh-hun Sung ),김홍희 ( Honghee Kim ),진동현 ( Donghyun Jin ),권채영 ( Chaeyoung Kwon ),허모랑 ( Morang Huh ),한경수 ( Kyung-soo 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.6

알베도는 태양에너지의 흡수량을 결정하는 주요 기후 변수 중 하나로서, 이러한 알베도를 산출하는 것은 기후 변화 연구에 있어 중요한 과정이다. 이 때, 산출된 알베도 자료를 효율적으로 사용하기 위해서는 높은 공간해상도와 장기간의 일관성 있는 산출이 중요하게 고려된다. 따라서 본 연구에서는 Landsat 8을 기반으로 Landsat 7과의 일관성을 유지한 고해상도 지표면 광대역 알베도를 산출하였다. 먼저, Landsat 7과 Landsat 8의 채널 별 일관성을 분석한 결과, 상관계수(R)가 평균 0.96으로 높은 상관성을 보였다. 이러한 결과를 바탕으로 Landsat 7 알베도와 Landsat 8 반사도 채널 자료를 다중회귀분석에 적용하여 Landsat 8 광대역 알베도 전환 식을 도출하였다. 도출된 식을 통해 Landsat 8 지표면 광대역 알베도를 산출하고, Landsat 7 알베도 자료와 비교하여 검증하였다. 그 결과 R-square(R²)가 0.89, Root Mean Square Error (RMSE)가 0.003의 높은 정확도를 보였다. Albedo is one of the climate variables that modulate absorption of solar energy, and its retrieval is important process for climate change study. High spatial resolution and long-term consistent periods are important considerations in order to efficiently use the retrieved albedo data. This study retrieved surface broadband albedo based on Landsat 8 as high resolution which is consistent with Landsat 7. First of all, we analyzed consistency of Landsat 7 channel and Landsat 8 channel. As a result, correlation coefficient(R) on all channels is average 0.96. Based on this analysis, we used multiple linear regression model using Landsat 7 albedo, which is being used in many studies, and Landsat 8 reflectance channel data. The regression coefficients of each channel calculated by regression analysis were used to derive a formula for converting the Landsat 8 reflectance channel data to broadband albedo. After Landsat 8 albedo calculated using the derived formula is compared with Landsat 7 albedo data, we confirmed consistency of two satellite using Root Mean Square Error (RMSE), R-square (R²) and bias. As a result, R² is 0.89 and RMSE is 0.003 between Landsat 7 albedo and Landsat 8 albedo.

가강수량의 변화패턴과 기후인자와의 상관성 분석

이다래 ( Darae Lee ),한경수 ( Kyung Soo Han ),권채영 ( Chaeyoung Kwon ),이경상 ( Kyeong Sang Lee ),서민지 ( Minji Seo ),최성원 ( Sungwon Choi ),성노훈 ( Noh Hun Seong ),이창석 ( Chang Suk Lee ) 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.3

수증기는 지구 장파 복사에너지의 주요 흡수인자이다. 따라서 수증기량의 변화를 모니터링하고 변화의 원인을 세밀하게 조사하는 것은 필수적이다. 본 연구에서는 위성관측에 의해 얻어지는 Total Precipitable Water (TPW)자료를 사용하여 가강수량의 변화패턴을 모니터링 하고자 한다. 또한 기후인자들 중 수증기를 통해 생성되어 수증기의 변화패턴을 분석하는데 있어 중요한 역할을 하는 강수량과 다른 기후인 자들에 비해 비교적 주기적으로 나타나는 엘니뇨를 통해 가강수량의 변화패턴과 기후인자와의 상관성분석을 실시하고자 한다. 본 연구에서는 TERRA/AQUA 위성의 Moderate-Resolution Imaging Spectroadiometer (MODIS) 센서를 통해 관측된 TPW의 장기적인 변화와 한반도 중남부지방의 강수량변화를 정량적으로 분석 하고, 이들의 관계를 엘니뇨와 함께 비교하였다. 이를 통해 엘니뇨의 발생이 한반도 중남부지방의 강수량과 TPW의 변화에 영향을 주고 있는 지에 대해 조사하고자 한다. 먼저, 시계열 분석을 통해 TPW와 중남부지방 강수량의 변화를 정량적으로 산출하고 anomaly분석을 통해 이들의 변화를 세밀하게 분석한 결과 서로 반대 의 양상을 띠는 부분이 발견되어 엘니뇨의 anomaly분석결과와 비교하였다. 그 결과 대부분 같은 양상을 띠고 있던 TPW와 강수량이 엘니뇨가 발생한 후 서로 반대의 양상을 띠는 것을 확인하였다. Water vapor is main absorption factor of outgoing longwave radiation. So, it is essential to monitoring the changes in the amount of water vapor and to understanding the causes of such changes. In this study, we monitor temporal variability of Total Precipitable Water (TPW) which observed by satellite. Among climate variables, precipitation play an important part to analyze temporal variability of water vapor because it is produced by water vapor. And El Nino is one of climate variables which appear regularly in comparison with the others. Through them, we analyze relationship between temporal variability of TPW and climate variable. In this study, we analyzed long-term change of TPW from Moderate-Resolution Imaging Spectroadiometer (MODIS) data and change of precipitation in middle area of Korea peninsula quantitatively. After these analysis, we compared relation of TPW and precipitation with El Nino. The aim of study is to research El Nino has an impact on TPW and precipitation change in middle area of Korea peninsula. First of all, we calculated TPW and precipitation from time series analysis quantitatively, and anomaly analysis is performed to analyze their correlation. As a result, TPW and precipitation has correlation mostly but the part had inverse correlation was found. This was compared with El Nino of anomaly results. As a result, TPW and precipitation had inverse correlation after El Nino occurred. It was found that El Nino have a decisive effect on change of TPW and precipitation.