http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과
박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.
대장암 주변에서 관찰되는 백색반점의 병리조직학적 특성과 임상적 의의
김효종,조진만,장린,동석호,김윤화,장영운,박일랑,김병호,이정일 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4
Background/Aims: To investigate the difference between colorectal adenocarcinomas with white spots (foamy cells) and those without white spots, clinically and histopathologically, were examined 37 cases of colorectal adenocarcinomas were classified in this study. Methods: Two groups: those with white spots and those without. In each case, evidence of lymph node and liver metastasis was sought. Immunoreactive staining for macrophage was performed. Results: Increased incidence of exophytic tumors was found (73%, p=0.028) in the group with white spots. The incidences of lymph node metastasis were 33% vs. 45% between the group with white spots and the group of without, but the difference was not statistically significant. Conclusions: These results suggested that foamy cells might have a beneficial role in colorectal cancer, although they were not statistically significant. Therefore, further prospective study be warranted.
Nguyen, Van Dao,Min, Byoung-Cheol,Kyung, Myung-Ok,Park, Jong-Tae,Lee, Byong Hoon,Choi, Chung-Hyo,Seo, Nam-Seok,Kim, Yong-Ro,Ahn, Dong Uk,Lee, Sung-Joon,Park, Cheon-Seok,Kim, Jung-Wan,Park, Kwan-Hwa John Wiley Sons, Ltd. 2009 Phytochemical analysis Vol.20 No.6
<P>Introduction – Kudzu root (Radix puerariae) is a rich source of isoflavones that are effective in preventing osteoporosis, heart disease and symptoms associated with menopause. The major isoflavonoids in kudzu root extracts were reported as puerarin, daidzin and daidzein. Recently, an unknown isoflavonoid (compound 1) was detected from one-year-old kudzu root cultivated in Vietnam.</P><P>Objective – To identify a novel compound 1 in kudzu root extract and determine the structure of the compound by ESI<SUP>+</SUP> TOF MS-MS, <SUP>1</SUP>H-, <SUP>13</SUP>C-NMR and enzymatic hydrolysis.</P><P>Methodology – Samples were prepared by extraction of one-year-old kudzu root with 50% ethanol and the isoflavonoids were purified using recycling preparative HPLC. Unknown compound 1 was detected using UV-light at 254 nm in TLC and HPLC analyses. The molecular weight of 1 was determined using a TOF mass spectrometer equipped with an electrospray ion source. The structure of 1 was determined from the <SUP>13</SUP>C and <SUP>1</SUP>H NMR spectra recorded at 100.40 and 400.0 MHz, respectively.</P><P>Results – ESI<SUP>+</SUP> TOF MS-MS analysis shows that 1 is a puerarin diglycoside. The interglycosidic linkage of diglycoside determined by <SUP>1</SUP>H-, <SUP>13</SUP>C-NMR, and enzymatic hydrolysis suggests that 1 has a glucosyl residue linked to puerarin by an α-1,6-glycosidic bond. This compound is the first naturally-occurring 8-[α-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]daidzein in kudzu root. The concentration of glucosyl-α-1,6-puerarin in kudzu root was 2.3 mg/g as determined by HPLC.</P><P>Conclusion – The results indicate that puerarin diglycoside is one of the major isoflavonoids in kudzu root and has a significant impact on the preparation of highly water-soluble glycosylated puerarin. Copyright © 2009 John Wiley & Sons, Ltd.</P>
Syk Plays a Critical Role in the Expression and Activation of IRAK1 in LPS-Treated Macrophages
Park, Jae Gwang,Son, Young-Jin,Yoo, Byong Chul,Yang, Woo Seok,Kim, Ji Hye,Kim, Jong-Hoon,Cho, Jae Youl Hindawi 2017 MEDIATORS OF INFLAMMATION Vol.2017 No.-
<P>To address how interleukin-1 receptor-associated kinase 1 (IRAK1) is controlled by other enzymes activated by toll-like receptor (TLR) 4, we investigated the possibility that spleen tyrosine kinase (Syk), a protein tyrosine kinase that is activated at an earlier stage during TLR4 activation, plays a central role in regulating the functional activation of IRAK1. Indeed, we found that overexpression of myeloid differentiation primary response gene 88 (MyD88), an adaptor molecule that drives TLR signaling, induced IRAK1 expression and that piceatannol, a Syk inhibitor, successfully suppressed the MyD88-dependent upregulation of IRAK1 under LPS treatment conditions. Interestingly, in Syk-knockout RAW264.7 cells, IRAK1 activity was almost completely blocked after LPS treatment, while providing a Syk-recovery gene to the knockout cells successfully restored IRAK1 expression. According to our measurements of IRAK1 mRNA levels, the transcriptional upregulation of IRAK1 was induced by LPS treatment between 4 and 60 min, and this can be suppressed in Syk knockout cells, providing an effect similar that that seen under piceatannol treatment. The overexpression of Syk reverses this effect and leads to a significantly higher IRAK1 mRNA level. Collectively, our results strongly suggest that Syk plays a critical role in regulating both the activity and transcriptional level of IRAK1.</P>
Park, Chin-Ju,Choi, Byong-Seok Blackwell Publishing Ltd 2006 FEBS JOURNAL Vol.273 No.8
<P>Xeroderma pigmentosum (XP) is an inherited disease in which cells from patients exhibit defects in nucleotide excision repair (NER). XP proteins A–G are crucial in the processes of DNA damage recognition and incision, and patients with XP can carry mutations in any of the genes that specify these proteins. In mammalian cells, NER is a dynamic process in which a variety of proteins interact with one another, via modular domains, to carry out their functions. XP proteins are key players in several steps of the NER process, including DNA strand discrimination (XPA, in complex with replication protein A), repair complex formation (XPC, in complex with hHR23B; XPF, in complex with ERCC1) and repair factor recruitment (transcription factor IIH, in complex with XPG). Through these protein–protein interactions, various types of bulky DNA adducts can be recognized and repaired. Communication between the NER system and other cellular pathways is also achieved by selected binding of the various structural domains. Here, we summarize recent studies on the domain structures of human NER components and the regulatory networks that utilize these proteins. Data provided by these studies have helped to illuminate the complex molecular interactions among NER factors in the context of DNA repair.</P>
Estimation of Optimum Organic Fertilizer Application under Fertilizer Recommendation System
Seok cheol Kim,Byong Gu Ko,Seong Jin Park,Myung Sook Kim,Seong Heon Kim,Chang Hoon Lee 한국토양비료학회 2018 한국토양비료학회지 Vol.51 No.3
Organic fertilizer has been one of soil management to improve crop productivity and soil fertility. Unfortunately, there is little information on optimum level of organic fertilizer for crop cultivation. In this study, we were tried to use the fertilizer recommendation system for determining organic fertilizer application under upland soil condition. This work was carried out; 1) to compare the effects of organic fertilizer and compost application on yields of Chinese cabbage, and 2) to estimate optimum levels on three types of organic fertilizer of 0, 50, 100, 200, and 400% with 320 kg N ha<SUP>-1</SUP>. The yield of Chinese cabbage in organic fertilizer plots was ranged from 71.3 to 74.1% compared to yield index of NPK. which was 2-7 times higher than in compost treatments due to improvement of N uptake efficiency. However, organic fertilizer was required addition of about 1.5-2.0 times amount to the 4 Mg ha<SUP>-1</SUP> to gain the same yield of NPK treatment, these was similar soil properties of NPK treatments. This result indicated that fertilizer recommendation system could be alternative to calculate optimum levels of organic fertilizer for crop cultivation in upland soil.