함암요법으로 골수기능이 억제된 악성종양환자에서 rhG-CSF의 임상적 효과

김원민,서영환,조경상,유병전,김상도,이승일,정춘해 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

We have studied the efficacy of rhG-CSF in patients with non-hodgkin's lymphoma, acute leukemia, and small cell lung cancer undergoing anticancer chemotherapy. These patients were below leukocyte count 3,000 cubic millimeter due to myelosuppression induced by the first cycle of intensive chemotherapy. Treatment with rhG-CSF (100㎍ per square meter of body surface area per day in a 30-minute intravenous infusion) was begun two days and for 14 consecutive days after the end of the second cycle of chemotherapy. The results were as follows. 1. The onset of myelosuppression was 6 days after chemotherapy, and the onset of recovery was 16.7 days after chemotherapy, and the duration of granulocytopenia was 10.7 days in patients with malignant tumor during contrast period. 2. The duration of granulocytopenia was shortened 5.2 days in patients administered rhG-CSF than without rhG-CSF, and we observed the shortest duration of granulocytopenia with increasing granulocyte in patients with small cell lung cancer. 3. Observing the differential count of leukocyte checked the highest level of leukocyte in contrast and rhG-CSF period, the persentage of neutrophil was increased in patients with acute leukemia and small cell lung cancer during rhG-CSF period, but not increased in patients with non-hodgkin's lymphoma. 4. rhG-CSF was not influenced on liver faction, renal fuction, uric acid, and glucose metabolism, also had no effect on recovery of platelet. In conclusion, rhG-CSF can be administered to patients with hematologic or nonhematologic malignant tumor that myelosuppression induced by anticancer chemotherapy result in shortening the duration of granulocytopenia and increasing the peripheral neutrophil, therefore full dose chemotherapy can be administered on time, and rhG-CSF may reduce the morbidity and mortality of patients with malignant tumor undergoing chemotherapy.

치매예방을 위한 기능성 보조식품의 섭취 제안

( Byeong Hwan Jeon ) 대한운동사협회 2019 대한운동사협회 운동사대회자료집 Vol.2019 No.-

The Change of Glutathione Peroxidase Concentration with the Exercise Intensities during the Progressive Maximal Exercise Test

Jeon, Byeong-Hwan,Jun, Tae-Won,Woo, Jae-Hong,Park, Ik-Ryeul,Kim, Kwang-Jun,Suk, Min-Hwa 한국체육무용국제교류학회 2003 한국체육무용국제교류학회지 Vol.9 No.-

This study examines the change of plasma glutathione peroxidase (GRx) concentration during the progressive maximal exercise test performed on 9 untrained males(28.67±2.45yr). The VO_(2max) was determined through the pretest(treadmill running by Bruce protocol). On the main test, the blood of 9 untrained males was sampled on the rest state, the intensities leveled at 50%, 60%, 70%, 80%, 90% and 100% of VO_(2max), as well as 3 minutes and 6 minutes after the recovery. With the collected blood samples, the concentration of plasma GPx was analyzed by ELISA(Enzyme-linked immunosorbent assay). In addition, the changes of lactate concentration and energy expenditure were analyzed to compare with that of plasma GPx concentration. The statistical differences were determined by applying one-way ANOVA (p<0.05). The results suggest that there is no significant change in the plasma GPx concentration with the incremental exercise intensities. Furthermore, there are no noticeable relationships between the GPx concentration and the lactate cancentration. or the energy expenditure in their changes.

쥐의 골격근에서 리튬, 인슐린 및 근수축 복합처치가 당수송 활성도에 미치는 영향

전병환(Byeong-Hwan Jeon) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.4

리튬은 기저수준의 당수송 활성도에 있어 단지 최소한의 효과만 있고, 반면 인슐린에 대한 민감성을 매우 증가시켜 인슐린에 의해 증가된 당수송 활성도를 증가시키는 것으로 알려져 있다. 또한 리튬은 인슐린의 반응성을 증가시키는 효과도 보이고 있다. 한편, 당수송 과정을 증가시키는 리튬의 효과는 인슐린 자극당수송에만 국한되는 것이 아니라, 최대하 수준의 근수축에 의한 당수송의 민감성을 증가시키는 것으로 알려져 있다. 하지만 사전실험을 통해 리튬이 최대수준의 근수축에서도 당수송의 활성도가 증가하는 당수송의 반응성의 가능성이 제기되었다. 따라서 본 연구에서는 최대수준의 당유입을 자극하는 근수축에 대해 리튬이 미치는 영향을 조사하여, 리튬이 근수축에 의한 당수송의 반응성도 강화시키는지의 여부를 확인하고자 하였다. 본 연구의 목적에 따라 쥐의 활차근을 분리하여, 당수송을 최대수준으로 활성화시키는 근수축 자극 그리고/ 혹은 인슐린 자극과 병행하여 리튬을 처치하였다. 그 결과 리튬은 근수축 그리고/혹은 인슐린-자극 당유입을 강화시켜 당수송의 반응성을 향상시키지만, 리튬의 단독 처치는 당수송에 대한 향상에 효과가 매우 적은 것으로 나타났다. 따라서 리튬은 근수축 그리고 혹은 인슐린과의 복합처치를 통해 당수송의 반응성을 증가시킴으로써 인슐린 저항성이나 당뇨 치료에 중요한 역할을 할 수 있는 가능성을 갖는 것으로 사료된다. Lithium has only a minimal effect on basal glucose transport activity, instead that lithium markedly increased the sensitivity of glucose transport to insulin by increasing in insulin induced glucose transport activity. And Lithium increases in insulin responsiveness as well. Previous studies has reported this enhancement of lithium to stimulate the glucose transport process is not only limited to insulin, it also induce the increases in the sensitivity of glucose transport by submaximal contractile activity. The preliminary study, however, leads that Lithium possibly improves the responsiveness of glucose transport with maximal muscle contraction. In this study, we investigated the effect of Lithium on contraction for the maximal glucose transport. For the purpose of this study, Epitrochlearis muscles of SD rat were isolated and treated Lithium with electric contraction and/or insulin to activate the maximal glucose transport. The results support that Lithium improves the responsiveness of glucose transport through potentiates contraction and /or insulin induced-glucose uptake in muscle. Consequently Lithium treated with muscle contraction and insulin has the important potential to improve the insulin resistance and diabetes.

골감소증 중년여성의 골밀도와 신체조성 및 근력, 혈중 대사기질 및 성장요인의 비교연구

전병환(Jeon, Byeong Hwan) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.1

To elucidate the relation among the osteopenia and sarcopenia, it has been analyzed the body composition, muscular strength and blood growth factors as their controlling expressive functions in osteopenic middle-aged women. The osteopenic group (n=12) and normal group (n=11) had measurements of bone mineral density, body composition, isokinetic muscular strength, substrates and growth related factors in blood. The results showed that lower limb muscle mass were significantly higher in the normal group than in the osteopenic group, and body fat mass was significantly higher in the osteopenic group than in the normal group. Isokinetic muscular strength was shown lower peak torque/body weight and total work at 60 degree/sec of knee extension, and lower peak torque/body weight and total work at 180 degree/sec of knee extension, as well. IGF-1 was significantly lower in the osteopenic group than in the normal group. In addition, there was a statistical correlation between T-score and dependent variables in lower limb muscle mass, a negative correlation in total fat mass and in muscular strength. In conclusion, osteopenia and sarcopenia seems to be closely related to fat mass, muscle mass and muscular strength in middle-aged women.

트위스트 운동 시 성별에 따른 심박수와 에너지 소모량의 비교

전병환(Byeong-Hwan JEON) 한국수산해양교육학회 2015 水産海洋敎育硏究 Vol.27 No.1

araA를 이용한 AMPK 활성 억제가 인슐린, 근수축, 저산소증, AICAR 유발 골격근내 포도당 이동률에 미치는 영향

전병환 ( Byeong Hwan Jeon ),정수련 ( Su Ryun Jung ) 한국운동생리학회(구-한국운동과학회) 2010 운동과학 Vol.19 No.4

본 연구의 목적은 근수축과 저산소증 유발 시 araA를 이용한 AMPK 활성 차단이 골격근의 당수송에 미치는 영향을 규명하는 것이다. 수컷 Wister계 흰쥐 65마리를 대상으로 1주일간의 환경 적응과 12시간 금식 후, epitrochlearis muscle을 적출하여 골격근내 포도당 이동률을 측정하였다. araA 처치후 각각 인슐린 (2mU/ml, 60min), AICAR (2mM, 60min), 근수축(tetanic, 100Hz-10s, 10min), 저산소 (95% N2, 5% CO2, 80min) 자극을 사용하여 근육내로 포도당을 이동시켰고, 포도당 이동률은 세포내외의 14C-mannitol과 3H-3-o-methylglucose의 radioactivity를 측정하여 산출하였다. 본 연구결과 araA 처치는 AICAR, 근수축, 저산소자극에 의한 골격근의 당수송을 약 65% 감소시켰다. 그러나 인슐린 자극에 의한 근육 당수송은 변화가 없었다. 요약하면 araA에 의한 AMPK 억제는 인슐린 자극에 의한 당수송에는 영향을 미치지 않고 근수축과 저산소증에 의한 당수송은 억제하였다. 이러한 결과는 근수축과 저산소증 자극에 의한 근육 당수송에는 AMPK 활성화가 중요한 역할을 한다는 가설을 지지하는 것이다. 또한 이는 인슐린 자극에 의한 골격근내 포도당 이동의 영향을 받지 않고 근수축과 저산소증 자극에 의한 골격근의 포도당 이동만을 차단할 수 있음을 암시하는 것으로 생각된다. We used araA to evaluate the hypothesis that AMPK activation is involved in the stimulation of muscle glucose transport by contractions and hypoxia. After 1 week of adaptation period to the laboratory environment, 65 male Wistar rats were fasted for 12 hr. Rats were anesthetized and the epitrochlearis muscles were removed to measure glucose transport rate in muscle. To evaluate the rate of contraction (tetanic, 100Hz-10s, 10min), hypoxia (95% N2, 5% CO2, 80min), AICAR (2mM, 60min), insulin (2mU/ml, 60min) stimulated glucose transport activity after araA treat, we use 5 processing steps (Recovery, preincubation, stimulation, rinse, incubation). After rinse, muscles were incubated with two tracer (14C-mannitol, 3H-3-o-methylglucose) for 10 min, and radioactivity was measured with scintillation counter. Preincubation of muscles with 2 mM araA inhibited the stimulation of glucose transport induced by AICAR, contractions, or hypoxia by ~65%. Insulin-stimulated muscle glucose transport was not inhibited by araA. These findings provide support for the hypothesis that activation of AMPK is involved in the stimulation of muscle glucose transport by contractions and hypoxia. They clearly show that it is possible to inhibit the stimulation of glucose transport by contractions and hypoxia without affecting insulin-stimulated glucose transport in skeletal muscle.

Effects of Low Intensity Blood Flow Restriction Training on Muscle Volume, Strength and Power in Healthy Middle-Aged Females

전병환(Byeong-hwan Jeon) 대한운동학회 2022 아시아 운동학 학술지 Vol.24 No.4

OBJECTIVES The purpose of this study is to investigate the efficacy of weight training with controlled blood flow occlusion compared to conventional resistance training, in the ageing population. METHODS Twenty-three healthy female subjects (aged 40-55) were randomly assigned to one of three groups; low intensity blood flow restriction training (LI-BFRT) (n = 9), conventional resistance training (RT) (n = 7) and control (CON) (n = 7). The RT group trained between 65-70% one repetition maximum (1RM) and the LI-BFRT group trained at 30% 1RM while wearing pressure cuffs inflated to 100-120% of brachial systolic blood pressure (bSBP). Relative appendicular skeletal muscle mass (ASM/weight), isokinetic strength and power were tested pre and post 8 weeks of training. RESULTS Upper limb ASM/weight increased significantly in the LI-BFRT and RT groups (both p < 0.001). Only LI-BFRT showed significant difference compared with the CON group (p < 0.01). Lower limb ASM/weight improved in both the LI-BFRT (p < 0.01) and CON (p < 0.01) groups without group differences. Lower limb flexion strength increased in the LI-BFRT and RT groups (both p < 0.01), with differences between groups (p < 0.01, LI-BFRT > RT > CON). Only RT increased extension muscle strength (p < 0.05). Lower limb flexion and extension power improved following LI-BFRT (p < 0.05 and p < 0.01, respectively), significantly greater than RT in both flexion (p < 0.001) and extension (p < 0.01). CONCLUSIONS LI-BFRT may be as, if not more effective than RT for increasing muscle volume, strength and power in middle-aged women.

일축 연신에 의한 폴리(트리메틸렌 테레프탈레이트)/폴리(에틸렌 테레프탈레이트) 블렌드의 구조 변화

전병환(Jeon Byeong Hwan),김환기(Kim Hwan Gi),강호종(Kang Ho Jong) 한국고분자학회 2004 폴리머 Vol.28 No.1

연신에 의한 폴리(트리메틸렌 테레프탈레이트)의 구조 변형

전병환(Jeon Byeong Hwan),김환기(Kim Hwan Gi),강호종(Kang Ho Jong) 한국고분자학회 2003 폴리머 Vol.27 No.5