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한국판 소아 양극성장애 설문지 2.0(Child Bipolar Questionnaire 2.0)의 신뢰도 및 타당도 연구
천근아,신동원,김보라,소윤섭,전진용,송동호 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3
Objectives : The Child Bipolar Questionnaire 2.0 (CBQ 2.0) is a rapid screener with a Core Index subscale of symptom dimensions frequently reported in childhood-onset bipolar disorder (BD) and scoring algorithms for DSM-Ⅳ BD, with and without ADHD, and the proposed Narrow, Broad, and Core phenotypes. This report provides preliminary data on the reliability and validity of the CBQ 2.0-Korean version. Methods : Core Index subscale to effectively predict diagnostic classification by structured interview was assessed using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version (K-SADS-PL-K). Test-retest and inter-rater reliabilities of the CBQ 2.0 were assessed. Correlation of Korean Child Behavior Checklist (K-CBCL) with CBQ 2.0-Korean version was performed. Results : The CBQ 2.0 screening algorithms performed with a specificity of 66.7% and a sensitivity of 94.7% in classifying subjects with K-SADS-PL-K diagnosis of BD vs. no BD. The Core Index subscale had “good” agreement with K-SADS-PL-K diagnosis (Kappa=0.676) in identifying BD, ADHD-only, and no diagnosis. Conclusion : This preliminary data is from a sample derived from the child and adolescent psychiatric clinics, further validation is needed with community based samples in which childhood-onset BD is rarer and diagnoses more diverse. The CBQ 2.0-Korean version shows potential for rapid and economically feasible identification of possible childhood-onset BD cases as defined by DSM-Ⅳ criteria as well as by alternate disease phenotypes.
Yoon, Bora,Shin, Hyora,Yarimaga, Oktay,Ham, Dae-Young,Kim, Jiwan,Park, In Sung,Kim, Jong-Man The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.17
<P>Owing to their flexible, light-weight and disposable properties, paper-based electronic and sensor systems have gained much attention. Efficient immobilization and patterning of functional materials on paper substrates are critical to device performance. Herein, we report an inkjet printable and photopolymerizable diacetylene (DA) containing microemulsion system that can be readily transferred to paper substrates using a common office inkjet printer. UV-induced polymerization afforded clean formation of polydiacetylene (PDA) supramolecules on paper and the polymer displayed a typical thermochromism. The resolution of the printed PDA images was found to be equivalent to that of conventional black ink. The randomly oriented DA in the oil phase was found to be transformed to self-assembled layered structures upon printing. The printed PDA supramolecules derived from 5,7-dodecadiyne-1,12-diol bis[((butoxycarbonyl)methyl)urethane] (4BCMU) displayed a blue-to-red-to-yellow color transition upon heating. Thus, the blue colored 4BCMU-derived polymer was converted to a red colored PDA at 100 °C and further heating to 180 °C resulted in the generation of a yellow colored PDA. Upon cooling to room temperature, the yellow colored PDA became red and a complete colorimetric reversibility was observed between red (30 °C) and yellow (180 °C). The thermally promoted reversible PDA phase transition was successfully applied to a banknote to demonstrate an application to a potential counterfeit prevention method.</P> <P>Graphic Abstract</P><P>By using diacetylene containing microemulsions, we were able to generate polydiacetylene images on paper substrates for flexible and disposable sensors. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm30301a'> </P>
Recent conceptual and technological advances in polydiacetylene-based supramolecular chemosensors
Yoon, Bora,Lee, Sumi,Kim, Jong-Man Royal Society of Chemistry 2009 Chemical Society reviews Vol.38 No.7
<P>Owing to the color (blue-to-red) and fluorescence (non-to-fluorescent) changes that take place in response to environmental perturbations, conjugated polydiacetylenes (PDAs) have been actively employed as sensory materials for the detection of biologically-, environmentally- and chemically-important target molecules. Until recently, the majority of PDA sensors have been prepared in the form of aqueous suspensions or Langmuir-type thin films on solid substrates. In order to overcome the limitations associated with conventional solution/film sensors, conceptually new formats, such as immobilized PDAs in and on solid substrates, microarrayed PDA sensors, microfluidic PDA sensors, as well as PDA-embedded electrospun fiber sensors and resonance energy transfer (RET)-based PDA sensors, have been developed recently. In this <I>tutorial review</I>, the recent conceptual and technological achievements made in the area of conjugated PDA chemosensors are described.</P> <P>Graphic Abstract</P><P>In this tutorial review, the recent conceptual and technological achievements made in the area of conjugated polydiacetylene (PDA) chemosensors are described. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b819539k'> </P>
Yoon, Bora,Ham, Dae‐,Young,Yarimaga, Oktay,An, Hyosung,Lee, Chan Woo,Kim, Jong‐,Man WILEY‐VCH Verlag 2011 Advanced materials Vol.23 No.46
<P><B>Inkjet‐printable aqueous suspensions of conjugated polymer precursors</B> <B>are developed for fabrication of patterned color images on paper substrates</B>. Printing of a diacetylene (DA)‐surfactant composite ink on unmodified paper and photopaper, as well as on a banknote, enables generation of latent images that are transformed to blue‐colored polydiacetylene (PDA) structures by UV irradiation. Both irreversible and reversible thermochromism with the PDA printed images are demonstrated and applied to flexible and disposable sensors and to displays.</P>
Yoon, Bora,Kim, Joong-Seok,Lee, Kwang-Soo,Kim, Bum-Soo,Chung, So-Ryoung,Kim, Yeong-In S. Karger AG 2006 European neurology Vol.56 No.3
<P>We evaluated the early pathological changes in patients with sporadic cerebellar ataxia by measuring fractional anisotropy (FA) values in diffusion tensor MRIs (DTI). FA and apparent diffusion coefficient (ADC) values were compared in the brain stem and cerebellum of 5 patients with idiopathic cerebellar ataxia-C and 7 age-matched controls. Patients with sporadic cerebellar ataxia had decreased FA values in the bilateral cerebellar peduncle and cerebellar hemisphere, but normal FA values in the basis pontes. Assuming that the loss in FA parallels neuronal changes, our results suggest that the derangement and altered fiber integrity of the cerebellum are present regardless of the presence of morphological alterations on conventional MRI. Therefore, DTI may be superior to conventional MRI in the evaluation of early pathological changes in patients with sporadic cerebellar ataxia.</P><P>Copyright © 2006 S. Karger AG, Basel</P>
윤보라 ( Yoon Bora ) 한국중국언어학회 2020 중국언어연구 Vol.0 No.88
An adjective of Standard Chinese can expand its meaning by duplication. A duplicated adjective tends to strengthen its meaning. During the course of duplication, changes occur not only in its form but in its sound. The primary stress is given to the second syllable, which often changes to the first tone with retroflexion. A monosyllabic adjective can constitute a prosodic foot by duplication. The second syllable changes to the high level tone in order to make it more salient. The retroflexion seems to be caused by the influence from spoken Pekingese. The stress and change of tone in SC duplicated adjectives mean that SC is in the verge of changes. This study is significant because it sheds light to the in the duplicated adjectives while past studies often pay attention only to syntactic, typological, and morphological aspects of them.
( Sang Yoon Chung ),( Ja Seol Koo ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Bora Keum ),( Beom Jae Lee ),( Yoon Tae Jeen ),( Sang Woo Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background/Aims: In Korea, the surveillance colonoscopy after initial negative colonoscopy is recommended 5 years after negative colonoscopy. We evaluated the risk factors for colorectal neoplasia after negative screening colonoscopy. Methods: Among the patients underwent screening colonoscopy at Korea University Ansan Hospital from Jan. 2002 to Dec. 2009, the subjects without adenomas wereenrolled in the study retrospectively. Baseline characteristics on index colonoscopy and surveillance colonoscopic fi ndings were reviewed. Advanced adenoma was de-fi ned as an adenoma that met more than one of the following criterias: a size =10 mm, the presence of a substantial villous component, the presence of high-grade dysplasia. The prevalence of any adenoma and advanced adenoma were identifi ed and the risk factors on surveillance colonoscopy after negative screening colonoscopy were evaluated by using Cox regression model. Results: Among total 3,516 patients with screening colonoscopy, 1,506 without any adenomas were enrolled. The median of follow up interval after screening colonoscopy was 47.3 months(range,12.0 ~ 124.8). The incidence of any adenoma within 5years after negative colonoscopy was 293(29.0%) and those of any adenoma from 5 to 10 years was 135(27.2%). The prevalences of same terms in advanced adenoma were23(2.5%) and 8(1.4%). In cox regression analysis, the prevalence of any adenoma on surveillance colonoscopy were significantly increased in male(P<0.001) and old age(P<0.001). However, male gender and age were not associated with risk of advanced adenoma. Conclusions: Among the subjects with no colorectal adenoma on initial screening colonoscopy, the incidence of advanced adenomas was 2.1% on 10 year follow up surveillance. Although gender and age is associated with metachronous colorectal adenoma on surveillance colonoscopy, those are not associated with advanced adenoma. Therefore, surveillance interval of colonoscopy can be prolonged to 10 years.