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( Hee Seung Hong ),( Jiwon Baek ),( Jae Chul Park ),( Ho-su Lee ),( Dohoon Park ),( A-ran Yoon ),( Soo Jung Park ),( Sung Noh Hong ),( Seong-joon Koh ),( Chang Kyun Lee ),( Bo-in Lee ),( Sung Wook Hwa 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6
Background/Aims: Chronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene. We aimed to investigate the clinical and genetic characteristics of Korean patients diagnosed with CEAS. Methods: From July 2018 to July 2021, we performed Sanger sequencing of the SLCO2A1 gene in 46 patients with chronic intestinal ulcers. CEAS was confirmed based on known SLCO2A1 mutations. We summarized the clinical characteristics of patients with confirmed CEAS. Results: Fourteen out of 46 patients (30.4%) had genetically confirmed CEAS, and two SLCO2A1 variants were detected (splicing site variant c.940+1G>A and nonsense mutation [p.R603X] in SLCO2A1). Twelve patients (85.7%) were females and the median age at diagnosis of CEAS was 44.5 years. All patients presented with abdominal pain, and 13 patients (92.9%) presented with anemia (median hemoglobin, 9.6 g/dL). Ten patients (71.4%) had hypoalbuminemia (median, 2.7 g/dL). The most commonly involved site was the ileum (13/14, 92.9%). Manifestations of primary hypertrophic osteoarthropathy (PHO), such as digital clubbing, pachydermia, and periostosis were observed in five patients (28.6%) and two male patients and one female patient satisfied all major PHO diagnostic criteria. Conclusions: The clinical and genetic characteristics of Korean patients with confirmed CEAS were similar to those reported in the literature. CEAS should be considered in the differential diagnosis for patients with unexplained chronic nonspecific ulcers of the small intestine. (Gut Liver 2022;16:942-951)
Yoon, Su-A,Lim, Ae-Ran Korean Magnetic Resonance Society 2011 Journal of the Korean Magnetic Resonance Society Vol.15 No.2
The line widths and spin-lattice relaxation times of protons in $[N(C_2H_5)_4]_2CoCl_4$ and $[N(CH_3)_4]_2CoCl_4$ single crystals were investigated in the temperature range 160-400 K. The temperature dependences of the spin-lattice relaxation times are attributed to the molecular motions of the ethyl and methyl groups in the $[N(C_2H_5)_4]^+$ and $[N(CH_3)_4]^+$ ions respectively. The NMR line widths indicate that the ethyl groups in $[N(C_2H_5)_4]_2CoCl_4$ have one more degree of freedom than the methyl groups in $[N(CH_3)_4]_2CoCl_4$. The experimental results are interpreted in terms of the reorientations of the methyl and ethyl groups.
Yoon, A-rum,Gao, Ran,Kaul, Zeenia,Choi, Il-Kyu,Ryu, Jihoon,Noble, Jane R.,Kato, Yoshio,Saito, Soichiro,Hirano, Takashi,Ishii, Tetsuro,Reddel, Roger R.,Yun, Chae-Ok,Kaul, Sunil C.,Wadhwa, Renu Oxford University Press 2011 Nucleic acids research Vol.39 No.18
<P>MicroRNAs (miRNAs) are a class of noncoding small RNAs that act as negative regulators of gene expression. To identify miRNAs that may regulate human cell immortalization and carcinogenesis, we performed comparative miRNA array profiling of human normal and SV40-T antigen immortalized cells. We found that miR-296 was upregulated in immortalized cells that also had activation of telomerase. By an independent experiment on genomic analysis of cancer cells we found that chromosome region (20q13.32), where miR-296 is located, was amplified in 28/36 cell lines, and most of these showed enriched miR-296 expression. Overexpression of miR-296 in human cancer cells, with and without telomerase activity, had no effect on their telomerase function. Instead, it suppressed p53 function that is frequently downregulated during human cell immortalization and carcinogenesis. By monitoring the activity of a luciferase reporter connected to p53 and p21<SUP>WAF1</SUP> (p21) untranslated regions (UTRs), we demonstrate that miR-296 interacts with the p21-3′UTR, and the Hu binding site of p21-3′UTR was identified as a potential miR-296 target site. We demonstrate for the first time that miR-296 is frequently upregulated during immortalization of human cells and contributes to carcinogenesis by downregulation of p53-p21<SUP>WAF1</SUP> pathway.</P>
TGF-β1 Expression by Proliferated Keratinocytes in the Skin of E-Irradiated Mice
A-Ran Yoon(윤아란),Do Nyun Kim(김도년),Min Koo Seo(서민구),Sang Taek Oh(오상택),Jung Seon Seo(서정선),Se Mo Jun(전세모),Jung-Ho Cha(차정호),Seungdeok Lee(이승덕),Suk Kyeong Lee(이숙경) 한국생명과학회 2012 생명과학회지 Vol.22 No.2
우리는 방사선피부염 동물 모델을 확립하여, 이차 면역 기관에서의 면역 세포 비율 변화를 관찰하였다. 또한, 방사선 조사에 의한 병소에서 transforming growth factor-β1 (TGF-β1)과 interlukin-10 (IL-10)의 발현을 증가시킨 세포를 분석하였다. Hairless-1 (HR-1) 쥐의 posterior dorsal 부위에 6 일간 매일 10 Gy 씩 electron (E)-ray를 국부 조사하여 방사선피부염 모델을 만들었다. FACS를 이용하여 면역 세포 비율의 변화를 분석한 결과 비장과 림프절에 존재하는 항원제시세포와 T 세포 및 B 세포들의 비율이 E-irradiation에 의해 영향을 받았다. 피부에서 세포 특이적인 마커와 사이토카인들의 발현 양상은 면역형광염색법으로 확인하였다. 방사선 조사 후, TGF-β1과 interlukin-17 (IL-17)은 regulatory T 세포(Treg)보다 keratin-14 (K-14)를 발현하는 진피의 끝부분에서 높게 발현되었다. Interlukin-10 (IL-10)는 Treg 뿐만 아니라 T helper 17 (Th17) 세포, dendritic 세포, macrophage 중 어느것과도 같은 위치에서 검출되지 않았다. 우리의 데이터는 방사선피부염 동물 모델의 병소 안에서, TGF-β1이 증식된 keratinocyte에 과발현된다는 것을 나타낸다. In this study, we established a radiodermatitis animal model and investigated the change in immune cell proportions in the secondary lymphoid organs. The cells responsible for the increased transforming growth factor-β1 (TGF-β1) and interleukin-10 (IL-10) production in the lesions following irradiation were also investigated. The radiodermatitis model was constructed by locally exposing the posterior dorsal region of hairless-1 (HR-1) mice to 10 Gy electron (E)-ray/day for six consecutive days. The change in immune cell proportions was analyzed by FACS. Immunohistochemistry was carried out to detect the expression of cytokines and cell-specific markers in the skin. The proportions of antigen-presenting cells, T cells, and B cells in the lymph nodes and spleen were affected by E-irradiation. After irradiation, TGF-β1 and IL-17 were co-localized in the papillary region of the dermis with keratin-14 (K-14)-positive cells rather than with regulatory T cells (Treg). IL-10 was not co-stained with Treg, T helper 17 (Th17) cells, dendritic cells, or macrophages. Our data indicate that TGF-β1 is over-expressed mainly by proliferated keratinocytes in the lesions of a radiodermatitis animal model.
김억(Auk Kim),김용태(Yong Tae Kim),조진아(Jin a Cho),구자란(Ja Ran Ku),허윤(Yoon Hur),서동원(Dong Won Suh),황일순(Il Soon Whang),박기호(Ki Ho Park),김은주(Eun Ju Kim),이성공(Seong Kong Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.3
Colorectal cancer during pregnancy is extremely rare. The diagnosis is frequently delayed because symptoms may be confused with those of normal pregnancy. In 1S35, Cruvethier reported the first case of colorectal carcinoma complicating pregnancy. Since then, about 200 or more cases were reported in western countries, but no case of these has been reported in Korea. We experienced a 29-year-old pregnant woman concomitantly developed an adenocarcinoma of the right colon with intestinal obstruction at 12 weeks of gestation. We performed right hemicolectomy at 14 weeks of gestation and therapeutic abortion at 17 weeks of gestation. We report a case of colon cancer during pregnancy with a review of the diagnosis and management. (Korean J Gastroenterol 1996; 28:457 - 461)
Case Report : Carvenous lymphangioma of the vulva
( Kyung Ran Yoon ),( A Jin Mo ),( Sung Ho Park ),( Yeon Sik Na ),( Sung Taek Park ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.1
Lymphangioma is a rare proliferation of the lymphatic system which is classified as either lymphangioma circumscription or carvenous lymphangioma. The involvement of the vulva is very rare and only a small number of case reports have been made on carvenous lymphangioma of the vulva. We herein report a case of 20-year-old unmarried girl presented with gradually expanding and painless tumor of the left labium majus. The mass was removed surgically and pathology confirmed as carvenous lymphangioma, with no recurrences to date.
정신보건사회복지사의 클라이언트 폭력경험과 외상후스트레스의 관계
윤명숙(Yoon, Myeong-sook),김성혜(Kim, Sung-hye),박아란(Park, A-ran) 한국정신건강사회복지학회 2015 정신보건과 사회사업 Vol.43 No.2
정신보건현장은 직무 특성상 다른 실천현장에 비해 상대적으로 클라이언트 폭력을 경험할 가능성이 높고 이는 외상후스트레스장애(PTSD)에 영향을 미칠 위험성이 높다. 본 연구는 정신보건사회복지사의 클라이언트 폭력경험과 PTSD의 관계를 살펴보고, 이 관계에서 사회적 지지와 직무스트레스의 다중매개효과를 검증하고자 하는 목적을 가진다. 이를 위해 전국의 정신보건기관에 종사하는 정신보건사회복지사 257명을 설문조사하였으며 구조방정식으로 분석하였다. 연구결과 첫째, 클라이언트 폭력경험은 PTSD에 유의미한 영향을 미치는 것으로 나타났다. 둘째, 클라이언트 폭력경험은 대상자의 사회적 지지와 직무스트레스에 영향을 미치는 것으로 나타났다. 즉 클라이언트 폭력경험이 많을수록 사회적 지지를 낮게 인식하고, 직무스트레스가 높아지는 것으로 나타났다. 또한 사회적 지지는 직무스트레스에 부(-)적 영향을 미치고 있어 사회적 지지가 높은 경우 직무스트레스는 낮아지는 것으로 나타났다. 셋째, 정신보건사회복지사의 PTSD에 클라이언트 폭력이 미치는 효과를 사회적 지지 및 직무스트레스가 부분매개하는 것으로 나타났다. 즉, 클라이언트 폭력은 사회적 지지, 직무스트레스를 통해 간접적으로 PTSD에 영향을 미친다. 이러한 연구결과를 바탕으로 클라이언트 폭력피해 정신보건사회복지사를 위한 위기개입프로그램 도입과 클라이언트 폭력예방 매뉴얼 개발, 다양한 보호 장비구비 등 제도적 안전장치 의무화, 정신보건 실천현장에 직장인 정신건강프로그램 도입등 개입 방안을 제시하였다. This study was to identify the mediating effects of social support and job stress on the relationship between clint violence and Post-Traumatic Stress Disorder(PTSD) among mental health social worker. The data were collected from 257 mental health social worker and analyzed by using structural equation model. The research findings were as follows: First, clint violence had on significant relationship to the PTSD of mental health social worker. Second, social support and job stress worked as partial mediators between the clint violence and PTSD among mental health social worker. The implications and limitations of these findings were discussed and directions for future studies were also proposed.
청소년 복합외상경험과 PTSD 관계에서 사회적 지지의 조절효과 검증
윤명숙(Yoon, Myeong Sook),박아란(Park, A Ran) 한국정신건강사회복지학회 2016 정신보건과 사회사업 Vol.44 No.3
본 연구는 청소년들의 복합외상경험이 PTSD(외상후스트레스장애)에 미치는 영향을 살펴보고, 이 관계에 영향을 미치는 사회적 지지의 조절효과를 검증하는 데 목적이 있다. 이를 위해 중학교에 재학 중인 학생 219명을 대상으로 조절회귀식을 이용하여 분석하였다. 연구결과 첫째, 청소년이 경험하는 복합외상경험들은 집단 따돌림 및 소외감, 신체적 폭력, 성학대 순으로 나타났으며 이 중 집단 따돌림과 소외감을 가장 많이 경험하는 것으로 나타났다. 둘째, 청소년들의 복합외상경험이 높을수록 PTSD 수준은 높아지는 것으로 나타났다. 셋째, 청소년의 복합외상경험과 PTSD 관계에서 사회적 지지는 조절효과를 가지는 것으로 나타났다. 이러한 연구결과를 바탕으로 청소년들의 복합외상문제에 주목하여, 복합외상경험 이후 전문적이고 체계적인 개입 전략의 필요성을 제시하고 청소년들의 건강한 삶과 정신건강 증진을 위한 효과적인 정신보건사회복지실천방안의 시사점을 도출하기 위한 제언을 하였다. The purpose of this study was to investigate moderating role of social support between complex trauma and PTSD(Post-Traumatic Stress Disorder) among adolescents. Data were collected from 219 middle school students. Collected data were analyzed by frequency, t-test, moderated multiple regression and simple slope analysis. The major findings of this study were as follows: First, subjects reported bullying, sense of alienation, physical abuse sexual abuse as complex trauma. Second, complex trauma were significantly related to the PTSD in adolescents. Third, social support moderated between the complex trauma and PTSD. These findings supported the importance of specified intervention for people with complex trauma in adolescents. Suggestions of mental health social work were discussed and proposed for future research.