High-j Proton h11/2 and g7/2 Intruder Bands in 113In

Ma Ke Yan,Lu Jing Bin,Ma Ying Jun,Li Jian,Yang Dong,Sun Wu Ji,Wang Hao,Pan Hao Nan,Wang Jia Qi,Yang Qing Yu,Zhang Da Ming,Zhu Li Hua,Wu Xiao Guang,Zheng Yun,Li Cong Bo 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.12

Excited states of 113In have been populated through the heavy-ion fusion evaporation reaction 110Pd(7Li, 4n)113In. A new band with the configuration of a proton d5/2 orbital is identified. Two ΔI = 2 intruder bands, built on the πh11/2 and the πg7/2 orbitals, have been extended to spins (63/2-)ħ and (55/2+)ħ, respectively. The negative-parity πh11/2 intruder band shows a smooth increase in aligned spin, which is attributed to a strong proton-neutron interaction. The properties of the positive-parity πg7/2 band are discussed based on tilted axis cranking model calculations, and the features of the antimagnetic rotation for this band are shown after backbend. Furthermore, the contributions of the two-shears-like mechanism, the neutron (gd)ν shell and the core rotation are investigated for the positive-parity πg7/2 band.

Synthesis, Structures and Photoluminescent Properties of Two Novel Zinc(II) Compounds Constructed from 5-Sulfoisophthalic Acid

Zhu, Yu-Lan,Tang, Xue-Ling,Ma, Kui-Rong,Chen, Hao,Ma, Feng,Zhao, Lian-Hua Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.7

Hydrothermal reaction of zinc(II) salts with 5-sulfoisophthalic acid monosodium salt ($NaO_3SC_6H_3$-1,3-(COOH)$_2$, $NaH_2$-SIP) and 1,10-phenanthroline (phen) led to two new compounds, [Zn(phen)$_3$$\cdot2H_2SIP\cdot4H_2O$ (1) and [Zn(phen)$_2(H_2O)_2]\cdot2H_2SIP\cdot2H_2O$ (2). They were characterized by element analysis, IR spectroscopy, thermalgravimetric analysis (TGA), X-ray powder diffraction (XRD), and single-crystal X-ray diffraction. Both compounds 1-2 represent the first example of Zn/phen/SIP system. The Zn (II) ion in 1 is six-coordinated by six nitrogen atoms from three phen molecules, and the $H_2SIP^-$ ligands engage in the formation of hydrogen bond. The Zn(II) ion in 2 is coordinated by four nitrogen atoms from two phen molecules and two oxygen atoms from two water molecules. Moreover, both 1 and 2 are assembled into 3D supramolecular architectures by hydrogen bonds (O-H$\ldots$O) and $\pi-\pi$ interactions. Solvent water molecules occupying voids of the compounds serve as receptors or donors of the extensive O-H$\ldots$O hydrogen bonds.

Developing a Dynamic Materialized View Index for Efficiently Discovering Usable Views for Progressive Queries

Zhu, Chao,Zhu, Qiang,Zuzarte, Calisto,Ma, Wenbin Korea Information Processing Society 2013 Journal of information processing systems Vol.9 No.4

Numerous data intensive applications demand the efficient processing of a new type of query, which is called a progressive query (PQ). A PQ consists of a set of unpredictable but inter-related step-queries (SQ) that are specified by its user in a sequence of steps. A conventional DBMS was not designed to efficiently process such PQs. In our earlier work, we introduced a materialized view based approach for efficiently processing PQs, where the focus was on selecting promising views for materialization. The problem of how to efficiently find usable views from the materialized set in order to answer the SQs for a PQ remains open. In this paper, we present a new index technique, called the Dynamic Materialized View Index (DMVI), to rapidly discover usable views for answering a given SQ. The structure of the proposed index is a special ordered tree where the SQ domain tables are used as search keys and some bitmaps are kept at the leaf nodes for refined filtering. A two-level priority rule is adopted to order domain tables in the tree, which facilitates the efficient maintenance of the tree by taking into account the dynamic characteristics of various types of materialized views for PQs. The bitmap encoding methods and the strategies/algorithms to construct, search, and maintain the DMVI are suggested. The extensive experimental results demonstrate that our index technique is quite promising in improving the performance of the materialized view based query processing approach for PQs.

Application Research on Mechanical Strength and Durability of Porous Basalt Concrete

Zhu, Yuelei,Li, Jingchun,Zhu, He,Jin, Long,Ren, Qifang,Ding, Yi,Li, Jinpeng,Sun, Qiqi,Wu, Zilong,Ma, Rui,Oh, Won-Chun Materials Research Society of Korea 2022 한국재료학회지 Vol.32 No.3

Porous basalt aggregate is commonly used in roadbed engineering, but its application in concrete has rarely been studied. This paper studies the application of porous basalt in concrete. Porous basalt aggregate is assessed for its effects on mechanical strength and durability of prepared C50 concrete; because it has a hole structure, porous basalt aggregate is known for its porosity, and porous basalt aggregates can be made full of water through changing the content of saturated basalt; after full-water condition is achieved in porous basalt aggregate mixture of C50 concrete, we discuss its mechanical properties and durability. The effects of C50 concrete prepared with basalt aggregate on the compressive strength, water absorption, and electric flux of concrete specimens of different ages were studied through experiments, and the effects of different replacement rates of saturated porous basalt aggregate on the properties of concrete were also studied. The results show that porous basalt aggregate can be prepared as C50 concrete. For early saturated porous basalt aggregate concrete, its compressive strength decreases with the increase of the replacement rate of saturated aggregate; this occurs up to concrete curing at 28 d, when the replacement rate of saturated basalt aggregate is greater than or equal to 40 %. The compressive strength of concrete increases with the increase of the replacement rate of saturated aggregate. The 28 d electric flux decreases with the increase of the replacement rate of saturated aggregate, indicating that saturated porous basalt aggregate can improve the chloride ion permeability resistance of concrete in later stages.

miR-9 Modulates Osteosarcoma Cell Growth by Targeting the GCIP Tumor Suppressor

Zhu, Shao-Wen,Li, Jian-Peng,Ma, Xin-Long,Ma, Jian-Xiong,Yang, Yang,Chen, Yang,Liu, Wei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11

Osteosarcoma is the most common primary bone tumor in humans, especially in childhood. However, the genetic etiology for its pathogenesis remains elusive. It is known that microRNAs (miRNAs) are involved in the development of tumor progression. Here we show that microRNA-9 (miR-9) is a potential oncogene upregulated in osteosarcoma cells. Knockdown of miR-9 in osteosarcoma resulted in suppressed colony formation and cell proliferation. Further study identified GCIP, a Grap2 and cyclin D interacting protein, as a direct target of miR-9. In addition, GCIP overexpression activated retinoblastoma 1 (Rb) and suppressed E2F transcriptional target expression in osteosarcoma cells. Moreover, GCIP depletion reversed miR-9 knockdown induced colony formation and cell proliferation suppression. In sum, these results highlight the importance of miR-9 as an oncogene in regulating the proliferation of osteosarcoma by directly targeting GCIP and may provide new insights into the pathogenesis of osteosarcoma.

Optimization design and dynamic stability analysis of 3-DOF cable-driven parallel robot with an elastic telescopic rod

Wei Zhu,Jiahong Liu,Kuanxiang Shi,Fei Qi,Huiping Shen,Zhu Xu,Zhilong Ma 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9

This paper proposes a three degree-of-freedoms (DOFs) cable-driven parallel robot (CDPR), which is actuated by three groups of parallel cables and tensioned by an elastic telescopic rod with a passive spring. Firstly, the architecture of the robot is briefly illustrated with emphasis on the three parallelogram arrangements of the cables and composition of elastic telescopic rod structure. This robot has larger workspace and greater tension than previous under-constrained CDPRs. Secondly, the kinematic and dynamic models of the robot are established. On this basis, the parameters of the spring installed in the telescopic rod are optimized and determined considering both the acceleration and cable force through using the differential evolution (DE) algorithm. Thirdly, dynamic stability analysis of the robot under impulsive disturbances is performed according to the Gauss principle of least constraint (GPLC). The results of a simulation case show that this robot has better dynamic stability in comparison with conventional under-constraint CDPR because of the presence of the elastic telescopic rod. The measurement results in the workspace are obtained through dynamic simulation. Finally, the experiments are performed based on numerical simulation. The feasibility of the CDPR is verified via the experiments and simulations.

Asymmetrical breakup and size distribution of droplets in a branching microfluidic T-junction

Pengcheng Ma,Taotao Fu,Chunying Zhu,Youguang Ma 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.1

The breakup and distribution of droplets at a branching T-junction were investigated experimentally by a high-speed camera. The effects of two-phase flow rates, two-phase Reynolds number and capillary number of the dispersed phase on droplet volume distribution were studied. The results indicated that the volume distribution ratio  decreases first and then increases with the increase of two-phase flow ratio Qd/Qc. Similarly, as the Reynolds number Rec of the continuous phase increases, the volume distribution ratio  also decreases at first and then increases. The increase of Reynolds number Red of the dispersed phase would lead to a reduction in the volume distribution ratio . Moreover, the increase of the capillary number Cad of dispersed phase could result in an increase in the volume distribution ratio . Correlations for predicting the volume distribution ratio were proposed, and the calculated results show good agreement with experimental data.

CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin

Jingbo Ma,Xiaolong Xu,Chunjin Fu,Peng Xia,Ming Tian,Liuhai Zheng,Kun Chen,Xiaolian Liu,Yilei Li,Le Yu,Qinchang Zhu,Yangyang Yu,Rongrong Fan,Haibo Jiang,Zhifen Li,Chuanbin Yang,Chengchao Xu,Ying Long,J 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer. Methods: Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo. Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil. Conclusions: The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobodybased immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.

Identification of two rare mutations c.1318G>A and c.6438+2T>G in a Chinese DMD family as genetic markers

Yingchuan Zhu,Lijun Yang,Tengjiao Ma,Yilu Lu,Dachang Tao,Yunqiang Liu,Yongxin Ma 한국유전학회 2020 Genes & Genomics Vol.42 No.9

Background Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disorder with no efective treatment, which underscores the importance of avoiding the birth of children with DMD by identifying pathogenic mutations and obtaining an accurate prenatal diagnosis. Objective The objective of this study was to analyze the genetic defect of a Chinese family where all male patients have died of DMD. Methods Multiplex ligation dependent probe analysis (MLPA) and next-generation sequencing (NGS) were employed to detect DMD mutations. The candidate mutations were then validated by Sanger sequencing. In vitro splicing assay was further conducted to examine the potential efect of the novel DMD splice site mutation on splicing. Results We found that two rare DMD mutations c.1318G>A and c.6438+2T>G passed from generation to generation among female carriers and they may be used as genetic markers in the Chinese DMD family. In vitro splicing assay further revealed that the novel classical splice site mutation c.6438+2T>G gave rise to a new donor splice site, which resulted in a frame shift of the transcripts and a premature termination at position 2159 in exon 45 (p.Y2144Nfs*16). Conclusion We found that two co-inherited mutations passed from generation to generation in female carriers and they may be used as genetic markers in the Chinese DMD family. Our fndings not only expanded the DMD mutation spectrum, but also provided an important basis for identifying of female carriers and avoiding the birth of afected male children in this DMD family.

Developing a Dynamic Materialized View Index for Efficiently Discovering Usable Views for Progressive Queries

( Chao Zhu ),( Qiang Zhu ),( Calisto Zuzarte ),( Wenbin Ma ) 한국정보처리학회 2013 Journal of information processing systems Vol.9 No.4

Numerous data intensive applications demand the efficient processing of a new type of query, which is called a progressive query (PQ). A PQ consists of a set of unpredictable but inter-related step-queries (SQ) that are specified by its user in a sequence of steps. A conventional DBMS was not designed to efficiently process such PQs. In our earlier work, we introduced a materialized view based approach for efficiently processing PQs, where the focus was on selecting promising views for materialization. The problem of how to efficiently find usable views from the materialized set in order to answer the SQs for a PQ remains open. In this paper, we present a new index technique, called the Dynamic Materialized View Index (DMVI), to rapidly discover usable views for answering a given SQ. The structure of the proposed index is a special ordered tree where the SQ domain tables are used as search keys and some bitmaps are kept at the leaf nodes for refined filtering. A two-level priority rule is adopted to order domain tables in the tree, which facilitates the efficient maintenance of the tree by taking into account the dynamic characteristics of various types of materialized views for PQs. The bitmap encoding methods and the strategies/algorithms to construct, search, and maintain the DMVI are suggested. The extensive experimental results demonstrate that our index technique is quite promising in improving the performance of the materialized view based query processing approach for PQs