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Cui, Zhi-Wen,Xia, Ye,Ye, Yi-Wang,Jiang, Zhi-Mao,Wang, Ya-Dong,Wu, Jian-Ting,Sun, Liang,Zhao, Jun,Fa, Ping-Ping,Sun, Xiao-Juan,Gui, Yao-Ting,Cai, Zhi-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
The molecular mechanisms involved in the progression of clear cell renal cell carcinomas (ccRCCs) are still unclear. The aim of this study was to analyse the relationships between expression of RALYL and clinical characteristics. In 41 paired samples of ccRCCs and adjacent normal tissues, we used real-time qPCR to evaluate the expression of RALYL mRNA. RALYL protein levels were determined in 146 samples of ccRCC and 37 adjacent normal tissues by immunohistochemistry. Statistical analysis was used to explore the relationships between expression of RALYL and the clinical characteristics (gender, age, tumor size, T stage, N stage, M stage, survival times and survival outcome) in ccRCC. In addition, these patients were follow-up period 64 months (range: 4~116months) to investigate the influence on prognosis. We found significantly differences between ccRCC tissues and normal tissues (p<0.001, paired-sample t test) in mRNA levels of RALYL. Immunohistochemistry analyses in 146 ccRCC samples and 37 adjacent normal tissues showed significantly lower RALYL protein levels in ccRCC samples (${\chi}^2$-test, p<0.001), inversely correlating with tumour size (p=0.024), T stage (0.005), N stage (p<0.001) as well as M stage (p=0.019), but not age (p=0.357) and gender (p=0.348). Kaplan-Meier survival analysis demonstrated that people with lower level of RALYL expression had a poorer survival rate than those with a higher level of RALYL expression, significantly different by the log-rank test (p=0.011). Cox regression analysis indicated that RALYL expression (p=0.039), N stage (p=0.008) and distant metastasis (p<0.001) were independent prognosis factors for the overall survival of ccRCC patients. We demonstrated that the expression of RALYL was significantly low in ccRCC and correlated with a poor prognosis in a large number of clinical samples. Our findings showed that RALYL may be a potential therapeutic target as well as a poor prognostic factor.
Zhi-Fu Guo,Xiang-Yu Long,Pan Dong,Yu-Ming Wei,Li-Ping Bai,Xiao-Xuan Dang,Hao-Lei Wan,Li-Jun Zhang,You-Liang Zheng 한국유전학회 2011 Genes & Genomics Vol.33 No.2
The α-gliadins from Crithopsis delileana (Schult) Roshev (2n=2x=14, KK) were investigated by Acid polyacrylamide gel electrophoresis (A-PAGE) analysis. It was indicated that the electrophoresis mobility of gliadins from C.delileana had obvious difference with those from common wheat in α, γand ω region. Using primers designed from published sequences of α-gliadin genes, three α-gliadin genes were isolated from C. delileana, which were designated as gli-ka1,gli-ka2 and gli-ka3, respectively. Two in-frame stop codons were found in the coding sequences of gli-ka3, indicating that gli-ka3 could be a pseudogene. The gli-ka2 was a gliadin with an odd number of cysteines, resulting from a non-synonymous mutation. This change might lead to the interactive behavior of gli-ka2. Three α-gliadin genes of C. delileana had the similar but not identical primary structures to the corresponding gene sequences from other wheat related species. By the alignment of α-gliadin genes from Triticeae,phylogenetic analysis indicated that three α-gliadin genes of C. delileana clustered together with all α-gliadin genes from Ee genome of Lophopyrum elongatum by an interior paralleled branch.
An Improved Variable Step Size MPPT Algorithm Based on INC
Zhi-rong Xu,Ping Yang,Dong-bao Zhou,Peng Li,Jin-yong Lei,Yuan-rui Chen 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2
In order to ensure that photovoltaic (PV) systems work at the maximum power point (MPP) and maximize the economic benefits, maximum power point tracking (MPPT) techniques are normally applied to these systems. One of the most widely applied MPPT methods is the incremental conductance (INC) method. However, the choice of the step size still remains controversial. This paper presents an improved variable step size INC MPPT algorithm that uses four different step sizes. This method has the advantages of INC but with the ability to validly adjust the step size to adapt to changes of the PV’s power curve. The presented algorithm also simultaneously achieves increased rapidity and accuracy when compared with the conventional fixed step size INC MPPT algorithm. In addition, the theoretical derivation and specific applications of the proposed algorithm are presented here. This method is validated by simulation and experimental results.
An Improved Variable Step Size MPPT Algorithm Based on INC
Xu, Zhi-Rong,Yang, Ping,Zhou, Dong-Bao,Li, Peng,Lei, Jin-Yong,Chen, Yuan-Rui The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2
In order to ensure that photovoltaic (PV) systems work at the maximum power point (MPP) and maximize the economic benefits, maximum power point tracking (MPPT) techniques are normally applied to these systems. One of the most widely applied MPPT methods is the incremental conductance (INC) method. However, the choice of the step size still remains controversial. This paper presents an improved variable step size INC MPPT algorithm that uses four different step sizes. This method has the advantages of INC but with the ability to validly adjust the step size to adapt to changes of the PV's power curve. The presented algorithm also simultaneously achieves increased rapidity and accuracy when compared with the conventional fixed step size INC MPPT algorithm. In addition, the theoretical derivation and specific applications of the proposed algorithm are presented here. This method is validated by simulation and experimental results.
Synthesis, structure and tribological performance of tungsten disulphide nanocomposites
Si, Ping-Zhan,Choi, Chul-Jin,Lee, Jae-Wook,Geng, Dian-Yu,Zhang, Zhi-Dong Elsevier Sequoia 2007 Materials science & engineering Structural materia Vol.443 No.1-2
<P><B>Abstract</B></P><P>Tungsten disulphide nanocomposites were prepared in large scale by employing the direct reaction between tungsten nanoparticles and sulphur powders. The nanocomposites include a variety of shapes such as isolated WS<SUB>2</SUB> multi-layered sheets, WS<SUB>2</SUB>-coated WO<SUB>3</SUB> nanoparticles, and enclosed fullerene-like WS<SUB>2</SUB> structures. Pin-on-disc wear tests indicate that the addition of a small amount (5wt%) of these nanoparticles to paraffin decreases significantly the wear loss of the pin. Additives of these WS<SUB>2</SUB>/WO<SUB>3</SUB> nanoparticles possess much better tribological performance than micrometer-sized WS<SUB>2</SUB> powders additives do. The surface topography of wear scar of the pins after wear tests with different additives and different loads were studied by scanning electron microscopy. Small (severe) damage of the pin surface was observed for WS<SUB>2</SUB>/WO<SUB>3</SUB> nanoparticles (WS<SUB>2</SUB> micropowders) additives.</P>
Hua-Ping Lin,Fan Zhou,Xiao-Wen Zhang,Dong-Bin Yu,Jun Li,Liang Zhang,Xue-Yin Jiang,Zhi-Lin Zhang 한국물리학회 2011 Current Applied Physics Vol.11 No.3
A double hole injection layer consisting of Ag_2O//MoO_x was applied to a 4,40-bis (2,2-diphenylvinyl)-1,10-biphenyl-based blue organic light-emitting device (OLED). The hole current injection of the devicewas improved and the performance of the blue OLED was enhanced. We have observed that the insertion of such double layer leads to a striking improvement in chromaticity and electrical characteristics. This device showed much better chromaticity and less current-induced color shift as compared to the corresponding single hole injection layer counterparts. Using this strategy, a striking improvement in the electrical properties with lower driving voltage, higher power efficiency and a weak current-induced fluorescence quenching was achieved. This could be explained by the fact that an interlayer of Ag_2O//MoO_x provided a stepped energy level which greatly facilitated hole injection and hence enhanced injection current. The result is verified by using the J―V curves of ‘only’ devices and further explained with the help of Fowler-Nordheim (F-N) tunneling theory.
Hua-Ping Lin,Fan Zhou,Jun Li,Xiao-Wen Zhang,Dong-Bin Yu,Liang Zhang,Xue-Yin Jiang,Zhi-Lin Zhang 한국공업화학회 2011 Journal of Industrial and Engineering Chemistry Vol.17 No.4
This work demonstrated the fabrication of white organic light-emitting devices (WOLEDs) using a dual emitting layer (d-EML) consisting of blue and ‘white’ emitters. In this d-EML system, the blue emitter not only emits but also assists the incomplete energy transfer. More importantly, it behaves as an effective trapping site for holes, which contributes to the efficient recombination of electron–hole pairs. The d-EML was constructed between the hole-transmitting layer (HTL) and the electron-transmitting layer (ETL) of Alq3 and BPhen. The thickness of the blue emitter used in the d-EML devices has an important effect on chromaticity and efficiency. Through the optimization of device structure, the reasonable white emission with Commission Internationale de L’Eclairage (CIE) color coordinates of (0.33, 0.33) and little color shift was obtained. The device showed an applicable luminance with its maximum luminance of 22,874 cd/m2 at a driving voltage of 16 V. The maximum luminance efficiency was achieved 8.10 cd/A,and the maximum power efficiency was reached 5.07 Lm/W. The result is explained with the help of the excitons generation and diffusion theory. According to the theory of excitons generation and diffusion,an equation has been set up which concerns electroluminescent spectra to the thickness of the two emitters and to the exciton diffusion length.
Genetic Effects of Polymorphisms in Myogenic Regulatory Factors on Chicken Muscle Fiber Traits
Yang, Zhi-Qin,Qing, Ying,Zhu, Qing,Zhao, Xiao-Ling,Wang, Yan,Li, Di-Yan,Liu, Yi-Ping,Yin, Hua-Dong Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.6
The myogenic regulatory factors is a family of transcription factors that play a key role in the development of skeletal muscle fibers, which are the main factors to affect the meat taste and texture. In the present study, we performed candidate gene analysis to identify single-nucleotide polymorphisms in the MyoD, Myf5, MyoG, and Mrf4 genes using polymerase chain reaction-single strand conformation polymorphism in 360 Erlang Mountain Chickens from three different housing systems (cage, pen, and free-range). The general linear model procedure was used to estimate the statistical significance of association between combined genotypes and muscle fiber traits of chickens. Two polymorphisms (g.39928301T>G and g.11579368C>T) were detected in the Mrf4 and MyoD gene, respectively. The diameters of thigh and pectoralis muscle fibers were higher in birds with the combined genotypes of GG-TT and TTCT (p<0.05). Moreover, the interaction between housing system and combined genotypes has no significant effect on the traits of muscle fiber (p>0.05). Our findings suggest that the combined genotypes of TT-CT and GG-TT might be advantageous for muscle fiber traits, and could be the potential genetic markers for breeding program in Erlang Mountain Chickens.
Yong-Ping Chen,Feng-Bin Lu,Da-Zhi Chen,Lu Chen,En-De Hu,Jin-Lu Wu,Hui Li,Yue-Wen Gong,Zhuo Lin,Xiao-Dong Wang,Ji Li,Xiao-Ya Jin,Lan-Man Xu 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.12
MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-223-3p to treat autoimmune hepatitis in an experimental model. We found that MSC-exosomes were successfully incorporated with miR-223-3p and delivered miR-223-3p into macrophages. Moreover, there was no toxic effect of exosomes on the macrophages. Furthermore, treatments of either exosomes or exosomes with miR-223-3p successfully attenuated inflammatory responses in the liver of autoimmune hepatitis and inflammatory cytokine release in both the liver and macrophages. The mechanism may be related to the regulation of miR-223-3p level and STAT3 expression in the liver and macrophages. These results suggest that MSC-exosomes can be used to deliver miR-223-3p for the treatment of autoimmune hepatitis.