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Yi Zheng,Yunlong Si,Xuejiao Xu,Hongming Gu,Zhen He,Zihan Zhao,Zhangkai Feng,Jiyong Su,Kevin H. Mayo,Yifa Zhou,Guihua Tai The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2
Background: Panax ginseng Meyer polysaccharides exhibit various biological functions, like antagonizing galectin-3-mediated cell adhesion and migration. Galectin-8 (Gal-8), with its linker-joined N- and C-terminal carbohydrate recognition domains (CRDs), is also crucial to these biological processes, and thus plays a role in various pathological disorders. Yet the effect of ginseng-derived polysaccharides in modulating Gal-8 function has remained unclear. Methods: P. ginseng-derived pectin was chromatographically isolated and enzymatically digested to obtain a series of polysaccharides. Biolayer Interferometry (BLI) quantified their binding affinity to Gal-8, and their inhibitory effects on Gal-8 was assessed by hemagglutination, cell migration and T-cell apoptosis. Results: Our ginseng-derived pectin polysaccharides consist mostly of rhamnogalacturonan-I (RG-I) and homogalacturonan (HG). BLI shows that Gal-8 binding rests primarily in RG-I and its β-1,4-galactan side chains, with sub-micromolar K<sub>D</sub> values. Both N- and C-terminal Gal-8 CRDs bind RG-I, with binding correlated with Gal-8-mediated function. Conclusion: P. ginseng RG-I pectin β-1,4-galactan side chains are crucial to binding Gal-8 and antagonizing its function. This study enhances our understanding of galectin-sugar interactions, information that may be used in the development of pharmaceutical agents targeting Gal-8.
A bi-directional valveless piezoelectric micropump based on the Coanda effect
Zheng Zhang,Lipeng He,Jianwen Zhou,Dianbin Hu,Yi Hou,Guangming Cheng 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.2
In this paper, the hydrodynamic characteristics of a piezoelectric micropump operate on the Coanda effect, and the mechanism of bi-directional pumping are analyzed by numerical simulation and experiments. The research focuses on the different positions of the fluid deflector and the influence on the output of the micropump. The results show that a closer fluid deflector to the inlet can produce greater vortices in the suction process due to the Coanda effect, and the backflow diminishing is more significant as well. Moreover, the different positions of the fluid deflector can cause a phenomenon that the micropump will achieve bi-directional pumping. As a finding, vortices arranged in pairs could improve the rectification efficiency of the micropump. The micropump achieves a maximum flow rate of 40.5 ml/min and back pressure of 5.76 cmH 2 o. In addition, the maximum flow rate per unit area can reach 305.2 μl/(min mm 2 ).
An analytical solution of bending thin plates with different moduli in tension and compression
He, Xiao-Ting,Hu, Xing-Jian,Sun, Jun-Yi,Zheng, Zhou-Lian Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.36 No.3
Materials which exhibit different elastic moduli in tension and compression are known as bimodular materials. The bimodular materials model, which is founded on the criterion of positive-negative signs of principal stress, is important for the structural analysis and design. However, due to the inherent complexity of the constitutive relation, it is difficult to obtain an analytical solution of a bimodular bending components except in particular simple problems. Based on the existent simplified model, this paper solves analytically bending thin plates with different moduli in tension and compression. By using the continuity conditions of stress components in unknown neutral layer, we determine the location of the neutral layer, and derive the governing differential equation for deflection, the flexural rigidity, and the internal forces in the thin plate. We also use a circular thin plate with bimodulus to illustrate the application of this solution derived in this paper. The results show that the introduction of different moduli has influences on the flexural stiffness of the bending thin plate.
Historical Long-term Exposure to Pentachlorophenol Causing Risk of Cancer - A Community Study
Zheng, Rui-Zhi,Zhang, Qing-He,He, Yi-Xin,Zhang, Qian,Yang, Lin-Shen,Zhang, Zhi-Hua,Zhang, Xiu-Jun,Hu, Jing-Ting,Huang, Fen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: Pervious studies suggested occupational workers exposure to pentachlorophenol (PCP) might contribute to increased risk of cancer. However, few studies have focused on associations between PCP and cancer risk at the community level. Objective: The present study was to explore the cancer risk for the community population living long-term in a PCP contaminated area. Methods: All the cancer cases diagnosed in 2009-2011 in Tongling City were collected. The cancer patients' residencies were geo-referenced in each district. The historical PCP usage for each district of Tongling was calculated as the PCP pollution index, which was further used to divide into PCP exposure categories. Standardized rate ratios (SRRs) of cancer incidence were applied to detect the cancer risk as exposure grade elevated. Correlation analysis was performed to analyze the relationship between PCP pollution and cancer incidence. Results: A total of 5,288 cancer cases (3,451 male and 1,837 female) were identified. PCP usage was correlated with the incidence of leukemia (r=0.88, P=0.002) for males, and with cancer of the esophagus for males (r=0.83, P=0.008) and females (r=0.71, P=0.020). Compared with the low exposure category, significant SRRs for total cancer sites was obtained for high PCP exposure category (SRR=1.61, 95%CI=1.59-1.62). Most SRR values of the cancer sites were significantly increased as exposure grade elevated and exposure time extended. Conclusion: The present study found that community residents living in the PCP contaminated area had increased risk of cancers. Leukemias, lymphomas and nasopharyngeal and esophageal cancers are most possibly associated with PCP exposure.
Wind-induced vibration fragility of outer-attached tower crane to super-tall buildings: A case study
Yi Lu,Luo Zhang,Zheng He,Fan Feng,Feng Pan 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.5
To gain insight into the wind-induced safety concerns associated with attached tower cranes during the construction of super-tall buildings, a 606 m level frame-core tube super-tall building is selected to investigate the wind-induced vibration response and fragility of an outer-attached tower crane at all stages of construction. The wind velocity time history samples are artificially generated and used to perform dynamic response analyses of the crane to observe the effects of wind velocity and wind direction under its working and non-working resting state. The adverse effects of the relative displacement response at different connection supports are also identified. The wind-resistant fragility curves of the crane are obtained by introducing the concept of incremental dynamic analysis. The results from the investigation indicate that a large relative displacement between the supports can substantially amplify the response of the crane at high levels. Such an effect becomes more serious when the lifting arm is perpendicular to the plane of the connection supports. The flexibility of super-tall buildings should be considered in the design of outer-attached tower cranes, especially for anchorage systems. Fragility analysis can be used to specify the maximum appropriate height of the tower crane for each performance level.
Synergistic effect in low temperature co-pyrolysis of sugarcane bagasse and lignite
Shuang Yi,Xuan-ming He,Hong-tao Lin,Hui Zheng,Cui-hua Li,Chong Li 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.10
Sugarcane bagasse was co-pyrolyzed with lignite in a fixed bed reactor to investigate the possible interaction during co-pyrolysis. GC-MS revealed that the concentration of phenols and aliphatic compounds in the tar increased with the addition of sugarcane bagasse, while the content of aromatic compounds had the contradictory tendency. The phenol content in co-pyrolyzed tar reached 20.35%, which increased by 142.26% compared with the calculated values. The sugarcane bagasse decomposition peak partly overlapped with lignite pyrolysis peak from TG-DTG curves, which meant more interaction between lignite and sugarcane bagasse during the pyrolysis process. The difference between the experimental and calculated values of pyrolysis products yield, tar components, DTG values and kinetics analysis indicated the synergetic effect between lignite and sugarcane bagasse.
Jun-yi Sun,Jian-li Hu,Zhou-lian Zheng,Xiao-ting He,Huan-huan Geng 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.12
In this paper, based on the exact analytical solution of axisymmetric deformation of the circular membrane fixed at its edge under the action of uniformly-distributed loads, we propose a new method to be able to simultaneously determine Poisson's ratio and Young's modulus of elasticity for thin films. We also present a set of exact formulas used for simultaneously determining Poisson's ratio and Young's modulus of elasticity for free-standing thin films or coating thin films without residual stresses or pre-tension. This method has the advantages of simplicity and reliability, and it doesn’t involve the substrate effect.
Jun-yi Sun,Yang Rong,Xiao-ting He,Xiao-wei Gao,Zhou-lian Zheng 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.5
In this paper, the problem of axisymmetric deformation of the circular membrane fixed at its perimeter under the action of uniformly-distributed loads was resolved by exactly using power series method, and the solution of the problem was presented. An investigation into the so-called Hencky transformation was carried out, based on the solution presented here. The results obtained here indicate that the well-known Hencky solution is, without doubt, correct, but in the published papers the statement about its derivation is incorrect, and the so-called Hencky transformation is invalid and hence may not be extended to use as a general mathematical method.
Sun, Jun-Yi,Rong, Yang,He, Xiao-Ting,Gao, Xiao-Wei,Zheng, Zhou-Lian Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.5
In this paper, the problem of axisymmetric deformation of the circular membrane fixed at its perimeter under the action of uniformly-distributed loads was resolved by exactly using power series method, and the solution of the problem was presented. An investigation into the so-called Hencky transformation was carried out, based on the solution presented here. The results obtained here indicate that the well-known Hencky solution is, without doubt, correct, but in the published papers the statement about its derivation is incorrect, and the so-called Hencky transformation is invalid and hence may not be extended to use as a general mathematical method.