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Zhou Yongqin,Huang Ce,Chen Junjie,Shi Guijun,Zhou Meilan 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.6
Due to synchronous rectification based on Phase-shift full bridge converter is difficult to work in a state of soft switch, to solve this problem, this paper sets out an control approach of synchronous rectification based on the ZVZCS phase-shifted full-bridge, and the drive signal of synchronous rectification side uses leading-leg drive waveform after a certain time delay and applies the resonant principle in the switching process,not only keeping full bridge ZVZCS soft switching but also realizing MOSFET of the synchronous rectification ZVS. The simulation of saber and experimental research show that the converter has a good performance.
Lin Wang,Chongzhi Wu,Yongqin Li,Hanlong Liu,Wengang Zhang,Xiang Chen 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.12
Probabilistic risk assessment of slope failure evaluates the slope safety in a quantitative manner, which considers the failure probability and failure consequence simultaneously. However, risk assessment of unsaturated slope accounting for spatially variable soil-water characteristic curve (SWCC) model parameter and saturated hydraulic conductivity has been rarely reported. A probabilistic risk assessment approach is proposed in current study for rationally quantifying the unsaturated slope failure risk with the aid of Monte Carlo (MC) simulation. The SEEP/W and SLOPE/W modules contained in Geostudio software are applied to carry out deterministic analysis, where factor of safety (FS) of the unsaturated slope is calculated by Morgenstern–Price method. The spatially variable hydraulic parameters are characterized by their respective random fields that are transferred from the random void ratio field in this study, rather than generating them separately. The proposed approach is subsequently employed to an unsaturated slope example for exploring the influences of spatially variable void ratio. Results show that the unsaturated slope failure risk is considerably affected by the spatially variable void ratio, and the single exponential autocorrelation function (ACF) popularized in geotechnical engineering tends to underestimate the failure risk in the unsaturated slope risk assessment.
Xiaojiao Sima,Bo Jiang,Jia Fang,Yongqin He,Zhongxiang Fang,Saravana Kumar KM,Wei Ren,Lingling Qiu,Xiaomin Chen,Bingsong Zheng 한국식물생명공학회 2015 Plant biotechnology reports Vol.9 No.3
MicroRNAs (miRNAs) play a vital role in plant development and growth through negative regulation of post-transcriptional gene expression. Carya cathayensis (hickory) is an important species for dried nuts and oil in China, with high nutritional and economic value. The graft technique is an important strategy for hickory cultivation. To understand the role of miRNAs involved in the hickory graft process, we constructed three small ribonucleic acid (RNA) libraries from hickory rootstock (2 years old) and scion (1 year old) at 0, 7, and 14 days post-graft. Sequence analysis of the three libraries identified 21 conserved miRNAs belonging to 13 families, and 10 novel and 8 potentially novel miRNAs belonging to 15 families. Among these miRNAs, 12 miRNAs were differentially expressed during the graft process in hickory and twothirds were downregulated. Quantitative real-time polymerase chain reaction validated that 14 miRNAs and their expression trends were similar to the results obtained by Solexa sequencing. Further, a total of 89 target genes for conserved and 26 target genes for novel miRNAs were predicted. This study will help in understanding the roles and regulatory modes of miRNAs involvement in the hickory graft process.
Therapeutic inhibition of SGK1 suppresses colorectal cancer
Xuchun Liang,Chunling Lan,Guanming Jiao,Wencheng Fu,Xuesha Long,Yu An,Kejin Wang,Jinzhe Zhou,Ting Chen,Yongqin Li,Jiahong Xu,Qi Huang,Bin Xu,Junjie Xiao 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Colorectal cancer (CRC) is one of the leading causes of death worldwide. Thus, the development of new therapeutic targets for CRC treatment is urgently needed. SGK1 is involved in various cellular activities, and its dysregulation can result in multiple cancers. However, little is known about its roles and associated molecular mechanisms in CRC. In present study, we found that SGK1 was highly expressed in tumor tissues compared with peri-tumor samples from CRC patients. In vitro experiments revealed that SGK1 overexpression promoted colonic tumor cell proliferation and migration and inhibited cell apoptosis induced by 5-fluorouracil (5-FU), while SGK1 shRNA and inhibitors showed the inverse effects. Using CRC xenograft mice models, we demonstrated that knockdown or therapeutic inhibition of SGK1 repressed tumor cell proliferation and tumor growth. Moreover, SGK1 inhibitors increased p27 expression and promoted p27 nuclear accumulation in colorectal cancer cells, and p27 siRNAs could attenuate the repression of CRC cell proliferation induced by SGK1 inhibitors. Collectively, SGK1 promotes colorectal cancer development via regulation