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Zhen‑Xing Li,Chang‑Sheng Li,Seong‑Hoon Kim,Dong‑Woo Suh 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.1
Effect of initial pearlite morphology on the microstructure evolution during spheroidization annealing and subsequent hardeningtreatment was studied in hot-rolled 1.0C–1.5Cr bearing steel. The ferrite-to-austenite transformation in spheroidizationannealing can be accelerated by refining the pearlite interlamellar spacing and pearlite colony size. Decreasing interlamellarspacing is also beneficial to increasing the number density of undissolved cementite, leading to the refining of final spheroidizedcementite. During the re-austenitizing process of hardening treatment, the smaller initial spheroidized cementiteleads to faster cementite dissolution and finer undissolved cementite particles. The prior austenite grain size after hardeningtreatment can also be decreased by refining the initial pearlite microstructure.
( Yi Xing ),( Xiu Ying Chen ),( Zhen Liu ),( Hao Li ),( Hua Xiang Liu ),( Zhen Zhong Li ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.3
Galanin (Gal) is a 29-amino-acid neuropeptide which is expressed in superior cervical ganglion (SCG) neurons and plays a trophic role in the adult animal and acts as an inhibitory modulator of cholinergic and noradrenergic neurotransmission. Whether activation or inhibition of alpha-adrenoreceptors infl uences Gal mRNA expression in SCG neurons remains unknown. Here, we have evaluated the possible regulation of Gal mRNA expression with acute (4 h) and chronic (4 days) stimulation of alpha 1- and alpha 2-adrenoreceptor agonists or antagonists in primary cultured SCG neurons. The results showed that the amount of Gal mRNA expression in cultured SCG neurons increased significantly after chronic stimulation with alpha 2-adrenoreceptor antagonist yohimbine compared with control SCG neurons at the same time point, whereas the amount of Gal mRNA expression decreased significantly after chronic stimulation with alpha 2-adrenoreceptor agonist clonidine as compared with that in control group. All these effects were not dose-dependent on the administration of alpha 2-adrenoreceptor agonist clonidine or alpha 2-adrenoreceptor antagonist yohimbine. Alpha 1-adrenoreceptor agonist phenylephrine or antagonist prazosin chronic stimulation did not have effects on Gal mRNA expression. Acute exposure of these agents did not have effects on Gal mRNA expression. The present study showed that Gal may be regulated by activation or inhibition of alpha 2-adrenoreceptors, but not alpha 1-adrenoreceptors in sympathetic neurons.
BanBan Li,Jia Lin Li,Na Li,Shi-Zhou Qi,이현선,Le Zhang,Shan-Shan Xing,Zhen Dong Tuo,Long Cui 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.11
Two new furofuran lignans were isolated fromthe stems of Acanthopanax senticosus, along with sevenknown compounds. Their structures were all determined byspectroscopic analyses and chemical methods. All theisolates were evaluated for in vitro inhibitory activityagainst DGAT1 and DGAT2. Compounds 1 and 2 werefound to exhibit selective inhibitory activity on DGAT1with IC50 values 89.5 ± 1.5 and 57.5 ± 1.3 lM,respectively.
( Ju-dong Li ),( Xin-fei Xu ),( Jiong-jie Yu ),( Zhen-li Li ),( Hao Xing ),( Han Wu ),( Han Zhang ),( Chao Li ),( Ming-da Wang ),( Meng-chao Wu ),( Wan-yee Lau ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: A family history of liver cancer is regarded as a risk factor for hepatocellular carcinoma (HCC) development. We investigated the association between family history and cancer recurrence and survival in patients with hepatitis B virus (HBV)- related HCC. Methods: Patients who underwent curative resection of HBV-related HCC between 2003 and 2013 from a tertiary hepatobiliary center in China were enrolled in this study. A family history was defined as a self-reported history of primary liver cancer in the first-degree relatives. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare the overall survival (OS) and recurrence-free survival (RFS) between patients with and without a family history of liver cancer. Results: Of 1,112 patients, 183 patients (16.5%) had a family history of liver cancer. A family history was not associated with OS and RFS (P=0.994 and 0.428) in the entire cohort. Using PSM, 179 pairs of patients with and without a family history but with comparable baseline characteristics and operative variables were created. A family history was associated with decreased OS and RFS (P=0.042 and 0.006) in the PSM cohort. On multivariable Cox-regression analyses, a family history was significantly associated with decreased OS (HR: 1.574, 95% CI: 1.171-2.116, P=0.003) and RFS (HR: 1.534, 95% CI: 1.176-2.002, P=0.002) after adjusting for other prognostic factors. Conclusions: A family history of liver cancer was associated with decreased OS and RFS rates after curative resection in patients with HBV-related HCC.
( Liang Lei ),( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Zhen-li Li ),( Jun Han ),( Han Zhang ),( Hao Xing ),( Han Wu ),( Ming-da Wang ),( Chao Li ),( Zheng Wang ),( Feng Shen ),( Meng-chao Wu ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is very poor. According to the BCLC treatment recommendations, sorafenib or other palliative treatment (PT) is recommended as the first-line therapy when it happens. In real world, however, a significant number of selected patients with HCC and PVTT suffered from surgical resection (SR). Methods: PubMed, Embase, Medline and Cochrane library were searched for studies comparing SR with PT (including TACE, sorafenib, etc.) for HCC with PVTT, which were published before September 2017. Results: 4,810 patients from 7 studies were enrolled in this meta-analysis, which divided into the SR group (n = 2,344) and the PT group (n = 2476). When compared with the PT group, the pooled hazard ratio (HR) for the 1, 3 and 5-year OS rates of the SR group were 0.56 (95% CI 0.52-0.60, P=0.03), 0.56 (95% CI 0.53-0.59, P<0.001) and 0.55 (95% CI 0.54-0.57, P<0.001). For subgroup analysis, when compared with the mere TACE group, the pooled HR for the 1, 3 and 5-year OS rates of the SR group were 0.54 (95% CI 0.43-0.67, P=0.81), 0.75 (95% CI 0.65-0.87, P=0.25) and 0.76 (95% CI 0.67-0.88, P=0.25). Conclusions: This meta-analysis demonstrated SR had better OS than TACE or other palliative therapy for HCC with PVTT. SR may be suitable as the first-line treatment for selected patients with resectable HCC and removable PVTT.
Xing Zheng,Qiao Huang,Qing-gang Zheng,Zhen Li 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.83 No.1
The stability of cable-stayed bridges is an important factor considered during design. In recent years, the novel spatial diamond-shaped bridge pylon has shown its advantages in various aspects, including the static response and the stability performance with the development of cable-stayed bridge towards long-span and heavy-load. Based on the energy approach, this paper presents a practical calculation method of the completed state stability of a cable-stayed bridge with two spatial diamond-shaped pylons. In the analysis, the possible transverse buckling of the girder, the top pylon column, and the mid pylon columns are considered simultaneously. The total potential energy of the spatial diamond-shaped pylon cable-stayed bridge is calculated. And based on the principle of stationary potential energy, the transverse buckling coefficients and corresponding buckling modes are obtained. Furthermore, an example is calculated using the design parameters of the Changtai Yangtze River Bridge, a 1176 m cable-stayed bridge under construction in China, to verify the effectiveness and accuracy of the proposed method in practical engineering. The critical loads and the buckling modes derived by the proposed method are in good agreement with the results of the finite element method. Finally, cable-stayed bridges varying pylon and girder stiffness ratios and pylon geometric dimensions are calculated to discuss the applicability and advantages of the proposed method. And a further discussion on the degrees of the polynomial functions when assuming buckling modes are presented.
Xing‑Quan Liu,Zhe Li,Zhen‑Jia Peng,Rui‑Xun Wang,Zhi‑Quan Liu 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.1
Electroplated copper is a key electronic interconnect material in integrated circuits and printed circuits and inevitablyexposed to corrosive media in manufacturing processes. The present work reports, for the first time, that corrosion resistanceof electroplated copper in 4 wt% NaOH is enhanced via nanotwinned microstructure engineering. Nucleation and growthof oxide/hydroxide on nanotwinned copper are inhibited, attributed to existence of highly (111)-preferred grain orientationand high-density parallelly-aligned coherent twin boundaries at surface. This study unveils a novel anti-corrosion strategyof nantowinned microstructure engineering against alkaline etchant, and exhibits great application values in industrial electroplatingof copper, silver, or their alloys.
Multiscale cooling technology for data centers
Xing Zhang,Zhen Li,Zhi Guang He,Tao Ding,Jian Feng Han,Hanwen Cao 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.4
Huge amount of heat is generated in data centers and it needs to be removed to outdoors through cooling equipment. In recent years the energy consumption and heat dissipation density of data centers increases sharply. The cooling technology of data centers has become a hot research focus. This article orderly introduces three types of cooling technologies in different scales and some relevant experiments are included. Besides, the energy consumption of each cooling technology is analyzed.
Upregulation and biological function of transmembrane protein 119 in osteosarcoma
Zhen-Huan Jiang,Jun Peng,Hui-Lin Yang,Xing-Li Fu,Jin-Zhi Wang,Lei Liu,Jian-Nong Jiang,Yong-Fei Tan,Zhi-Jun Ge 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Osteosarcoma is suggested to be caused by genetic and molecular alterations that disrupt osteoblast differentiation. Recent studies have reported that transmembrane protein 119 (TMEM119) contributes to osteoblast differentiation and bone development. However, the level of TMEM119 expression and its roles in osteosarcoma have not yet been elucidated. In the present study, TMEM119 mRNA and protein expression was found to be up-regulated in osteosarcoma compared with normal bone cyst tissues. The level of TMEM119 protein expression was strongly associated with tumor size, clinical stage, distant metastasis and overall survival time. Moreover, gene set enrichment analysis (GSEA) of the Gene Expression Omnibus (GEO) GSE42352 dataset revealed TMEM119 expression in osteosarcoma tissues to be positively correlated with cell cycle, apoptosis, metastasis and TGF-β signaling. We then knocked down TMEM119 expression in U2OS and MG63 cells using small interfering RNA, which revealed that downregulation of TMEM119 could inhibit the proliferation of osteosarcoma cells by inducing cell cycle arrest in G0/G1 phase and apoptosis. We also found that TMEM119 knockdown significantly inhibited cell migration and invasion, and decreased the expression of TGF-β pathway-related factors (BMP2, BMP7 and TGF-β). TGF-β application rescued the inhibitory effects of TMEM119 knockdown on osteosarcoma cell migration and invasion. Further in vitro experiments with a TGF-β inhibitor (SB431542) or BMP inhibitor (dorsomorphin) suggested that TMEM119 significantly promotes cell migration and invasion, partly through TGF-β/BMP signaling. In conclusion, our data support the notion that TMEM119 contributes to the proliferation, migration and invasion of osteosarcoma cells, and functions as an oncogene in osteosarcoma.