Non-Contrast Cine Cardiac Magnetic Resonance Derived-Radiomics for the Prediction of Left Ventricular Adverse Remodeling in Patients With ST-Segment Elevation Myocardial Infarction

A Xin,Liu Mingliang,Chen Tong,Chen Feng,Qian Geng,Zhang Ying,Chen Yundai 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.9

Objective: To investigate the predictive value of radiomics features based on cardiac magnetic resonance (CMR) cine images for left ventricular adverse remodeling (LVAR) after acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods: We conducted a retrospective, single-center, cohort study involving 244 patients (random-split into 170 and 74 for training and testing, respectively) having an acute STEMI (88.5% males, 57.0 ± 10.3 years of age) who underwent CMR examination at one week and six months after percutaneous coronary intervention. LVAR was defined as a 20% increase in left ventricular end-diastolic volume 6 months after acute STEMI. Radiomics features were extracted from the oneweek CMR cine images using the least absolute shrinkage and selection operator regression (LASSO) analysis. The predictive performance of the selected features was evaluated using receiver operating characteristic curve analysis and the area under the curve (AUC). Results: Nine radiomics features with non-zero coefficients were included in the LASSO regression of the radiomics score (RAD score). Infarct size (odds ratio [OR]: 1.04 (1.00–1.07); P = 0.031) and RAD score (OR: 3.43 (2.34–5.28); P < 0.001) were independent predictors of LVAR. The RAD score predicted LVAR, with an AUC (95% confidence interval [CI]) of 0.82 (0.75–0.89) in the training set and 0.75 (0.62–0.89) in the testing set. Combining the RAD score with infarct size yielded favorable performance in predicting LVAR, with an AUC of 0.84 (0.72–0.95). Moreover, the addition of the RAD score to the left ventricular ejection fraction (LVEF) significantly increased the AUC from 0.68 (0.52–0.84) to 0.82 (0.70–0.93) (P = 0.018), which was also comparable to the prediction provided by the combined microvascular obstruction, infarct size, and LVEF with an AUC of 0.79 (0.65–0.94) (P = 0.727). Conclusion: Radiomics analysis using non-contrast cine CMR can predict LVAR after STEMI independently and incrementally to LVEF and may provide an alternative to traditional CMR parameters.

OsMSR15 encoding a rice C2H2-type zinc finger protein confers enhanced drought tolerance in transgenic Arabidopsis

Xin Zhang,Bin Zhang,Ming Juan Li,Xu Ming Yin,Li Fang Huang,Yan Chun Cui,Man Ling Wang,Xin Jie Xia 한국식물학회 2016 Journal of Plant Biology Vol.59 No.3

Zinc nger proteins (ZFPs) play important roles in plant responses to biotic and abiotic stresses. Through microarray analysis, an Oryza sativa L. multi-stress-responsive gene, OsMSR15, was identied and subsequently cloned from rice Pei’ai 64S (Oryza sativa L.). Expression of OsMSR15 was strongly up-regulated by cold, drought and heat stresses in different tissues at different developmental stages of rice. OsMSR15 contains two C2H2-type zinc nger motifs, a nuclear localization signal (B box), a Leu-rich domain (L-box) and a conserved EAR-motif close to its C-terminus. The OsMSR15-GFP fusion protein was localized to the nucleus. Yeast-one hybrid assay showed that OsMSR15 possesses transcriptional activation ability. Expression of OsMSR15 in Arabidopsis conferred drought tolerance, and transgenic plants showed hypersensitivity to exogenous ABA during the seed germination and post-germination stages. Transgenic plants also showed higher levels of free proline, less electrolyte leakage and increased expressions of a number of stress-responsive genes, including LEA3, RD29A, DREB1A and P5CS1 under drought stress. The obtained results indicate that OsMSR15 is an important regulator involved in plant response to drought stress.

Risk of Treatment-related Mortality with Sorafenib in Patients with Cancer

Zhang, Xin-Ji,Zhang, Tian-Yi,Yu, Fei-Fei,Wei, Xin,Li, Ye-Sheng,Xu, Feng,Wei, Li-Xin,He, Jia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

Baseline Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT Predict Outcomes in T-Cell Lymphoblastic Lymphoma

Xiaoyan Feng,Xin Wen,Ling Li,Zhenchang Sun,Xin Li,Lei Zhang,Jingjing Wu,Xiaorui Fu,Xinhua Wang,Hui Yu,Xinran Ma,Xudong Zhang,Xinli Xie,Xingmin Han,Mingzhi Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3

Purpose There is no optimal prognostic model for T-cell lymphoblastic lymphoma (T-LBL). Here, we discussed the predictive value of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured on 18F-fluorodeoxyglucose positron emission tomography–computed tomography (PET-CT) in T-LBL.Materials and Methods Thirty-seven treatment naïve T-LBL patients with PET-CT scans were enrolled. TMTV was obtained using the 41% maximum standardized uptake value (SUVmax) threshold method, and TLG was measured as metabolic tumor volume multiplied by the mean SUV. Progression-free survival (PFS) and overall survival (OS) were analyzed by Kaplan-Meier curves and compared by the log-rank test.Results The optimal cutoff values for SUVmax, TMTV, and TLG were 12.7, 302 cm3, and 890, respectively. A high SUVmax, TMTV, and TLG indicated a shorten PFS and OS. On multivariable analysis, TMTV ≥ 302 cm3, and central nervous system (CNS) involvement predicted inferior PFS, while high SUVmax, TLG and CNS involvement were associated with worse OS. Subsequently, we generated a risk model comprising high SUVmax, TMTV or TLG and CNS involvement, which stratified the population into three risk groups, which had significantly different median PFS of not reached, 14 months, and 7 months for low-risk group, mediate-risk group, and high-risk group, respectively (p < 0.001). Median OS were not reached, 27 months, and 13 months, respectively (p < 0.001).Conclusion Baseline SUVmax, TMTV, and TLG measured on PET-CT are strong predictors of worse outcome in T-LBL. A risk model integrating these three parameters with CNS involvement identifies patients at high risk of disease progression.

Fabrication of Photopolymer Hierarchical Micronanostructures by Coupling Electrospinning and Photolithography for SERS Substrates

Wen-Yi Zhang,Xin-Ze Xiao,Chao Lv,Jia Zhao,Gong Wang,Xuan Gu,Ran Zhang,Bin-Bin Xu,Dan-Dan Zhang,Ai-Wu Li,Yong-Lai Zhang,Hong-Bo Sun 한국고분자학회 2013 Macromolecular Research Vol.21 No.3

Reported here is the fabrication of photopolymer hierarchical micronanostructures through a combinative process of electrospinning and subsequent photolithography. Electrospun SU-8 (epoxy-based negative photoresist)nanofiber films have been patterned into gratings with periods of 100, 200, 300, and 400 μm, respectively. Deposition of a silver nanolayer on these interlaced nanofiber films would lead to the formation of various plasmonic nanostructures,and therefore, giving rise to abundant surface-enhanced Raman scattering (SERS) “hot spots”. In the detection of Rhodamine 6G (R6G), probing molecule, the resultant SERS substrates show both high sensitivity and good reproducibility. The SERS enhancement factor could reach as high as ~108, indicating high efficiency. The fabrication of patterned, highly efficient SERS substrates may hold a great promise for the integration of SERS substrates in various microdevices such as microfluidic chips.

A Boundary Protection for Power Distribution Line Based on Equivalent Boundary Effect

Zhang Xin,Mu Long-hua 대한전기학회 2013 Journal of Electrical Engineering & Technology Vol.8 No.2

A boundary protection method for power distribution line based on equivalent boundary effect is presented in this paper. In the proposed scheme, the equivalent resonance component with a certain central frequency is sleeve-mounted at the beginning of protected zone. The ‘Line Boundary’ is built by using boundary effect, which is created by introducing impedance in the primary-side of line. The ‘Line Boundary’ is significantly different from line wave impedance. Therefore, the boundary protection principle can be applied to power distribution line without line traps. To analyze the frequency characteristic corresponding to traveling-waves of introducing impedance in the primaryside of line, distributed parameters model of equivalent resonance component is established. The results of PSCAD/EMTDC simulation prove the obvious difference of voltage high frequency component between internal faults and external faults due to equivalent resonance component, and validate the scheme.

Surface structure-dependent hydrophobicity/oleophilicity of pyrite and its influence on coal flotation

Xin Qi,Xin Li,Yannan Liang,Hainan Wang,Wei Guo,Xingshun Cong,Fakui Lv,Haijun Zhang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.87 No.-

Flotation is an important method to remove the inorganic sulfur from coal. Its effect depends on thedifference in adhesion between coal and pyrite to air bubbles andflotation reagents. In this study, theinterface properties of coal powder/plate and pyrite powder/crystals were investigated using acomprehensive approach combining wetting process, induction time, contact angle, and X-rayphotoelectron spectroscopy. The experimental results show that the spreading and adsorption speedof diethyl phthalate on pyrite crystals and powder is close to that on coal surface in the air. However, theadsorption rate of pyrite to water is much higher than that of coal. In aqueous environment, it is difficultfor diethyl phthalate to spread on pyrite crystals, especially in alkaline solution. The difference ofhydrophobicity between coal and pyrite at air–water interface is smaller than that at oil–water interface. The adhesion of air bubble and reagent droplet on three pyrite facets is also different. The oxidation ofpyrite {100} is faster and greater than that of {210} and {111} facets in alkaline solution, which is beneficialto the coal desulfurization. Thesefindings disclose the hydrophobicity/oleophilicity and structure-reactivity dependence of pyrite in theflotation.

A New Multi-View and Controllable Community-Uncovering Algorithm

Zhang Xin,Wang Xiaolong,Liu Bingquan 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.7

This paper introduces a new multi-view and controllable community-uncovering algorithm, an achievement of improving PageRank algorithm and Spin-glass model, which can avoid the overlapping community structure in the process of detecting communities by means of other algorithms and also helps to improve the usual community-expansion model.The process of uncovering communities by the introduced algorithms can be divided into three steps: first, identifying the nuclear one among nodes ranked by the advanced PageRank algorithms; Second, through using multi-view recognition modularity provided by Potts spin-glass model, optimizing the expansion model of local community that is found by applying the improved Iterative Greedy algorithm to eliminate the traditional modularity’s limits in the resolution limit and the following negative effects. Finally, grasping the overlapping structure and notes carefully. By analyzing and comparing the two results of respectively using PRSGMFCA and traditional technical schemes in both computer simulation network and the real network, it proves that the former enjoys stronger stability and higher accuracy than the latter, and its computation complexity is also acceptable.

Research on the Model, Structure and Characteristics of a New Vibration Generator

Zhang, Qing-Xin,Yu, Li,Lin, Tong,Gao, Yun-Hong,Wang, Lu-Ping The Korean Institute of Electrical and Electronic 2016 Transactions on Electrical and Electronic Material Vol.17 No.6

The vibrational energy is prevalent in the natural environment, which is studied by energy researchers as a new energy resource in recent years. Vibration generation utilizes electromagnetic induction technology, piezoelectric technology and certain characteristics of smart materials to convert mechanical energy into electrical energy. In this paper, a new method of using MSMA (magnetic shape memory alloy) to generate electricity is proposed and the principle of generating electricity is demonstrated. Martensitic variants and magnetic domain characteristics of MSMA are analyzed. Combining with Gibbs free energy function thermal theory, the mathematics model of MSMA vibration generator is established. The basic structure of MSMA vibration generator is designed and simulation is done to analyze that the effects of generator output voltage when the input amplitude and frequency of vibration stress change. The simulation experiments verify the feasibility of using MSMA to make the micro vibration generators and the correctness of the mathematical model, which lays a good foundation for the further research and application of MSMA vibration generator.

Investigation on mechanics performance of cable-stayed-suspension hybrid bridges

Xin-Jun Zhang 한국풍공학회 2007 Wind and Structures, An International Journal (WAS Vol.10 No.6

The cable-stayed-suspension hybrid bridge is a cooperative system of the cable-stayed bridge and suspension bridge, and takes some advantages and also makes up some deficiencies of both the two bridge systems, and therefore becomes strong in spanning. By taking the cable-stayed-suspension hybrid bridge, suspension bridge and cable-stayed bridge with main span of 1400 m as examples, the mechanics performance including the static and dynamic characteristics, the aerostatic and aerodynamic stability etc is investigated by 3D nonlinear analysis. The results show that as compared to the suspension bridge and cable-stayed bridge, the cable-stayed-suspension hybrid bridge has greater structural stiffness, less internal forces and better wind stability, and is favorable to be used in super long-span bridges.